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1. 发明授权

US07794471B1 Compliant anastomosis system 有权
标题翻译：吻合吻合系统
公开(公告)号：US07794471B1
公开(公告)日：2010-09-14
申请号：US10877971
申请日：2004-06-25
申请人： Theodore M. Bender , Luke W. Clauson , Philipe R. Manoux , Zachary Warder-Gabaldon , Tenny Chang , Kathleen H. Davies , Stephen A. Yencho , Brian R. DuBois , Bernard A. Hausen , Bryan D. Knodel
发明人： Theodore M. Bender , Luke W. Clauson , Philipe R. Manoux , Zachary Warder-Gabaldon , Tenny Chang , Kathleen H. Davies , Stephen A. Yencho , Brian R. DuBois , Bernard A. Hausen , Bryan D. Knodel
IPC分类号： A61B17/11
CPC分类号： A61B17/0491 , A61B17/11 , A61B17/1152 , A61B17/1155 , A61B17/1285 , A61B17/32053 , A61B17/320758 , A61B2017/00349 , A61B2017/00685 , A61B2017/1103 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2090/061
摘要： An integrated anastomosis tool may include an effector that both makes an opening in the wall of a target vessel and connects a graft vessel to the target vessel. The connection between the graft vessel and the target vessel may be compliant, and may be achieved by deploying a plurality of connectors such as staples into tissue. The effector may include a cutter assembly and a connection module that are independently actuatable. The cutter assembly and/or the connection module may be cable-actuated.
摘要翻译：整合的吻合工具可以包括两个在目标血管的壁上形成开口并将移植血管连接到目标血管的效应器。移植血管与目标血管之间的连接可以是顺应性的，并且可以通过将诸如钉的多个连接器部署到组织中来实现。效应器可以包括可独立致动的切割器组件和连接模块。切割器组件和/或连接模块可以是电缆致动的。

2. 发明授权

US08574246B1 Compliant anastomosis system utilizing suture 有权
标题翻译：吻合吻合系统利用缝合
公开(公告)号：US08574246B1
公开(公告)日：2013-11-05
申请号：US11004777
申请日：2004-12-03
申请人： Theodore M. Bender , Luke W. Clauson , Philipe R. Manoux , Zachary Warder-Gabaldon , Kathleen H. Davies , Bryan D. Knodel
发明人： Theodore M. Bender , Luke W. Clauson , Philipe R. Manoux , Zachary Warder-Gabaldon , Kathleen H. Davies , Bryan D. Knodel
IPC分类号： A61B17/11
CPC分类号： A61B17/11 , A61B17/0469 , A61B17/1152 , A61B17/1155 , A61B17/1285 , A61B17/32053 , A61B17/320758 , A61B2017/00349 , A61B2017/00685 , A61B2017/0472 , A61B2017/06009 , A61B2017/1103 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2090/061
摘要： An integrated anastomosis tool may include an effector that both makes an opening in the wall of a target vessel and connects a graft vessel to the target vessel. The effector may include a cutter assembly and a connection module that are independently actuatable. The connection between the graft vessel and the target vessel may be compliant, and may be achieved by suturing an end of the graft vessel to the side of the target vessel with the connection module.
摘要翻译：整合的吻合工具可以包括两个在目标血管的壁上形成开口并将移植血管连接到目标血管的效应器。效应器可以包括可独立致动的切割器组件和连接模块。移植脉管和目标血管之间的连接可以是顺从的，并且可以通过用连接模块将移植脉管的端部缝合到目标血管侧。

