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1. 发明授权

US10231706B2 Integrated multimodality intravascular imaging system that combines optical coherence tomography, ultrasound imaging, and acoustic radiation force optical coherence elastography 有权
公开(公告)号：US10231706B2
公开(公告)日：2019-03-19
申请号：US14213904
申请日：2014-03-14
申请人： The Regents of the University of California
发明人： Zhongping Chen , Wenjuan Qi , Rui Li
IPC分类号： A61B8/00 , A61B8/08 , A61B5/00 , A61B5/02 , A61B8/12
摘要： An integrated intraluminal imaging system includes an optical coherence tomography interferometer (OCT), an ultrasound subsystem (US) and a phase resolved acoustic radiation force optical coherence elastography subsystem (PR-RAF-OCE). The steps include performing OCT to generate a returned optical signal, performing US imaging to generate a returned ultrasound signal, performing PRARF-OCE to generate a returned PR-ARF-OCE signal by generating a amplitude modulated ultrasound beam or chirped amplitude modulated ultrasound beam to frequency sweep the acoustic radiation force, measuring the ARF induced tissue displacement using phase resolved OCT, and the frequency dependence of the PR-ARF-OCE signal, processing the returned optical signal, the returned ultrasound signal and the measured frequency dependence of the returned PR-ARF-OCE optical coherence elastographic signal to quantitatively measure the mechanical properties of the identified tissues with both spectral and spatial resolution using enhanced materials response at mechanically resonant frequencies.

2. 发明申请

US20160208314A1 GEL EXTRACTION DEVICE AND METHODS TO RECOVER BIOMOLECULES FROM AGAR AND AGAROSE GELS 审中-公开
标题翻译：凝胶提取装置和从AGAR和AGAROSE凝胶回收生物分子的方法
公开(公告)号：US20160208314A1
公开(公告)日：2016-07-21
申请号：US15002386
申请日：2016-01-20
申请人： The Regents of the University of California
发明人： Rui Li , Peggy A. Mauk , Carol J. Lovatt
IPC分类号： C12Q1/68 , G01N1/08
CPC分类号： C12Q1/6806 , G01N1/08 , C12Q2527/101
摘要： The disclosure provides for a gel extraction device comprising multifunctional and reusable forceps, a removable cutting element, and a sampler component. The disclosure further provides for a freeze/thaw method which can be used to recover biomolecules from agar or agarose gels.
摘要翻译：本公开提供了一种凝胶提取装置，其包括多功能和可重复使用的镊子，可移除切割元件和采样器部件。本公开进一步提供了可用于从琼脂或琼脂糖凝胶中回收生物分子的冷冻/融化方法。

3. 发明申请

US20150351722A1 Integrated Multimodality Intravascular Imaging System that Combines Optical Coherence Tomography, Ultrasound Imaging, and Acoustic Radiation Force Optical Coherence Elastography 审中-公开
标题翻译：综合多模式血管内成像系统，结合光学相干断层扫描，超声成像和声辐射力光学相干弹性成像
公开(公告)号：US20150351722A1
公开(公告)日：2015-12-10
申请号：US14213904
申请日：2014-03-14
申请人： The Regents of the University of California
发明人： Zhongping Chen , Wenjuan Qi , Rui Li
IPC分类号： A61B8/08 , A61B5/00 , A61B8/12 , A61B8/00
CPC分类号： A61B8/485 , A61B5/0035 , A61B5/0066 , A61B5/02007 , A61B8/12 , A61B8/4416 , A61B8/445 , A61B8/5261
摘要： A method of using an integrated intraluminal imaging system includes an optical coherence tomography interferometer (OCT), an ultrasound subsystem (US) and a phase resolved acoustic radiation force optical coherence elastography subsystem (PR-RAF-OCE). The steps include performing OCT to generate a returned optical signal, performing US imaging to generate a returned ultrasound signal, performing PR-ARF-OCE to generate a returned PR-ARF-OCE signal by generating a amplitude modulated ultrasound beam or chirped amplitude modulated ultrasound beam to frequency sweep the acoustic radiation force, measuring the ARF induced tissue displacement using phase resolved OCT method, and the frequency dependence of the PR-ARF-OCE signal, processing the returned optical signal, the returned ultrasound signal and the measured frequency dependence of the returned PR-ARF-OCE optical coherence elastographic signal to quantitatively measure the mechanical properties of the identified tissues with both spectral and spatial resolution using enhanced materials response at mechanically resonant frequencies to distinguish tissues with varying stiffness, to identify tissues with different biomechanical properties and to measure structural and mechanical properties simultaneously.
摘要翻译：使用集成的管腔内成像系统的方法包括光学相干断层扫描干涉仪（OCT），超声子系统（US）和相位分辨声辐射力光学相干弹性成像子系统（PR-RAF-OCE）。这些步骤包括执行OCT以产生返回的光信号，执行US成像以产生返回的超声信号，执行PR-ARF-OCE以通过生成调幅超声波束或啁啾幅度调制超声波来产生返回的PR-ARF-OCE信号光束扫频声辐射力，使用相位分辨OCT方法测量ARF诱导的组织位移，以及PR-ARF-OCE信号的频率依赖性，处理返回的光信号，返回的超声信号和测量的频率依赖性返回的PR-ARF-OCE光学相干弹性成像信号，以在机械共振频率下使用增强的材料响应来定量测量所识别的组织的光谱和空间分辨率的机械性质，以区分具有变化刚度的组织，以鉴定具有不同生物力学性质的组织，测量结构和机械性能同时。

