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1. 发明授权

US09279802B2 Cell sorter and cell sorting method 有权
标题翻译：细胞分选机和细胞分选方法
公开(公告)号：US09279802B2
公开(公告)日：2016-03-08
申请号：US14342583
申请日：2012-08-16
申请人： Tatsuya Munaka , Hirohisa Abe , Masaki Kanai , Taira Maekawa , Shinya Kimura , Eishi Ashihara
发明人： Tatsuya Munaka , Hirohisa Abe , Masaki Kanai , Taira Maekawa , Shinya Kimura , Eishi Ashihara
IPC分类号： C12M3/00 , G01N33/50 , C12Q1/28 , C12M1/00
CPC分类号： G01N33/5029 , C12M47/04 , C12Q1/28
摘要： A cell sorter including a well that has a microspace filled with a liquid and having a typical length of 1 mm or less, and that has a bottom surface made of a light-permeable material allowing optical observation of an interior of the microspace; a matrix provided on the bottom surface in the well; a bone fragment placed on the matrix in the well; and osteoclasts placed between the matrix and the bone fragment.
摘要翻译：一种细胞分选机，包括具有填充有液体并且具有1mm或更小的典型长度的微空间的孔，并且具有由允许光学观察微空间内部的透光材料制成的底表面的孔; 设置在井底面的基体; 将骨片放置在孔中的基质上; 和破骨细胞置于基质和骨片之间。

2. 发明申请

US20130164848A1 CELL CULTURE CONTAINER AND CELL CULTURE METHOD USING THE CONTAINER 审中-公开
标题翻译：细胞培养容器和细胞培养方法使用容器
公开(公告)号：US20130164848A1
公开(公告)日：2013-06-27
申请号：US13821063
申请日：2011-07-08
申请人： Tatsuya Munaka , Hirohisa Abe , Masaki Kanai , Masakazu Akechi , Taira Maekawa , Shinya Kimura , Eishi Asihara , Shuichi Shoji , Kentaro Kawai
发明人： Tatsuya Munaka , Hirohisa Abe , Masaki Kanai , Masakazu Akechi , Taira Maekawa , Shinya Kimura , Eishi Asihara , Shuichi Shoji , Kentaro Kawai
IPC分类号： C12M1/00 , C12N5/074
CPC分类号： C12M23/24 , C12M23/04 , C12M23/12 , C12M29/00 , C12N5/0607
摘要： A well has a pair of side surfaces, and one of the side surfaces is in contact with a compartment of a first channel with a gas-permeable membrane being interposed therebetween and the other side surface is in contact with a compartment of a second channel with a gas-permeable membrane being interposed therebetween. The well is filled with a liquid cell culture medium, and in such a state, a high-concentration gas and a low-concentration gas, which are different in the concentration of a specific component from each other, are allowed to flow through the first and second channels, respectively, to form a concentration distribution of the specific component in the well.
摘要翻译：井具有一对侧面，一个侧面与第一通道的隔室接触，其间插入有透气膜，另一侧表面与第二通道的隔室接触，插入其间的透气膜。用液体细胞培养基填充该孔，在这种状态下允许特定成分的浓度彼此不同的高浓度气体和低浓度气体流过第一和第二通道，以形成井中特定组分的浓度分布。