3. 发明授权

US07458978B1 Vascular closure system utilizing a staple 失效
标题翻译：使用钉的血管闭合系统
公开(公告)号：US07458978B1
公开(公告)日：2008-12-02
申请号：US11282177
申请日：2005-11-18
申请人： Theodore M. Bender , Zachary Warder-Gabaldon , Matthew B. Newell , Bernard A. Hausen , Bryan D. Knodel
发明人： Theodore M. Bender , Zachary Warder-Gabaldon , Matthew B. Newell , Bernard A. Hausen , Bryan D. Knodel
IPC分类号： A61B17/10
CPC分类号： A61B17/0057 , A61B17/0218 , A61B17/0644 , A61B17/10 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672
摘要： A system for closing an opening in tissue may include an end effector that holds a staple, where the staple is deformed to a splayed configuration for engaging tissue, then deformed to a closed condition for closing the opening. The system may include one or more butterfly members configured to register the opening to the end effector.
摘要翻译：用于关闭组织中的开口的系统可以包括保持钉的末端执行器，其中钉被变形到用于接合组织的展开构型，然后变形到关闭开口的关闭状态。该系统可以包括一个或多个蝶形构件，其构造成将开口对准到端部执行器。

4. 发明授权

US07344544B2 Vascular closure system 失效
标题翻译：血管闭合系统
公开(公告)号：US07344544B2
公开(公告)日：2008-03-18
申请号：US11093003
申请日：2005-03-28
申请人： Theodore M. Bender , Zachary Warder-Gabaldon , Matthew B. Newell , Bernard A. Hausen , Brian R. DuBois , Bryan D. Knodel
发明人： Theodore M. Bender , Zachary Warder-Gabaldon , Matthew B. Newell , Bernard A. Hausen , Brian R. DuBois , Bryan D. Knodel
IPC分类号： A61B17/10
CPC分类号： A61B17/0684 , A61B17/0057 , A61B17/0644 , A61B17/10 , A61B2017/00243 , A61B2017/00637 , A61B2017/00668
摘要： A system for closing an opening in tissue may include an end effector that holds a staple, where the staple is plastically deformed to a splayed configuration for engaging tissue, then plastically deformed to a closed condition for closing the opening. The system may include one or more butterfly members configured to register the opening to the end effector.
摘要翻译：用于封闭组织中的开口的系统可以包括保持订书钉的端部执行器，其中订书钉被塑性变形到用于接合组织的展开构型，然后塑性变形到关闭开口的关闭状态。该系统可以包括一个或多个蝶形构件，其构造成将开口对准到端部执行器。

5. 发明授权

US07320692B1 Tissue closure system 有权
标题翻译：组织闭合系统
公开(公告)号：US07320692B1
公开(公告)日：2008-01-22
申请号：US11158414
申请日：2005-06-22
申请人： Theodore M. Bender , Zachary Warder-Gabaldon , Matthew B. Newell , Bernard A. Hausen , Brian R. DuBois , Bryan D. Knodel
发明人： Theodore M. Bender , Zachary Warder-Gabaldon , Matthew B. Newell , Bernard A. Hausen , Brian R. DuBois , Bryan D. Knodel
IPC分类号： A61B17/10
CPC分类号： A61B17/0684 , A61B17/0057 , A61B17/0644 , A61B17/10 , A61B2017/00243 , A61B2017/00637 , A61B2017/00668
摘要： A method for closing an opening in tissue, such as an opening in heart tissue, may include moving a housing to a location in proximity to the opening, registering the housing to the opening, and deploying a staple from the housing into tissue in proximity to the opening. The opening in heart tissue may be a patent foramen ovale, atrial septal defect, or other opening. The housing may be moved to the opening through the vasculature, utilizing a guidewire, steering catheter, or other mechanism.
摘要翻译：用于闭合组织中的开口（例如心脏组织中的开口）的方法可以包括将壳体移动到靠近开口的位置，将壳体对准开口，并将钉子从壳体部署到组织中开幕。心脏组织中的开口可能是卵圆孔，房间隔缺损或其他开口的专利。壳体可以通过脉管系统移动到开口，利用导丝，转向导管或其他机构。

