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1. 发明授权

US08236280B2 Polyamides for nucleic acid delivery 有权
标题翻译：用于核酸输送的聚酰胺
公开(公告)号：US08236280B2
公开(公告)日：2012-08-07
申请号：US13044969
申请日：2011-03-10
申请人： Theresa M. Reineke
发明人： Theresa M. Reineke
IPC分类号： A61K51/00 , C12N15/00 , C07H21/04 , A01K61/00 , D06M14/22
CPC分类号： C12N15/113 , C12N2310/13 , C12N2310/51
摘要： A new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications, including a gene transfer vector that has comparable efficiency to a viral vector without the potential for a life-threatening immune response is provided. Complexes including a cellular delivery molecule or agent that can facilitate the translocation of the complex or portion thereof into cells are also provided. The cellular delivery molecules may include one or more polymers, e.g., polyamides, dendritic macromolecules and carbohydrate-containing degradable polyesters.
摘要翻译：提供了可用于体内和体外应用的新一类非病毒转导载体，包括与病毒载体具有可比效的基因转移载体，而不具有危及生命的免疫应答潜力。还提供了包括可以促进复合物或其部分转运到细胞中的细胞递送分子或试剂的复合物。细胞递送分子可以包括一种或多种聚合物，例如聚酰胺，树枝状大分子和含碳水化合物的可降解聚酯。

2. 发明申请

US20090203131A1 Polyamides for nucleic acid delivery 有权
标题翻译：用于核酸输送的聚酰胺
公开(公告)号：US20090203131A1
公开(公告)日：2009-08-13
申请号：US10596520
申请日：2004-12-20
申请人： Theresa M. Reineke , Walter Keith Jones
发明人： Theresa M. Reineke , Walter Keith Jones
IPC分类号： A61K31/7088 , C12N15/11 , C12N5/06
CPC分类号： C12N15/113 , C12N2310/13 , C12N2310/51
摘要： The present invention describes reagents and methods for using concatermized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers consist of a variable number of end-to-end copies of a short dsDNA containing a sequence or sequences that act as transcription factor decoys.
摘要翻译：本发明描述了用于转录因子诱饵的连接双链寡核苷酸分子（CODN）的试剂和方法。在一个实施方案中，所述连续体由可变数量的包含作为转录因子诱饵的序列或序列的短dsDNA的端对端拷贝组成。

3. 发明申请

US20110183417A1 POLYAMIDES FOR NUCLEIC ACID DELIVERY 有权
标题翻译：用于核酸递送的聚酰胺
公开(公告)号：US20110183417A1
公开(公告)日：2011-07-28
申请号：US13044969
申请日：2011-03-10
申请人： Theresa M. Reineke
发明人： Theresa M. Reineke
IPC分类号： C12N15/64
CPC分类号： C12N15/113 , C12N2310/13 , C12N2310/51
摘要： The present invention provides a new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications. In particular, these vectors can be used for gene transfer applications. These new gene transduction vectors can achieve transfer efficiencies far greater to commercially available polymeric and liposomal gene transfer vectors while maintaining little or no toxicity in vitro. Their low in vitro toxicity makes them ideal candidates for in vivo use. The present invention also provides a gene transfer vector that has comparable efficiency to a viral vector without the potential for a life-threatening immune response. Furthermore, the unique polycationic structure of these polymers associates with many suitable biologically active molecule, including oligonucleotides and polypeptides and other compounds that poses multiple cationic sites. The polymer can act as a delivery vehicle for the associated biologically active molecule, in vivo or in vitro, to the cells of interest for the biologically active molecule. Complexes according to the invention or portions thereof, can comprise a cellular delivery molecule or agent that can facilitate the translocation of the complex or portion thereof into cells. In some embodiments, cellular delivery molecules for use in the present invention may comprise one or more one or more polymers of the present invention, e.g., polyamides, dendritic macromolecules (polymers comprising an oligoamine shell and a cyclodextrin core), and carbohydrate-containing degradable polyesters.
摘要翻译：本发明提供了可用于体内和体外应用的新一类非病毒转导载体。特别地，这些载体可用于基因转移应用。这些新的基因转导载体可以实现远远大于商业上可获得的聚合物和脂质体基因转移载体的转移效率，同时在体外保持很少或没有毒性。它们的低体外毒性使其成为体内使用的理想候选物。本发明还提供了具有与病毒载体相当的效率而不具有危及生命的免疫应答潜力的基因转移载体。此外，这些聚合物的独特的聚阳离子结构与许多合适的生物活性分子结合，包括寡核苷酸和多肽以及构成多个阳离子位点的其它化合物。聚合物可以作为生物活性分子感兴趣的细胞在体内或体外作为相关生物活性分子的递送载体。根据本发明或其部分的复合物可以包含可以促进复合物或其部分转运到细胞中的细胞递送分子或试剂。在一些实施方案中，用于本发明的细胞递送分子可以包含本发明的一种或多种一种或多种聚合物，例如聚酰胺，树突状大分子（包含寡胺壳和环糊精核心的聚合物）和含碳水化合物的可降解聚酯。