3. 发明申请

US20100068713A1 PROBE FOR DETECTING MUTATION IN JAK2 GENE AND USE THEREOF 审中-公开
标题翻译：用于检测JAK2基因中的突变的探针及其用途
公开(公告)号：US20100068713A1
公开(公告)日：2010-03-18
申请号：US12513642
申请日：2008-07-11
申请人： Mitsuharu Hirai , Satoshi Majima , Taira Maekawa , Shinya Kimura
发明人： Mitsuharu Hirai , Satoshi Majima , Taira Maekawa , Shinya Kimura
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/156 , Y10T436/143333
摘要： A probe for detecting a mutation in the JAK2 gene is provided that can detect a target sequence containing a mutation even when the target sequence containing the mutation and a non-target sequence containing no mutation coexist, which are different only in a single base from each other. The probe to be used is an oligonucleotide that is at least one oligonucleotide having a sequence identical to that of a region extending from a cytosine base (C) at position 84 to be considered as the first base to any one of the 17th to 22nd bases in the direction toward the 5′ end in exon 12 of the JAK2 gene consisting of the base sequence of SEQ ID NO: 1, with the cytosine base (C) being the 3′ end. Even in the case of a sample containing both the JAK2 genes with a mutation that has occurred and without a mutation that has occurred, the use of such a probe in, for example, Tm analysis allows the former mutation to be detected. Preferably, the probe is labeled with a fluorescent dye.
摘要翻译：提供了用于检测JAK2基因突变的探针，即使当含有突变的靶序列和不含突变的非靶序列共存时也可以检测到含有突变的靶序列，其仅在单个碱基中不同其他。要使用的探针是至少一种寡核苷酸，其具有与从第84位的胞嘧啶碱基（C）延伸的区域的序列相同的寡核苷酸，被认为是第17位至第22位碱基的第一碱基在由SEQ ID NO：1的碱基序列组成的JAK2基因的外显子12的5'端的方向上，胞嘧啶碱基（C）为3'末端。即使在含有具有发生突变且没有发生突变的JAK2基因的样品的情况下，在例如Tm分析中使用这种探针也可以检测到前述突变。优选地，探针用荧光染料标记。

4. 发明申请

US20090176231A1 PROBE FOR DETECTING ABL GENE MUTATION AND USES THEREOF 有权
标题翻译：检测ABL基因突变的探针及其用途
公开(公告)号：US20090176231A1
公开(公告)日：2009-07-09
申请号：US12293916
申请日：2008-02-19
申请人： Mitsuharu Hirai , Satoshi Majima , Taira Maekawa , Shinya Kimura
发明人： Mitsuharu Hirai , Satoshi Majima , Taira Maekawa , Shinya Kimura
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/172
摘要： Detection probes are provided that are capable of detecting a sequence to be detected containing a mutation even when a sequence not to be detected containing no mutation coexists with the sequence to be detected containing a mutation, which are different only in a single base from each other. At least one oligonucleotide selected from the group consisting of SEQ ID NOs: 2˜16 is used as a probe. Even in a sample containing an abl gene in which a mutation has occurred and an abl gene in which no mutation has occurred, the use of such probes in, for example, Tm analysis allows the mutation to be detected.
摘要翻译：提供检测探针，即使在不含检测的序列的情况下，也可以检测到含有突变的检测序列，所述序列与含有突变的检测序列共存，所述突变仅在单个碱基中不同。使用选自SEQ ID NO：2〜16的至少一种寡核苷酸作为探针。即使在含有发生突变的abl基因的样品和没有发生突变的abl基因的情况下，在例如Tm分析中使用这种探针也可以检测突变。

5. 发明授权

US09012619B2 Probe for detecting ABL gene mutation and uses thereof 有权
标题翻译：探测ABL基因突变及其用途
公开(公告)号：US09012619B2
公开(公告)日：2015-04-21
申请号：US12293916
申请日：2008-02-19
申请人： Mitsuharu Hirai , Satoshi Majima , Taira Maekawa , Shinya Kimura
发明人： Mitsuharu Hirai , Satoshi Majima , Taira Maekawa , Shinya Kimura
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/172
摘要： Detection probes are provided that are capable of detecting a sequence to be detected containing a mutation even when a sequence not to be detected containing no mutation coexists with the sequence to be detected containing a mutation, which are different only in a single base from each other. At least one oligonucleotide selected from the group consisting of SEQ ID NOs: 2˜16 is used as a probe. Even in a sample containing an abl gene in which a mutation has occurred and an abl gene in which no mutation has occurred, the use of such probes in, for example, Tm analysis allows the mutation to be detected.
摘要翻译：提供检测探针，即使在不含检测的序列的情况下，也可以检测到含有突变的检测序列，所述序列与含有突变的检测序列共存，所述突变仅在单个碱基中不同。使用选自SEQ ID NO：2〜16的至少一种寡核苷酸作为探针。即使在含有发生突变的abl基因的样品和没有发生突变的abl基因的情况下，也可以使用例如Tm分析中的这种探针来检测突变。

