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1. 发明授权

US5843468A Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate 失效
公开(公告)号：US5843468A
公开(公告)日：1998-12-01
申请号：US644922
申请日：1996-05-13
申请人： Terry L. Burkoth , Lina T. Taskovich , Russell D. Beste , Robert M. Gale , Eun Soo Lee , Richard D. Hamlin , Su LL Yum
发明人： Terry L. Burkoth , Lina T. Taskovich , Russell D. Beste , Robert M. Gale , Eun Soo Lee , Richard D. Hamlin , Su LL Yum
IPC分类号： A61K9/00 , A61K9/70 , A61K47/14 , A61F13/02
CPC分类号： A61K9/7053 , A61K47/14 , A61K9/0014 , A61K9/7069 , A61K9/7084 , Y10S514/946 , Y10S514/947
摘要： Compositions, devices, and methods for transdermal administration of an active agent are disclosed using a novel dual permeation enhancer mixture comprising lauryl acetate and a monoglyceride, preferably glycerol monolaurate. The dual permeation enhancer mixture comprising lauryl acetate is a potent permeation enhancer and provides stable systems which are more readily characterized.

2. 发明授权

US5614211A Oxybutynin transdermal device having decreased delamination 失效
标题翻译：奥昔布宁经皮装置具有降低的分层
公开(公告)号：US5614211A
公开(公告)日：1997-03-25
申请号：US481544
申请日：1995-06-07
申请人： Robert M. Gale , Eun Soo Lee , Lina T. Taskovich , Terry L. Burkoth
发明人： Robert M. Gale , Eun Soo Lee , Lina T. Taskovich , Terry L. Burkoth
IPC分类号： A61M37/00 , A61K9/70 , A61F13/00
CPC分类号： A61K9/7084
摘要： A device for the transdermal administration of oxybutynin comprising a microporous tie layer located between the oxybutynin reservoir and the contact adhesive. The tie layer eliminates blooming and delamination and has no appreciable adverse effect on either the oxybutynin flux or release rate from the device.
摘要翻译：用于透皮给药奥昔布宁的装置，其包含位于奥昔布宁储库和接触粘合剂之间的微孔连接层。连结层消除了起霜和分层，并且对奥昔布宁通量或来自装置的释放速率没有明显的不利影响。

3. 发明授权

US5900250A Monoglyceride/lactate ester permeation enhancer for oxybutnin 失效
标题翻译：羟丁酸甘油酯/乳酸酯渗透增强剂
公开(公告)号：US5900250A
公开(公告)日：1999-05-04
申请号：US070492
申请日：1998-04-30
申请人： Eun Soo Lee , Tyler Watanabe , Robert M. Gale , Terry L. Burkoth
发明人： Eun Soo Lee , Tyler Watanabe , Robert M. Gale , Terry L. Burkoth
IPC分类号： A61K9/00 , A61K9/70 , A61K31/216 , A61K47/14 , A61F13/02
CPC分类号： A61K9/7084 , A61K31/216 , A61K47/14 , A61K9/0014 , Y10S514/946
摘要： A composition of matter for application to a body surface or membrane to administer oxybutynin by permeation through the body surface or membrane, the composition comprising, in combination, the oxybutynin to be administered, in a therapeutically effective amount; and a permeation-enhancing mixture comprising a monoglyceride or a mixture of monoglycerides, and a lactic ester or a mixture of lactate esters; present in specific concentrations.
摘要翻译：一种用于施用于身体表面或膜的物质的组合物，以通过穿过身体表面或膜的渗透来施用奥昔布宁，所述组合物以治疗有效量组合包含待施用的奥昔布宁; 和包含单酸甘油酯或单酸甘油酯和乳酸酯或乳酸酯混合物的混合物的渗透增强混合物; 以特定浓度存在。

