专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20230063827A1 Methods and Compositions for the Diagnosis of Ovarian Cancer 有权
公开(公告)号：US20230063827A1
公开(公告)日：2023-03-02
申请号：US17812060
申请日：2022-07-12
申请人： The Wistar Institute of Anatomy and Biology
发明人： David W. Speicher , Hsin Yao Tang , Lynn A. Beer
IPC分类号： G01N33/574 , C07K16/30 , C12Q1/6886 , G01N33/68
摘要： A diagnostic reagent or device comprises at least one ligand capable of specifically complexing with, binding to, or quantitatively detecting or identifying the biomarker chloride intracellular channel protein 4 (CLIC4) or an isoform, pro-form, modified molecular form including posttranslational modification, or unique peptide fragment or nucleic acid fragment thereof. An alternative diagnostic reagent or device comprises ligand or ligands capable of specifically complexing with, binding to, or quantitatively detecting or identifying multiple tropomyosin biomarkers. Optionally, such reagent or device includes a signaling molecule and/or a substrate on which the ligand is immobilized. Other reagents and methods of diagnosing ovarian cancer include use of CLIC4 ligands and/or multiple tropomyosin ligands with an additional ovarian cancer biomarker. For example, CLIC4 combined with one or more of CLIC1 and/or one or multiple members of the tropomyosin family, e.g., TPM1, TPM2, TPM3 or TPM4, and further optionally including CTSD-30 kDa and/or PRDX-6, among other ovarian cancer biomarkers can form a characteristic diagnostic pattern or profile of expression that is diagnostic of the disease. Still other embodiments are described.

2. 发明申请

US20140121127A1 Methods and Compositions for Diagnosis of Ovarian Cancer 审中-公开
标题翻译：用于诊断卵巢癌的方法和组成
公开(公告)号：US20140121127A1
公开(公告)日：2014-05-01
申请号：US14065923
申请日：2013-10-29
申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
发明人： David W. Speicher , Hsin Yao Tang , Lynn A. Beer
IPC分类号： G01N33/68
CPC分类号： G01N33/57449 , G01N2800/52 , G01N2800/60
摘要： Methods and compositions are provided for diagnosing ovarian cancer in a mammalian subject, preferably in a serum or plasma sample of a human subject. The methods and compositions enable the detection or measurement in the sample or from a protein level profile generated from the sample, the protein level of one or more specified biomarkers. Comparing the protein level(s) of the biomarker(s) in the subject's sample or from protein abundance profile of multiple biomarkers, with the level of the same biomarker(s) or profile in a reference standard, permits the determination of a diagnosis of ovarian cancer, or the identification of a risk of developing ovarian cancer, or enables the monitoring of the status of progression or remission of ovarian cancer in the subject followed during a therapeutic protocol.
摘要翻译：提供了用于诊断哺乳动物受试者，优选在人受试者的血清或血浆样品中的卵巢癌的方法和组合物。所述方法和组合物能够在样品中检测或测量或从样品产生的蛋白质水平分布，一种或多种特定生物标志物的蛋白质水平。比较受试者样品中生物标志物的蛋白质水平或多个生物标志物的蛋白质丰度曲线与参考标准中相同生物标志物或分布水平的蛋白质水平，可以确定卵巢癌或确定发生卵巢癌的风险，或者可以在治疗方案期间监测受试者卵巢癌进展或缓解的状态。

