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1. 发明授权

US09557321B2 Method for screening drugs for suppressing inflammasome activity 有权
标题翻译：用于筛选药物以抑制炎症性活性的方法
公开(公告)号：US09557321B2
公开(公告)日：2017-01-31
申请号：US13885950
申请日：2011-11-17
申请人： Tatsutoshi Nakahata , Megumu Saito , Takayuki Tanaka , Shinya Yamanaka
发明人： Tatsutoshi Nakahata , Megumu Saito , Takayuki Tanaka , Shinya Yamanaka
IPC分类号： C12N5/00 , G01N33/50 , C12N5/074 , G01N33/68
CPC分类号： G01N33/5055 , C12N5/0696 , G01N33/6869 , G01N33/6872 , G01N2333/545 , G01N2500/10
摘要： The present invention provides a method for screening drugs for suppressing inflammasome activity, using macrophages derived from induced pluripotent stem cells (iPS cells) having mutant NLRP3 gene.
摘要翻译：本发明提供了使用衍生自具有突变体NLRP3基因的诱导多能干细胞（iPS细胞）的巨噬细胞来筛选用于抑制炎症性活性的药物的方法。

2. 发明申请

US20130273588A1 METHOD FOR SCREENING DRUGS FOR SUPPRESSING INFLAMMASOME ACTIVITY 有权
标题翻译：用于筛选用于抑制炎症活性的药物的方法
公开(公告)号：US20130273588A1
公开(公告)日：2013-10-17
申请号：US13885950
申请日：2011-11-17
申请人： Tatsutoshi Nakahata , Megumu Saito , Takayuki Tanaka , Shinya Yamanaka
发明人： Tatsutoshi Nakahata , Megumu Saito , Takayuki Tanaka , Shinya Yamanaka
IPC分类号： G01N33/50
CPC分类号： G01N33/5055 , C12N5/0696 , G01N33/6869 , G01N33/6872 , G01N2333/545 , G01N2500/10
摘要： The present invention provides a method for screening drugs for suppressing inflammasome activity, using macrophages derived from induced pluripotent stem cells (iPS cells) having mutant NLRP3 gene.
摘要翻译：本发明提供了使用衍生自具有突变体NLRP3基因的诱导多能干细胞（iPS细胞）的巨噬细胞来筛选用于抑制炎症性活性的药物的方法。

3. 发明授权

US09005976B2 Selection method of induced pluripotent stem cells 有权
标题翻译：诱导多能干细胞的选择方法
公开(公告)号：US09005976B2
公开(公告)日：2015-04-14
申请号：US13393528
申请日：2010-09-01
申请人： Shinya Yamanaka , Takayuki Tanaka
发明人： Shinya Yamanaka , Takayuki Tanaka
IPC分类号： C12N15/00 , C12Q1/68
CPC分类号： C12Q1/6881 , C12N5/0696 , C12N5/10 , C12Q2600/158
摘要： The present invention relates to a method for selecting induced pluripotent stem (iPS) cells. More particularly, the present invention provides: a method for selecting an iPS cell, comprising the steps of: (1a) measuring the expression level of an exogenous nuclear reprogramming gene(s) in a test iPS cell; and (2a) selecting an iPS cell in which the expression level(s) of an exogenous nuclear reprogramming gene(s) is/are less than or equal to the expression level(s) in control iPS cells; and a method for selecting an iPS cell, comprising the steps of: (1b) measuring the expression level of an exogenous nuclear reprogramming gene(s) and the sum the expression levels of the exogenous nuclear reprogramming gene(s) and the corresponding endogenous gene iPS cell; and (2b) selecting an iPS cell in which the ratio of the expression level of an exogenous nuclear reprogramming gene(s) relative to the sum of the expression levels of the exogenous transgene(s) and the corresponding endogenous gene(s) is less than 1 to the ratio in the control iPS cell.
摘要翻译：本发明涉及一种选择诱导多能干细胞（iPS）细胞的方法。更具体地，本发明提供：选择iPS细胞的方法，包括以下步骤：（1a）测量测试iPS细胞中外源核重编程基因的表达水平; 和（2a）选择其中外源性核重编程基因的表达水平小于或等于对照iPS细胞中的表达水平的iPS细胞; 和选择iPS细胞的方法，包括以下步骤：（1b）测量外源核重编程基因的表达水平和外源核重编程基因和相应内源基因的表达水平之和 iPS细胞; 和（2b）选择其中外源核重编程基因的表达水平相对于外源转基因和相应的内源基因的表达水平之和的比例更小的iPS细胞超过1对比控制iPS细胞。

