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1. 发明授权

US4963265A Plasma processing device with anaphylatoxin remover 失效
标题翻译：带过敏毒素去除剂的等离子体处理装置
公开(公告)号：US4963265A
公开(公告)日：1990-10-16
申请号：US191039
申请日：1988-05-06
申请人： Thomas B. Okarma , Brian R. Clark , L. Bernard Lerch , Chin-Hai Chang
发明人： Thomas B. Okarma , Brian R. Clark , L. Bernard Lerch , Chin-Hai Chang
IPC分类号： A61K35/16 , A61M1/36
CPC分类号： A61K35/16 , A61M1/3679 , Y10S210/908
摘要： Blood derived fluids are subjected to modification resulting in the production of anaphylatoxins. The anaphylatoxins may then be removed by passing the modified blood through silicic acid particles in an amount sufficient to substantially reduce the anaphylatoxins, while still retaining the other blood components and without affecting adversely the use of the blood for the patient.
摘要翻译：血液衍生的液体经过改变，导致过敏毒素的产生。然后可以通过使修饰的血液通过硅酸颗粒以足以大大减少过敏毒素的量，同时仍然保留其它血液成分并且不会不利地影响患者血液的使用而将经过过敏反应除去。

2. 发明授权

US5022988A Device for plasma modification--composition and remodeling 失效
标题翻译：用于等离子体改性的装置 - 组成和重塑
公开(公告)号：US5022988A
公开(公告)日：1991-06-11
申请号：US260382
申请日：1988-10-20
申请人： Thomas B. Okarma , Chin-Hai Chang , Brian R. Clark , L. Bernard Lerch
发明人： Thomas B. Okarma , Chin-Hai Chang , Brian R. Clark , L. Bernard Lerch
IPC分类号： A61K35/16 , A61M1/36
CPC分类号： A61M1/3679 , A61K35/16 , Y10S210/908 , Y10S530/814 , Y10T436/255
摘要： Compositions and devices are provided for the specific removal of components of plasma in efficient and economical ways. The devices provide for a tortuous path of the plasma through a high surface material to which is bound a binding compound for removal of the fluid component. The devices find particular application with plasma, in diagnosis, therapy, and for production of specific physiologically active materials.
摘要翻译：提供组合物和装置，用于以有效和经济的方式具体去除等离子体的组分。这些装置提供等离子体通过高表面材料的曲折路径，其中结合了结合化合物以去除流体组分。该装置在等离子体，诊断，治疗和用于生产特定生理活性物质方面具有特殊应用。

3. 发明授权

US5225328A Stable alkaline phosphatase compositions with color enhancement and their use in assays 失效
标题翻译：稳定的碱性磷酸酶组合物与颜色增强及其在测定中的使用
公开(公告)号：US5225328A
公开(公告)日：1993-07-06
申请号：US707718
申请日：1991-05-30
申请人： Chin-Hai Chang
发明人： Chin-Hai Chang
IPC分类号： G01N33/535
CPC分类号： G01N33/535
摘要： Methods and compositions for membrane flow-through assays using substrate and enzyme conjugate is described. A preferred method of the present invention comprises providing E. coli alkaline phosphatase (ECAP) conjugate, with additional color enhancement provided by combining lithium salt with the substrate, calcium and/or magnesium salts with the conjugate, and polyalcohol polymers with the conjugate. Color development is further enhanced by spotting tetrazolium dyes, such as the Nitro Blue tetrazolium series, onto the membrane.
摘要翻译：描述了使用底物和酶缀合物进行膜流通测定的方法和组合物。本发明的优选方法包括提供大肠杆菌碱性磷酸酶（ECAP）缀合物，其具有通过将锂盐与底物组合的另外的颜色增强，与缀合物的钙盐和/或镁盐以及与缀合物的多元醇聚合物。通过将四唑鎓染料（例如硝基蓝四唑系列）发现到膜上，进一步增强了显色。