3. 发明申请

US20140100130A1 Methods and Compositions for the Diagnosis of Ovarian Cancer 有权
标题翻译：用于诊断卵巢癌的方法和组成
公开(公告)号：US20140100130A1
公开(公告)日：2014-04-10
申请号：US14045452
申请日：2013-10-03
申请人： The Wistar Institute of Anatomy and Biology
发明人： David W. Speicher , Hsin Yao Tang , Lynn A. Beer
IPC分类号： G01N33/574 , C12Q1/68 , C07K16/30
CPC分类号： G01N33/57449 , C07K16/3069 , C12Q1/6886 , C40B40/06 , C40B40/10 , G01N33/6887 , G01N2333/4712 , G01N2800/52
摘要： A diagnostic reagent or device comprises at least one ligand capable of specifically complexing with, binding to, or quantitatively detecting or identifying the biomarker chloride intracellular channel protein 4 (CLIC4) or an isoform, pro-form, modified molecular form including posttranslational modification, or unique peptide fragment or nucleic acid fragment thereof. An alternative diagnostic reagent or device comprises ligand or ligands capable of specifically complexing with, binding to, or quantitatively detecting or identifying multiple tropomyosin biomarkers. Optionally, such reagent or device includes a signaling molecule and/or a substrate on which the ligand is immobilized. Other reagents and methods of diagnosing ovarian cancer include use of CLIC4 ligands and/or multiple tropomyosin ligands with an additional ovarian cancer biomarker. For example, CLIC4 combined with one or more of CLIC1 and/or one or multiple members of the tropomyosin family, e.g., TPM1, TPM2, TPM3 or TPM4, and further optionally including CTSD-30 kDa and/or PRDX-6, among other ovarian cancer biomarkers can form a characteristic diagnostic pattern or profile of expression that is diagnostic of the disease. Still other embodiments are described.
摘要翻译：诊断试剂或装置包含至少一种能够与生物标志物氯化物细胞内通道蛋白4（CLIC4）特异性复合，结合或定量检测或鉴定的至少一种配体，包括翻译后修饰的同种型，前体形式，修饰的分子形式，或独特的肽片段或其核酸片段。另一种诊断试剂或装置包括能够与多个原肌球蛋白生物标志物特异性配合，结合或定量检测或鉴定的配体或配体。任选地，这种试剂或装置包括信号分子和/或其上固定有配体的底物。诊断卵巢癌的其它试剂和方法包括使用CLIC4配体和/或多种原肌球蛋白配体与另外的卵巢癌生物标志物。例如，CLIC4与原肌球蛋白家族的一个或多个CLIM1和/或一个或多个成员结合，例如TPM1，TPM2，TPM3或TPM4，并且还可任选地包括CTSD-30kDa和/或PRDX-6等卵巢癌生物标志物可以形成诊断疾病的特征性诊断模式或表达谱。还描述了其它实施例。

4. 发明申请

US20200033350A1 Methods and Compositions for the Diagnosis of Ovarian Cancer 审中-公开
公开(公告)号：US20200033350A1
公开(公告)日：2020-01-30
申请号：US16450602
申请日：2019-06-24
申请人： The Wistar Institute of Anatomy and Biology
发明人： David W. Speicher , Hsin Yao Tang , Lynn A. Beer
IPC分类号： G01N33/574 , C07K16/30 , C12Q1/6886 , G01N33/68
摘要： A diagnostic reagent or device comprises at least one ligand capable of specifically complexing with, binding to, or quantitatively detecting or identifying the biomarker chloride intracellular channel protein 4 (CLIC4) or an isoform, pro-form, modified molecular form including posttranslational modification, or unique peptide fragment or nucleic acid fragment thereof. An alternative diagnostic reagent or device comprises ligand or ligands capable of specifically complexing with, binding to, or quantitatively detecting or identifying multiple tropomyosin biomarkers. Optionally, such reagent or device includes a signaling molecule and/or a substrate on which the ligand is immobilized. Other reagents and methods of diagnosing ovarian cancer include use of CLIC4 ligands and/or multiple tropomyosin ligands with an additional ovarian cancer biomarker. For example, CLIC4 combined with one or more of CLIC1 and/or one or multiple members of the tropomyosin family, e.g., TPM1, TPM2, TPM3 or TPM4, and further optionally including CTSD-30 kDa and/or PRDX-6, among other ovarian cancer biomarkers can form a characteristic diagnostic pattern or profile of expression that is diagnostic of the disease. Still other embodiments are described.

5. 发明授权

US09903870B2 Methods and compositions for the diagnosis of ovarian cancer 有权
公开(公告)号：US09903870B2
公开(公告)日：2018-02-27
申请号：US14045452
申请日：2013-10-03
申请人： The Wistar Institute of Anatomy and Biology
发明人： David W. Speicher , Hsin Yao Tang , Lynn A. Beer
IPC分类号： G01N33/574 , C07K16/30 , C12Q1/68 , C40B40/06 , C40B40/10 , G01N33/68
CPC分类号： G01N33/57449 , C07K16/3069 , C12Q1/6886 , C40B40/06 , C40B40/10 , G01N33/6887 , G01N2333/4712 , G01N2800/52
摘要： A diagnostic reagent or device comprises at least one ligand capable of specifically complexing with, binding to, or quantitatively detecting or identifying the biomarker chloride intracellular channel protein 4 (CLIC4) or an isoform, pro-form, modified molecular form including posttranslational modification, or unique peptide fragment or nucleic acid fragment thereof. An alternative diagnostic reagent or device comprises ligand or ligands capable of specifically complexing with, binding to, or quantitatively detecting or identifying multiple tropomyosin biomarkers. Optionally, such reagent or device includes a signaling molecule and/or a substrate on which the ligand is immobilized. Other reagents and methods of diagnosing ovarian cancer include use of CLIC4 ligands and/or multiple tropomyosin ligands with an additional ovarian cancer biomarker. For example, CLIC4 combined with one or more of CLIC1 and/or one or multiple members of the tropomyosin family, e.g., TPM1, TPM2, TPM3 or TPM4, and further optionally including CTSD-30 kDa and/or PRDX-6, among other ovarian cancer biomarkers can form a characteristic diagnostic pattern or profile of expression that is diagnostic of the disease. Still other embodiments are described.

