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1. 发明授权

US08729099B2 Pharmaceutically active piperidine derivatives 有权
标题翻译：药学活性哌啶衍生物
公开(公告)号：US08729099B2
公开(公告)日：2014-05-20
申请号：US11196153
申请日：2005-08-03
申请人： Terence D. Butters , Raymond A. Dwek , George W. J. Fleet , Michael Glen Orchard , Frances Mary Platt
发明人： Terence D. Butters , Raymond A. Dwek , George W. J. Fleet , Michael Glen Orchard , Frances Mary Platt
IPC分类号： A61K31/445 , C07D211/22
CPC分类号： C07D211/46 , A61K31/445 , A61K31/451 , A61K45/06 , C07H15/12 , A61K2300/00
摘要： Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.
摘要翻译：式（I）的化合物：其中R表示各种取代基，可用作葡萄糖神经酰胺合酶的抑制剂。

2. 发明授权

US09199935B2 Pharmaceutically active piperidine derivatives 有权
标题翻译：药学活性哌啶衍生物
公开(公告)号：US09199935B2
公开(公告)日：2015-12-01
申请号：US14246879
申请日：2014-04-07
申请人： Terence D. Butters , Raymond A. Dwek , George W. J. Fleet , Michael Glen Orchard , Frances Mary Platt
发明人： Terence D. Butters , Raymond A. Dwek , George W. J. Fleet , Michael Glen Orchard , Frances Mary Platt
IPC分类号： C07D211/46 , A61K31/445 , A61K31/451 , A61K45/06 , C07H15/12
CPC分类号： C07D211/46 , A61K31/445 , A61K31/451 , A61K45/06 , C07H15/12 , A61K2300/00
摘要： Compounds of formula (I): wherein R represents various substituent groups, are useful as inhibitors of glucosylceramide synthase.
摘要翻译：式（I）的化合物：其中R表示各种取代基，可用作葡萄糖神经酰胺合酶的抑制剂。

3. 发明授权

US5089520A Method of inhibiting virus 失效
标题翻译：抑制病毒的方法
公开(公告)号：US5089520A
公开(公告)日：1992-02-18
申请号：US584982
申请日：1990-09-20
申请人： George W. J. Fleet , Thomas W. Rademacher , Raymond A. Dwek
发明人： George W. J. Fleet , Thomas W. Rademacher , Raymond A. Dwek
IPC分类号： A61K31/40 , A61K31/445 , C07D207/12 , C07D211/46 , C07D211/88
CPC分类号： A61K31/40 , A61K31/445 , C07D207/12 , C07D211/46 , C07D211/88
摘要： A group of five- and six-membered heterocyclic compounds having a nitrogen in the ring and 2 to 3 hydroxyl substituents on the ring are effective inhibitory agents of human immunodeficiency virus.
摘要翻译：一组在环中具有氮和环上2至3个羟基取代基的五元和六元杂环化合物是人类免疫缺陷病毒的有效抑制剂。

4. 发明授权

US09089515B2 Long chain N-alkyl compounds and oxa-derivatives thereof 有权
标题翻译：长链N-烷基化合物及其氧杂衍生物
公开(公告)号：US09089515B2
公开(公告)日：2015-07-28
申请号：US13064116
申请日：2011-03-07
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号： A61K31/45 , A61P31/12 , A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译：描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。长链N-烷基是C8-C16烷基。长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。

5. 发明申请

US20110184019A1 Long chain N-Alkyl compounds and oxa-derivatives thereof 有权
标题翻译：长链N-烷基化合物及其氧杂衍生物
公开(公告)号：US20110184019A1
公开(公告)日：2011-07-28
申请号：US13064116
申请日：2011-03-07
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号： A61K31/45 , C12N5/071 , A61P31/12
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译：描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。长链N-烷基是C8-C16烷基。长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。

6. 发明授权

US5043416A Method of inhibiting virus 失效
标题翻译：抑制病毒的方法
公开(公告)号：US5043416A
公开(公告)日：1991-08-27
申请号：US483616
申请日：1990-02-23
申请人： George W. J. Fleet , Thomas W. Rademacher , Raymond A. Dwek
发明人： George W. J. Fleet , Thomas W. Rademacher , Raymond A. Dwek
IPC分类号： A61K31/40 , A61K31/445 , C07D207/12 , C07D211/46 , C07D211/88
CPC分类号： C07D207/12 , A61K31/40 , A61K31/445 , C07D211/46 , C07D211/88
摘要： A group of five- and six-membered heterocyclic compounds having a nitrogen in the ring and 2 to 3 hydroxyl substituents on the ring are effective inhibitory agents of human immunodeficiency virus.
摘要翻译：一组在环中具有氮和环上2至3个羟基取代基的五元和六元杂环化合物是人类免疫缺陷病毒的有效抑制剂。