6. 发明申请

US20100216123A1 METHOD OF DETECTING MUTATION AND KIT USED IN THE SAME 审中-公开
标题翻译：检测其中的突变和套件的方法
公开(公告)号：US20100216123A1
公开(公告)日：2010-08-26
申请号：US12376534
申请日：2007-07-27
申请人： Mitsuharu Hirai , Satoshi Majima , Taira Maekawa , Shinya Kimura
发明人： Mitsuharu Hirai , Satoshi Majima , Taira Maekawa , Shinya Kimura
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6827 , C12Q2527/107 , C12Q2537/143
摘要： A method of detecting a mutation is provided that uses Tm analysis and is excellent in detection sensitivity. A detection probe consisting of a polynucleotide complementary to a sequence to be detected containing a detection site that has been mutated and an inhibitory polynucleotide complementary to a sequence not to be detected containing the detection site that is unmutated are added to a sample containing a DNA to be detected in which the detection site has been mutated and a DNA not to be detected in which the detection site is unmutated, so that the detection probe is hybridized with the DNA. Then while the hybridization product between the DNA and the detection probe is heated, a signal variation associated with an increase in temperature is measured, then the signal variation is analyzed, and thereby a Tm value is determined, based on which the presence of the mutation is determined.
摘要翻译：提供检测突变的方法，其使用Tm分析，检测灵敏度优异。将含有与待检测的序列互补的多核苷酸的检测探针与含有未突变的检测部位的未检测部位互补的抑制性多核苷酸添加到含有检测部位的检测位点上，检测其中已检测位点已被突变，并且检测不被检测的DNA未突变，使得检测探针与DNA杂交。然后，当加热DNA和检测探针之间的杂交产物时，测量与温度升高相关联的信号变化，然后分析信号变化，从而确定Tm值，基于该值，存在突变决心，决意，决定。

7. 发明授权

US08559428B2 Network system 有权
公开(公告)号：US08559428B2
公开(公告)日：2013-10-15
申请号：US12348058
申请日：2009-01-02
申请人： Shinya Kimura , Takahiro Sasaki , Motoki Nakade , Yoshiyuki Kunito , Akihiro Hokimoto , Makoto Oka , Shinako Matsuyama , Atsushi Shionozaki
发明人： Shinya Kimura , Takahiro Sasaki , Motoki Nakade , Yoshiyuki Kunito , Akihiro Hokimoto , Makoto Oka , Shinako Matsuyama , Atsushi Shionozaki
IPC分类号： H04L12/28
CPC分类号： H04L63/0807 , H04L12/2803 , H04L12/2898 , H04L29/06 , H04L29/12216 , H04L61/2015 , H04L63/101 , H04L67/14 , H04L69/329 , H04N21/4126 , H04W12/06 , H04W12/08
摘要： MTID of a terminal apparatus is preliminarily registered into a database of an ISP. In step S2, when a power source of the terminal apparatus is turned on first, (MTID=B) is transmitted from the terminal apparatus to a router. A transmission signal is received by the router and (HGWID=A, MTID=B) is transmitted from the router to the ISP. If (HGWID=A, MTID=B) has been registered in the database, the ISP transmits a permission message in step S5. In step S6, an IP address for a new terminal apparatus is allocated and the new terminal apparatus can participate in a homenetwork. If (HGWID=A, MTID=B) is not registered, a refusal message is sent to the router.

