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1. 发明授权

US5872006A Family of MAP2 protein kinases 失效
公开(公告)号：US5872006A
公开(公告)日：1999-02-16
申请号：US461985
申请日：1995-06-05
申请人： Teri G. Boulton , Melanie H. Cobb , George D. Yancopoulos , Steven Nye , Nikos Panayotatos
发明人： Teri G. Boulton , Melanie H. Cobb , George D. Yancopoulos , Steven Nye , Nikos Panayotatos
IPC分类号： C12N1/21 , C12N9/12 , C12N15/09 , C12N15/54 , C12P21/08 , C12Q1/02 , C12Q1/48 , C12R1/19 , C12R1/91 , G01N33/50 , G01N33/573 , C12N15/63
CPC分类号： G01N33/5041 , C12N9/12 , C12Q1/485 , G01N33/5008 , G01N33/573 , G01N2333/9121 , G01N2500/00
摘要： The present invention relates to a newly identified family of protein serine/threonine kinases which phosphorylate microtubule-associated protein 2 (MAP2). It is based, in part, on the cloning and characterization of novel MAP2 kinases designated extracellular signal-regulated kinase 1, 2, and 3 (ERK1, ERK2, ERK3) which are expressed in the central nervous system, and on the identification of another ERK family member, ERK4, with antisera. The present invention provides for recombinant nucleic acid molecules and proteins representing members of the MAP2 kinase family, and also for microorganisms, transgenic animals, and cell lines comprising recombinant MAP2 kinase molecules. In additional embodiments of the invention, the present invention provides for methods for assaying cellular factor activity, including, but not limited to, nerve growth factor activity, in which the activation of MAP2 kinase serves as an indicator of cellular factor activity. These methods may be extremely useful in screening compounds for the presence of a desired cellular factor activity. In specific embodiments, compounds which may be useful in the treatment of Alzheimer's disease, peripheral neuropathies, and diabetes may be identified using the methods of the invention.

2. 发明授权

US5914261A Family of MAP2 protein kinases 失效
标题翻译：家族的MAP2蛋白激酶
公开(公告)号：US5914261A
公开(公告)日：1999-06-22
申请号：US458887
申请日：1995-06-02
申请人： Teri G. Boulton , Melanie H. Cobb , George D. Yancopoulos , Steven Nye , Nikos Panayotatos
发明人： Teri G. Boulton , Melanie H. Cobb , George D. Yancopoulos , Steven Nye , Nikos Panayotatos
IPC分类号： C12N1/21 , C12N9/12 , C12N15/09 , C12N15/54 , C12P21/08 , C12Q1/02 , C12Q1/48 , C12R1/19 , C12R1/91 , G01N33/50 , G01N33/573 , C12P19/34 , C12N1/00 , C12N1/20 , C12N5/00
CPC分类号： G01N33/5041 , C12N9/12 , C12Q1/485 , G01N33/5008 , G01N33/573 , G01N2333/9121 , G01N2500/00
摘要： The present invention relates to a newly identified family of protein serine/threonine kinases which phosphorylate microtubule-associated protein 2 (MAP2). It is based, in part, on the cloning and characterization of novel MAP2 kinases designated extracellular signal-regulated kinase 1, 2, and 3 (ERK1, ERK2, ERK3) which are expressed in the central nervous system, and on the identification of another ERK family member, ERK4, with antisera. The present invention provides for recombinant nucleic acid molecules and proteins representing members of the MAP2 kinase family, and also for microorganisms, transgenic animals, and cell lines comprising recombinant MAP2 kinase molecules. In additional embodiments of the invention, the present invention provides for methods for assaying cellular factor activity, including, but not limited to, nerve growth factor activity, in which the activation of MAP2 kinase serves as an indicator of cellular factor activity. These methods may be extremely useful in screening compounds for the presence of a desired cellular factor activity. In specific embodiments, compounds which may be useful in the treatment of Alzheimer's disease, peripheral neuropathies, and diabetes may be identified using the methods of the invention.
摘要翻译：本发明涉及磷酸化微管相关蛋白2（MAP2）的新鉴定的蛋白丝氨酸/苏氨酸激酶家族。它部分地基于在中枢神经系统中表达的称为细胞外信号调节激酶1,2和3（ERK1，ERK2，ERK3）的新型MAP2激酶的克隆和表征，以及鉴定另一种 ERK家族成员，ERK4，具有抗血清。本发明提供了代表MAP2激酶家族成员的重组核酸分子和蛋白质，还提供了包含重组MAP2激酶分子的微生物，转基因动物和细胞系。在本发明的另外的实施方案中，本发明提供了测定细胞因子活性的方法，包括但不限于神经生长因子活性，其中MAP2激酶的活化用作细胞因子活性的指标。这些方法在筛选化合物中以期存在所需的细胞因子活性可能是非常有用的。在具体实施方案中，可以使用本发明的方法鉴定可用于治疗阿尔茨海默氏病，周围神经病和糖尿病的化合物。

