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    • 1. 发明申请
    • Interpenetrating Polymer Network Hydrogel
    • 互穿聚合物网络水凝胶
    • US20140357559A1
    • 2014-12-04
    • US14463161
    • 2014-08-19
    • The Board of Trustees of the Leland Stanford Junior University
    • David MyungLaura HartmannJaan NoolandiChristopher N. TaCurtis W. Frank
    • A61K47/48
    • A61L27/52A61K47/58A61K47/60A61K47/6903A61L27/38
    • A strain-hardened interpenetrating polymer network (IPN) hydrogel is provided. The interpenetrating polymer network hydrogel is based on two different networks. The first network is a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups. The second network is a non-silicone network of ionizable monomers. The second network has been polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. An aqueous salt solution having a neutral pH is used to ionize and swell the second network in the interpenetrating polymer network. The swelling of the second network is constrained by the first network, and this constraining effect results in an increase in effective physical cross-links within the interpenetrating polymer network, and, in turn, an increase its elastic modulus. The strain-hardened interpenetrating polymer network hydrogel is attractive and useful for medical, industrial, and personal hygiene purposes.
    • 提供了应变硬化的互穿聚合物网络(IPN)水凝胶。 互穿聚合物网络水凝胶基于两个不同的网络。 第一个网络是通过其端基聚合化学交联的预制亲水非离子遥爪大分子单体的非硅氧烷网络。 第二个网络是可离子化单体的无硅网络。 第二网络已经在第一网络的存在下被聚合和化学交联,并且与第一网络形成了物理交叉连接。 使用具有中性pH的盐水溶液使互穿聚合物网络中的第二网络离子化并溶胀。 第二网络的膨胀由第一网络约束,并且这种约束效应导致互穿聚合物网络内的有效物理交联的增加,并且进而增加其弹性模量。 应变硬化的互穿聚合物网络水凝胶对于医疗,工业和个人卫生目的是有吸引力和有用的。