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1. 发明申请

US20160202241A1 NANOFIBROUS PHOTOCLICKABLE HYDROGEL MICROARRAYS 审中-公开
公开(公告)号：US20160202241A1
公开(公告)日：2016-07-14
申请号：US14991889
申请日：2016-01-08
申请人： The Regents of the University of Colorado, a body corporate
发明人： Michael Floren , Wei Tan , Sadhana Sharma , Stephanie Bryant
IPC分类号： G01N33/50 , B05D1/00 , B05D1/18
CPC分类号： G01N33/502 , B01J2219/00385 , B01J2219/00644 , B01J2219/00743 , B01L3/5085 , B01L2300/069 , B01L2300/089 , B01L2300/123 , C12M25/14 , C12N11/04 , C40B60/12 , G01N33/5023 , G01N33/5026
摘要： Nanofibrous hydrogel microarray systems that act as facile, high throughput platforms for in vitro drug discovery and investigation and screening of combinatorial effects of physical and biochemical cues on maturation and differentiation of mammalian cells.
摘要翻译：纳米纤维水凝胶微阵列系统，作为体外药物发现和调查的筛选和物理和生化指标组合影响哺乳动物细胞成熟和分化的平台，高通量平台。

2. 发明申请

US20140037708A1 COMPOSITION FOR SPATIO AND/OR TEMPORAL RELEASE OF BIOACTIVE MATERIAL 审中-公开
标题翻译：用于生物材料的空间和/或时间释放的组合物
公开(公告)号：US20140037708A1
公开(公告)日：2014-02-06
申请号：US13954789
申请日：2013-07-30
申请人： The Regents of the University of Colorado, a body corporate
发明人： Wei Tan , Walter Bonani
IPC分类号： A61K47/34 , A61K9/70
CPC分类号： A61K47/34 , A61K9/7007 , A61L27/26 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/604 , A61L2400/12 , C08L67/04
摘要： The present invention provides a biocompatible composition that comprises a bioactive material and a method for using the same. In particular, the composition of the invention is useful for spatio and/or temporal release of the bioactive material. Specifically, the composition of the invention comprises at least one polymeric mixture layer comprising a plurality of biodegradable polymers. The polymeric mixture layer comprises a first biodegradable polymer and a second biodegradable polymer. The relative amount of the first biodegradable polymer or the second biodegradable polymer increases within the polymeric mixture layer in one direction, and the relative amount of the other biodegradable polymer decreases in the polymeric mixture layer in the same direction. The rate of degradation of the first biodegradable polymer is different from the rate of degradation of the second biodegradable polymer. In this manner, the composition allows spatio and/or temporal release of the bioactive material.
摘要翻译：本发明提供一种生物相容性组合物，其包含生物活性物质及其使用方法。特别地，本发明的组合物可用于生物活性材料的空间和/或时间释放。具体地说，本发明的组合物包括至少一个包含多个可生物降解的聚合物的聚合物混合物层。聚合物混合物层包括第一可生物降解聚合物和第二可生物降解聚合物。第一可生物降解聚合物或第二可生物降解聚合物的相对量在聚合物混合物层中在一个方向上增加，并且其它可生物降解聚合物的相对量在聚合物混合物层中在相同方向上降低。第一可生物降解聚合物的降解速率与第二生物可降解聚合物的降解速率不同。以这种方式，组合物允许生物活性材料的空间和/或时间释放。

3. 发明申请

US20210260256A1 PRO-HEALING, PRO-REGENERATIVE NANOFIBROUS COATING FOR MEDICAL IMPLANTS 有权
公开(公告)号：US20210260256A1
公开(公告)日：2021-08-26
申请号：US17255879
申请日：2019-06-28
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
发明人： Parnaz Boodagh , Wei Tan , Michael Floren
IPC分类号： A61L31/10 , A61L31/16
摘要： The present invention relates to a medical implant, and more particularly, to a vascular implant having a dual coating structure for preventing in-stent restenosis and thrombosis. In one embodiment, the invention contemplates a vascular stent with a coating comprising a hydrophobic, degradable core with a coaxial sheath comprising at least one polyethylene-glycol derivative. In one embodiment, said at least one polyethylene-glycol derivative comprises polyethylene-glycol dimethacrylate.

4. 发明授权

US11944725B2 Pro-healing, pro-regenerative nanofibrous coating for medical implants 有权
公开(公告)号：US11944725B2
公开(公告)日：2024-04-02
申请号：US17255879
申请日：2019-06-28
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
发明人： Parnaz Boodagh , Wei Tan , Michael Floren
IPC分类号： A61L27/50 , A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L31/16 , A61L27/507 , A61L2300/416 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2400/12 , A61L2420/02 , A61L2430/20
摘要： The present invention relates to a medical implant, and more particularly, to a vascular implant having a dual coating structure for preventing in-stent restenosis and thrombosis. In one embodiment, the invention contemplates a vascular stent with a coating comprising a hydrophobic, degradable core with a coaxial sheath comprising at least one polyethylene-glycol derivative. In one embodiment, the at least one polyethylene-glycol derivative comprises polyethylene-glycol dimethacrylate.

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