4. 发明申请

US20100045774A1 SOLID-STATE PANORAMIC IMAGE CAPTURE APPARATUS 有权
标题翻译：固态全景图像捕捉设备
公开(公告)号：US20100045774A1
公开(公告)日：2010-02-25
申请号：US12545296
申请日：2009-08-21
申请人： Mei LEN , Chin-Hai Chang
发明人： Mei LEN , Chin-Hai Chang
IPC分类号： H04N7/00 , G02B13/06
CPC分类号： G02B13/06 , G03B37/00 , H04N5/2254 , H04N5/2259 , H04N5/23238
摘要： A panoramic camera system is disclosed that includes an unified optical system, an image capture device, and a processing unit. The unified optical system may include a first set of lenses that guide images received from horizontal directions of a target scene that surrounds the unified optical system. The unified optical system may also include a deflecting device that deflects the images guided through the first set of lenses and a second set of lenses that projects the images deflected by the deflecting device. The image capture device collects the projected images into a determined pattern based on the second set of lenses. Moreover, the processing unit processes the collected images from the image capture device to generate at least one of image signals and video signals representing a panoramic rendition of the target scene.
摘要翻译：公开了一种全景相机系统，其包括统一的光学系统，图像捕获装置和处理单元。统一的光学系统可以包括引导从包围统一光学系统的目标场景的水平方向接收的图像的第一组透镜。统一的光学系统还可以包括偏转装置，该偏转装置偏转引导穿过第一组透镜的图像和投影由偏转装置偏转的图像的第二组透镜。图像捕获装置基于第二组透镜将投影图像收集成确定的图案。此外，处理单元处理从图像捕获装置收集的图像，以产生表示目标场景的全景再现的图像信号和视频信号中的至少一个。

5. 发明授权

US06643841B2 Tape-out system of mask tooling network for multiple supply chain 有权
标题翻译：面向多个供应链的面具工具网络系统
公开(公告)号：US06643841B2
公开(公告)日：2003-11-04
申请号：US09956513
申请日：2001-09-19
申请人： Chin-Hai Chang , Teh-Sen Perng
发明人： Chin-Hai Chang , Teh-Sen Perng
IPC分类号： G06F1750
CPC分类号： G06F17/50
摘要： A tape-out system of a mask tooling network for multiple supply chain. The tape-out system includes an integrated circuit (IC) designer computer, a design service computer, and a mask house computer; wherein the IC designer computer, the design service computer and the mask house computer are the multi-users for the tape-out system. A network connects the IC designer computer, the design service computer and the mask house computer. A device design data and a product mask data are provided through the network from the IC designer computer to the design service computer. The device design data and the product mask data undergo a processing step and a summarizing step, so that a product mask tooling data is obtained, which is then transmitted through the network to the mark house computer and the IC designer computer. The mask house computer fabricates a mask in accordance with the product mask tooling data.
摘要翻译：用于多个供应链的掩模工具网络的出口系统。输出系统包括集成电路（IC）设计者计算机，设计服务计算机和面罩房屋计算机; 其中IC设计者计算机，设计服务计算机和面罩室计算机是用于带出系统的多用户。网络连接IC设计师计算机，设计服务计算机和面罩室电脑。通过网络从IC设计人员计算机向设计服务计算机提供设备设计数据和产品掩码数据。设备设计数据和产品掩模数据经历处理步骤和总结步骤，从而获得产品掩模工具数据，然后通过网络将其传送到标记室计算机和IC设计者计算机。面罩屋计算机根据产品掩模工具数据制造面罩。

