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1. 发明申请

US20070233038A1 APPARATUS AND METHODS FOR DELIVERING FLUID AND MATERIAL TO A SUBJECT 有权
标题翻译：装置和方法将流体和材料输送到主体
公开(公告)号：US20070233038A1
公开(公告)日：2007-10-04
申请号：US11672675
申请日：2007-02-08
申请人： Terrell Pruitt , Stephen Cochran , Bryan Marshall , Yandong Su , Kurt Stenn , Kenneth Washenik , John DePiano , Gary Prokop , Martin Rathgeber
发明人： Terrell Pruitt , Stephen Cochran , Bryan Marshall , Yandong Su , Kurt Stenn , Kenneth Washenik , John DePiano , Gary Prokop , Martin Rathgeber
IPC分类号： A61M5/00 , A61M31/00
CPC分类号： A61M37/00 , A61M5/3148 , A61M5/31551 , A61M5/31573 , A61M5/31586 , A61M2005/2411 , A61M2005/2414 , A61M2005/341 , A61M2005/342
摘要： The present invention provides fluid and material delivery methods and devices for practicing the methods. The invention provides a method of delivering cellular material comprising injecting the cellular material into a subject such that the injected cells retain their inherent morphologic characteristics upon injection. The method comprises the steps of aspirating the cellular material into a fluid delivery device which incorporates a syringe arrangement. The cellular material is aspirated into the main body of the syringe until the desired amount of a material has filled the syringe body. The needle of the fluid delivery device is then inserted into the skin of a subject at an angle about parallel to the skin until a desired depth has been reached. The cellular material is then injected in the subject until the desired volume of material has been injected. The needle of the device is then rotated approximately 45 to 90 degrees and the needle is removed from the injection site.
摘要翻译：本发明提供了用于实施该方法的流体和材料输送方法和装置。本发明提供递送细胞材料的方法，包括将细胞材料注射到受试者中，使得注射的细胞在注射时保持其固有的形态特征。该方法包括将多孔材料吸入包含注射器装置的流体递送装置中的步骤。将细胞材料吸入注射器的主体中，直到所需量的材料填充注射器体。然后将流体输送装置的针以与皮肤平行的角度插入受试者的皮肤中，直到达到所需的深度。然后将细胞材料注射到受试者中，直到注入了所需体积的材料。然后将装置的针旋转约45度至90度，并将针从注射部位移除。

2. 发明申请

US20070092496A1 METHOD OF DELIVERING CELLS TO THE SKIN 审中-公开
标题翻译：将细胞传递给皮肤的方法
公开(公告)号：US20070092496A1
公开(公告)日：2007-04-26
申请号：US11550007
申请日：2006-10-17
申请人： Ying Zheng , Xiaobing Du , Kenneth Washenik , Kurt Stenn
发明人： Ying Zheng , Xiaobing Du , Kenneth Washenik , Kurt Stenn
IPC分类号： A61K35/32
CPC分类号： A61K35/36 , A61K35/12 , A61L27/3813 , A61L27/3834 , A61L2430/18 , C12N5/0627 , C12N5/0629
摘要： The present invention is a method of forming egressing hair shafts comprising making a wound in the skin and placing hair follicle progenitor cells on the wound, wherein an egressing hair shaft is formed from the hair follicle progenitor cells. The present invention is also a method of forming new skin comprising making a wound in the skin and placing skin forming cells on the wound, wherein new skin is formed from the skin forming cells.
摘要翻译：本发明是一种形成流出毛茸的方法，包括在皮肤上制造伤口并将毛囊祖细胞置于伤口上，其中由毛囊祖细胞形成出血的毛干。本发明也是形成新皮肤的方法，包括在皮肤上制造伤口并将皮肤形成细胞置于伤口上，其中由皮肤形成细胞形成新的皮肤。

3. 发明申请

US20120095445A1 METHODS AND COMPOSITIONS FOR INCREASING TRICHOGENIC POTENCY OF DERMAL CELLS 审中-公开
标题翻译：增加细胞的多发性磷酸化的方法和组合物
公开(公告)号：US20120095445A1
公开(公告)日：2012-04-19
申请号：US13378732
申请日：2010-06-16
申请人： Ying Zheng , Marylene Boucher , Ying Homan , Charles Hollow , Polina Mamontov , Kurt Stenn
发明人： Ying Zheng , Marylene Boucher , Ying Homan , Charles Hollow , Polina Mamontov , Kurt Stenn
IPC分类号： A61K35/12 , A61P17/14 , A61M37/00 , C12N5/071
CPC分类号： C07D409/12 , A61K31/381 , A61K31/4436
摘要： Methods and compositions for increasing trichogenicity of cells in culture are provided. One embodiment provides culturing dissociated mammalian dermal cells in vitro in the presence of an effective amount of one or more sonic hedgehog (Shh) pathway agonists to increase the trichogenicity of the dissociated mammalian dermal cells compared to untreated dissociated mammalian dermal cells. The cell culture optionally includes epidermal cells. Preferred Shh agonists include, but are not limited to CUR-0236715 and CUR-0201365 available from Curis, Inc. Trichogenicity is measured using the Aderans Hair Patch Assay™. The cultured dermal cells can be maintained in culture in the presence of the one or more Shh agonists for at least 1 to 7 or more days prior to harvest. The treated, cultured dermal cells can be used to treat hair loss in a mammalian subject, preferably a human, by implanting them in an effective amount to induce hair follicle formation.
摘要翻译：提供了用于增加培养物中细胞的致毛性的方法和组合物。一个实施方案在有效量的一种或多种声刺猬（Shh）途径激动剂的存在下提供培养解离的哺乳动物真皮细胞，以增加与未处理的解离的哺乳动物真皮细胞相比，解离的哺乳动物真皮细胞的致毛性。细胞培养物任选地包括表皮细胞。优选的Shh激动剂包括但不限于可从Curis，Inc。获得的CUR-0236715和CUR-0201365。使用Aderans Hair Patch Assay TM测量Trichoigenicity。培养的真皮细胞可以在收获前至少1至7天或更多天在一种或多种Shh激动剂存在下保持培养。经处理的培养的真皮细胞可用于通过将它们植入有效量以诱导毛囊形成来治疗哺乳动物受试者，优选人类的脱发。