3. 发明授权

US5776751A Family of MAP2 protein kinases 失效
公开(公告)号：US5776751A
公开(公告)日：1998-07-07
申请号：US463862
申请日：1995-06-05
申请人： Teri G. Boulton , Melanie H. Cobb , George D. Yancopoulos , Steven Nye , Nikos Panayotatos
发明人： Teri G. Boulton , Melanie H. Cobb , George D. Yancopoulos , Steven Nye , Nikos Panayotatos
IPC分类号： C12N1/21 , C12N9/12 , C12N15/09 , C12N15/54 , C12P21/08 , C12Q1/02 , C12Q1/48 , C12R1/19 , C12R1/91 , G01N33/50 , G01N33/573 , C12N15/00 , C07H21/04
CPC分类号： G01N33/5041 , C12N9/12 , C12Q1/485 , G01N33/5008 , G01N33/573 , G01N2333/9121 , G01N2500/00
摘要： The present invention relates to a newly identified family of protein serine/threonine kinases which phosphorylate microtubule-associated protein 2 (MAP2). It is based, in part, on the cloning and characterization of novel MAP2 kinases designated extracellular signal-regulated kinase 1, 2, and 3 (ERK1, ERK2, ERK3) which are expressed in the central nervous system, and on the identification of another ERK family member, ERK4, with antisera. The present invention provides for recombinant nucleic acid molecules and proteins representing members of the MAP2 kinase family, and also for microorganisms, transgenic animals, and cell lines comprising recombinant MAP2 kinase molecules. In additional embodiments of the invention, the present invention provides for methods for assaying cellular factor activity, including, but not limited to, nerve growth factor activity, in which the activation of MAP2 kinase serves as an indicator of cellular factor activity. These methods may be extremely useful in screening compounds for the presence of a desired cellular factor activity. In specific embodiments, compounds which may be useful in the treatment of Alzheimer's disease, peripheral neuropathies, and diabetes may be identified using the methods of the invention.

4. 发明授权

US06303358B1 ERK3 MAP2 protein kinase 失效
标题翻译： ERK3 MAP2蛋白激酶
公开(公告)号：US06303358B1
公开(公告)日：2001-10-16
申请号：US08888818
申请日：1997-07-07
申请人： Teri G. Boulton , Melanie H. Cobb , George D. Yancopoulos , Steven Nye , Nikos Panayotatos
发明人： Teri G. Boulton , Melanie H. Cobb , George D. Yancopoulos , Steven Nye , Nikos Panayotatos
IPC分类号： C12N912
CPC分类号： G01N33/5041 , C12N9/12 , C12Q1/485 , G01N33/5008 , G01N33/573 , G01N2333/9121 , G01N2500/00
摘要： The present invention relates to a newly identified family of protein serine/threonine kinases which phosphorylate microtubule-associated protein 2 (MAP2). It is based, in part, on the cloning and characterization of novel MAP2 kinases designated extracellular signal-regulated kinase 1, 2, and 3 (ERK1, ERK2, ERK3) which are expressed in the central nervous system, and on the identification of another ERK family member, ERK4, with antisera. The present invention provides for recombinant nucleic acid molecules and proteins representing members of the MAP2 kinase family, and also for microorganisms, transgenic animals, and cell lines comprising recombinant MAP2 kinase molecules. In additional embodiments of the invention, the present invention provides for methods for assaying cellular factor activity, including, but not limited to, nerve growth factor activity, in which the activation of MAP2 kinase serves as an indicator of cellular factor activity. These methods may be extremely useful in screening compounds for the presence of a desired cellular factor activity. In specific embodiments, compounds which may be useful in the treatment of Alzheimer's disease, peripheral neuropathies, and diabetes may be identified using the methods of the invention.
摘要翻译：本发明涉及磷酸化微管相关蛋白2（MAP2）的新鉴定的蛋白丝氨酸/苏氨酸激酶家族。它部分地基于在中枢神经系统中表达的称为细胞外信号调节激酶1,2和3（ERK1，ERK2，ERK3）的新型MAP2激酶的克隆和表征，以及鉴定另一种 ERK家族成员，ERK4，具有抗血清。本发明提供了代表MAP2激酶家族成员的重组核酸分子和蛋白质，还提供了包含重组MAP2激酶分子的微生物，转基因动物和细胞系。在本发明的另外的实施方案中，本发明提供了测定细胞因子活性的方法，包括但不限于神经生长因子活性，其中MAP2激酶的活化用作细胞因子活性的指标。这些方法在筛选化合物中以期存在所需的细胞因子活性可能是非常有用的。在具体实施方案中，可以使用本发明的方法鉴定可用于治疗阿尔茨海默氏病，周围神经病和糖尿病的化合物。