4. 发明授权

US5747065A Monoglyceride/lactate ester permeation enhancer for oxybutynin 失效
标题翻译：奥昔布宁的单酸甘油酯/乳酸酯渗透增强剂
公开(公告)号：US5747065A
公开(公告)日：1998-05-05
申请号：US617763
申请日：1996-03-15
申请人： Eun Soo Lee , Tyler Watanabe , Robert M. Gale , Terry L. Burkoth
发明人： Eun Soo Lee , Tyler Watanabe , Robert M. Gale , Terry L. Burkoth
IPC分类号： A61K9/00 , A61K9/70 , A61K31/215 , A61K31/216 , A61K31/57 , A61K47/14 , A61K47/32 , A61P13/02 , A61P15/00 , A61P17/00 , A61P21/00 , A61F13/02
CPC分类号： A61K9/7053 , A61K31/215 , A61K31/216 , A61K31/57 , A61K47/14 , A61K9/0014 , A61K9/7084 , Y10S514/946 , Y10S514/947
摘要： A composition of matter for application to a body surface or membrane to administer oxybutynin by permeation through the body surface or membrane, the composition comprising, in combination the oxybutynin to be administered, in a therapeutically effective amount; and a permeation enhancing mixture comprising a monoglyceride or a mixture of monoglycerides, and a lactic ester or a mixture of lactate esters, present in specific concentrations.
摘要翻译： PCT No.PCT / US94 / 11226 Sec。 371日期：1996年3月15日 102（e）1996年3月15日PCT 1994年9月29日PCT PCT。公开号WO95 / 09007 日期1995年4月6日用于通过渗透身体表面或膜施用于身体表面或膜以施用奥昔布宁的物质的组合物，所述组合物以治疗有效量组合包含待施用的奥昔布宁; 以及包含单酸甘油酯或单酸甘油酯和乳酸酯或乳酸酯混合物的混合物的渗透增强混合物，其以特定浓度存在。

5. 发明授权

US4588580A Transdermal administration of fentanyl and device therefor 失效
标题翻译：透皮给药芬太尼及其装置
公开(公告)号：US4588580A
公开(公告)日：1986-05-13
申请号：US633762
申请日：1984-07-23
申请人： Robert M. Gale , Victor Goetz , Eun S. Lee , Lina T. Taskovich , Su I. Yum
发明人： Robert M. Gale , Victor Goetz , Eun S. Lee , Lina T. Taskovich , Su I. Yum
IPC分类号： C07D211/58 , A61K9/70 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61K31/455 , A61K31/465 , C07D211/66 , C07D409/06 , A01N25/24
CPC分类号： A61K9/7053 , A61K31/445 , A61K9/7069 , A61K9/7084 , A61K9/7092
摘要： Transdermal delivery systems for delivery of fentanyl and its analgetically effective derivatives for extended periods of time are disclosed which deliver the base form of the drug at a rate of from 0.5 to 10 .mu.g/cm.sup.2 /hr for a substantial portion of their useful life. The systems can be from 5-100 cm.sup.2 in releasing surface and preferably employ an in-line amine resistant adhesive. Preferred rate controlled systems utilize an aqueous ethanolic gel to minimize drug content.
摘要翻译：公开了用于递送芬太尼及其止痛有效衍生物延长时间的透皮递送系统，其在其使用寿命的大部分时间内以0.5至10μg/ cm 2 / hr的速率递送药物的基础形式。系统的释放表面可以为5-100cm 2，优选采用直列耐胺粘合剂。优选的速率控制系统利用含水乙醇凝胶来最小化药物含量。

6. 发明授权

US5635203A Transdermal device having decreased delamination 失效
标题翻译：透皮装置具有降低的分层
公开(公告)号：US5635203A
公开(公告)日：1997-06-03
申请号：US315043
申请日：1994-09-29
申请人： Robert M. Gale , Eun Soo Lee
发明人： Robert M. Gale , Eun Soo Lee
IPC分类号： A61M37/00 , A61K9/70 , A61F13/00
CPC分类号： A61K9/7084
摘要： A device for the transdermal administration of a drug comprising a microporous tie layer located between the drug reservoir and the contact adhesive. The tie layer eliminates blooming and delamination and has no appreciable adverse effect on either the drug flux or release rate from the device.
摘要翻译：用于经皮给药的药物的装置，其包含位于药物储存器和接触粘合剂之间的微孔连接层。连接层消除了起霜和分层，并且对药物通量或来自装置的释放速率没有明显的不利影响。