6. 发明授权

US5256541A Detection of soluble alloantigen immune complexes 失效
标题翻译：可溶性同种异体抗原免疫复合物的检测
公开(公告)号：US5256541A
公开(公告)日：1993-10-26
申请号：US788488
申请日：1991-11-06
申请人： Philippe J. Pouletty , Chin-Hai Chang
发明人： Philippe J. Pouletty , Chin-Hai Chang
IPC分类号： G01N33/569 , G01N33/539 , G01N33/543 , G01N33/564
CPC分类号： G01N33/56977
摘要： Reactivity between alloantigen and alloantigen-specific ligand, such as HLA and anti-HLA antibody, is detectable in a sample by separating from the sample a portion of a targeted class of ligands (including such ligands complexed with alloantigen) and measuring the amount of alloantigen in such complex containing fractions. In another embodiment of the invention, reactivity between a plurality of samples is detected by measuring soluble alloantigen in at least first and second biological samples and in a mixture of the samples. Since the formation of alloantigen immune-complexes in the mixture alters the physical and immunological behavior of soluble alloantigen, a divergence between the measured and expected concentration of the mixture indicates reactivity.
摘要翻译：通过从样品中分离一部分目标类型的配体（包括与同种异体抗原复合的配体）和测量同种异体抗体的量，可以在样品中检测同种异体抗原和同种抗原特异性配体之间的反应性，例如HLA和抗HLA抗体在这种复杂含有的馏分中。在本发明的另一个实施方案中，通过在至少第一和第二生物样品中和样品的混合物中测量可溶性同种抗原来检测多个样品之间的反应性。由于混合物中同种异体抗原免疫复合物的形成改变了可溶性同种异体抗原的物理和免疫学行为，所以混合物的测量浓度和预期浓度之间的差异表明反应性。

7. 发明授权

US08305425B2 Solid-state panoramic image capture apparatus 有权
标题翻译：固态全景图像采集设备
公开(公告)号：US08305425B2
公开(公告)日：2012-11-06
申请号：US12545296
申请日：2009-08-21
申请人： Mei Len , Chin-Hai Chang
发明人： Mei Len , Chin-Hai Chang
IPC分类号： H04N7/00 , G02B13/06
CPC分类号： G02B13/06 , G03B37/00 , H04N5/2254 , H04N5/2259 , H04N5/23238
摘要： A panoramic camera system is disclosed that includes an unified optical system, an image capture device, and a processing unit. The unified optical system may include a first set of lenses that guide images received from horizontal directions of a target scene that surrounds the unified optical system. The unified optical system may also include a deflecting device that deflects the images guided through the first set of lenses and a second set of lenses that projects the images deflected by the deflecting device. The image capture device collects the projected images into a determined pattern based on the second set of lenses. Moreover, the processing unit processes the collected images from the image capture device to generate at least one of image signals and video signals representing a panoramic rendition of the target scene.
摘要翻译：公开了一种全景相机系统，其包括统一的光学系统，图像捕获装置和处理单元。统一的光学系统可以包括引导从包围统一光学系统的目标场景的水平方向接收的图像的第一组透镜。统一的光学系统还可以包括偏转装置，该偏转装置偏转引导穿过第一组透镜的图像和投影由偏转装置偏转的图像的第二组透镜。图像捕获装置基于第二组透镜将投影图像收集成确定的图案。此外，处理单元处理从图像捕获装置收集的图像，以产生表示目标场景的全景再现的图像信号和视频信号中的至少一个。

8. 发明授权

US5534412A Alloantigen enhancement assay 失效
标题翻译：异源抗原增强试验
公开(公告)号：US5534412A
公开(公告)日：1996-07-09
申请号：US315203
申请日：1994-09-29
申请人： Philippe Pouletty , Chin-Hai Chang
发明人： Philippe Pouletty , Chin-Hai Chang
IPC分类号： G01N33/569 , G01N33/536 , G01N33/543
CPC分类号： G01N33/56977 , Y10S435/962 , Y10S435/967
摘要： Methods and compositions are provided for the determination of cross-reactive alleles, where there is no antibody which will specifically distinguish between the two alleles. Particularly, the method employs an antibody which binds to the two alleles bound to a surface, an antibody specific for one of the alleles, a labeled conjugate which binds to a consensus sequence present in both alleles and positive and negative controls. By having an enhanced value where the interfering allele is present as compared to a value for the target allele, one can distinguish between the various alternatives involving the presence or absence of one or both alleles.
摘要翻译：提供了用于确定交叉反应性等位基因的方法和组合物，其中不存在将特异性区分两个等位基因的抗体。特别地，该方法采用结合表面的两个等位基因的抗体，对一个等位基因特异性的抗体，与两个等位基因和阳性和阴性对照中存在的共有序列结合的标记的缀合物。通过与目标等位基因的值相比，具有干扰等位基因存在的增强值，可以区分涉及一个或两个等位基因的存在或不存在的各种替代物。