8. 发明申请

US20060179073A1 Information management system 审中-公开
标题翻译：信息管理系统
公开(公告)号：US20060179073A1
公开(公告)日：2006-08-10
申请号：US10549308
申请日：2003-03-20
申请人： Shinya Kimura
发明人： Shinya Kimura
IPC分类号： G06F17/00
CPC分类号： G06F21/6254 , G06F21/6245 , G06F2221/2117 , G06Q50/10
摘要： Provided is an information management system capable of reliably protecting personal data while ensuring the usefulness of the information when data containing personal data are processed. In an information management system (1), processing-object data containing personal data are acquired by an information management apparatus (2), the personal data are extracted from the processing-object data, and the extracted personal data are processed by means of a one-way function to generate a unique code. The personal data contained in the processing-object data are replaced with the unique code to generate primary conversion data, the primary conversion data are transmitted from the information management apparatus (2) to an information center apparatus (4), and they are stored in a data base (5) and used for statistical processing.
摘要翻译：提供一种能够可靠地保护个人数据的信息管理系统，同时在包含个人数据的数据被处理时确保信息的有用性。在信息管理系统（1）中，由信息管理装置（2）获取包含个人数据的处理对象数据，从处理对象数据中提取个人数据，并且通过单向函数生成唯一的代码。包含在处理对象数据中的个人数据被替换为唯一代码以生成主转换数据，主要转换数据从信息管理装置（2）发送到信息中心装置（4），并将它们存储在数据库（5），用于统计处理。

9. 发明授权

US08771676B2 Agrochemically active microbial formulation 有权
标题翻译：农药活性微生物制剂
公开(公告)号：US08771676B2
公开(公告)日：2014-07-08
申请号：US11767095
申请日：2007-06-22
申请人： Shinya Kimura , Yoshiki Takashima , Takeshi Maruyama
发明人： Shinya Kimura , Yoshiki Takashima , Takeshi Maruyama
IPC分类号： A61K38/00
CPC分类号： A01N63/04 , A01N37/12 , A01N37/02 , A01N25/30 , A01N2300/00
摘要： The present invention provides an agrochemically active microbial formulation comprising a combination of an agrochemically active microbe with a specified ester compound and a surfactant, the formulation exhibiting a stable pest controlling effect with no harmful effect on a plant and having highly stable viability of the agrochemically active microbe.
摘要翻译：本发明提供了农业化学活性微生物制剂，其包含农业化学活性微生物与特定的酯化合物和表面活性剂的组合，该制剂表现出对植物没有有害影响并且具有高度稳定的农业化学活性的可行性的稳定的害虫防治效果微生物。

10. 发明申请

US20110256102A1 PLANT DISEASE CONTROLLING COMPOSITION, PLANT DISEASE CONTROLLING METHOD, AND NOVEL MICROORGANISM 失效
标题翻译：植物病害控制组合物，植物病害控制方法和新型微生物
公开(公告)号：US20110256102A1
公开(公告)日：2011-10-20
申请号：US13140450
申请日：2009-12-18
申请人： Shinya Kimura , Masashi Fujinaga
发明人： Shinya Kimura , Masashi Fujinaga
IPC分类号： A01N63/04 , A01P1/00 , C12N1/14
CPC分类号： A01N63/04 , C12N1/14 , C12R1/645
摘要： Disclosed are a plant disease controlling composition that contains as an active ingredient a microorganism belonging to genus Plectosphaerella and having a plant disease controlling ability; a plant disease controlling method that uses said composition; and a novel microorganism that belongs to genus Plectosphaerella and has a plant disease controlling ability.
摘要翻译：公开了一种植物病害控制组合物，其包含作为活性成分的属于球菌属的微生物并具有植物病害防治能力; 使用所述组合物的植物病害防治方法; 以及属于鳞翅目属的新型微生物，具有植物病害防治能力。

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