4. 发明申请

US20120156684A1 SELECTION METHOD OF INDUCED PLURIPOTENT STEM CELLS 有权
标题翻译：诱导性脑干干细胞的选择方法
公开(公告)号：US20120156684A1
公开(公告)日：2012-06-21
申请号：US13393528
申请日：2010-09-01
申请人： Shinya Yamanaka , Takayuki Tanaka
发明人： Shinya Yamanaka , Takayuki Tanaka
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12N5/0696 , C12N5/10 , C12Q2600/158
摘要： The present invention relates to a method for selecting induced pluripotent stem (iPS) cells. More particularly, the present invention provides: a method for selecting an iPS cell, comprising the steps of: (1a) measuring the expression level of an exogenous nuclear reprogramming gene(s) in a test iPS cell; and (2a) selecting an iPS cell in which the expression level(s) of an exogenous nuclear reprogramming gene(s) is/are less than or equal to the expression level(s) in control iPS cells; and a method for selecting an iPS cell, comprising the steps of: (1b) measuring the expression level of an exogenous nuclear reprogramming gene(s) and the sum the expression levels of the exogenous nuclear reprogramming gene(s) and the corresponding endogenous gene iPS cell; and (2b) selecting an iPS cell in which the ratio of the expression level of an exogenous nuclear reprogramming gene(s) relative to the sum of the expression levels of the exogenous transgene(s) and the corresponding endogenous gene(s) is less than 1 to the ratio in the control iPS cell.
摘要翻译：本发明涉及一种选择诱导多能干细胞（iPS）细胞的方法。更具体地，本发明提供：选择iPS细胞的方法，包括以下步骤：（1a）测量测试iPS细胞中外源核重编程基因的表达水平; 和（2a）选择其中外源性核重编程基因的表达水平小于或等于对照iPS细胞中的表达水平的iPS细胞; 和选择iPS细胞的方法，包括以下步骤：（1b）测量外源核重编程基因的表达水平和外源核重编程基因和相应内源基因的表达水平之和 iPS细胞; 和（2b）选择其中外源核重编程基因的表达水平相对于外源转基因和相应的内源基因的表达水平之和的比例更小的iPS细胞超过1对比控制iPS细胞。

5. 发明授权

US09465031B2 Method of evaluating prostatic disease 有权
标题翻译：评估前列腺疾病的方法
公开(公告)号：US09465031B2
公开(公告)日：2016-10-11
申请号：US12971419
申请日：2010-12-17
申请人： Naoyuki Okamoto , Takeshi Miura , Yohei Miyagi , Akira Imaizumi , Hiroshi Yamamoto , Takayuki Tanaka , Takahiko Muramatsu , Toshihiko Ando , Noriko Takahashi
发明人： Naoyuki Okamoto , Takeshi Miura , Yohei Miyagi , Akira Imaizumi , Hiroshi Yamamoto , Takayuki Tanaka , Takahiko Muramatsu , Toshihiko Ando , Noriko Takahashi
IPC分类号： G01N33/48 , G01N33/574 , G01N33/68
CPC分类号： G01N33/57434 , G01N33/6812 , G01N2800/342
摘要： According to the method of evaluating prostatic disease of the present invention, amino acid concentration data on concentration values of amino acids in blood collected from a subject to be evaluated is measured, and the state of prostatic disease including at least one of prostatic cancer and prostatic hypertrophy in the subject is evaluated based on the concentration value of at least one of Tau, Thr, Ser, Asn, Glu, Pro, Gly, Ala, Cit, ABA, Val, Met, Ile, Leu, Phe, His, Trp, Orn, Lys, and Cys2 contained in the measured amino acid concentration data of the subject.
摘要翻译：根据本发明的前列腺疾病的评价方法，测定从被评价对象收集的血液中的氨基酸的浓度值的氨基酸浓度数据，前列腺疾病的状态，包括前列腺癌和前列腺中的至少一种基于Tau，Thr，Ser，Asn，Glu，Pro，Gly，Ala，Cit，ABA，Val，Met，Ile，Leu，Phe，His，Trp中的至少一种的浓度值来评价受试者的肥大， Orn，Lys和Cys2包含在受试者的测量的氨基酸浓度数据中。

