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1. 发明申请

US20070059828A1 Carrier for nucleic acid molecule delivery 审中-公开
标题翻译：载体用于核酸分子递送
公开(公告)号：US20070059828A1
公开(公告)日：2007-03-15
申请号：US10578283
申请日：2004-11-05
申请人： Tetsuji Yamaoka , Yutaka Tokiwa , Masaru Kitagawa
发明人： Tetsuji Yamaoka , Yutaka Tokiwa , Masaru Kitagawa
IPC分类号： C12N15/00 , C08G63/91
CPC分类号： A61K31/7088 , A61K47/34 , A61K47/61 , C08F251/00 , C12N15/87
摘要： A carrier for nucleic acid molecule delivery formed from a saccharified copolymer comprising repeating unit (A) having a cationic group, saccharified repeating unit (B). There is further provided a carrier for nucleic acid molecule delivery formed from a saccharified copolymer comprising, in addition to the repeating units (A) and (B), repeating unit (C) having a hydrophobic substituent.
摘要翻译：由包含具有阳离子基团的重复单元（A），糖化重复单元（B）的糖化共聚物形成的核酸分子递送载体。还提供了由糖化共聚物形成的用于核酸分子递送的载体，除了具有疏水性取代基的重复单元（A）和（B））外，还包含重复单元（C）。

2. 发明授权

US07754864B2 Tyrosinase activity controlling agent, process for producing the same and external preparation containing the same 有权
标题翻译：酪氨酸酶活性控制剂，其制备方法和含有其的外用制剂
公开(公告)号：US07754864B2
公开(公告)日：2010-07-13
申请号：US10530789
申请日：2003-10-10
申请人： Yutaka Tokiwa , Masaru Kitagawa , Kenji Yoshino , Shusaku Yanagidani , Takao Raku , Tetsuzo Totani , Hiromi Shimakawa
发明人： Yutaka Tokiwa , Masaru Kitagawa , Kenji Yoshino , Shusaku Yanagidani , Takao Raku , Tetsuzo Totani , Hiromi Shimakawa
IPC分类号： C07G3/00 , C07H15/00 , C07H17/00 , A61K31/70 , A01N43/04 , A61K8/18 , A61Q5/08 , A61Q19/02
CPC分类号： C07H15/203 , A61K8/602 , A61K31/201 , A61K31/375 , A61K31/7024 , A61K31/7034 , A61K2800/782 , A61Q5/08 , A61Q19/02 , A61Q19/08 , C07H13/06 , C12P19/46
摘要： Disclosed is a tyrosinase activity controlling agent comprising, as an active ingredient, a compound that has tyrosinase inhibiting or promoting activity, an external preparation comprising the controlling agent, and a process for producing the compound.
摘要翻译：公开了一种酪氨酸酶活性控制剂，其包含具有酪氨酸酶抑制或促进活性的化合物作为活性成分，包含所述控制剂的外用制剂及其制备方法。

3. 发明申请

US20060052318A1 Tyrosinase activity cntrolling agent, process for producing the same and external preparations containing the same 有权
标题翻译：酪氨酸酶活性调节剂，制备含有相同的外用制剂的方法
公开(公告)号：US20060052318A1
公开(公告)日：2006-03-09
申请号：US10530789
申请日：2003-10-10
申请人： Yutaka Tokiwa , Masaru Kitagawa , Kenji Yoshino , Shusaku Yanagidani , Takao Raku , Tetsuzo Totani , Hiromi Shimakawa
发明人： Yutaka Tokiwa , Masaru Kitagawa , Kenji Yoshino , Shusaku Yanagidani , Takao Raku , Tetsuzo Totani , Hiromi Shimakawa
IPC分类号： A61K31/704 , C07H15/00
CPC分类号： C07H15/203 , A61K8/602 , A61K31/201 , A61K31/375 , A61K31/7024 , A61K31/7034 , A61K2800/782 , A61Q5/08 , A61Q19/02 , A61Q19/08 , C07H13/06 , C12P19/46
摘要： Disclosed is a tyrosinase activity controlling agent comprising, as an active ingredient, a compound that has tyrosinase inhibiting or promoting activity, an external preparation comprising the controlling agent, and a process for producing the compound.
摘要翻译：公开了一种酪氨酸酶活性控制剂，其包含具有酪氨酸酶抑制或促进活性的化合物作为活性成分，包含所述控制剂的外用制剂及其制备方法。

