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1. 发明授权

US4849412A Methods and compositions for treating viral infections 失效
标题翻译：用于治疗病毒感染的方法和组合物
公开(公告)号：US4849412A
公开(公告)日：1989-07-18
申请号：US944301
申请日：1986-12-19
申请人： Thomas Albrecht , Chan H. Lee , Odd S. Steinsland
发明人： Thomas Albrecht , Chan H. Lee , Odd S. Steinsland
IPC分类号： A61K31/485 , A61K31/52 , A61K38/21 , A61K45/06
CPC分类号： A61K45/06 , A61K31/485 , A61K31/52 , A61K38/212 , Y10S514/934
摘要： The disclosure demonstrates the inhibition of replication of human cytomegalovirus (HCMV) in cultured human embryo skin muscle cells by two separate subclasses of direct-acting smooth muscle relaxing agents alone or in combination with each other. These two subclasses are characterized mechanistically as calcium influx blockers (or calcium channel blockers) and cyclic nucleotide modulators. More specifically, the class of calcium influx blockers is exemplified by the drugs verapamil (and methoxyverapamil), nifedipine (the prototype drug of 1,4 dihydropyridines), and diltiazem. The class of cyclic nucleotide modulators is exemplified by the drugs isobutylmethylxanthine, papaverine (and its synthetic analog dioxyline), forskolin, and sodium nitroprusside. In addition, the present disclosure demonstrates that agents from one class, e.g., a calcium influx blocker, act synergistically when used in combination with agents from the other class, e.g., cyclic nucleotide modulators. The calcium influx blockers are shown to act synergistically when used in combination with alpha inThe government may own rights in the present invention pursuant to NIH contract NO1-AI42557.
摘要翻译：本公开内容显示了通过直接作用的平滑肌松弛剂单独或彼此组合的两个独立的亚类，抑制人巨细胞病毒（HCMV）在培养的人类胚胎皮肤细胞中的复制。这两个亚类机械地表征为钙流入阻断剂（或钙通道阻滞剂）和环状核苷酸调节剂。更具体地，钙流入阻断剂的类别是药物维拉帕米（和甲氧威韦帕米），硝苯地平（1,4二氢吡啶类的原型药物）和地尔硫卓。环状核苷酸调节剂的类别由药物异丁基甲基黄嘌呤，罂粟碱（及其合成的模拟二恶草毒素），福斯高林和硝普钠钠来举例说明。此外，本公开内容表明，当与来自另一类的试剂（例如环状核苷酸调节剂）组合使用时，来自一类的药剂，例如钙流入阻断剂，协同作用。当与α-干扰素组合使用时，钙流出阻断剂显示出协同作用。在另外的实施方案中，罂粟碱家族成员被证明与抗病毒核苷类似物协同地发挥抗病毒活性。

2. 发明授权

US4782065A Methods and compositions for treating viral infections 失效
标题翻译：用于治疗病毒感染的方法和组合物
公开(公告)号：US4782065A
公开(公告)日：1988-11-01
申请号：US2981
申请日：1987-01-13
申请人： Thomas Albrecht , Odd S. Steinsland
发明人： Thomas Albrecht , Odd S. Steinsland
IPC分类号： A61K31/275 , A61K31/35 , A61K31/44 , A61K31/485 , A61K31/52 , A61K31/55 , A61K33/26 , A61K31/47
CPC分类号： A61K31/44 , A61K31/275 , A61K31/35 , A61K31/485 , A61K31/52 , A61K31/55 , A61K33/26 , Y10S514/934
摘要： The disclosure demonstrates the inhibition of replication of human cytomegalovirus (HCMV) in cultured human embryo skin muscle cells by two separate subclasses of direct-acting smooth muscle relaxing agents. These two subclasses are characterized mechanistically as calcium influx blockers (or calcium channel blockers) and cyclic nucleotide modulators. More specifically, the class of calcium influx blockers is exemplified by the drugs verapamil (and methoxyverapamil), nifedipine (the prototype drug of 1,4 dihydropyridines), and diltiazem. The class of cyclic nucleotide modulators is exemplified by the drugs isobutylmethylxanthine, papaverine (and its synthetic analog dioxyline), forskolin, and sodium nitroprusside. All of these agents inhibit replication of HCMV and HSV.
摘要翻译：该公开内容显示通过直接作用的平滑肌松弛剂的两个独立的亚类抑制人巨细胞病毒（HCMV）在培养的人胚胎皮肤细胞中的复制。这两个亚类机械地表征为钙流入阻断剂（或钙通道阻滞剂）和环状核苷酸调节剂。更具体地，钙流入阻断剂的类别是药物维拉帕米（和甲氧威韦帕米），硝苯地平（1,4二氢吡啶类的原型药物）和地尔硫卓。环状核苷酸调节剂的类别由药物异丁基甲基黄嘌呤，罂粟碱（及其合成的模拟二恶草毒素），福斯高林和硝普钠钠来举例说明。所有这些药物都抑制HCMV和HSV的复制。

3. 发明授权

US4663317A Methods and compositions for treating viral infections 失效
公开(公告)号：US4663317A
公开(公告)日：1987-05-05
申请号：US601471
申请日：1984-04-18
申请人： Thomas Albrecht , Odd S. Steinsland
发明人： Thomas Albrecht , Odd S. Steinsland
IPC分类号： A61K31/275 , A61K31/35 , A61K31/44 , A61K31/485 , A61K31/52 , A61K31/55 , A61K33/26
CPC分类号： A61K33/26 , A61K31/275 , A61K31/35 , A61K31/44 , A61K31/485 , A61K31/52 , A61K31/55 , Y10S514/929 , Y10S514/934
摘要： The disclosure demonstrates the inhibition of replication of human cytomegalovirus (HCMV) in cultured human embryo skin muscle cells by two separate subclasses of direct-acting smooth muscle relaxing agents. These two subclasses are characterized mechanistically as calcium influx blockers (or calcium channel blockers) and cyclic nucleotide modulators. More specifically, the class of calcium influx blockers is exemplified by the drugs verapamil (and methoxyverapamil), nifedipine (the prototype drug of 1,4 dihydropyridines), and diltiazem. The class of cyclic nucleotide modulators is exemplified by the drugs isobutylmethylxanthine, papaverine (and its synthetic analog dioxyline), forskolin, and sodium nitroprusside. All of these agents inhibit replication of HCMV and HSV.

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