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1. 发明授权

US08337755B2 Operator independent programmable sample preparation and analysis system 有权
标题翻译：操作员独立的可编程样品制备和分析系统
公开(公告)号：US08337755B2
公开(公告)日：2012-12-25
申请号：US11374623
申请日：2006-03-13
申请人： Teresa Bendele , Thomas Harbart , Dave Howard , Michael Kagan , Douglas Keene , Dave Lapeus , Jared Mayes , Douglas Paynter , Jerry Prohaska , Herman Rutner
发明人： Teresa Bendele , Thomas Harbart , Dave Howard , Michael Kagan , Douglas Keene , Dave Lapeus , Jared Mayes , Douglas Paynter , Jerry Prohaska , Herman Rutner
IPC分类号： B01L3/02
CPC分类号： G01N33/491 , Y10T436/11 , Y10T436/113332
摘要： The present invention provides a protocol and apparatus for enriching circulating tumor cells and other rare cells from blood, including debris and other components, from samples with high precision and at high throughput rates. This invention discloses an improved processing system from previously described semi-automated sample processing. The system further reduces operator intervention and hands-on time from prior systems. While this system has general utility in processing diverse materials, the system is configured for sample processing of biological specimens to provide an enriched fraction suitable for detection, enumeration and identification of target cells by appropriate analytical methodologies. The presence and quantities of such target cells in a sample specimen can utilized for screening and detection in disease such as cancer, assessing early stage pre-metastatic cancer, monitoring for disease remission in response to therapy and selection of more effective dose regimens or alternative therapies in case of relapse.
摘要翻译：本发明提供了一种用于从高精度和高生产率的样品中富集来自血液的循环肿瘤细胞和其它稀有细胞（包括碎片和其他成分）的方案和装置。本发明公开了一种来自先前描述的半自动化样品处理的改进的处理系统。该系统进一步减少了现有系统的操作员干预和实际操作时间。虽然该系统在处理不同材料方面具有一般效用，但是该系统被配置用于生物样品的样品处理，以通过适当的分析方法提供适合于靶细胞的检测，计数和鉴定的富集级分。样品样本中的这种靶细胞的存在和数量可以用于疾病如癌症中的筛选和检测，评估早期转移前癌症，响应治疗监测疾病缓解和选择更有效的剂量方案或替代疗法在复发的情况下。

2. 发明申请

US20070212698A1 Operator independent programmable sample preparation and analysis system 有权
标题翻译：操作员独立的可编程样品制备和分析系统
公开(公告)号：US20070212698A1
公开(公告)日：2007-09-13
申请号：US11374623
申请日：2006-03-13
申请人： Teresa Bendele , Thomas Harbart , Dave Howard , Michael Kagan , Douglas Keene , Dave Lapeus , Jared Mayes , Douglas Paynter , Jerry Prohaska , Herman Rutner
发明人： Teresa Bendele , Thomas Harbart , Dave Howard , Michael Kagan , Douglas Keene , Dave Lapeus , Jared Mayes , Douglas Paynter , Jerry Prohaska , Herman Rutner
IPC分类号： C12Q1/68 , G06F19/00 , C12M3/00
CPC分类号： G01N33/491 , Y10T436/11 , Y10T436/113332
摘要： The present invention provides a protocol and apparatus for enriching circulating tumor cells and other rare cells from blood, including debris and other components, from samples with high precision and at high throughput rates. This invention discloses an improved processing system from previously described semi-automated sample processing. The system further reduces operator intervention and hands-on time from prior systems. While this system has general utility in processing diverse materials, the system is configured for sample processing of biological specimens to provide an enriched fraction suitable for detection, enumeration and identification of target cells by appropriate analytical methodologies. The presence and quantities of such target cells in a sample specimen can utilized for screening and detection in disease such as cancer, assessing early stage pre-metastatic cancer, monitoring for disease remission in response to therapy and selection of more effective dose regimens or alternative therapies in case of relapse.
摘要翻译：本发明提供了一种用于从高精度和高生产率的样品中富集来自血液的循环肿瘤细胞和其它稀有细胞（包括碎片和其他成分）的方案和装置。本发明公开了一种来自先前描述的半自动化样品处理的改进的处理系统。该系统进一步减少了现有系统的操作员干预和实际操作时间。虽然该系统在处理不同材料方面具有一般效用，但是该系统被配置用于生物样品的样品处理，以通过适当的分析方法提供适合于靶细胞的检测，计数和鉴定的富集级分。样品样本中的这种靶细胞的存在和数量可以用于疾病如癌症中的筛选和检测，评估早期转移前癌症，响应治疗监测疾病缓解和选择更有效的剂量方案或替代疗法在复发的情况下。

3. 发明授权

US08562086B1 Rail system for supporting equipment in a rack 有权
标题翻译：轨道系统，用于支撑机架中的设备
公开(公告)号：US08562086B1
公开(公告)日：2013-10-22
申请号：US13095310
申请日：2011-04-27
申请人： David J. Baik , David Willheim , Russell Read , Dave Howard
发明人： David J. Baik , David Willheim , Russell Read , Dave Howard
IPC分类号： A47B88/00
CPC分类号： A47B88/0085 , A47B88/931 , H05K7/1489 , Y10T403/1616
摘要： A rail system for supporting equipment in a rack is disclosed. The rail system may include: a first support rail assembly extending between a pair of vertical columns; a second support rail assembly extending between a different pair of vertical columns. Each support rail assembly may include: a support rail having opposite ends; aligners configured to align the opposite ends of the support rail with apertures of vertical columns; and mounting plates configured to removably secure the aligners to the opposite ends of the support rail. At least one mounting plate may be further configured to define at least one receiving portion for receiving a fastener for securing an equipment supportable in the rack.
摘要翻译：公开了一种用于在机架中支撑设备的轨道系统。轨道系统可以包括：在一对竖直柱之间延伸的第一支撑轨道组件; 在不同的一对垂直柱之间延伸的第二支撑轨组件。每个支撑轨道组件可以包括：具有相对端部的支撑轨道; 对准器构造成将支撑轨道的相对端与垂直柱的孔对齐; 以及安装板，其构造成将对准器可移除地固定到支撑轨的相对端。至少一个安装板可进一步构造成限定至少一个接收部分，用于接收用于固定可支撑在机架中的设备的紧固件。

4. 植物专利

USPP5359P Golden Sycamore 失效
公开(公告)号：USPP5359P
公开(公告)日：1984-11-27
申请号：US465874
申请日：1983-04-08
申请人： Dave Howard
发明人： Dave Howard
摘要： A sycamore tree having new foliage of a lemon-yellow color, turning yellow-green with maturity.

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