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1. 发明申请

US20050147647A1 Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same 有权
标题翻译：包含亲水物质的可植入医疗装置用涂料及其制造方法
公开(公告)号：US20050147647A1
公开(公告)日：2005-07-07
申请号：US10746483
申请日：2003-12-24
申请人： Thierry Glauser , Connie Kwok , Charles Claude , Eugene Michal , Yiwen Tang , Irina Astafieva , Stephen Pacetti , John Whatley , Ashok Shah
发明人： Thierry Glauser , Connie Kwok , Charles Claude , Eugene Michal , Yiwen Tang , Irina Astafieva , Stephen Pacetti , John Whatley , Ashok Shah
IPC分类号： A61F2/00 , A61L31/10 , A61L31/16 , A61F2/06
CPC分类号： A61L31/16 , A61F2250/0067 , A61L31/10 , A61L2300/252 , A61L2300/606 , C08L75/04
摘要： A segmented polyurethane and an amphiphilic random or block copolymer are disclosed. The segmented polyurethane and the amphiphilic random or block copolymer can be used for fabricating a coating for an implantable medical device such as a stent.
摘要翻译：公开了一种分段聚氨酯和两亲无规或嵌段共聚物。分段聚氨酯和两亲无规或嵌段共聚物可用于制造可植入医疗装置例如支架的涂层。

2. 发明申请

US20050244363A1 Hyaluronic acid based copolymers 有权
标题翻译：透明质酸基共聚物
公开(公告)号：US20050244363A1
公开(公告)日：2005-11-03
申请号：US10835912
申请日：2004-04-30
申请人： Syed Hossainy , Eugene Michal , Thierry Glauser , Connie Kwok , Stephen Pacetti
发明人： Syed Hossainy , Eugene Michal , Thierry Glauser , Connie Kwok , Stephen Pacetti
IPC分类号： A61K31/727 , A61K31/728 , A61K31/785 , A61L27/00 , A61L31/10 , C08G63/48
CPC分类号： A61L31/10 , A61K31/727 , A61K31/728 , A61K31/785 , A61L31/16 , A61K2300/00 , C08L5/08 , C08L5/10
摘要： Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
摘要翻译：提供了用于涂覆可植入装置的透明质酸（HA）缀合物或交联的HA组合物。可植入装置可用于治疗动脉粥样硬化，血栓形成，再狭窄，高胆固醇，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管梗阻，输尿管阻塞，肿瘤阻塞及其组合。

3. 发明授权

US08293890B2 Hyaluronic acid based copolymers 有权
标题翻译：透明质酸基共聚物
公开(公告)号：US08293890B2
公开(公告)日：2012-10-23
申请号：US10835912
申请日：2004-04-30
申请人： Syed Faiyaz Ahmed Hossainy , Eugene Michal , Thierry Glauser , Connie Kwok , Stephen Dirk Pacetti
发明人： Syed Faiyaz Ahmed Hossainy , Eugene Michal , Thierry Glauser , Connie Kwok , Stephen Dirk Pacetti
IPC分类号： A61F2/00 , C07H3/00 , C08B37/00 , C12P19/04
CPC分类号： A61L31/10 , A61K31/727 , A61K31/728 , A61K31/785 , A61L31/16 , A61K2300/00 , C08L5/08 , C08L5/10
摘要： Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
摘要翻译：提供了用于涂覆可植入装置的透明质酸（HA）缀合物或交联的HA组合物。可植入装置可用于治疗动脉粥样硬化，血栓形成，再狭窄，高胆固醇，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管梗阻，输尿管阻塞，肿瘤阻塞及其组合。