4. 发明授权

US10400265B2 Gel extraction device and methods to recover biomolecules from agar and agarose gels 有权
公开(公告)号：US10400265B2
公开(公告)日：2019-09-03
申请号：US15002386
申请日：2016-01-20
申请人： The Regents of the University of California
发明人： Rui Li , Peggy A. Mauk , Carol J. Lovatt
IPC分类号： G01N1/08 , C12Q1/6806
摘要： The disclosure provides for a gel extraction device comprising multifunctional and reusable forceps, a removable cutting element, and a sampler component. The disclosure further provides for a freeze/thaw method which can be used to recover biomolecules from agar or agarose gels.

5. 发明申请

US20140376837A1 SEMI-ACTIVE INSOLATORS BASED ON MAGNETORHEOLOGICAL NANOCOMPOSITES 有权
标题翻译：基于磁流变纳米复合材料的半导体绝缘体
公开(公告)号：US20140376837A1
公开(公告)日：2014-12-25
申请号：US14312559
申请日：2014-06-23
申请人： The Regents of the University of California
发明人： Lizhi Sun , Hang Sun , Rui Li
IPC分类号： F16C33/02 , H01F1/42 , F16C29/00
CPC分类号： F16F1/361 , B82Y25/00 , B82Y30/00 , F16C32/0637 , F16C33/1035 , F16C33/6644 , F16C2210/06 , H01F1/447
摘要： Systems, devices, uses and methods relating to magnetorhological materials including carbon nanotubes, such as single-walled and multi-walled carbon nanotubes, are disclosed. Uses of magnetorheological materials such as in motion damping/vibration isolation are also disclosed.
摘要翻译：公开了与包括碳纳米管在内的磁性材料相关的系统，装置，用途和方法，例如单壁和多壁碳纳米管。还公开了诸如运动阻尼/隔振的磁流变材料的使用。

6. 发明授权

US09581214B2 Semi-active isolators based on magnetorheological nanocomposites 有权
标题翻译：基于磁流变纳米复合材料的半主动隔离器
公开(公告)号：US09581214B2
公开(公告)日：2017-02-28
申请号：US14312559
申请日：2014-06-23
申请人： The Regents of the University of California
发明人： Lizhi Sun , Hang Sun , Rui Li
IPC分类号： F16F1/36 , H01F1/44 , B82Y25/00 , F16C33/10 , B82Y30/00 , F16C32/06 , F16C33/66
CPC分类号： F16F1/361 , B82Y25/00 , B82Y30/00 , F16C32/0637 , F16C33/1035 , F16C33/6644 , F16C2210/06 , H01F1/447
摘要： Systems, devices, uses and methods relating to magnetorhological materials including carbon nanotubes, such as single-walled and multi-walled carbon nanotubes, are disclosed. Uses of magnetorheological materials such as in motion damping/vibration isolation are also disclosed.
摘要翻译：公开了与包括碳纳米管在内的磁性材料相关的系统，装置，用途和方法，例如单壁和多壁碳纳米管。还公开了诸如运动阻尼/隔振的磁流变材料的使用。

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