7. 发明授权

US4849430A Method of inhibiting virus 失效
标题翻译：抑制病毒的方法
公开(公告)号：US4849430A
公开(公告)日：1989-07-18
申请号：US248461
申请日：1988-09-23
申请人： George W. J. Fleet , Thomas W. Rademacher , Raymond A. Dwek
发明人： George W. J. Fleet , Thomas W. Rademacher , Raymond A. Dwek
IPC分类号： A61K31/445
CPC分类号： A61K31/445
摘要： A method of inhibiting human immunodeficiency virus is disclosed which comprises administering to a patient infected with said virus a virally inhibitory effective amount of the N-butyl derivative of deoxynojirimycin or a pharmaceutically acceptable salt derivative thereof.
摘要翻译：公开了一种抑制人类免疫缺陷病毒的方法，其包括对感染了所述病毒的患者施用病毒抑制有效量的脱氧野尻霉素的N-丁基衍生物或其药学上可接受的盐衍生物。

8. 发明授权

US08975280B2 Deoxynojirimycin and D-arabinitol analogs and methods of using 有权
标题翻译：脱氧野尻霉素和D-阿拉伯糖醇类似物及其使用方法
公开(公告)号：US08975280B2
公开(公告)日：2015-03-10
申请号：US11752015
申请日：2007-05-22
申请人： Terry D. Butters , Raymond A. Dwek , George W. J. Fleet
发明人： Terry D. Butters , Raymond A. Dwek , George W. J. Fleet
IPC分类号： A61K31/445 , C07D211/48 , C07D211/46
CPC分类号： C07D211/48 , C07D211/46
摘要： A compound of Formula I are provided: wherein R is: R1 is a substituted or unsubstituted alkyl group; W1-4 are independently selected from hydrogen, substituted or unsubstituted alkyl groups, substituted or unsubstituted haloalkyl groups, substituted or unsubstituted alkanoyl groups, substituted or unsubstituted aroyl groups, or substituted or unsubstituted haloalkanoyl groups; X1-5 are independently selected from H, NO2, N3, and NH2; Y is absent or is a substituted or unsubstituted C1-alkyl group, other than carbonyl; Z is selected from a bond or NH, provided that when Z is a bond, Y is absent, and provided that when Z is NH, Y is a substituted or unsubstituted C1-alkyl group, other than carbonyl. Also provided are D-arabinitol compounds, methods for preparing such compounds and compositions of such compounds, and methods of using such compounds.
摘要翻译：提供式I化合物：其中R是：R 1是取代或未取代的烷基; 取代或未取代的烷基，取代或未取代的烷酰基，取代或未取代的烷酰基，取代或未取代的芳酰基，或取代或未取代的卤代烷酰基; X1-5独立地选自H，NO2，N3和NH2; Y不存在或是除羰基以外的取代或未取代的C 1 - 烷基; Z选自键或NH，条件是当Z为键时，Y不存在，条件是当Z为NH时，Y为除羰基以外的取代或未取代的C 1 - 烷基。还提供了D-阿拉伯糖醇化合物，制备这些化合物的方法和这些化合物的组合物，以及使用这些化合物的方法。

9. 发明授权

US07816560B1 Long chain n-alkyl compounds and oxa-derivatives thereof 有权
标题翻译：长链正烷基化合物及其氧杂衍生物
公开(公告)号：US07816560B1
公开(公告)日：2010-10-19
申请号：US10031145
申请日：2000-08-10
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号： C07C211/00 , C07C303/00 , C07C307/00 , C07C309/00
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译：描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。长链N-烷基是C8-C16烷基。长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。

10. 发明授权

US4999360A Method of inhibiting virus 失效
标题翻译：抑制病毒的方法
公开(公告)号：US4999360A
公开(公告)日：1991-03-12
申请号：US249144
申请日：1988-09-26
申请人： George W. J. Fleet , Thomas W. Rademacher , Raymond A. Dwek
发明人： George W. J. Fleet , Thomas W. Rademacher , Raymond A. Dwek
IPC分类号： A61K31/40 , A61K31/445 , A61P31/12 , A61P37/04 , C07D207/08 , C07D207/12 , C07D211/46 , C07D211/76 , C07D211/88
CPC分类号： C07D211/46 , A61K31/40 , A61K31/445 , C07D207/12 , C07D211/88
摘要： A group of five- and six-membered heterocyclic compounds having a nitrogen in the ring and 2 to 3 hydroxyl substituents on the ring are effective inhibitory agents of human immunodeficiency virus.

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