4. 发明申请

US20090105115A1 POLYAMIDES FOR NUCLEIC ACID DELIVERY 有权
标题翻译：用于核酸递送的聚酰胺
公开(公告)号：US20090105115A1
公开(公告)日：2009-04-23
申请号：US10596522
申请日：2004-12-20
申请人： Theresa M. Reineke
发明人： Theresa M. Reineke
IPC分类号： A61K38/02 , C12N5/06 , C12N15/87 , C12N15/11 , A61K31/7105 , C07H21/04 , C08G69/48 , C08G63/91 , C07H21/02 , A61K31/711 , C12N15/00 , A61K31/7088
CPC分类号： C12N15/113 , C12N2310/13 , C12N2310/51
摘要： The present invention provides a new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications. The present invention also provides a gene transfer vector that has comparable efficiency to a viral vector without the potential for a life-threatening immune response. Complexes according to the invention or portions thereof, can comprise a cellular delivery molecule or agent that can facilitate the translocation of the complex or portion thereof into cells. In some embodiments, cellular delivery molecules for use in the present invention may comprise one or more polymers of the present invention, e.g., polyamides, dendritic macromolecules and carbohydrate-containing degradable polyesters.
摘要翻译：本发明提供了可用于体内和体外应用的新一类非病毒转导载体。本发明还提供了具有与病毒载体相当的效率而不具有危及生命的免疫应答潜力的基因转移载体。根据本发明或其部分的复合物可以包含可以促进复合物或其部分转运到细胞中的细胞递送分子或试剂。在一些实施方案中，用于本发明的细胞递送分子可以包含一种或多种本发明的聚合物，例如聚酰胺，树枝状大分子和含碳水化合物的可降解聚酯。

5. 发明授权

US07927873B2 Polyamides for nucleic acid delivery 有权
标题翻译：用于核酸输送的聚酰胺
公开(公告)号：US07927873B2
公开(公告)日：2011-04-19
申请号：US10596522
申请日：2004-12-20
申请人： Theresa M. Reineke
发明人： Theresa M. Reineke
IPC分类号： C12N15/00 , A61K48/00 , A61K31/715 , A61K31/44
CPC分类号： C12N15/113 , C12N2310/13 , C12N2310/51
摘要： The present invention provides a new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications. The present invention also provides a gene transfer vector that has comparable efficiency to a viral vector without the potential for a life-threatening immune response. Complexes according to the invention or portions thereof, can comprise a cellular delivery molecule or agent that can facilitate the translocation of the complex or portion thereof into cells. In some embodiments, cellular delivery molecules for use in the present invention may comprise one or more polymers of the present invention, e.g., polyamides, dendritic macromolecules and carbohydrate-containing degradable polyesters.
摘要翻译：本发明提供了可用于体内和体外应用的新一类非病毒转导载体。本发明还提供了具有与病毒载体相当的效率而不具有危及生命的免疫应答潜力的基因转移载体。根据本发明或其部分的复合物可以包含可以促进复合物或其部分转运到细胞中的细胞递送分子或试剂。在一些实施方案中，用于本发明的细胞递送分子可以包含一种或多种本发明的聚合物，例如聚酰胺，树枝状大分子和含碳水化合物的可降解聚酯。

