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1. 发明授权

US09414926B2 Implant for restoring normal range flexion and kinematics of the knee 有权
标题翻译：用于恢复正常范围屈曲和膝关节运动学的植入物
公开(公告)号：US09414926B2
公开(公告)日：2016-08-16
申请号：US14550755
申请日：2014-11-21
申请人： The General Hospital Corporation
发明人： Guoan Li , Harry E. Rubash , Kartik Mangudi Varadarajan
IPC分类号： A61F2/38
CPC分类号： A61F2/389 , A61F2/38 , A61F2/3836 , A61F2230/0063
摘要： Embodiments of the invention provide knee prostheses which more faithfully and closely replicate the function, anatomy and physiology of the normal human knee yielding a number of advantages. Among other things, such prostheses can provide an increased range of motion and function more normally particularly in extension, deep flexion and during normal gait. Knee prostheses according to various aspects of the invention recognize that during movement of the knee, particularly during flexion, the kinematics of the bones of the knee are a result of achieving equilibrium of the forces that cause motion of the knee. In addition, the shape of the articular surfaces acting in combination with forces imposed by various muscles, ligaments and tendons, determines the direction of the large contact forces.
摘要翻译：本发明的实施例提供膝关节假体，其更真实和更密切地复制正常人膝盖的功能，解剖和生理学，产生许多优点。除此之外，这样的假体可以提供更大范围的运动和更普遍的功能，特别是在伸展，深屈曲和正常步态期间。根据本发明的各个方面的膝关节假体认识到，在膝盖运动期间，特别是在弯曲期间，膝盖的骨骼的运动学是实现引起膝盖运动的力的平衡的结果。此外，与各种肌肉，韧带和腱施加的力组合起来的关节表面的形状决定了大的接触力的方向。

2. 发明申请

US20150164646A1 Methods and Devices for Knee Joint Replacement with Anterior Cruciate Ligament Substitution 有权
标题翻译：膝关节置换与前交叉韧带替代术的方法和装置
公开(公告)号：US20150164646A1
公开(公告)日：2015-06-18
申请号：US14630421
申请日：2015-02-24
申请人： The General Hospital Corporation
发明人： Orhun K. Muratoglu , Kartik Mangudi Varadarajan , Guoan Li , Harry E. Rubash , Thomas Zumbrunn
IPC分类号： A61F2/38
CPC分类号： A61F2/3836 , A61F2/08 , A61F2/0811 , A61F2/3886 , A61F2002/30688
摘要： Methods and devices are provided for knee joint replacement with anterior cruciate ligament (ACL) substitution. Generally, the methods and devices can allow a knee joint to be partially or totally replaced in conjunction with substitution of the knee joint's ACL. In one embodiment, a knee replacement prosthesis can include a medial or lateral femoral implant, a femoral intercondylar notch structure, a medial or lateral tibial insert, and an ACL-substitution member. The ACL-substitution member can be configured to engage with the femoral intercondylar notch structure during a full range of knee motion and/or during only early knee flexion.
摘要翻译：方法和装置用于膝关节置换前交叉韧带（ACL）替代。通常，所述方法和装置可以允许膝关节部分地或完全地被替换为膝关节的ACL。在一个实施例中，膝关节置换假体可以包括内侧或外侧股骨植入物，股骨髁间隙结构，内侧或外侧胫骨插入物和ACL取代构件。 ACL取代构件可以被构造成在全膝关节运动范围和/或仅在早期膝关节屈曲期间与股骨髁间隙结构接合。

3. 发明公开

US20230260113A1 DETERMINING A CLINICAL PARAMETER VIA EVALUATION OF SEQUENTIAL MEDICAL IMAGES 审中-公开
公开(公告)号：US20230260113A1
公开(公告)日：2023-08-17
申请号：US18015021
申请日：2023-01-06
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Kartik Mangudi Varadarajan , Alireza Borjali , Orhun K. Muratoglu
IPC分类号： G06T7/00 , G06T5/50 , G16H50/20 , G16H20/00
CPC分类号： G06T7/0012 , G06T5/50 , G16H20/00 , G16H50/20 , G06T2207/10081 , G06T2207/10088 , G06T2207/20084 , G06T2207/20221
摘要： Systems and methods are provided for determining a clinical parameter via evaluation of sequential medical images. A sequence of at least three medical images for a patient are captured at a scanner. A set of at least two difference images are generated from the sequence of at least three medical images. Each difference image represents a difference in content between two adjacent images in the sequence of at least three medical images. The set of at least two difference images are provided to a predictive model. The predictive model includes an artificial neural network having at least one convolutional layer. A clinical parameter for the patient is determined at the predictive model from at least the set of at least two difference images.