6. 发明授权

US08826562B2 Drying apparatus 有权
标题翻译：干燥装置
公开(公告)号：US08826562B2
公开(公告)日：2014-09-09
申请号：US12530066
申请日：2008-02-27
申请人： Shinichirou Kobayashi , Tomonori Kikuno , Teruo Kido , Yasuhiro Utsumi , Takayuki Tanaka , Satoshi Tokuno
发明人： Shinichirou Kobayashi , Tomonori Kikuno , Teruo Kido , Yasuhiro Utsumi , Takayuki Tanaka , Satoshi Tokuno
IPC分类号： F26B3/347 , H05B6/78 , F26B15/10 , F26B15/14 , F26B25/00
CPC分类号： H05B6/78 , F26B3/347 , F26B15/10 , F26B15/14 , F26B25/001 , H05B2206/046
摘要： A former unit (20) as a drying apparatus includes a horizontally oriented main casing (21). Space inside the main casing (21) is divided into four irradiation zones (31-34). Each of the irradiation zones (31-34) contains one tray unit (10). Each of the tray units (10) contains four metallic transfer trays (14) aligned in the vertical direction, with a distance between the transfer trays (14) set to half a wavelength of a microwave (λ/2) or larger. Each of the transfer trays (14) carries wet PTFE powder. In the irradiation zones (31-34), the tray units (10) sequentially move from the first irradiation zone (31) to the fourth irradiation zone (34), and the microwave is laterally applied to the transfer trays (14).
摘要翻译：作为干燥装置的前置单元（20）包括水平取向的主壳体（21）。主壳体（21）内的空间分为四个照射区（31-34）。每个照射区域（31-34）包含一个托盘单元（10）。每个托盘单元（10）包含在垂直方向上排列的四个金属转移托盘（14），转移托盘（14）之间的距离设置为微波的一半波长（λ/ 2）或更大。每个转移盘（14）携带湿PTFE粉末。在照射区域（31-34）中，托盘单元（10）从第一照射区域（31）顺序地移动到第四照射区域（34），并且微波被横向地施加到转印盘（14）。

7. 发明授权

US08810793B2 Color measurement device and method for detecting malfunction of color measurement device 有权
标题翻译：色彩测量装置及其检测方法
公开(公告)号：US08810793B2
公开(公告)日：2014-08-19
申请号：US13188786
申请日：2011-07-22
申请人： Takayuki Tanaka
发明人： Takayuki Tanaka
IPC分类号： G01J3/46 , H04N1/60 , B41J2/21 , B41J29/38 , B41J13/22
CPC分类号： B41J29/38 , B41J2/2132 , B41J13/22 , H04N1/6044
摘要： The present invention is a color measurement device for color measurement of a printed pattern printed onto a medium, the color measurement device characterized by comprising a pressing member for pressing the medium; a color measurement section for performing color measurement of the printed pattern; a power supply for outputting power for the pressing member to press the medium; a detection section for detecting displacement of an output section of the power supply; and a controller for causing the color measurement section to perform color measurement of the printed pattern which was printed onto the medium pressed by the pressing member, the controller being adapted to reduce the power output by the power supply from a state in which the pressing member was pressed against the medium, and to detect a malfunction of the power supply on the basis of the detection result obtained from the detection section.
摘要翻译：本发明是一种用于对印刷在介质上的印刷图案进行颜色测量的颜色测量装置，该颜色测量装置的特征在于包括用于按压介质的按压部件; 用于执行印刷图案的颜色测量的颜色测量部分; 用于输出用于按压构件以按压介质的电力的电源; 检测部，其检测所述电源的输出部的位移; 以及控制器，用于使得所述颜色测量部分对印刷在由所述按压部件按压的介质上的印刷图案进行颜色测量，所述控制器适于从所述按压部件的状态减小所述电源的输出功率被按压在介质上，并且根据从检测部获得的检测结果来检测电源的故障。