6. 发明申请

US20090039138A1 Vascular Closure System With Splayable Staple 审中-公开
标题翻译：血管闭合系统与可张开的订书钉
公开(公告)号：US20090039138A1
公开(公告)日：2009-02-12
申请号：US12254743
申请日：2008-10-20
申请人： Theodore M. Bender , Zachary Warder-Gabaldon , Matthew B. Newell , Bemard A. Hausen , Bryan D. Knodel
发明人： Theodore M. Bender , Zachary Warder-Gabaldon , Matthew B. Newell , Bemard A. Hausen , Bryan D. Knodel
IPC分类号： A61B17/068 , A61B17/064
CPC分类号： A61B17/0057 , A61B17/0218 , A61B17/0644 , A61B17/10 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672
摘要： A medical device for closing an opening in tissue may include a staple with a plurality of tines, where the staple is deformable from an initial configuration to a splayed configuration and then to a closed configuration; a cradle that includes a distal stop and a proximal stop proximal to the distal stop extending therefrom, where the cradle holds a portion of the staple between the proximal stop and the distal stop, and where the proximal stop and distal stop are spaced apart from one another a fixed distance substantially equal to the thickness of the portion of the staple held therebetween, where that portion of the staple substantially contacts both stops in the initial configuration; and a housing, where the cradle is movable relative to that housing.
摘要翻译：用于封闭组织中的开口的医疗装置可以包括具有多个尖齿的钉，其中钉可以从初始构型变形到展开的构型，然后到闭合构型; 支架，其包括远端止动件和靠近从其延伸的远端止动件的近端止动件，其中托架将近端止动件和远端止动件之间的钉的一部分保持在其中，并且其中近端止动件和远端止动件与一个另一固定距离基本上等于保持在其间的钉的部分的厚度，其中订书钉的该部分在初始构型中基本上接触两个止挡件; 和一个壳体，其中支架相对于该壳体是可移动的。

7. 发明授权

US07727245B2 Method for closing an opening in tissue with a splayable staple 有权
标题翻译：用可张开的钉子封闭组织中的开口的方法
公开(公告)号：US07727245B2
公开(公告)日：2010-06-01
申请号：US12013334
申请日：2008-01-11
申请人： Theodore M. Bender , Zachary Warder-Gabaldon , Matthew B. Newell , Bernard A. Hausen , Brian R. DuBois , Bryan D. Knodel
发明人： Theodore M. Bender , Zachary Warder-Gabaldon , Matthew B. Newell , Bernard A. Hausen , Brian R. DuBois , Bryan D. Knodel
IPC分类号： A61B17/10
CPC分类号： A61B17/0684 , A61B17/0057 , A61B17/0644 , A61B17/10 , A61B2017/00243 , A61B2017/00637 , A61B2017/00668
摘要： One method for closing an opening in tissue may include providing a substantially continuous solid staple having a plurality of tines and a longitudinal centerline, plastically deforming the staple to a splayed configuration; penetrating at least one tine into tissue in proximity to the opening; and plastically deforming the staple to a closed configuration. Another method for closing an opening in tissue may include providing a staple having a plurality of tines; plastically deforming the staple to a splayed configuration by applying force in the distal direction against a proximal surface of the staple; penetrating at least one tine into tissue in proximity to the opening; and plastically deforming the staple from the splayed configuration to a closed configuration by applying force in the distal direction against a proximal surface of the staple.
摘要翻译：用于关闭组织中的开口的一种方法可以包括提供具有多个尖齿和纵向中心线的基本上连续的实心短纤维，使订书钉塑形地变形成张开的构型; 将至少一个刺入到靠近开口的组织中; 并将钉子塑形变形成闭合构型。关闭组织中的开口的另一种方法可以包括提供具有多个齿的钉; 通过在远侧方向上施加相对于钉的近端表面的力，将钉子塑性变形成张开的构型; 将至少一个刺入到靠近开口的组织中; 并且通过在远侧方向上施加相对于钉的近端表面的力，将钉从张开形状塑造变形为闭合构型。

