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1. 发明授权

US10312071B2 Dynamic range improvement for isotope ratio mass spectrometry 有权
公开(公告)号：US10312071B2
公开(公告)日：2019-06-04
申请号：US15227196
申请日：2016-08-03
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Jens Radke , Andreas Hilkert , Anne Trinquier , Johannes Schwieters
IPC分类号： B01D59/44 , H01J49/00 , H01J49/02 , H01J49/30
摘要： In a mass spectrometer, a mass-to-charge dispersive element separates received ions spatially according to their mass-to-charge ratios, to provide a dispersed ion beam thereby. An ion detection arrangement that detects the dispersed ion beam comprises: at least one primary ion detector, each detecting spatially separated ions having mass-to-charge ratios within a respective desired range and each providing a respective main beam signal based on its respective detected ions; and at least one secondary ion detector, each detecting ions having mass-to-charge ratios outside all of the desired ranges simultaneously with the at least one primary ion detector detecting the spatially separated ions and each providing a respective background signal based on its respective detected ions. At least one mass intensity measurement is provided for the received ions having a mass-to-charge ratio within the desired range, based on the at least one main beam signal and the at least one background signal.

2. 发明申请

US20160266031A1 Method of Measuring Isotope Ratio 有权
标题翻译：测量同位素比率的方法
公开(公告)号：US20160266031A1
公开(公告)日：2016-09-15
申请号：US15035736
申请日：2014-11-10
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Hans-Juergen Schlueter , Oliver Kracht , Jens Radke , Benno Strasser , Johannes Schwieters , Eric Wapelhorst
IPC分类号： G01N21/27 , G01N33/00 , G01N21/31
CPC分类号： G01N21/276 , G01N21/31 , G01N21/3504 , G01N33/0006 , G01N33/004 , H01J49/0009
摘要： An isotope ratio of a continuous sample is measured in an isotope ratio spectrometer. At least one sample isotope ratio is measured over a measurement time period tns, (n≧1) and a sample concentration cns is measured over at least a part of the measurement time period cns. A reference gas concentration cnref for the spectrometer is selected for reference to the sample measured during the measurement time period tns, on the basis of the measured sample concentration cnref. An isotope ratio of the reference gas is measured at the selected reference gas concentration cnref in the spectrometer. The at least one isotope ratio of the sample measured during the measurement time period tnref is calibrated using the measured isotope ratio of the reference gas at the corresponding reference gas concentration cnref and a plurality of calibrated isotope ratios and a plurality of sample gas concentration measurements are determined, each being for a different time.
摘要翻译：在同位素比光谱仪中测量连续样品的同位素比。在测量时间段tns（n≥1）下测量至少一个样品同位素比，并且在测量时间段cns的至少一部分上测量样品浓度cns。选择用于光谱仪的参考气体浓度cnref以参考在测量时间段tns期间测量的样品，基于测量的样品浓度cnref。在光谱仪中以选定的参考气体浓度cnref测量参考气体的同位素比。在测量时间段tnref期间测量的样品的至少一个同位素比使用在相应参考气体浓度cnref和多个校准同位素比率下的参考气体的测量同位素比进行校准，并且多个样品气体浓度测量值确定，每个都在不同的时间。

3. 发明授权

US11024496B2 Inert non-adsorbing crimpable capillaries and devices for adjusting gas flow in isotope ratio analysis 有权
公开(公告)号：US11024496B2
公开(公告)日：2021-06-01
申请号：US16290443
申请日：2019-03-01
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Michael Krummen , Jens Radke , Johannes Schwieters , Nils Stoebener , Ronald Seedorf
IPC分类号： H01J49/00 , H01J49/04
摘要： A gas transfer system for transferring gas into an analytical instrument for isotope ratio analysis comprises a capillary for delivering sample and/or reference gas from a gas source, a first connector for connecting the capillary to the gas source, a second connector for connecting the capillary to the analytical instrument, a crimping device, wherein the internal surface of the capillary comprises a coating material to prevent or minimize adsorption of water to the surface. Also provided is a device for regulating gas flow in a gas inlet system of an analytical instrument, comprising a body member having an internal gas flow channel, and a clamping member for attachment to the body member such that when the clamping member is tightened onto the body member, the internal gas flow channel is adjustably and reversibly crimped, to adjust gas flow therethrough.

