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1. 发明申请

US20090186364A1 Method of Constructing Recombinant Proteoliposome for Diagnostic Use 失效
标题翻译：构建用于诊断用途的重组蛋白脂质体的方法
公开(公告)号：US20090186364A1
公开(公告)日：2009-07-23
申请号：US12223975
申请日：2007-02-15
申请人： Tetsuro Yoshimura , Kanta Tsumoto , Kouji Imamura , Kazuhiko Morino , Jun Kobayashi
发明人： Tetsuro Yoshimura , Kanta Tsumoto , Kouji Imamura , Kazuhiko Morino , Jun Kobayashi
IPC分类号： G01N33/53 , C12P21/00 , B32B9/04
CPC分类号： G01N33/5432 , C12N15/86 , C12N15/88 , C12N2710/14143 , C12N2810/855 , G01N33/564 , G01N33/56983 , G01N2333/01 , G01N2469/20
摘要： [PROBLEMS] To provide a method for preparation of recombinant proteoliposomes suitable for diagnostic applications, a detection plate coated with the recombinant proteoliposomes, a detection kit and so on.[PROBLEM-SOLVING MEANS] Recombinant proteoliposomes are prepared by fusion of budded virus particles of a recombinant baculovirus, expressing a target membrane receptor (such as human thyroid-stimulating hormone receptor, acetylcholine receptor, insulin receptor, β1 adrenergic receptor, asialoglycoprotein receptor, etc., each participating in an autoantibody-related disease), with liposomes. Compared with the recombinant baculoviruses, these proteoliposomes have an improved ability to bind to an autoantibody and makes it possible to produce easily a kit for its detection.
摘要翻译： [问题]提供一种适用于诊断应用的重组蛋白脂质体的制备方法，用重组蛋白脂质体包被的检测板，检测试剂盒等。 [问题解决方案]重组蛋白脂质体通过表达靶膜受体（如人甲状腺激素受体，乙酰胆碱受体，胰岛素受体，β1肾上腺素能受体，脱唾液酸糖蛋白受体等）的重组杆状病毒的发芽病毒颗粒的融合而制备，各自参与自身抗体相关疾病），与脂质体。与重组杆状病毒相比，这些蛋白脂质体具有改进的与自身抗体结合的能力，并且使得可以容易地制备用于其检测的试剂盒。

2. 发明授权

US08563291B2 Method of constructing recombinant proteoliposome for diagnostic use 失效
标题翻译：构建重组蛋白脂质体用于诊断用途的方法
公开(公告)号：US08563291B2
公开(公告)日：2013-10-22
申请号：US12223975
申请日：2007-02-15
申请人： Tetsuro Yoshimura , Kanta Tsumoto , Kouji Imamura , Kazuhiko Morino , Jun Kobayashi
发明人： Tetsuro Yoshimura , Kanta Tsumoto , Kouji Imamura , Kazuhiko Morino , Jun Kobayashi
IPC分类号： C07K14/00 , C12N15/00
CPC分类号： G01N33/5432 , C12N15/86 , C12N15/88 , C12N2710/14143 , C12N2810/855 , G01N33/564 , G01N33/56983 , G01N2333/01 , G01N2469/20
摘要： [PROBLEMS] To provide a method for preparation of recombinant proteoliposomes suitable for diagnostic applications, a detection plate coated with the recombinant proteoliposomes, a detection kit and so on.[PROBLEM-SOLVING MEANS] Recombinant proteoliposomes are prepared by fusion of budded virus particles of a recombinant baculovirus, expressing a target membrane receptor (such as human thyroid-stimulating hormone receptor, acetylcholine receptor, insulin receptor, β1 adrenergic receptor, asialoglycoprotein receptor, etc., each participating in an autoantibody-related disease), with liposomes. Compared with the recombinant baculoviruses, these proteoliposomes have an improved ability to bind to an autoantibody and makes it possible to produce easily a kit for its detection.
摘要翻译： [问题]提供一种适用于诊断应用的重组蛋白脂质体的制备方法，用重组蛋白脂质体包被的检测板，检测试剂盒等。 [问题解决方案]重组蛋白脂质体通过表达靶膜受体（如人甲状腺激素受体，乙酰胆碱受体，胰岛素受体，β1肾上腺素能受体，脱唾液酸糖蛋白受体等）的重组杆状病毒的发芽病毒颗粒的融合而制备，各自参与自身抗体相关疾病），与脂质体。与重组杆状病毒相比，这些蛋白脂质体具有改进的与自身抗体结合的能力，并且使得可以容易地制备用于其检测的试剂盒。