9. 发明授权

US5270169A Detection of HLA antigen-containing immune complexes 失效
标题翻译：检测含HLA抗原的免疫复合物
公开(公告)号：US5270169A
公开(公告)日：1993-12-14
申请号：US902971
申请日：1992-06-23
申请人： Chin-Hai Chang , Philippe Pouletty
发明人： Chin-Hai Chang , Philippe Pouletty
IPC分类号： G01N33/564 , G01N33/569 , G01N33/537 , G01N33/577
CPC分类号： G01N33/564 , G01N33/56977 , Y10S435/969 , Y10S435/975
摘要： The invention provides for methods and compositions to detect the presence of anti-HLA antibodies, HLA antigen or preformed HLA-containing immune complexes in biological samples. The complement protein Clq is bound to a solid substrate, then mixed with a biological sample containing immune complexes. The immune complexes are preformed, or formed by adding HLA antigens to a biological sample containing antibodies to HLA, or alternatively, by combining a biological sample containing HLA antigens with defined antibodies to HLA. The immune complexes bind to Clq, and are then detected by the addition of a labeled reagent.
摘要翻译：本发明提供了用于检测生物样品中抗HLA抗体，HLA抗原或预先含有HLA的免疫复合物的存在的方法和组合物。补体蛋白Clq与固体底物结合，然后与含有免疫复合物的生物样品混合。免疫复合物预先形成，或者通过将HLA抗原加入到含HLA抗体的生物样品中，或者通过将含有HLA抗原的生物样品与HLA的定义的抗体组合而形成。免疫复合物与Clq结合，然后通过加入标记的试剂进行检测。

10. 发明授权

US4599307A Method for elimination of selected cell populations in analytic cytology 失效
标题翻译：在分析细胞学中消除所选细胞群的方法
公开(公告)号：US4599307A
公开(公告)日：1986-07-08
申请号：US514425
申请日：1983-07-18
申请人： Alex M. Saunders , Chin-Hai Chang
发明人： Alex M. Saunders , Chin-Hai Chang
IPC分类号： G01N33/52 , G01N33/50 , G01N33/53 , G01N33/569 , G01N33/533
CPC分类号： G01N33/56972
摘要： A method for identifying subpopulations of cells of interest without interference from other cells. In the method, a sample of at least three (3) types of cells, including a first and second type of cell which form a subpopulation of cells of interest and a third type of cell which interferes with the identification of said subpopulation, is divided into at least two (2) aliquots. A first antibody which is specific for the third type of interfering cells but not for the subpopulation, is labeled with two (2) fluorochromes, each of the fluorochromes having distinct emission spectra. The labeled first antibody is then added to a first one of the sample aliquots so as to label the third type of cells with the first antibody. A first analysis is performed by analyzing each cell to determine the fluorescence emitted and to count the third type of cells so as to distinguish the third type of cells from the subpopulation. The information obtained from the first analysis is retained for subsequent use. The above steps are repeated for the subpopulation of cells of interest and a second analysis is obtained. The retained information from the first analysis is used to remove the effect of the third type of interfering cells and to provide a direct proportional analysis of the first and second types of cells in the subpopulation of cells of interest.
摘要翻译：用于识别感兴趣的细胞的亚群而不受其他细胞的干扰的方法。在该方法中，分离至少三（3）种细胞的样品，包括形成感兴趣细胞亚群的第一和第二类型的细胞和干扰所述亚群体的鉴定的第三类细胞被分割至少两（2）份。对于第三种类型的干扰细胞而言不是亚群的第一种抗体用两（2）种荧光染料标记，每种荧光染料具有不同的发射光谱。然后将标记的第一抗体加入到样品等分试样的第一个样品中，以便用第一抗体标记第三类型的细胞。通过分析每个细胞以确定发射的荧光并计数第三类型的细胞以便将第三类型的细胞与亚群区分开来进行第一次分析。从第一次分析获得的信息保留供后续使用。针对感兴趣的细胞的亚群重复上述步骤，并获得第二次分析。来自第一次分析的保留的信息用于去除第三类干扰细胞的作用，并提供感兴趣的细胞亚群中第一和第二类细胞的直接比例分析。

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