7. 发明授权

US5284660A Delayed onset transdermal delivery device 失效
标题翻译：延迟发作透皮递送装置
公开(公告)号：US5284660A
公开(公告)日：1994-02-08
申请号：US933423
申请日：1992-08-21
申请人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
发明人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
IPC分类号： A61K9/00 , A61K9/22 , A61K9/70 , A61F13/00
CPC分类号： A61K9/7084 , A61K9/7069 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir, which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.
摘要翻译：描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。合适的方法包括设置在释放表面和药剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初不能渗透到试剂中，然后变得可渗透。可以提供由一种或多种这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

8. 发明授权

US08440220B2 Transdermal analgesic systems with reduced abuse potential 失效
标题翻译：具有降低滥用潜力的透皮止痛系统
公开(公告)号：US08440220B2
公开(公告)日：2013-05-14
申请号：US10420428
申请日：2003-04-22
申请人： Robert M. Gale , Thomas M. Stein , Jay Audett , Jane Stepic , Joseph B. Phipps , Michel J. N. Cormier
发明人： Robert M. Gale , Thomas M. Stein , Jay Audett , Jane Stepic , Joseph B. Phipps , Michel J. N. Cormier
IPC分类号： A61K9/70
CPC分类号： A61K9/7092 , A61K9/7061 , A61K31/4468 , A61K31/4535 , A61K45/06 , A61K2300/00
摘要： A transdermal analgesic system having reduced potential for abuse, wherein the system provides for the controlled release of the antagonist at a rate sufficient to provide an abuse limiting release rate ratio of the antagonist to the analgesic when the dosage form is subject to abuse is disclosed.
摘要翻译：一种具有降低的滥用可能性的透皮镇痛系统，其中所述系统以足以在剂型受到滥用时提供拮抗剂与镇痛剂的滥用限制释放速率比的速率提供拮抗剂的受控释放。

9. 发明申请

US20120310187A1 TRANSPARENT TRANSDERMAL NICOTINE DELIVERY DEVICES 有权
标题翻译：透明转基因输送装置
公开(公告)号：US20120310187A1
公开(公告)日：2012-12-06
申请号：US13311437
申请日：2011-12-05
申请人： Robert M. Gale
发明人： Robert M. Gale
IPC分类号： A61M35/00
CPC分类号： A61K31/465 , A61K9/0014 , A61K9/7023 , A61K9/703 , A61K9/7084 , A61K31/4465 , A61K47/32 , A61K47/34 , A61K2800/262
摘要： A transparent transdermal delivery device for delivering nicotine which has an Opacity Index of less than 48.6%.
摘要翻译：用于输送不透明度指数小于48.6％的尼古丁的透明透皮递送装置。

10. 发明授权

US07011844B2 Formulations for the administration of fluoxetine 有权
公开(公告)号：US07011844B2
公开(公告)日：2006-03-14
申请号：US10302490
申请日：2002-11-22
申请人： Robert M. Gale , Melinda K. Nelson , Michel J. N. Cormier , Suneel K. Gupta , Patricia S. Campbell
发明人： Robert M. Gale , Melinda K. Nelson , Michel J. N. Cormier , Suneel K. Gupta , Patricia S. Campbell
IPC分类号： A61K9/70
CPC分类号： A61K9/7084 , A61K31/135 , A61K31/138 , A61K31/57 , A61K2300/00
摘要： Composition of matter for application to a body surface or membrane to administer fluoxetine by permeation through the body surface or membrane, the composition comprising fluoxetine to be administered, at a therapeutically effective rate, alone or in combination with a permeation enhancer or mixture. A preferred embodiment is directed to the transdermal administration of fluoxetine at reduced skin irritation levels wherein fluoxetine, preferably provided as fluoxetine acetate, is coadministered with a corticosteroid such as hydrocortisone. Also disclosed are drug delivery devices containing the fluoxetine or fluoxetine and enhancer composition and methods for the transdermal administration of the fluoxetine and fluoxetine/enhancer composition.

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