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    • 2. 发明授权
    • Adamantanemethanol derivatives and production processes thereof
    • 金刚烷甲醇衍生物及其制备方法
    • US06344590B1
    • 2002-02-05
    • US09468326
    • 1999-12-21
    • Tatsuya NakanoHiroshi Shimojitosyo
    • Tatsuya NakanoHiroshi Shimojitosyo
    • C07C4330
    • C07C31/278C07C31/137C07C43/315C07C2603/74Y02P20/55
    • An adamantanemethanol derivative of the invention is represented by the following formula (1), wherein Ra is a hydrogen atom or a hydrocarbon group; Rb is a hydrocarbon group having a carbon atom, to which carbon atom at least one hydrogen atom is bonded, at a bonding site with the adjacent carbon atom; Rc, Rd and Re are each a hydrogen atom, a hydroxyl group which may be protected by a protective group or the like; provided that a hydroxyl group protected by a protective group or the like is bonded to at least one carbon atom constituting the adamantane skeleton when Ra is a hydrogen atom or a methyl group and Rb is a methyl group; and at least one substituent, in addition to the HO—C(Ra)(Rb)— group indicated in the formula (1), is bonded to the adamantane ring when one of Ra and Rb is a methyl group and the other is an ethyl group.
    • 本发明的金刚烷甲醇衍生物由下式(1)表示,其中Ra为氢原子或烃基; Rb是在与相邻碳原子的键合位置处具有与碳原子键合至少一个氢原子的碳原子的烃基; Rc,Rd和Re各自为氢原子,可被保护基等保护的羟基; 条件是当Ra为氢原子或甲基且Rb为甲基时,由保护基等保护的羟基与构成金刚烷骨架的至少一个碳原子键合; 并且当R a和R b中的一个为甲基时,与式(1)中所示的HO-C(Ra)(Rb) - 基团相比,至少一个取代基与金刚烷环结合,另一个为金刚烷环 乙基。