8. 发明授权

US07670348B2 Heart defect closure apparatus 失效
标题翻译：心脏缺陷闭合装置
公开(公告)号：US07670348B2
公开(公告)日：2010-03-02
申请号：US11953791
申请日：2007-12-10
申请人： Bernard A. Hausen , Theodore M. Bender , Zachary Warder-Gabaldon , Matthew B. Newell , Brian R. DuBois , Bryan D. Knodel
发明人： Bernard A. Hausen , Theodore M. Bender , Zachary Warder-Gabaldon , Matthew B. Newell , Brian R. DuBois , Bryan D. Knodel
IPC分类号： A61B17/10
CPC分类号： A61B17/0684 , A61B17/0057 , A61B17/0644 , A61B17/10 , A61B2017/00243 , A61B2017/00637 , A61B2017/00668
摘要： An exemplary medical apparatus insertable into the vasculature of a patient at an insertion point for treating a defect in the heart, may include an elongated, flexible driver sufficient in length to extend from the insertion point to the defect in the heart; and a staple frangibly attached to the distal end of the driver. Another exemplary medical apparatus may include a catheter sufficient in length to extend from the insertion point to the patent foramen ovale; a housing attached to the distal end of the catheter; a driver extending into the housing; and a staple frangibly attached to the driver. Another exemplary medical apparatus may include a steering catheter sufficient in length to extend from the insertion point to the patent foramen ovale; an end effector attached to the distal end of the steering catheter, the end effector having a cross-section sufficiently small to allow it to be moved through the vasculature to the patent foramen ovale; and a staple held by the end effector, wherein the staple is frangibly separable from and deployable out of the end effector to close the patent foramen ovale.
摘要翻译：在插入点处可插入患者脉管系统中以治疗心脏缺陷的示例性医疗装置可以包括长度足以从插入点延伸到心脏缺陷的细长柔性驱动器; 以及可滑动地附接到驾驶员的远端的钉子。另一示例性医疗装置可以包括长度足以从插入点延伸到卵孔卵泡的专利的导管; 附接到所述导管的远端的壳体; 司机延伸到房屋内; 和一个易碎的司机的钥匙。另一个示例性的医疗设备可以包括足够长度的转导导管，以从插入点延伸到卵孔的专利; 附接到转向导管的远端的末端执行器，末端执行器具有足够小的横截面以允许其移动通过脉管系统到卵孔的专利; 以及由末端执行器保持的订书钉，其中所述订书钉从所述末端执行器可分离和可部署，以封闭所述卵孔的专利。