4. 发明申请

US20120022433A1 METHODS FOR INCREASING TRICHOGENICITY OF DERMAL CELLS 审中-公开
标题翻译：增加细胞的致癌性的方法
公开(公告)号：US20120022433A1
公开(公告)日：2012-01-26
申请号：US13250536
申请日：2011-09-30
申请人： Ying Zheng , Arben Nace , Luke Sergott , Michael Ensslin , Ying Homan , Kurt Stenn
发明人： Ying Zheng , Arben Nace , Luke Sergott , Michael Ensslin , Ying Homan , Kurt Stenn
IPC分类号： A61M37/00 , C12N5/071
CPC分类号： A61B18/203 , A61B2018/00452 , A61K35/36
摘要： Methods for increasing trichogenic activity of populations of dermal cells by inducing local trauma to skin tissue that serves as a source of the dermal cells are provided. Methods for obtaining dermal cells with increased trichogenic activity and for using the disclosed dermal cells to implant into a mammalian host at a site of desired follicle generation are also provided.
摘要翻译：提供了通过诱导作为真皮细胞来源的皮肤组织的局部创伤来增加真皮细胞群体的致毛菌活性的方法。还提供了获得具有增加的致毛细胞活性的真皮细胞和使用公开的真皮细胞在期望的卵泡发生部位植入哺乳动物宿主的方法。

5. 发明申请

US20100291580A1 BIOMARKERS FOR TRICHOGENICITY 审中-公开
标题翻译：生物标志物的生物多样性
公开(公告)号：US20100291580A1
公开(公告)日：2010-11-18
申请号：US12808623
申请日：2008-12-18
申请人： Satish Parimoo , Honghua Yang , Ying Homan , Wei Chen , Ying Zheng , Kurt Stenn
发明人： Satish Parimoo , Honghua Yang , Ying Homan , Wei Chen , Ying Zheng , Kurt Stenn
IPC分类号： C12Q1/68 , G01N33/566 , C12N15/79
CPC分类号： C12Q1/6881 , C12Q2600/178 , G01N33/6881 , G01N33/6893 , G01N2500/10
摘要： Biomarkers for identifying trichogenic cells have been identified. The biomarkers include microRNA as wells as mRNA and proteins. Certain biomarkers are upregulated in trichogenic cells compared to non-trichogenic cells; whereas, other biomarkers are down-regulated in trichogenic cells compared to non-trichogenic cells. The cells can be dermal cells, epidermal cells, or a combination thereof. Preferably the cells are mammalian, more preferably the cells are human. One embodiment provides a method for selecting trichogenic cells by assaying the cells for expression of one or more biomarkers for trichogenicity, and selecting the cells having increased expression of the one or more biomarkers relative to a control, wherein increased expression of the a biomarker in the cells is indicative of trichogenicity. Preferably, the one or more biomarkers are selected from the group consisting of hsa-miR-200c, hsa-miR-205, hsa-miR-200a*, hsa-miR-200a, hsa-miR-141, hsa-miR-182, DEPDC1, hFLEG1, ESM1, TOME-1, THBD and combinations thereof.
摘要翻译：已鉴定出用于鉴定发生细胞的生物标志物。生物标志物包括微RNA作为mRNA和蛋白质的孔。与非致毛细胞相比，某些生物标志物在致毛细胞中上调; 而与非致毛细胞相比，其他生物标志物在发育细胞中下调。细胞可以是真皮细胞，表皮细胞或其组合。优选地，细胞是哺乳动物，更优选细胞是人。一个实施方案提供了一种用于通过测定细胞用于表达一种或多种针刺性生物标志物的细胞并选择相对于对照而增加一种或多种生物标志物表达的细胞的方法，其中所述生物标志物在细胞表示毛发性。优选地，一种或多种生物标志物选自hsa-miR-200c，hsa-miR-205，hsa-miR-200a *，hsa-miR-200a，hsa-miR-141，hsa-miR-182 ，DEPDC1，hFLEG1，ESM1，TOME-1，THBD及其组合。