3. 发明申请

US20110221082A1 LIPOSOME MANUFACTURING DEVICE 审中-公开
标题翻译： LIPOSOME制造设备
公开(公告)号：US20110221082A1
公开(公告)日：2011-09-15
申请号：US13123680
申请日：2009-10-09
申请人： Tetsuro Yoshimura , Kanta Tsumoto , Masatoshi Hashimoto , Toshihiko Yamagata , Kunitate Aoki
发明人： Tetsuro Yoshimura , Kanta Tsumoto , Masatoshi Hashimoto , Toshihiko Yamagata , Kunitate Aoki
IPC分类号： B29C35/02
CPC分类号： B01J13/04 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61K47/6911 , C12N2710/14011
摘要： Provided is a liposome manufacturing device which is a relatively small, multipurpose liposome manufacturing device that uses a motor, and that can reliably manufacture various types of liposomes and reconfigured liposomes. The multipurpose liposome manufacturing device is provided with an eccentric motor (3) that generates a vortex flow in a solution held inside a reaction space (2A), a heater (15), an aqueous solution line (6A) that can introduce an aqueous solution into the reaction space, a first bottle (9) that holds the aqueous solution, a first pump (14A) that moves the aqueous solution, an inert gas line (7B) that can introduce nitrogen gas into the reaction space, a decompression line (7B) that decompresses the reaction space, a vacuum pump (21) that decompresses the decompression line, a lipid line (6B) that can introduce an organic solvent in which a lipid is dissolved into the reaction space, a second bottle (10) that holds the organic solvent, and a second pump (14B) that moves the organic solvent to the reaction space through the lipid line (6B). The inert gas is introduced into a reaction vessel (2), the motor (3) is driven, and inside the reaction space (2A), while a vortex flow is generated in the organic solvent in which the lipid held in the reaction space (2A) is dissolved, the vacuum pump (21) is driven, the reaction space (2A) is decompressed to gasify the organic solvent from the reaction space (2A), and a thin lipid film is prepared on the inside wall of the reaction vessel (2). The inert gas is then introduced into the reaction space (2A), and the aqueous solution is added to the thin lipid film, the motor (3) is driven to generate a vortex flow in the aqueous solution, and liposomes are produced.
摘要翻译：提供了一种脂质体制造装置，其是使用电动机的相对小的多用途脂质体制造装置，其可以可靠地制造各种类型的脂质体和重新配置的脂质体。多用途脂质体制造装置设置有偏心马达（3），其在保持在反应空间（2A）内的溶液中产生涡流，加热器（15），能够引入水溶液的水溶液线（6A）进入反应空间，保持水溶液的第一瓶（9），使水溶液移动的第一泵（14A），可将氮气引入反应空间的惰性气体管线（7B），减压管线（ 7B），对所述反应空间进行减压，使减压管线减压的真空泵（21），能够将溶解有脂质的有机溶剂引入反应空间的脂质线（6B）;第二瓶（10）保持有机溶剂，以及通过脂质线（6B）将有机溶剂移动到反应空间的第二泵（14B）。惰性气体被引入反应容器（2）中，电动机（3）被驱动并且在反应空间（2A）内部，同时在保持在反应空间中的脂质的有机溶剂中产生涡流 2A）被溶解，驱动真空泵（21），将反应空间（2A）减压，从反应空间（2A）中气化有机溶剂，并在反应容器的内壁上制备薄脂质膜（2）。然后将惰性气体引入到反应空间（2A）中，并且将水溶液加入到薄脂质膜中，驱动马达（3）以在水溶液中产生涡流，并产生脂质体。

4. 发明申请

US20110187012A1 AUTOMATIC MULTIFUNCTIONAL LIPOSOME MANUFACTURING DEVICE 审中-公开
标题翻译：自动多功能液体制造装置
公开(公告)号：US20110187012A1
公开(公告)日：2011-08-04
申请号：US13124048
申请日：2009-10-13
申请人： Tetsuro Yoshimura , Masatoshi Hashimoto
发明人： Tetsuro Yoshimura , Masatoshi Hashimoto
IPC分类号： B01J13/02 , B01J19/00 , B06B1/00 , A61J3/07 , A61K9/127
CPC分类号： B01J13/04
摘要： Provided is a device for formulating a large quantity of many kinds of liposomes quickly and efficiently using a small amount of organic solvent through computer-based automatic control. To this end, an automatic multifunctional liposome manufacturing device (1) is equipped with a cylindrical reaction vessel (2), an eccentric motor (3), a heater (4), a vacuum pump (10), a syringe pump (SP3) for supplying an organic solvent into a reaction space, a syringe pump (SP4) for supplying an aqueous solution into the reaction space, an ultrasonic processor (6), and a computer (15) for automatic control of the individual mechanisms in accordance with a program.
摘要翻译：提供了一种通过基于计算机的自动控制，通过少量有机溶剂快速有效地配制大量多种脂质体的装置。为此，自动多功能脂质体制造装置（1）装备有圆柱形反应容器（2），偏心马达（3），加热器（4），真空泵（10），注射泵（SP3）用于将有机溶剂供应到反应空间中，用于将水溶液供应到反应空间的注射泵（SP4），超声波处理器（6）和用于根据程序。

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