4. 发明授权

US5859217A Process for producing polymerization sugar esters 失效
标题翻译：可聚合糖酯的制备方法
公开(公告)号：US5859217A
公开(公告)日：1999-01-12
申请号：US674810
申请日：1996-07-03
申请人： Yutaka Tokiwa , Shigeo Shibatani
发明人： Yutaka Tokiwa , Shigeo Shibatani
IPC分类号： C12P19/44 , C07H13/06 , C07H15/04 , C08B37/00 , C07H1/00
CPC分类号： C07H13/06
摘要： Disclosed are a polymerizable sugar ester of the formula shown below and a process for the production thereof:S(OH).sub.q-1 --OOC--R--COOCH.dbd.CH.sub.2wherein S(OH).sub.q-1, represents a sugar residue obtained by removing one hydroxyl group from a sugar compound composed of a sugar skeleton S and q number of hydroxyl groups bonded thereto, and R represents an alkylene group. The polymerizable sugar ester is produced by reacting a sugar compound represented by the following general formula:S(OH).sub.qwherein S represents the sugar skeleton and q is the number of the hydroxyl groups bonded thereto, with a divinyl ester of an aliphatic dicarboxylic acid represented by the following general formula:CH.sub.2 .dbd.CHOOC--R--COOCH.dbd.CH.sub.2in the presence of a hydrolytic enzyme. The polymerizable sugar ester gives a sugar-based polymer by polymerization.
摘要翻译：公开了下述式的可聚合糖酯及其制备方法：S（OH）q-1-OOC-R-COOCH = CH 2，其中S（OH）q-1表示通过除去一个由糖骨架S构成的糖化合物的羟基，q个与其键合的羟基数，R表示亚烷基。可聚合糖酯通过使由以下通式表示的糖化合物S（OH）q反应来制备：S（OH）q，其中S表示糖骨架，q表示与其键合的羟基数，表示为脂族二羧酸的二乙烯基酯通过以下通式：在水解酶的存在下，CH2 = CHOOC-R-COOCH = CH2。可聚合糖酯通过聚合得到糖基聚合物。

5. 发明授权

US5674740A Enzymatic decomposition of polycarbonate resin 失效
标题翻译：聚碳酸酯树脂的酶分解
公开(公告)号：US5674740A
公开(公告)日：1997-10-07
申请号：US559573
申请日：1995-11-16
申请人： Tetsushi Suyama , Yutaka Tokiwa
发明人： Tetsushi Suyama , Yutaka Tokiwa
IPC分类号： C12N9/20 , C08G64/42 , C08J11/04 , C08J11/22 , C08L101/16 , C12P1/04 , C12R1/38 , C12S99/00 , D06M16/00
CPC分类号： C08J11/105 , A62D3/02 , C12P1/04 , A62D2101/20 , C08J2369/00 , Y02W30/702
摘要： A polycarbonate resin, such as a poly(tetramethylene carbonate) resin, is enzymatically decomposed by contacting the polycarbonate resin with at least one enzyme selected from porcine pancreas lipase, Pseudomonas sp. lipase and Pseudomonas sp. lipoprotein lipase in the presence of water.
摘要翻译：聚碳酸酯树脂如聚（碳酸四亚甲基酯）树脂通过使聚碳酸酯树脂与选自猪胰脂肪酶，假单胞菌属（Pseudomonas sp。）的至少一种酶接触而被酶促分解。脂肪酶和假单胞菌属脂蛋白脂肪酶在水的存在下。

6. 发明申请

US20100065750A1 BURN-UP PROFILE MEASURING METHOD, BURN-UP PROFILE MEASURING APPARATUS, RADIATION SIGNAL DISTRIBUTION MEASURING APPARATUS, AND BURN-UP PROFILE MEASURING PROGRAM 有权
标题翻译：燃烧轮廓测量方法，燃烧轮廓测量装置，辐射信号分布测量装置和燃烧轮廓测量程序
公开(公告)号：US20100065750A1
公开(公告)日：2010-03-18
申请号：US12595546
申请日：2008-04-11
申请人： Hironori Kumanomido , Naotaka Oda , Yutaka Tokiwa , Makoto Ueda
发明人： Hironori Kumanomido , Naotaka Oda , Yutaka Tokiwa , Makoto Ueda
IPC分类号： G01T3/00 , G01T1/185
CPC分类号： G21C17/063 , G21Y2002/201 , G21Y2002/204 , G21Y2004/30 , G21Y2004/40
摘要： An upper detector and a lower detector that face at least one side of a fuel assembly, on which neutrons are irradiated in a nuclear reactor, and detect radiation are set at a predetermined interval in an axial direction of the fuel assembly. Distributions of radiation signals are measured by the upper detector and the lower detector while the fuel assembly and the upper detector and the lower detectors are relatively moved along the axial direction of the fuel assembly. Soundness of radiation signals measured by the upper detector and the lower detector is determined in every measurement by comparing radiation signal distributions obtained by measuring the same portion in the axial direction of the fuel assembly in a multiplexed manner with the upper detector and the lower detector. Thereafter, relative burn-up is calculated by utilizing the measured radiation signals to measure a burn-up profile. According to the present invention, it is possible to measure a burn-up profile of the fuel assembly while securing reliability of a measurement result.
摘要翻译：面向燃料组件的至少一侧的上检测器和下检测器，其中在核反应堆中辐射中子并检测辐射，沿燃料组件的轴向方向被设定为预定的间隔。辐射信号的分布由上检测器和下检测器测量，而燃料组件和上检测器和下检测器沿着燃料组件的轴向方向相对移动。通过比较通过以多路复用方式与上部检测器和下部检测器测量燃料组件的轴向方向上的相同部分而获得的辐射信号分布，在每次测量中确定由上部检测器和下部检测器测量的辐射信号的良好性。此后，通过利用测量的辐射信号来计算相对燃耗以测量燃尽曲线。根据本发明，可以在确保测量结果的可靠性的同时测量燃料组件的燃尽曲线。