4. 发明申请

US20090226519A1 Hydrogel bioscaffoldings and biomedical device coatings 有权
标题翻译：水凝胶生物支架和生物医学装置涂料
公开(公告)号：US20090226519A1
公开(公告)日：2009-09-10
申请号：US11110223
申请日：2005-04-19
申请人： Charles Claude , Connie Kwok , Gene Michal , Jihong Qu , Sophia Liao
发明人： Charles Claude , Connie Kwok , Gene Michal , Jihong Qu , Sophia Liao
IPC分类号： A61K9/14 , A61K35/12 , A61K38/16 , A61P9/00
CPC分类号： A61L27/3834 , A61L27/26 , A61L27/3826 , A61L27/383 , A61L27/3873 , A61L27/52 , C08L89/06 , C08L5/08
摘要： Bioscaffoldings formed of hydrogels that are crosslinked in situ in an infarcted region of the heart (myocardium) by a Michael's addition reaction or by a disulfide bond formed by an oxidative process are described. Each of the bioscaffoldings described includes hyaluronan as one of the hydrogel components and the other component is selected from collagen, collagen-laminin, poly-1-lysine, and fibrin. The bioscaffolding may further include an alginate component. The bioscaffoldings may have biofunctional groups such as angiogenic factors and stem cell homing factors bound to the collagen, collagen-laminin, poly-1-lysine, or fibrinogen hydrogel component. In particular, the biofunctional groups may be PR11, PR39, VEGF, bFGF, a polyarginine/DNA plasmid complex, or a DNA/polyethyleneimine (PEI) complex. Additionally, the hydrogel components may be injected into the infarct region along with stem cells and microspheres containing stem cell homing factors. The bioscaffolding may be formed on a stent or a cardiac medical device.
摘要翻译：描述了由水凝胶形成的生物支架，其通过迈克尔加成反应或通过氧化过程形成的二硫键在心脏（心肌）的梗死区域原位交联。所描述的每个生物支架包括透明质酸作为水凝胶组分之一，另一组分选自胶原，胶原 - 层粘连蛋白，聚-1-赖氨酸和纤维蛋白。生物支架还可包括藻酸盐组分。生物支架可具有诸如血管生成因子和与胶原，胶原 - 层粘连蛋白，聚-1-赖氨酸或纤维蛋白原水凝胶组分结合的干细胞归巢因子的生物功能组。特别地，生物功能组可以是PR11，PR39，VEGF，bFGF，聚精氨酸/ DNA质粒复合物或DNA /聚乙烯亚胺（PEI）复合物。此外，水凝胶组分可以与含有干细胞归巢因子的干细胞和微球一起注入梗塞区域。生物支架可以形成在支架或心脏医疗装置上。

5. 发明授权

US08828433B2 Hydrogel bioscaffoldings and biomedical device coatings 有权
标题翻译：水凝胶生物支架和生物医学装置涂料
公开(公告)号：US08828433B2
公开(公告)日：2014-09-09
申请号：US11110223
申请日：2005-04-19
申请人： Charles Claude , Connie Kwok , Gene Michal , Jihong Qu , Sophia Liao
发明人： Charles Claude , Connie Kwok , Gene Michal , Jihong Qu , Sophia Liao
IPC分类号： A61K9/14
CPC分类号： A61L27/3834 , A61L27/26 , A61L27/3826 , A61L27/383 , A61L27/3873 , A61L27/52 , C08L89/06 , C08L5/08
摘要： Bioscaffoldings formed of hydrogels that are crosslinked in situ in an infarcted region of the heart (myocardium) by a Michael's addition reaction or by a disulfide bond formed by an oxidative process are described. Each of the bioscaffoldings described includes hyaluronan as one of the hydrogel components and the other component is selected from collagen, collagen-laminin, poly-1-lysine, and fibrin. The bioscaffolding may further include an alginate component. The bioscaffoldings may have biofunctional groups such as angiogenic factors and stem cell homing factors bound to the collagen, collagen-laminin, poly-1-lysine, or fibrinogen hydrogel component. In particular, the biofunctional groups may be PR11, PR39, VEGF, bFGF, a polyarginine/DNA plasmid complex, or a DNA/polyethyleneimine (PEI) complex. Additionally, the hydrogel components may be injected into the infarct region along with stem cells and microspheres containing stem cell homing factors. The bioscaffolding may be formed on a stent or a cardiac medical device.
摘要翻译：描述了由水凝胶形成的生物支架，其通过迈克尔加成反应或通过氧化过程形成的二硫键在心脏（心肌）的梗死区域原位交联。所描述的每个生物支架包括透明质酸作为水凝胶组分之一，另一组分选自胶原，胶原 - 层粘连蛋白，聚-1-赖氨酸和纤维蛋白。生物支架还可包括藻酸盐组分。生物支架可具有诸如血管生成因子和与胶原，胶原 - 层粘连蛋白，聚-1-赖氨酸或纤维蛋白原水凝胶组分结合的干细胞归巢因子的生物功能组。特别地，生物功能组可以是PR11，PR39，VEGF，bFGF，聚精氨酸/ DNA质粒复合物或DNA /聚乙烯亚胺（PEI）复合物。此外，水凝胶组分可以与含有干细胞归巢因子的干细胞和微球一起注入梗塞区域。生物支架可以形成在支架或心脏医疗装置上。

