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1. 发明授权

US08845911B2 Method for production of a microstructured molded object 有权
标题翻译：微结构化成型体的制造方法
公开(公告)号：US08845911B2
公开(公告)日：2014-09-30
申请号：US13862023
申请日：2013-04-12
申请人： Technische Universitaet Ilmenau
发明人： Joerg Hampl , Frank Weise , Gregor Schlingloff , Andreas Schober , Uta Fernekorn
IPC分类号： C03C15/00 , B81C99/00 , B44C1/22
CPC分类号： B44C1/227 , B81B2201/06 , B81B2203/0346 , B81B2207/056 , B81C99/0085 , B81C2201/034 , Y10T428/24281
摘要： A method is provided for producing a microstructured molded object that is intended for culturing of biological cells. According to this method, a plastically deformable first porous film is prepared, as well as a deformable second film and a deformable sacrificial film. The first, second and sacrificial film are placed in a stack. Next, the sacrificial film is subjected to pressure to press the stack into a mold. The mold has recesses, such that deformed regions in the form of cavities are produced in the sacrificial film, the first film and the second film, and undeformed regions remain. During the pressing of the film stack into the mold, the first film and the second film are joined to each other, so that they form a composite film. At least portions of the deformed regions of the second film are etched so that sections of the second film are chemically dissolved. In these sections of the second film, sections in the deformed regions of the first film are opened up, so that the pores in these sections are again free.
摘要翻译：提供了用于生产用于培养生物细胞的微结构模制物体的方法。根据该方法，制备可塑性变形的第一多孔膜，以及可变形的第二膜和可变形的牺牲膜。第一，第二和牺牲膜被放置在堆叠中。接下来，牺牲膜经受压力以将叠层压入模具中。模具具有凹部，使得在牺牲膜，第一膜和第二膜中产生空腔形式的变形区域，并且保留未变形的区域。在将膜堆叠压入模具期间，第一膜和第二膜彼此接合，从而形成复合膜。蚀刻第二膜的变形区域的至少部分，使得第二膜的部分化学溶解。在第二膜的这些部分中，第一膜的变形区域中的部分被打开，使得这些部分中的孔再次游离。

2. 发明授权

US10780613B2 Reproduction of a stem cell niche of an organism and method for the generation thereof 有权
公开(公告)号：US10780613B2
公开(公告)日：2020-09-22
申请号：US15578214
申请日：2016-05-26
申请人： TECHNISCHE UNIVERSITAET ILMENAU , UNIVERSITAETSKLINIKUM JENA
发明人： Andreas Schober , Joerg Hampl , Frank Weise , Justyna Borowiec , Uta Fernekorn , Michael Gebinoga , Sukhdeep Singh , Gregor Schlingloff , Sebastian Haefner , James Beck , Angelika Mueller , Astrid Voigt
IPC分类号： B29C39/14 , C12N5/00 , G03F7/00 , G03F7/20 , G03F1/00 , C12N5/0775 , C12M1/12 , G03F1/70 , B82Y40/00
摘要： The present invention relates firstly to a method for reproducing a stem cell niche of an organism. The invention further relates to a reproduction of a stem cell niche of an organism. According to the invention, an image of a tissue of an organism is generated, which tissue comprises at least one stem cell niche. The image is filtered in order to obtain a structural pattern of the imaged stem cell niche. In a further step, a lithographic mask is generated from the structural pattern. According to the invention, a starting material of a substrate is structured by means of indirect or direct application of the lithographic mask, whereby a structured substrate is obtained which represents the reproduction of the imaged stem cell niche of the organism. The reproduction can be characterised as biolithomorphic.

3. 发明授权

US12146129B2 Microbioreactor assembly 有权
公开(公告)号：US12146129B2
公开(公告)日：2024-11-19
申请号：US16772946
申请日：2017-12-15
申请人： TECHNISCHE UNIVERSITAET ILMENAU
发明人： Andreas Schober , Frank Weise , Joerg Hampl , Gregor Schlingloff
IPC分类号： C12M1/12 , C12M1/00 , C12M1/32
CPC分类号： C12M25/04 , C12M23/12 , C12M23/22 , C12M23/38 , C12M23/40 , C12M25/14 , C12M37/04
摘要： The invention relates to a microbioreactor assembly (01) having a plurality of microbioreactors. The microbioreactor assembly comprises a microtiter plate (02) having numerous wells (09) in a predefined grid arrangement, a closed bottom surface (14) and an open upper face. An insert unit (03) is also provided, which is arranged on the upper face of the microtiter plate (02) and has numerous inserts (11) in the same grid arrangement, each insert (11) engaging in a well (09), and the well (09) being divided into at least two regions (12, 17). Finally, the microbioreactor assembly comprises an activation unit (04), which is placed on the insert unit (03) and has numerous pumps (26), each of which is connected to supply channels (19), which allow the transport of fluid between the two regions (12, 17).