7. 发明申请

US20070259413A1 Method of Decomposing Polyhydroxyalkanoate Resin 审中-公开
标题翻译：分解聚羟基链烷酸酯树脂的方法
公开(公告)号：US20070259413A1
公开(公告)日：2007-11-08
申请号：US10578331
申请日：2004-11-05
申请人： Yutaka Tokiwa
发明人： Yutaka Tokiwa
IPC分类号： C12P1/06 , C12N9/16
CPC分类号： C12P1/06
摘要： A novel microorganism that directly and biologically degrades a polyhydroxyalkanoate resin and plastic containing the resin and a method therefor are provided. A method for degrading the polyhydroxyalkanoate resin, which comprises degrading the resin using a thermophile belonging to the genus Streptomyces, is provided.
摘要翻译：提供直接和生物降解聚羟基链烷酸酯树脂的新型微生物和含有树脂的塑料及其方法。提供了使用属于链霉菌属的嗜热菌降解树脂的降解聚羟基链烷酸酯树脂的方法。

8. 发明申请

US20050032181A1 Method for degrading polylactide resins 失效
标题翻译：降解聚丙交酯树脂的方法
公开(公告)号：US20050032181A1
公开(公告)日：2005-02-10
申请号：US10942463
申请日：2004-09-16
申请人： Yutaka Tokiwa
发明人： Yutaka Tokiwa
IPC分类号： C12N1/20 , C12P1/06 , C12S99/00 , C12P7/62
CPC分类号： C12P1/06 , Y10S435/822
摘要： The present invention provides novel microorganisms that directly biodegrade polylactide resins and plastics containing the same as well as a method therefor. Specifically, the present invention provides a method for degrading polylactide resins, wherein the polylactide resins are degraded by an actinomycete belonging to the genus Saccharothrix, Streptoalloteichus, Kibdelosporangium, Lentzea, Actinokineospora, Saccharomonospora, Saccharopolyspora, or Actinopolyspora.
摘要翻译：本发明提供了直接生物降解聚丙交酯树脂和含有其的塑料的新型微生物及其方法。具体地说，本发明提供一种降解聚交酯树脂的方法，其中所述聚丙交酯树脂由属于Saccharothrix，Streptoalloteichus，Kibdelosporangium，Lentzea，Actinokineospora，Saccharomonospora，Saccharopolyspora或Actinopolyspora的放线菌降解。

9. 发明授权

US5854058A Method of decomposing hard type rubber products 失效
标题翻译：分解硬质橡胶制品的方法
公开(公告)号：US5854058A
公开(公告)日：1998-12-29
申请号：US789331
申请日：1997-01-23
申请人： Akio Tsuchii , Kiyoshi Takeda , Yutaka Tokiwa
发明人： Akio Tsuchii , Kiyoshi Takeda , Yutaka Tokiwa
IPC分类号： C12N1/20 , C08J11/06 , C08J11/18 , C12P1/04 , C12R1/365 , C12S99/00 , C12S13/00
CPC分类号： C08J11/18 , C12P1/04 , C08J2321/00 , Y02W30/706 , Y10S435/872
摘要： The present invention relates to a method of decomposing hard type rubber products, which comprises treating hard type rubber products with a microorganism belonging to the genus Nocardia in the presence of soft type rubber products. According to the present invention, hard type rubber products, particularly tires, can be efficiently decomposed.
摘要翻译：本发明涉及一种分解硬质橡胶制品的方法，其包括在软质橡胶制品存在下用属于诺卡氏菌属的微生物处理硬质橡胶制品。根据本发明，可以有效地分解硬质橡胶制品，特别是轮胎。

10. 发明授权

US06669771B2 Biodegradable resin compositions 失效
公开(公告)号：US06669771B2
公开(公告)日：2003-12-30
申请号：US10149276
申请日：2002-09-13
申请人： Yutaka Tokiwa , Akihito Tsuchiya
发明人： Yutaka Tokiwa , Akihito Tsuchiya
IPC分类号： C08L10116
CPC分类号： C08L5/14 , C08L1/12 , C08L67/02 , C08L67/04 , C08L2666/02 , C08L2666/26
摘要： The present invention provides a biodegradable resin composition with improved biodegradability or with an additional useful function (antibacterial properties), while maintaining the mechanical properties of the biodegradable resin. More specifically, the present invention provides a biodegradable resin composition containing a biodegradable resin such as a polylactic acid polymer and a mamman digestion product such as a mannooligosaccharide. The present invention further provides various biodegradable products produced by molding this biodegradable resin composition into desired shapes.

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