4. 发明申请

US20210113208A1 WOUND CLOSURE DEVICE 有权
公开(公告)号：US20210113208A1
公开(公告)日：2021-04-22
申请号：US16981955
申请日：2019-03-21
申请人： The General Hospital Corporation
发明人： Kartik Mangudi Varadarajan , Harry E. Rubash
IPC分类号： A61B17/08
摘要： A wound closure device is provided. The wound closure device includes a first pad with an adhesive surface and a second pad with an adhesive surface. The wound closure device also includes a first tension adjusting pad with a first section, a first connecting element and a second connecting element. The first tension adjust pad is configured to move the first pad towards the second pad when the first tension adjusting pad is moved away from the first pad. The wound closure device also includes a second tension adjusting pad with a second section, a third connecting element and fourth connecting element. The second tension adjusting pad is configured to move the second pad towards the first pad when the second tension adjusting pad is moved away from the second pad. The wound closure device further includes a first cross bar for securing the first and third connecting elements.

5. 发明申请

US20170135820A1 Femoral Heads, Mobile Inserts, Acetabular Components, and Modular Junctions for Orthopedic Implants and Methods of Using Femoral Heads, Mobile Insets, Acetabular Components, and Modular Junctions for Orthopedic Implants 审中-公开
公开(公告)号：US20170135820A1
公开(公告)日：2017-05-18
申请号：US15269622
申请日：2016-09-19
申请人： The General Hospital Corporation
发明人： Orhun K. Muratoglu , Kartik Mangudi Varadarajan , Henrik Malchau , Harry E. Rubash , Andrew A. Freiberg , Michael Patrick Duffy , Thomas Zumbrunn
IPC分类号： A61F2/36 , A61F2/30
CPC分类号： A61F2/3609 , A61F2/30 , A61F2/30771 , A61F2/32 , A61F2/36 , A61F2/3603 , A61F2/468 , A61F2002/2828 , A61F2002/30092 , A61F2002/30299 , A61F2002/30347 , A61F2002/30474 , A61F2002/30688 , A61F2002/3082 , A61F2002/30937 , A61F2002/3208 , A61F2002/3611 , A61F2002/3615 , A61F2002/3617 , A61F2002/3623 , A61F2002/365
摘要： Femoral heads, mobile inserts, acetabular components, and modular junctions for orthopedic implants, e.g., hip replacement implants, and methods of using femoral heads, mobile inserts, acetabular components, and modular junctions for orthopedic implants are provided. Prosthetic femoral heads, mobile inserts, and acetabular components are provided that can alleviate soft tissue impingement, reduce implant wear, and/or reduce frictional torque. Modular junctions are provided that can minimize the incidence of loosening and micromotion that can occur at modular junctions of orthopedic implants.

6. 发明申请

US20180116809A1 PROSTHESIS AND METHOD FOR USING PROSTHESIS TO FACILITATE DEEP KNEE FLEXION 审中-公开
公开(公告)号：US20180116809A1
公开(公告)日：2018-05-03
申请号：US15801630
申请日：2017-11-02
申请人： The General Hospital Corporation
发明人： Guoan Li , Kartik Mangudi Varadarajan , Harry E. Rubash
IPC分类号： A61F2/38 , A61F2/46 , A61F2/30
CPC分类号： A61F2/3859 , A61F2/461 , A61F2002/30326 , A61F2002/30327 , A61F2002/30934
摘要： The present invention provides a femoral prosthesis for a femur which can enable or allow deep knee flexion without creating excessive tension in the ligamentous structure of the knee. The femoral prosthesis includes an internal non-articulating surface, an external articulating surface, a medial condyle and a lateral condyle. The height of the medial condyle is less than the height of the lateral condyle. A proximal-posterior tip of the medial condyle is rounded and is shifted inwards relative to the native level of the proximal-posterior region of the femur bone to facilitate knee flexion. A method of mounting a femoral prosthesis on a femur is also described.

7. 发明授权

US09820855B2 Prosthesis and method for using prosthesis to facilitate deep knee flexion 有权
公开(公告)号：US09820855B2
公开(公告)日：2017-11-21
申请号：US14790694
申请日：2015-07-02
申请人： The General Hospital Corporation
发明人： Guoan Li , Kartik Mangudi Varadarajan , Harry E. Rubash
IPC分类号： A61F2/38 , A61F2/46 , A61F2/30
CPC分类号： A61F2/3859 , A61F2/461 , A61F2002/30326 , A61F2002/30327 , A61F2002/30934
摘要： The present invention provides a femoral prosthesis for a femur which can enable or allow deep knee flexion without creating excessive tension in the ligamentous structure of the knee. The femoral prosthesis includes an internal non-articulating surface, an external articulating surface, a medial condyle and a lateral condyle. The height of the medial condyle is less than the height of the lateral condyle. A proximal-posterior tip of the medial condyle is rounded and is shifted inwards relative to the native level of the proximal-posterior region of the femur bone to facilitate knee flexion. A method of mounting a femoral prosthesis on a femur is also described.