6. 发明申请

US20060204537A1 Silicone blends and composites for drug delivery 审中-公开
标题翻译：硅胶混合物和复合材料用于药物递送
公开(公告)号：US20060204537A1
公开(公告)日：2006-09-14
申请号：US10518562
申请日：2003-06-20
申请人： Buddy Ratner , Connie Kwok , Katie Walline , Erika Johnston , Robert Miller
发明人： Buddy Ratner , Connie Kwok , Katie Walline , Erika Johnston , Robert Miller
IPC分类号： A61K48/00 , A61K31/4745 , A61F2/02
CPC分类号： A61K9/0024 , A61K9/2031 , A61K9/2036 , A61K9/7007 , A61K48/00 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , A61L2300/602 , A61L2420/06 , A61L2420/08 , C08L83/04
摘要： The present invention provides a composition for use in delivering a drug into the body of a mammal, wherein the composition comprises silicone elastomer, an adjuvant polymer, and the drug. This composition may be part of an implantable medical device, such as a stent or a vascular or other graft or sheath, among other configurations. When the compositions are used as coating, the coating may further include a topcoat of silicone or silicone and adjuvant polymer mixture.
摘要翻译：本发明提供了用于将药物递送到哺乳动物体内的组合物，其中所述组合物包含硅氧烷弹性体，辅助聚合物和药物。该组合物可以是植入式医疗装置的一部分，例如支架或血管或其它移植物或鞘，以及其它构型。当组合物用作涂层时，涂层还可以包括硅氧烷或硅氧烷和助剂聚合物混合物的面漆。

7. 发明申请

US20060127320A1 Method of delivering parathyroid hormone to a human 审中-公开
标题翻译：甲状旁腺激素给人的方法
公开(公告)号：US20060127320A1
公开(公告)日：2006-06-15
申请号：US11347551
申请日：2006-02-03
申请人： Henry Costantino , Connie Kwok
发明人： Henry Costantino , Connie Kwok
IPC分类号： A61L9/04 , A61M11/00 , A61K38/29
CPC分类号： A61K9/0043 , A61K31/724 , A61K38/29 , A61K47/40 , A61M15/08
摘要： What is described is a method of delivering PTH to a human, comprising exposing a layer of mucosal cells to a mixture of PTH and an enhancer, wherein the enhancer is capable of modulating the barrier function of a cellular tight junction. Specifically, the method of delivering PTH to a human by intranasal administration comprises use of an aqueous solution of growth and excipients in a bottle and a droplet-generating actuator attached to the bottle and fluidly connected to the PTH solution in the container, wherein the actuator produces a spray of the PTH solution through a tip of the actuator when the actuator is engaged, wherein the spray of PTH solution has a spray pattern ellipticity ratio of from about 1.0 to about 1.4 when measured at a height of 3.0 cm from the actuator tip.
摘要翻译：所描述的是将PTH递送到人的方法，包括将粘膜细胞层暴露于PTH和增强子的混合物，其中增强剂能够调节细胞紧密连接的屏障功能。具体地说，通过鼻内给药将PTH递送给人的方法包括使用瓶中的生长和赋形剂的水溶液和附着在瓶子上的液滴产生致动器并且流体连接到容器中的PTH溶液，其中致动器当致动器接合时，通过致动器的尖端产生PTH溶液的喷雾，其中在距离致动器尖端3.0cm的高度处测量时，PTH溶液的喷雾具有约1.0至约1.4的喷雾图案椭圆率。

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