9. 发明授权

US08915934B2 Anastomosis system with anvil entry hole sealer 有权
标题翻译：吻合系统与砧进入孔密封
公开(公告)号：US08915934B2
公开(公告)日：2014-12-23
申请号：US11865893
申请日：2007-10-02
申请人： James T. Nielsen , Nathan H. White , Theodore M. Bender , Philipe R. Manoux , David L. Bombard , Brendan M. Donohoe , Bryan D. Knodel
发明人： James T. Nielsen , Nathan H. White , Theodore M. Bender , Philipe R. Manoux , David L. Bombard , Brendan M. Donohoe , Bryan D. Knodel
IPC分类号： A61B17/11 , A61B17/072 , A61B17/115 , A61B17/064 , A61B17/02 , A61B17/32 , A61B17/00 , A61B17/08 , A61B17/10 , A61B17/068 , A61B19/00 , A61B17/06 , A61B17/122
CPC分类号： A61B17/0057 , A61B17/00491 , A61B17/0206 , A61B17/06166 , A61B17/064 , A61B17/0644 , A61B17/0686 , A61B17/072 , A61B17/07207 , A61B17/08 , A61B17/10 , A61B17/115 , A61B17/1152 , A61B17/122 , A61B17/32 , A61B90/50 , A61B2017/00654 , A61B2017/00893 , A61B2017/0641 , A61B2017/0688 , A61B2017/07214 , A61B2017/1103 , A61B2017/1107 , A61B2017/1135 , A61B2017/1157 , A61B2017/320052 , A61B2090/08021
摘要： A system for connecting the end of a graft vessel to the side of a target vessel may include an anvil configured to enter the target vessel through an anvil entry hole in the wall of the target vessel; a holder movable relative to the anvil, where that holder may deploy at least one connector through the graft vessel and into the target vessel at a location spaced apart from the anvil entry hole; and at least one sealer that may be detachably connected to the anvil and/or said holder; where at least one sealer may be configured to substantially close the anvil entry hole in the target vessel. A method for performing anastomosis between a graft vessel and a target vessel may include inserting an anvil through the wall of the target vessel into the lumen of the target vessel from outside of the target vessel through an anvil entry hole; connecting an end of the graft vessel to the side of the target vessel with a plurality of connectors at a location spaced apart from the anvil entry hole; creating an opening in the side of the target vessel, where the opening is located within a perimeter defined by the connectors and spaced apart from the anvil entry hole; withdrawing the anvil through the anvil entry hole; and substantially sealing the anvil entry hole.
摘要翻译：用于将移植物容器的端部连接到靶容器侧的系统可以包括构造成通过目标容器的壁中的砧孔入口进入靶容器的砧座; 相对于砧座可移动的保持器，其中该保持器可以在与砧座入口孔间隔开的位置处将至少一个连接器展开穿过移植物容器并进入目标血管; 以及可以可拆卸地连接到所述砧和/或所述保持器的至少一个密封件; 其中至少一个密封件可以构造成基本上封闭靶容器中的砧孔入口。用于在移植物容器和目标血管之间进行吻合的方法可以包括通过砧座入口孔将目标血管壁从目标血管外部插入到目标血管的内腔中; 在与所述砧座入口孔间隔开的位置处，使多个连接器将所述移植脉管的端部连接到所述靶容器侧; 在目标容器的侧面形成开口，其中开口位于由连接器限定的周边中并与砧座入口孔间隔开; 通过砧座入口将砧座取出; 并且基本上密封砧进入孔。

10. 发明授权

US08475493B2 Surgical staple for anastomosis 有权
标题翻译：手术缝合吻合
公开(公告)号：US08475493B2
公开(公告)日：2013-07-02
申请号：US11759319
申请日：2007-06-07
申请人： Theodore M. Bender , David L. Bombard , Philipe R. Manoux , Tenny Chang , Jaime S. Vargas , Bryan D. Knodel
发明人： Theodore M. Bender , David L. Bombard , Philipe R. Manoux , Tenny Chang , Jaime S. Vargas , Bryan D. Knodel
IPC分类号： A61B17/08
CPC分类号： A61B17/0644 , A61B17/0684 , A61B17/11 , A61B17/115 , A61B2017/0641 , A61B2017/1107 , A61B2017/1135
摘要： A surgical staple for connecting two tubular tissue structures may include a substantially rectangular base having a first edge and a second edge substantially parallel to one another, and a third edge substantially perpendicular to the first and said second edges; and may also include at least three deformable tines extending from the first and second edges of said base; where no tine that extends from the first edge may be positioned at substantially the same distance from the third edge as any said tine that extends from the second edge; and where deformation of the tines secures the tubular tissue structures together.
摘要翻译：用于连接两个管状组织结构的外科手术钉可以包括基本上矩形的基部，其具有基本上彼此平行的第一边缘和第二边缘，以及基本上垂直于第一边缘和所述第二边缘的第三边缘; 并且还可以包括从所述基座的第一和第二边缘延伸的至少三个可变形齿; 其中没有从第一边缘延伸的齿可以定位成与从第二边缘延伸的任何所述齿大致相距离第三边缘; 并且其中尖齿的变形将管状组织结构固定在一起。

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