5. 发明授权

US06297035B1 ERK1 MAP2 protein kinase 失效
标题翻译： ERK1 MAP2蛋白激酶
公开(公告)号：US06297035B1
公开(公告)日：2001-10-02
申请号：US08932012
申请日：1997-09-17
申请人： Teri G. Boulton , Melanie H. Cobb , George D. Yancopoulos , Steven Nye , Nikos Panayotatos
发明人： Teri G. Boulton , Melanie H. Cobb , George D. Yancopoulos , Steven Nye , Nikos Panayotatos
IPC分类号： C12N912
CPC分类号： G01N33/5041 , C12N9/12 , C12Q1/485 , G01N33/5008 , G01N33/573 , G01N2333/9121 , G01N2500/00
摘要： The present invention relates to a newly identified family of protein serine/threonine kinases which phosphorylate microtubule-associated protein 2 (MAP2). It is based, in part, on the cloning and characterization of novel MAP2 kinases designated extracellular signal-regulated kinase 1, 2, and 3 (ERK1, ERK2, ERK3) which are expressed in the central nervous system, and on the identification of another ERK family member, ERK4, with antisera. The present invention provides for recombinant nucleic acid molecules and proteins representing members of the MAP2 kinase family, and also for microorganisms, transgenic animals, and cell lines comprising recombinant MAP2 kinase molecules. In additional embodiments of the invention, the present invention provides for methods for assaying cellular factor activity, including, but not limited to, nerve growth factor activity, in which the activation of MAP2 kinase serves as an indicator of cellular factor activity. These methods may be extremely useful in screening compounds for the presence of a desired cellular factor activity. In specific embodiments, compounds which may be useful in the treatment of Alzheimer's disease, peripheral neuropathies, and diabetes may be identified using the methods of the invention.
摘要翻译：本发明涉及磷酸化微管相关蛋白2（MAP2）的新鉴定的蛋白丝氨酸/苏氨酸激酶家族。它部分地基于在中枢神经系统中表达的称为细胞外信号调节激酶1,2和3（ERK1，ERK2，ERK3）的新型MAP2激酶的克隆和表征，以及鉴定另一种 ERK家族成员，ERK4，具有抗血清。本发明提供了代表MAP2激酶家族成员的重组核酸分子和蛋白质，还提供了包含重组MAP2激酶分子的微生物，转基因动物和细胞系。在本发明的另外的实施方案中，本发明提供了测定细胞因子活性的方法，包括但不限于神经生长因子活性，其中MAP2激酶的活化用作细胞因子活性的指标。这些方法在筛选化合物中以期存在所需的细胞因子活性可能是非常有用的。在具体实施方案中，可以使用本发明的方法鉴定可用于治疗阿尔茨海默氏病，周围神经病和糖尿病的化合物。