4. 发明申请

US20170274119A1 MOULDING FOR REPLICATING A STRUCTURE OF A BIOLOGICAL TISSUE AND METHOD FOR PRODUCING THE SAME 审中-公开
公开(公告)号：US20170274119A1
公开(公告)日：2017-09-28
申请号：US15508565
申请日：2015-08-26
申请人： Technische Universitaet Ilmenau
发明人： Andreas Schober , Joerg Hampl , Sebastian Haefner , Justyna Tobola , Frank Weise , Sukhdeep Singh , Gregor Schlingloff
IPC分类号： A61L27/16 , A61L27/50 , H01L29/06 , A61L29/14 , A61L31/14 , A61B17/34 , A61L29/08
CPC分类号： A61L27/16 , A61B17/3417 , A61B2017/00849 , A61F2002/0086 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/14 , A61L2400/12 , A61L2400/18 , A61L2430/26 , A61L2430/28 , A61L2430/30 , A61L2430/34 , H01L29/06
摘要： A method for replicating a structure of a biological tissue provides a plastically deformable film that is subjected to a pressure in order to press it into a mold. The mold comprises formations for pit-like depressions, recesses and notches. The recesses each border on at least one of the pit-like depressions and are opened up. The notches form at least one film hinge in the film. The shaped film is folded into a stack having at least two layers of film, the film hinge forming the folding edge for the folding process. The pit-like depressions are closed along their direction of extension by a neighboring layer of the stack and form each time a capillary. At least two of the opened recesses are arranged one on top of another and form a canal arranged perpendicular to the plane of extension of the film.

5. 发明申请

US20130270225A1 METHOD FOR PRODUCTION OF A MICROSTRUCTURED MOLDED OBJECT 有权
标题翻译：生产微结构模制物体的方法
公开(公告)号：US20130270225A1
公开(公告)日：2013-10-17
申请号：US13862023
申请日：2013-04-12
申请人： Technische Universitaet Ilmenau
发明人： Joerg Hampl , Frank Weise , Gregor Schlingloff , Andreas Schober , Uta Fernekorn
IPC分类号： B44C1/22
CPC分类号： B44C1/227 , B81B2201/06 , B81B2203/0346 , B81B2207/056 , B81C99/0085 , B81C2201/034 , Y10T428/24281
摘要： A method is provided for producing a microstructured molded object that is intended for culturing of biological cells. According to this method, a plastically deformable first porous film is prepared, as well as a deformable second film and a deformable sacrificial film. The first, second and sacrificial film are placed in a stack. Next, the sacrificial film is subjected to pressure to press the stack into a mold. The mold has recesses, such that deformed regions in the form of cavities are produced in the sacrificial film, the first film and the second film, and undeformed regions remain. During the pressing of the film stack into the mold, the first film and the second film are joined to each other, so that they form a composite film. At least portions of the deformed regions of the second film are etched so that sections of the second film are chemically dissolved. In these sections of the second film, sections in the deformed regions of the first film are opened up, so that the pores in these sections are again free.
摘要翻译：提供了用于生产用于培养生物细胞的微结构模制物体的方法。根据该方法，制备可塑性变形的第一多孔膜，以及可变形的第二膜和可变形的牺牲膜。第一，第二和牺牲膜被放置在堆叠中。接下来，牺牲膜经受压力以将叠层压入模具中。模具具有凹部，使得在牺牲膜，第一膜和第二膜中产生空腔形式的变形区域，并且保留未变形的区域。在将膜堆叠压入模具期间，第一膜和第二膜彼此接合，从而形成复合膜。蚀刻第二膜的变形区域的至少部分，使得第二膜的部分化学溶解。在第二膜的这些部分中，第一膜的变形区域中的部分被打开，使得这些部分中的孔再次游离。

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