6. 发明授权

US08685368B2 Polyamides for nucleic acid delivery 有权
标题翻译：用于核酸输送的聚酰胺
公开(公告)号：US08685368B2
公开(公告)日：2014-04-01
申请号：US13541098
申请日：2012-07-03
申请人： Theresa M. Reineke
发明人： Theresa M. Reineke
IPC分类号： A61K51/00 , C12N15/00 , C07H21/04 , A01K61/00 , D06M14/22
CPC分类号： C12N15/113 , C12N2310/13 , C12N2310/51
摘要： A new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications, including, a gene transfer vector that has comparable efficiency to a viral vector without the potential for a life-threatening immune response is provided. Complexes including a cellular delivery molecule or agent that can facilitate the translocation of the complex or portion thereof into cells is also provided. The cellular delivery molecules may include one or more polymers, e.g., polyamides, dendritic macromolecules and carbohydrate-containing degradable polyesters.
摘要翻译：提供了可用于体内和体外应用的一类新型非病毒转导载体，包括与病毒载体具有可比效的基因转移载体，而不具有危及生命的免疫应答潜力。还提供了包括可以促进复合物或其部分转运到细胞中的细胞递送分子或试剂的复合物。细胞递送分子可以包括一种或多种聚合物，例如聚酰胺，树枝状大分子和含碳水化合物的可降解聚酯。

7. 发明授权

US08501478B2 Trehalose click polymers for delivery of biologically active molecules 有权
标题翻译：用于输送生物活性分子的海藻糖点击聚合物
公开(公告)号：US08501478B2
公开(公告)日：2013-08-06
申请号：US12134556
申请日：2008-06-06
申请人： Theresa M. Reineke , Sathya Srinivasachari
发明人： Theresa M. Reineke , Sathya Srinivasachari
IPC分类号： C12N15/00 , A61K31/44 , A61K31/715 , A61K48/00
CPC分类号： A61K31/7088 , A61K31/7105 , A61K31/715 , A61K47/34
摘要： Novel trehalose click polymers have in vitro and in vivo application in the cellular delivery of biologically active molecules, including nucleic acids and polypeptides. The trehalose click polymers of the present invention provide increased stability in serum as compared with other non-viral vectors, and are particularly useful in protecting nucleic acids against degradation.
摘要翻译：新型海藻糖点击聚合物在生物活性分子（包括核酸和多肽）的细胞递送中具有体外和体内应用。与其它非病毒载体相比，本发明的海藻糖点击聚合物在血清中提供了更高的稳定性，并且特别可用于保护核酸免于降解。

8. 发明申请

US20120270927A1 Polyamides For Nucleic Acid Delivery 有权
标题翻译：用于核酸递送的聚酰胺
公开(公告)号：US20120270927A1
公开(公告)日：2012-10-25
申请号：US13541098
申请日：2012-07-03
申请人： Theresa M. Reineke
发明人： Theresa M. Reineke
IPC分类号： A61K47/48 , C12N15/12 , C12N15/64 , A61K31/711 , A61K31/713 , C08B37/16 , C12N15/113
CPC分类号： C12N15/113 , C12N2310/13 , C12N2310/51
摘要： A new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications, including, a gene transfer vector that has comparable efficiency to a viral vector without the potential for a life-threatening immune response is provided. Complexes including a cellular delivery molecule or agent that can facilitate the translocation of the complex or portion thereof into cells is also provided. The cellular delivery molecules may include one or more polymers, e.g., polyamides, dendritic macromolecules and carbohydrate-containing degradable polyesters.
摘要翻译：提供了可用于体内和体外应用的一类新型非病毒转导载体，包括与病毒载体具有可比效的基因转移载体，而不具有危及生命的免疫应答潜力。还提供了包括可以促进复合物或其部分转运到细胞中的细胞递送分子或试剂的复合物。细胞递送分子可以包括一种或多种聚合物，例如聚酰胺，树枝状大分子和含碳水化合物的可降解聚酯。

9. 发明授权

US08034619B2 Polyamides for nucleic acid delivery 有权
标题翻译：用于核酸输送的聚酰胺
公开(公告)号：US08034619B2
公开(公告)日：2011-10-11
申请号：US10596520
申请日：2004-12-20
申请人： Theresa M. Reineke , Walter Keith Jones
发明人： Theresa M. Reineke , Walter Keith Jones
IPC分类号： C12N15/00 , A61K48/00 , A61K31/715 , A61K31/44
CPC分类号： C12N15/113 , C12N2310/13 , C12N2310/51
摘要： The present invention describes reagents and methods for using concatermized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers consist of a variable number of end-to-end copies of a short dsDNA containing a sequence or sequences that act as transcription factor decoys.
摘要翻译：本发明描述了用于转录因子诱饵的连接双链寡核苷酸分子（CODN）的试剂和方法。在一个实施方案中，所述连续体由可变数量的包含作为转录因子诱饵的序列或序列的短dsDNA的端对端拷贝组成。

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