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1. 发明授权

US11099172B2 In vitro assays for inhibition of microglial activation 有权
公开(公告)号：US11099172B2
公开(公告)日：2021-08-24
申请号：US15943474
申请日：2018-04-02
申请人： The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone , The Regents of the University of California
发明人： Katerina Akassoglou , Michelle Arkin , Kean-Hooi Ang , Anke Meyer-Franke , Christopher Wilson
IPC分类号： G01N33/50
摘要： The present invention provides cell-based assays, including high throughput cell-based assays, for identification of candidate therapeutic agents with the ability to inhibit microglial activation in vivo in response to different ligands.

2. 发明授权

US10451611B2 Compositions and methods for in vitro assays of fibrin activity 有权
公开(公告)号：US10451611B2
公开(公告)日：2019-10-22
申请号：US15109160
申请日：2015-01-09
申请人： THE J. DAVID GLADSTONE INSTITUTES
发明人： Katerina Akassoglou , Jae Kyu Ryu , Anke Meyer-Franke
IPC分类号： G01N33/50
摘要： The present invention provides compositions exhibiting in vivo activity of fibrin in an in vitro setting, in vitro assays comprising such compositions, methods of producing such compositions, and methods of using such compositions and assays. The compositions of the invention include molecules with the biochemical properties of 1) high affinity binding to fibrin receptors and 2) activation of cell-signaling systems comparable to that observed in vivo by fibrin. The fibrin compositions of the invention are compatible both in biochemical assays and cell-based assays, and thus useful for in vitro assays for screening of test agents that modulate cell activation and/or signaling pathways mediated by fibrin or associated with fibrin activity.

3. 发明授权

US11573222B2 Compositions and methods for in vitro assays of fibrin activity 有权
公开(公告)号：US11573222B2
公开(公告)日：2023-02-07
申请号：US16572365
申请日：2019-09-16
申请人： The J. David Gladstone Institutes
发明人： Katerina Akassoglou , Jae Kyu Ryu , Anke Meyer-Franke
IPC分类号： G01N33/50
摘要： The present invention provides compositions exhibiting in vivo activity of fibrin in an in vitro setting, in vitro assays comprising such compositions, methods of producing such compositions, and methods of using such compositions and assays. The compositions of the invention include molecules with the biochemical properties of 1) high affinity binding to fibrin receptors and 2) activation of cell-signaling systems comparable to that observed in vivo by fibrin. The fibrin compositions of the invention are compatible both in biochemical assays and cell-based assays, and thus useful for in vitro assays for screening of test agents that modulate cell activation and/or signaling pathways mediated by fibrin or associated with fibrin activity.

4. 发明申请

US20170003280A1 IN VITRO ASSAYS FOR INHIBITION OF MICROGLIAL ACTIVATION 审中-公开
标题翻译：用于抑制微量激活的体外测定
公开(公告)号：US20170003280A1
公开(公告)日：2017-01-05
申请号：US15109163
申请日：2015-01-09
申请人： THE J. DAVID GLADSTONE INSTITUTES , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Katerina Akassoglou , Michelle Arkin , Kean-Hooi Ang , Anke Meyer-Franke , Christopher Wilson
IPC分类号： G01N33/50
CPC分类号： G01N33/5058 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/5044 , G01N33/5047 , G01N2500/00 , G01N2800/28 , G01N2800/7095
摘要： The present invention provides cell-based assays, including high throughput cell-based assays, for identification of candidate therapeutic agent with no known agents with the ability to inhibit microglial activation in vivo in response to different ligands.
摘要翻译：本发明提供基于细胞的测定法，包括基于细胞的高通量测定法，用于鉴定候选治疗剂，其中没有已知的具有抑制响应于不同配体的体内小胶质细胞活化的能力的试剂。

5. 发明申请

US20160320370A1 COMPOSITIONS AND METHODS FOR IN VITRO ASSAYS OF FIBRIN ACTIVITY 审中-公开
标题翻译： FIBRIN活动的体外测定的组合物和方法
公开(公告)号：US20160320370A1
公开(公告)日：2016-11-03
申请号：US15109160
申请日：2015-01-09
申请人： THE J. DAVID GLADSTONE INSTITUTES
发明人： Katerina Akassoglou , Jae Kyu Ryu , Anke Meyer-Franke
IPC分类号： G01N33/50
CPC分类号： G01N33/5058 , G01N33/5055 , G01N2333/70553 , G01N2333/75
摘要： The present invention provides compositions exhibiting in vivo activity of fibrin in an in vitro setting, in vitro assays comprising such compositions, methods of producing such compositions, and methods of using such compositions and assays. The compositions of the invention include molecules with the biochemical properties of 1) high affinity binding to fibrin receptors and 2) activation of cell-signaling systems comparable to that observed in vivo by fibrin. The fibrin compositions of the invention are compatible both in biochemical assays and cell-based assays, and thus useful for in vitro assays for screening of test agents that modulate cell activation and/or signaling pathways mediated by fibrin or associated with fibrin activity.
摘要翻译：本发明提供在体外凝固中显示纤维蛋白体内活性的组合物，包含这种组合物的体外测定法，生产此类组合物的方法，以及使用这种组合物和测定法的方法。本发明的组合物包括具有生物化学性质的分子：1）与纤维蛋白受体的高亲和力结合，以及2）与通过纤维蛋白体内观察到的细胞信号传导系统相当的活化。本发明的纤维蛋白组合物在生物化学测定和基于细胞的测定中都是相容的，因此可用于筛选调节由纤维蛋白介导的或与纤维蛋白活性相关的细胞活化和/或信号传导途径的测试剂的体外测定。

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