8. 发明授权

US09707085B2 Methods and devices for knee joint replacement with anterior cruciate ligament substitution 有权
公开(公告)号：US09707085B2
公开(公告)日：2017-07-18
申请号：US14630421
申请日：2015-02-24
申请人： The General Hospital Corporation
发明人： Orhun K. Muratoglu , Kartik Mangudi Varadarajan , Guoan Li , Harry E. Rubash , Thomas Zumbrunn
IPC分类号： A61F2/38 , A61F2/08 , A61F2/30
CPC分类号： A61F2/3836 , A61F2/08 , A61F2/0811 , A61F2/3886 , A61F2002/30688
摘要： Methods and devices are provided for knee joint replacement with anterior cruciate ligament (ACL) substitution. Generally, the methods and devices can allow a knee joint to be partially or totally replaced in conjunction with substitution of the knee joint's ACL. In one embodiment, a knee replacement prosthesis can include a medial or lateral femoral implant, a femoral intercondylar notch structure, a medial or lateral tibial insert, and an ACL-substitution member. The ACL-substitution member can be configured to engage with the femoral intercondylar notch structure during a full range of knee motion and/or during only early knee flexion.

9. 发明申请

US20150297352A1 PROSTHESIS AND METHOD FOR USING PROSTHESIS TO FACILITATE DEEP KNEE FLEXION 有权
标题翻译：使用前景促进深层康复的前景和方法
公开(公告)号：US20150297352A1
公开(公告)日：2015-10-22
申请号：US14790694
申请日：2015-07-02
申请人： The General Hospital Corporation
发明人： Guoan Li , Kartik Mangudi Varadarajan , Harry E. Rubash
IPC分类号： A61F2/38 , A61F2/46
CPC分类号： A61F2/3859 , A61F2/461 , A61F2002/30326 , A61F2002/30327 , A61F2002/30934
摘要： The present invention provides a femoral prosthesis for a femur which can enable or allow deep knee flexion without creating excessive tension in the ligamentous structure of the knee. The femoral prosthesis includes an internal non-articulating surface, an external articulating surface, a medial condyle and a lateral condyle. The height of the medial condyle is less than the height of the lateral condyle. A proximal-posterior tip of the medial condyle is rounded and is shifted inwards relative to the native level of the proximal-posterior region of the femur bone to facilitate knee flexion. A method of mounting a femoral prosthesis on a femur is also described.
摘要翻译：本发明提供一种用于股骨的股骨假体，其能够或允许深膝屈曲而不会在膝盖的韧带结构中产生过度的张力。股骨假体包括内部非关节表面，外部关节表面，内侧髁和外侧髁。内侧髁的高度小于外侧髁的高度。内侧髁的近端 - 后尖端是圆形的并且相对于股骨的近端 - 后部区域的天然水平向内移动以便于膝部屈曲。还描述了将股骨假体安装在股骨上的方法。

10. 发明申请

US20210298631A1 SYSTEM AND METHOD FOR MONITORING IMPLANT FIXATION USING ELECTRICAL IMPEDANCE TOMOGRAPHY 有权
公开(公告)号：US20210298631A1
公开(公告)日：2021-09-30
申请号：US17269763
申请日：2019-08-22
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Kartik Mangudi Varadarajan , Tyler Tallman , A. John Hart
IPC分类号： A61B5/0536 , A61B5/00
摘要： A system for determining conditions within or near an implant apparatus in region of a subject includes an implant apparatus configured to be piezoresistive, the implant apparatus positioned in a region of a subject having a surface, and an electrical impedance tomography system. The electrical impedance tomography system includes a plurality of electrodes disposed on the surface of the region of the subject, each of the plurality of electrodes configured to apply a current to the region of the subject and to receive measurement signals from the region of the subject in response to an applied current. The electrical impedance tomography system further includes a current source coupled to the plurality of electrodes and configured to provide a current to at least one of the plurality of electrodes and a controller coupled to the plurality of electrodes and the current source, the controller configured to control the current source to provide a current to at least one of the plurality of electrodes, to receive the measurement signals from at least one of the plurality of electrodes, and to determine at least one electrical property associated with the implant apparatus based on the measurement signals. The electrical impedance tomography system also includes a display coupled to the controller and configured to display the at least one electrical property.

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