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1. 发明申请

US20060088915A1 Novel physiologically active peptide and use thereof 失效
标题翻译：新型生理活性肽及其用途
公开(公告)号：US20060088915A1
公开(公告)日：2006-04-27
申请号：US11304129
申请日：2005-12-15
申请人： Tetsuya Ohtaki , Yasushi Masuda , Yoshihiro Takatsu , Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Syuji Hinuma
发明人： Tetsuya Ohtaki , Yasushi Masuda , Yoshihiro Takatsu , Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Syuji Hinuma
IPC分类号： C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , G01N33/566 , G01N33/74 , G01N2500/02
摘要： The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity of the peptide, a compound or its salt obtained by the screening, a drug comprising the compound or its salt, etc. The peptide of the invention and the DNA encoding the same are usable, e.g., for the diagnosis, treatment, prevention, etc. of digestive diseases, etc. Moreover, the peptide of the invention is useful as a reagent for screening a compound or its salt that promotes or inhibits the activity of the protein of the invention.
摘要翻译：本发明意图提供一种新的肽及其用途。更具体地说，本发明提供新的肽和编码该肽的DNA，包含肽或DNA的药物，用于促进或抑制肽的活性的化合物或其盐的筛选方法/筛选试剂盒，化合物或其通过筛选获得的盐，包含该化合物或其盐的药物等。本发明的肽及其编码的DNA可用于例如消化系统疾病的诊断，治疗，预防等。此外，本发明的肽可用作筛选促进或抑制本发明的蛋白质的活性的化合物或其盐的试剂。

2. 发明授权

US07419956B2 Isolated physiologically active peptide and use thereof 失效
标题翻译：分离的生理活性肽及其用途
公开(公告)号：US07419956B2
公开(公告)日：2008-09-02
申请号：US11304129
申请日：2005-12-15
申请人： Tetsuya Ohtaki , Yasushi Masuda , Yoshihiro Takatsu , Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Syuji Hinuma
发明人： Tetsuya Ohtaki , Yasushi Masuda , Yoshihiro Takatsu , Takuya Watanabe , Yasuko Terao , Yasushi Shintani , Syuji Hinuma
IPC分类号： A61K38/00
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , G01N33/566 , G01N33/74 , G01N2500/02
摘要： The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity of the peptide, a compound or its salt obtained by the screening, a drug comprising the compound or its salt, etc.The peptide of the invention and the DNA encoding the same are usable, e.g., for the diagnosis, treatment, prevention, etc. of digestive diseases, etc. Moreover, the peptide of the invention is useful as a reagent for screening a compound or its salt that promotes or inhibits the activity of the protein of the invention.
摘要翻译：本发明意图提供一种新的肽及其用途。更具体地说，本发明提供新的肽和编码该肽的DNA，包含肽或DNA的药物，用于促进或抑制肽的活性的化合物或其盐的筛选方法/筛选试剂盒，化合物或其通过筛选获得的盐，包含该化合物或其盐的药物等。本发明的肽及其编码的DNA可用于例如消化系统疾病的诊断，治疗，预防等。此外，本发明的肽可用作筛选促进或抑制本发明的蛋白质的活性的化合物或其盐的试剂。

3. 发明授权

US07045299B2 Physiologically active peptide and use thereof 失效
标题翻译：生理活性肽及其用途
公开(公告)号：US07045299B2
公开(公告)日：2006-05-16
申请号：US10333192
申请日：2001-07-17
申请人： Tetsuya Ohtaki , Yasushi Masuda , Yoshihiro Takatsu , Takuya Watanabe , Yasuko Terao , Yasushi Shintani
发明人： Tetsuya Ohtaki , Yasushi Masuda , Yoshihiro Takatsu , Takuya Watanabe , Yasuko Terao , Yasushi Shintani
IPC分类号： G01N33/53 , C12P2/06 , C07K14/00 , C07K2/00
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , G01N33/566 , G01N33/74 , G01N2500/02
摘要： The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity of the peptide, a compound or its salt obtained by the screening, a drug comprising the compound or its salt, etc.The peptide of the invention and the DNA encoding the same are usable, e.g., for the diagnosis, treatment, prevention, etc. of digestive diseases, etc. Moreover, the peptide of the invention is useful as a reagent for screening a compound or its salt that promotes or inhibits the activity of the protein of the invention.
摘要翻译：本发明意图提供一种新的肽及其用途。更具体地说，本发明提供新的肽和编码该肽的DNA，包含肽或DNA的药物，用于促进或抑制肽的活性的化合物或其盐的筛选方法/筛选试剂盒，化合物或其通过筛选获得的盐，包含该化合物或其盐的药物等。本发明的肽及其编码的DNA可用于例如消化系统疾病的诊断，治疗，预防等。此外，本发明的肽可用作筛选促进或抑制本发明的蛋白质的活性的化合物或其盐的试剂。