6. 发明申请

US20100179492A1 METHODS FOR INCREASING TRICHOGENICITY OF DERMAL CELLS 审中-公开
标题翻译：增加细胞的致癌性的方法
公开(公告)号：US20100179492A1
公开(公告)日：2010-07-15
申请号：US12353699
申请日：2009-01-14
申请人： Ying Zheng , Arben Nace , Luke Sergott , Michael Ensslin , Ying Homan , Kurt Stenn
发明人： Ying Zheng , Arben Nace , Luke Sergott , Michael Ensslin , Ying Homan , Kurt Stenn
IPC分类号： A61M35/00 , C12N5/08 , A61B17/50 , A61B18/20 , A61B18/04 , A61K35/12
CPC分类号： A61B18/203 , A61B2018/00452 , A61K35/36
摘要： Methods for increasing trichogenic activity of populations of dermal cells by inducing local trauma to skin tissue that serves as a source of the dermal cells are provided. Methods for obtaining dermal cells with increased trichogenic activity and for using the disclosed dermal cells to implant into a mammalian host at a site of desired follicle generation are also provided.
摘要翻译：提供了通过诱导作为真皮细胞来源的皮肤组织的局部创伤来增加真皮细胞群体的致毛菌活性的方法。还提供了获得具有增加的致毛细胞活性的真皮细胞和使用公开的真皮细胞在期望的卵泡发生部位植入哺乳动物宿主的方法。

7. 发明申请

US20060062770A1 Organogenesis from dissociated cells 审中-公开
标题翻译：解离细胞的器官发生
公开(公告)号：US20060062770A1
公开(公告)日：2006-03-23
申请号：US11203804
申请日：2005-08-15
申请人： Ying Zheng , Xiaobing Du , Wei Wang , Marylene Boucher , Satish Parimoo , Kurt Stenn
发明人： Ying Zheng , Xiaobing Du , Wei Wang , Marylene Boucher , Satish Parimoo , Kurt Stenn
IPC分类号： A61K35/36
CPC分类号： A61K35/36 , A61K8/02 , A61K8/985 , A61K35/12 , A61Q7/00 , C12N5/0627
摘要： A method assay for rapidly and reproducibly generating hair follicles from dissociated epithelial and mesenchymal cells is disclosed. The method serves both as a tool for measuring the trichogenic (i.e., hair growth-inducing) property of cells and for studying the mechanisms dissociated cells employ to assemble an organ. In a method of this application dissociated cells, isolated from newborn mouse skin, are injected into adult mouse truncal skin, hair follicles develop. This process involves the aggregation of epithelial cells to form clusters which are sculpted by apoptosis to generate “infundibular cysts”. From the “infundibular cysts” hair germs form followed by follicular buds and then pegs which grow asymmetrically to differentiate into cycling mature pilosebaceous structures. Using various techniques, exposure of the “infundibular cysts” by puncturing, piercing, or scratching the skin and, in an approach, covering the exposed cysts with a wound dressing material produced egressing hair follicles.
摘要翻译：公开了一种用于从解离的上皮和间充质细胞中快速和可重复地产生毛囊的方法测定法。该方法既用于测量细胞的致毛体（即毛发生长诱导）性质和用于研究解离的细胞用于组装器官的机制。在这种方法中，从新生小鼠皮肤分离的解离的细胞被注射到成年小鼠的截肢皮肤中，形成毛囊。该过程涉及上皮细胞的聚集以形成通过凋亡而雕刻以产生“漏斗状囊肿”的簇。从“漏斗状囊肿”毛发细胞形式，然后是滤泡芽，然后是不对称生长的分离成循环成熟的皮脂状结构的栓。使用各种技术，通过穿刺，刺穿或刮伤皮肤暴露“漏斗状囊肿”，并且在使用产生流出毛囊的伤口敷料材料覆盖暴露的囊肿的方法中。

8. 发明授权

US6156323A Tricot-like pouch for the delivery of topical drugs and cosmetics 失效
标题翻译： Tricot样袋用于递送局部药物和化妆品
公开(公告)号：US6156323A
公开(公告)日：2000-12-05
申请号：US495727
申请日：1995-06-08
申请人： Robert J. Verdicchio , Morris Yang , Samuel E. Carasso , Kurt Stenn
发明人： Robert J. Verdicchio , Morris Yang , Samuel E. Carasso , Kurt Stenn
IPC分类号： A61K8/02 , A61K9/70 , A61Q19/00 , A61F13/02
CPC分类号： A61K9/703 , A61K8/0208 , A61K9/70 , A61Q19/00 , A61Q1/12 , A61Q17/005 , A61Q19/10 , A61Q5/02 , Y10T428/31913
摘要： This invention relates to pouch or pledget delivery system having an apertured film or fabric covering which assists in evenly and safely distributing topical medicaments.
摘要翻译：本发明涉及具有有助于均匀和安全地分布局部药物的多孔膜或织物覆盖物的袋或药物输送系统。

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