6. 发明授权

US06277963B1 Antibodies directed toward extracellular signal-related kinases 失效
标题翻译：针对细胞外信号相关激酶的抗体
公开(公告)号：US06277963B1
公开(公告)日：2001-08-21
申请号：US08932787
申请日：1997-09-18
申请人： Teri G. Boulton , Melanie H. Cobb , George D. Yancopoulos , Steven Nye , Nikos Panayotatos
发明人： Teri G. Boulton , Melanie H. Cobb , George D. Yancopoulos , Steven Nye , Nikos Panayotatos
IPC分类号： C07K1640
CPC分类号： G01N33/5041 , C12N9/12 , C12Q1/485 , G01N33/5008 , G01N33/573 , G01N2333/9121 , G01N2500/00
摘要： The present invention relates to a newly identified family of protein serine/threonine kinases which phosphorylate microtubule-associated protein 2 (MAP2). It is based, in part, on the cloning and characterization of novel MAP2 kinases designated extracellular signal-regulated kinase 1, 2, and 3 (ERK1, ERK2, ERK3) which are expressed in the central nervous system, and on the identification of another ERK family member, ERK4, with antisera. The present invention provides for recombinant nucleic acid molecules and proteins representing members of the MAP2 kinase family, and also for microorganisms, transgenic animals, and cell lines comprising recombinant MAP2 kinase molecules. In additional embodiments of the invention, the present invention provides for methods for assaying cellular factor activity, including, but not limited to, nerve growth factor activity, in which the activation of MAP2 kinase serves as an indicator of cellular factor activity. These methods may be extremely useful in screening compounds for the presence of a desired cellular factor activity. In specific embodiments, compounds which may be useful in the treatment of Alzheimer's disease, peripheral neuropathies, and diabetes may be identified using the methods of the invention.
摘要翻译：本发明涉及磷酸化微管相关蛋白2（MAP2）的新鉴定的蛋白丝氨酸/苏氨酸激酶家族。它部分地基于在中枢神经系统中表达的称为细胞外信号调节激酶1,2和3（ERK1，ERK2，ERK3）的新型MAP2激酶的克隆和表征，以及鉴定另一种 ERK家族成员，ERK4，具有抗血清。本发明提供了代表MAP2激酶家族成员的重组核酸分子和蛋白质，还提供了包含重组MAP2激酶分子的微生物，转基因动物和细胞系。在本发明的另外的实施方案中，本发明提供了测定细胞因子活性的方法，包括但不限于神经生长因子活性，其中MAP2激酶的活化用作细胞因子活性的指标。这些方法在筛选化合物中以期存在所需的细胞因子活性可能是非常有用的。在具体实施方案中，可以使用本发明的方法鉴定可用于治疗阿尔茨海默氏病，周围神经病和糖尿病的化合物。

7. 发明授权

US5595904A Family of map2 protein kinases 失效
标题翻译： Map2蛋白激酶家族
公开(公告)号：US5595904A
公开(公告)日：1997-01-21
申请号：US176620
申请日：1994-01-03
申请人： Teri G. Boulton , Melanie H. Cobb , George D. Yancopoulos , Steven Nye , Nikos Panayotatos
发明人： Teri G. Boulton , Melanie H. Cobb , George D. Yancopoulos , Steven Nye , Nikos Panayotatos
IPC分类号： C12N1/21 , C12N9/12 , C12N15/09 , C12N15/54 , C12P21/08 , C12Q1/02 , C12Q1/48 , C12R1/19 , C12R1/91 , G01N33/50 , G01N33/573 , C12N5/00
CPC分类号： G01N33/5041 , C12N9/12 , C12Q1/485 , G01N33/5008 , G01N33/573 , G01N2333/9121 , G01N2500/00
摘要： The present invention relates to a newly identified family of protein serine/threonine kinases which phosphorylate microtubule-associated protein 2 (MAP2). It is based, in part, on the cloning and characterization of novel MAP2 kinases designated extracellular signal-regulated kinase 1, 2, and 3 (ERK1, ERK2, ERK3) which are expressed in the central nervous system, and on the identification of another ERK family member, ERK4, with antisera. The present invention provides for recombinant nucleic acid molecules and proteins representing members of the MAP2 kinase family, and also for microorganisms, transgenic animals, and cell lines comprising recombinant MAP2 kinase molecules. In additional embodiments of the invention, the present invention provides for methods for assaying cellular factor activity, including, but not limited to, nerve growth factor activity, in which the activation of MAP2 kinase serves as an indicator of cellular factor activity. These methods may be extremely useful in screening compounds for the presence of a desired cellular factor activity. In specific embodiments, compounds which may be useful in the treatment of Alzheimer's disease, peripheral neuropathies, and diabetes may be identified using the methods of the invention.
摘要翻译：本发明涉及磷酸化微管相关蛋白2（MAP2）的新鉴定的蛋白丝氨酸/苏氨酸激酶家族。其部分基于在中枢神经系统中表达的命名为细胞外信号调节激酶1,2和3（ERK1，ERK2，ERK3）的新型MAP2激酶的克隆和表征，以及鉴定另一种 ERK家族成员，ERK4，具有抗血清。本发明提供了代表MAP2激酶家族成员的重组核酸分子和蛋白质，还提供了包含重组MAP2激酶分子的微生物，转基因动物和细胞系。在本发明的另外的实施方案中，本发明提供了测定细胞因子活性的方法，包括但不限于神经生长因子活性，其中MAP2激酶的活化用作细胞因子活性的指标。这些方法在筛选化合物中以期存在所需的细胞因子活性可能是非常有用的。在具体实施方案中，可以使用本发明的方法鉴定可用于治疗阿尔茨海默氏病，周围神经病和糖尿病的化合物。

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