4. 发明申请

US20050176632A1 Angiogenesis inhibitors 审中-公开
标题翻译：血管生成抑制剂
公开(公告)号：US20050176632A1
公开(公告)日：2005-08-11
申请号：US10503554
申请日：2003-02-03
申请人： Tetsuya Ohtaki , Yasushi Masuda , Yoshihiro Takatsu
发明人： Tetsuya Ohtaki , Yasushi Masuda , Yoshihiro Takatsu
IPC分类号： A61K31/7088 , A61K38/00 , A61K39/00 , A61K48/00 , A61P15/08 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/71 , C12N15/12 , C12Q1/68 , A61K38/17 , A61K39/395 , C07H21/04 , C07K14/82 , C07K16/30
CPC分类号： A61K31/7088 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C07K14/71
摘要： The present invention provides a method of screening a compound or its salt promoting or inhibiting the activity of a novel protein, etc; a screening kit therefor; compounds or salt thereof obtained by the screening; drugs containing these compounds or salts thereof; and so on. These drugs are usable as, for example, angiogenesis, inhibitors in prevention /remedies for cancer, ovary diseases, inflammatory diseases, diabetic retinopathy, etc.
摘要翻译：本发明提供筛选促进或抑制新型蛋白质的活性的化合物或其盐的方法等; 一个筛选工具包; 通过筛选获得的化合物或其盐; 含有这些化合物或其盐的药物; 等等。这些药物可用作例如血管发生，癌症预防/治疗抑制剂，卵巢疾病，炎性疾病，糖尿病性视网膜病变等。

5. 发明授权

US06534163B1 Display board and production method therefor 失效
标题翻译：显示板及其制作方法
公开(公告)号：US06534163B1
公开(公告)日：2003-03-18
申请号：US09744590
申请日：2001-01-26
申请人： Yoshihiro Takatsu
发明人： Yoshihiro Takatsu
IPC分类号： B32B300
CPC分类号： G09F13/10 , G09F13/04 , G09F13/08 , Y10T428/24876 , Y10T428/24942
摘要： A white display layer 3 for forming a display part 2 of scales, characters and numerals is provided on the front side of a light transmitting substrate 1, and a black opaque layer 4 is formed by printing on a position except the display part 2. A transparent protective layer 5A is provided to cover the display part 2 and the opaque layer 4. Transparent and colorless beads are oriented in the protective layer 5A on the front side. Therefore, the surface of the display panel has a state of fine unevenness.
摘要翻译：在透光基板1的前侧设置用于形成刻度，字符和数字的显示部分2的白色显示层3，并且在除了显示部分2之外的位置上印刷形成黑色不透明层4。提供透明保护层5A以覆盖显示部分2和不透明层4.透明和无色珠粒在前侧的保护层5A中取向。因此，显示面板的表面具有微细凹凸的状态。

6. 发明申请

US20070026457A1 Screening method 失效
标题翻译：筛选方法
公开(公告)号：US20070026457A1
公开(公告)日：2007-02-01
申请号：US10571300
申请日：2004-09-09
申请人： Atsuko Katano , Yoshihiro Takatsu , Hiroyuki Kobayashi
发明人： Atsuko Katano , Yoshihiro Takatsu , Hiroyuki Kobayashi
IPC分类号： G01N33/53 , A61K38/17 , C07K14/72 , C07H21/04 , C12P21/06 , A61K31/11 , A61K31/07 , A61K31/015
CPC分类号： A61K31/00 , G01N33/5011 , G01N33/743
摘要： The present invention provides a method of screening an agent for the prevention/treatment of cancer. More specifically, the present invention provides a screening method/screening kit for screening a compound or its salt that changes the binding properties of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or salts thereof, to a ligand capable of binding specifically to the protein, which comprises using (a) the protein, its partial peptides, or salts thereof and (b) the ligand capable of binding specifically to the protein; compounds obtained by the screening or salts thereof; agents for the prevention/treatment of cancer comprising the compounds or salts thereof; and so on.
摘要翻译：本发明提供了筛选癌症预防/治疗药物的方法。更具体地，本发明提供了筛选化合物或其盐的筛选方法/筛选试剂盒，其改变包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列的蛋白质的结合特性或其盐与能够与蛋白质特异性结合的配体，其包括使用（a）蛋白质，其部分肽或其盐和（b）能够特异性结合蛋白质的配体; 通过筛选获得的化合物或其盐; 包含其化合物或其盐的预防/治疗癌症的药剂; 等等。

7. 发明授权

US07625696B2 Screening method 失效
标题翻译：筛选方法
公开(公告)号：US07625696B2
公开(公告)日：2009-12-01
申请号：US10571300
申请日：2004-09-09
申请人： Atsuko Katano , Yoshihiro Takatsu , Hiroyuki Kobayashi
发明人： Atsuko Katano , Yoshihiro Takatsu , Hiroyuki Kobayashi
IPC分类号： C12Q1/00
CPC分类号： A61K31/00 , G01N33/5011 , G01N33/743
摘要： The present invention provides a method of screening an agent for the prevention/treatment of cancer. More specifically, the present invention provides a screening method/screening kit for screening a compound or its salt that changes the binding properties of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or salts thereof, to a ligand capable of binding specifically to the protein, which comprises using (a) the protein, its partial peptides, or salts thereof and (b) the ligand capable of binding specifically to the protein; compounds obtained by the screening or salts thereof; agents for the prevention/treatment of cancer comprising the compounds or salts thereof; and so on.
摘要翻译：本发明提供了筛选癌症预防/治疗药物的方法。更具体地，本发明提供了筛选化合物或其盐的筛选方法/筛选试剂盒，其改变包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列的蛋白质的结合特性或其盐与能够与蛋白质特异性结合的配体，其包括使用（a）蛋白质，其部分肽或其盐和（b）能够特异性结合蛋白质的配体; 通过筛选获得的化合物或其盐; 包含其化合物或其盐的预防/治疗癌症的药剂; 等等。

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