4. 发明授权

US11583805B2 Isotope ratio measurement 有权
公开(公告)号：US11583805B2
公开(公告)日：2023-02-21
申请号：US16526646
申请日：2019-07-30
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Nils Stöbener , Jens Radke , Johannes Schwieters , Holger Jeglinski
IPC分类号： H01J49/00 , B01D59/44 , G16C20/20 , H01J49/04
摘要： An isotope ratio spectrometer is operated for measurement of a sample. First isotope ratios and first signal intensities are measured for a reference in the spectrometer, over a first measurement time period. A first relationship comprising a relationship between the first isotope ratios and the first signal intensities is determined. Sample isotope ratios and sample signal intensities are measured in the spectrometer, over a second measurement time period subsequent to the first measurement time period. Second isotope ratios and second signal intensities for a reference are measured in the spectrometer, over a third measurement time period subsequent to the second measurement time period. A second relationship comprising a relationship between the second isotope ratios and the second signal intensities is determined. A reference isotope ratio is estimated for a time X within the second measurement time period, based on the first relationship and the second relationship.

5. 发明申请

US20200047123A1 Isotope Ratio Measurement 审中-公开
公开(公告)号：US20200047123A1
公开(公告)日：2020-02-13
申请号：US16526646
申请日：2019-07-30
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Nils Stöbener , Jens Radke , Johannes Schwieters , Holger Jeglinski
IPC分类号： B01D59/44 , G16C20/20
摘要： An isotope ratio spectrometer is operated for measurement of a sample. First isotope ratios and first signal intensities are measured for a reference in the spectrometer, over a first measurement time period. A first relationship comprising a relationship between the first isotope ratios and the first signal intensities is determined. Sample isotope ratios and sample signal intensities are measured in the spectrometer, over a second measurement time period subsequent to the first measurement time period. Second isotope ratios and second signal intensities for a reference are measured in the spectrometer, over a third measurement time period subsequent to the second measurement time period. A second relationship comprising a relationship between the second isotope ratios and the second signal intensities is determined. A reference isotope ratio is estimated for a time X within the second measurement time period, based on the first relationship and the second relationship.

6. 发明授权

US09874513B2 Method of measuring isotope ratio 有权
公开(公告)号：US09874513B2
公开(公告)日：2018-01-23
申请号：US15035736
申请日：2014-11-10
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Hans-Juergen Schlueter , Oliver Kracht , Jens Radke , Benno Strasser , Johannes Schwieters , Eric Wapelhorst
IPC分类号： G01N21/00 , G01N21/27 , H01J49/00 , G01N33/00 , G01N21/31 , G01N21/3504
CPC分类号： G01N21/276 , G01N21/31 , G01N21/3504 , G01N33/0006 , G01N33/004 , H01J49/0009
摘要： An isotope ratio of a continuous sample is measured in an isotope ratio spectrometer. At least one sample isotope ratio is measured over a measurement time period tns, (n≧1) and a sample concentration cns is measured over at least a part of the measurement time period tns. A reference gas concentration cnref for the spectrometer is selected for reference to the sample measured during the measurement time period tns, on the basis of the measured sample concentration cnref. An isotope ratio of the reference gas is measured at the selected reference gas concentration cnref in the spectrometer. The at least one isotope ratio of the sample measured during the measurement time period tns is calibrated using the measured isotope ratio of the reference gas at the corresponding reference gas concentration cnref and a plurality of calibrated isotope ratios and a plurality of sample gas concentration measurements are determined, each being for a different time.

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