6. 发明授权

US10338076B2 Methods and compositions for the diagnosis of ovarian cancer 有权
公开(公告)号：US10338076B2
公开(公告)日：2019-07-02
申请号：US15884691
申请日：2018-01-31
申请人： The Wistar Institute of Anatomy and Biology
发明人： David W. Speicher , Hsin Yao Tang , Lynn A. Beer
IPC分类号： G01N33/574 , C12Q1/6886 , G01N33/68 , C07K16/30 , C40B40/06 , C40B40/10
摘要： A diagnostic reagent or device comprises at least one ligand capable of specifically complexing with, binding to, or quantitatively detecting or identifying the biomarker chloride intracellular channel protein 4 (CLIC4) or an isoform, pro-form, modified molecular form including posttranslational modification, or unique peptide fragment or nucleic acid fragment thereof. An alternative diagnostic reagent or device comprises ligand or ligands capable of specifically complexing with, binding to, or quantitatively detecting or identifying multiple tropomyosin biomarkers. Optionally, such reagent or device includes a signaling molecule and/or a substrate on which the ligand is immobilized. Other reagents and methods of diagnosing ovarian cancer include use of CLIC4 ligands and/or multiple tropomyosin ligands with an additional ovarian cancer biomarker. For example, CLIC4 combined with one or more of CLIC1 and/or one or multiple members of the tropomyosin family, e.g., TPM1, TPM2, TPM3 or TPM4, and further optionally including CTSD-30 kDa and/or PRDX-6, among other ovarian cancer biomarkers can form a characteristic diagnostic pattern or profile of expression that is diagnostic of the disease. Still other embodiments are described.

7. 发明申请

US20180231559A1 Methods and Compositions for the Diagnosis of Ovarian Cancer 审中-公开
公开(公告)号：US20180231559A1
公开(公告)日：2018-08-16
申请号：US15884691
申请日：2018-01-31
申请人： The Wistar Institute of Anatomy and Biology
发明人： David W. Speicher , Hsin Yao Tang , Lynn A. Beer
IPC分类号： G01N33/574 , G01N33/68 , C12Q1/6886 , C07K16/30 , C40B40/06 , C40B40/10
CPC分类号： G01N33/57449 , C07K16/3069 , C12Q1/6886 , C40B40/06 , C40B40/10 , G01N33/6887 , G01N2333/4712 , G01N2800/52
摘要： A diagnostic reagent or device comprises at least one ligand capable of specifically complexing with, binding to, or quantitatively detecting or identifying the biomarker chloride intracellular channel protein 4 (CLIC4) or an isoform, pro-form, modified molecular form including posttranslational modification, or unique peptide fragment or nucleic acid fragment thereof. An alternative diagnostic reagent or device comprises ligand or ligands capable of specifically complexing with, binding to, or quantitatively detecting or identifying multiple tropomyosin biomarkers. Optionally, such reagent or device includes a signaling molecule and/or a substrate on which the ligand is immobilized. Other reagents and methods of diagnosing ovarian cancer include use of CLIC4 ligands and/or multiple tropomyosin ligands with an additional ovarian cancer biomarker. For example, CLIC4 combined with one or more of CLIC1 and/or one or multiple members of the tropomyosin family, e.g., TPM1, TPM2, TPM3 or TPM4, and further optionally including CTSD-30 kDa and/or PRDX-6, among other ovarian cancer biomarkers can form a characteristic diagnostic pattern or profile of expression that is diagnostic of the disease. Still other embodiments are described.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式