8. 发明授权

US08269598B2 Thermistor device 有权
标题翻译：热敏电阻器件
公开(公告)号：US08269598B2
公开(公告)日：2012-09-18
申请号：US12706402
申请日：2010-02-16
申请人： Hirokazu Kobayashi , Takayuki Tanaka
发明人： Hirokazu Kobayashi , Takayuki Tanaka
IPC分类号： H01C7/10
CPC分类号： H01C7/18 , G01K7/22 , G01K2205/04 , H01C1/028 , H01C1/148 , H01C7/008
摘要： The present invention relates to a laminate thermistor device comprising a lead terminal 12 connected to a terminal electrode 10. A device main body 4 is a rectangular parallelepiped having mutually perpendicular first side 4a, second side 4b and third side 4c, and when a length of the first side is α, a length of the second side is β and a length of the third side is γ, the length of each side α, β and γ satisfies a relation of α≧β>γ. The terminal electrodes 10 are respectively formed on two plane surfaces including the first side 4a and second side 4b, and the lead terminals 12 are connected to the terminal electrodes 10 respectively to sandwich the third side 4c of the device main body 4 in a length direction therebetween.
摘要翻译：本发明涉及一种层叠热敏电阻器件，其包括连接到端子电极10的引线端子12.器件主体4是具有相互垂直的第一侧4a，第二侧4b和第三侧4c的长方体，并且当长度为第一面是α，第二面的长度为＆bgr; 并且第三侧的长度为γ，每边的长度α＆amp; bgr; γ满足α≧＆Bgr>γ的关系。端子电极10分别形成在包括第一侧面4a和第二侧面4b的两个平面上，并且引线端子12分别连接到端子电极10以将器件主体4的第三侧面4c沿长度方向之间。

9. 发明申请

US20110138889A1 Method of evaluating prostatic disease 有权
标题翻译：评估前列腺疾病的方法
公开(公告)号：US20110138889A1
公开(公告)日：2011-06-16
申请号：US12971419
申请日：2010-12-17
申请人： Naoyuki Okamoto , Takeshi Miura , Yohei Miyagi , Akira Imaizumi , Hiroshi Yamamoto , Takayuki Tanaka , Takahiko Muramatsu , Toshihiko Ando , Noriko Takahashi
发明人： Naoyuki Okamoto , Takeshi Miura , Yohei Miyagi , Akira Imaizumi , Hiroshi Yamamoto , Takayuki Tanaka , Takahiko Muramatsu , Toshihiko Ando , Noriko Takahashi
IPC分类号： G01N30/02
CPC分类号： G01N33/57434 , G01N33/6812 , G01N2800/342
摘要： According to the method of evaluating prostatic disease of the present invention, amino acid concentration data on concentration values of amino acids in blood collected from a subject to be evaluated is measured, and the state of prostatic disease including at least one of prostatic cancer and prostatic hypertrophy in the subject is evaluated based on the concentration value of at least one of Tau, Thr, Ser, Asn, Glu, Pro, Gly, Ala, Cit, ABA, Val, Met, Ile, Leu, Phe, His, Trp, Orn, Lys, and Cys2 contained in the measured amino acid concentration data of the subject.
摘要翻译：根据本发明的前列腺疾病的评价方法，测定从被评价对象收集的血液中的氨基酸的浓度值的氨基酸浓度数据，前列腺疾病的状态，包括前列腺癌和前列腺中的至少一种基于Tau，Thr，Ser，Asn，Glu，Pro，Gly，Ala，Cit，ABA，Val，Met，Ile，Leu，Phe，His，Trp中的至少一种的浓度值来评价受试者的肥大， Orn，Lys和Cys2包含在受试者的测量的氨基酸浓度数据中。

10. 发明申请

US20100005682A1 DRYING APPARATUS 有权
标题翻译：干燥装置
公开(公告)号：US20100005682A1
公开(公告)日：2010-01-14
申请号：US12530066
申请日：2008-02-27
申请人： Shinichirou Kobayashi , Tomonori Kikuno , Teruo Kido , Yasuhiro Utsumi , Takayuki Tanaka , Satoshi Tokuno
发明人： Shinichirou Kobayashi , Tomonori Kikuno , Teruo Kido , Yasuhiro Utsumi , Takayuki Tanaka , Satoshi Tokuno
IPC分类号： F26B3/347
CPC分类号： H05B6/78 , F26B3/347 , F26B15/10 , F26B15/14 , F26B25/001 , H05B2206/046
摘要： A former unit (20) as a drying apparatus includes a horizontally oriented main casing (21). Space inside the main casing (21) is divided into four irradiation zones (31-34). Each of the irradiation zones (31-34) contains one tray unit (10). Each of the tray units (10) contains four metallic transfer trays (14) aligned in the vertical direction, with a distance between the transfer trays (14) set to half a wavelength of a microwave (λ/2) or larger. Each of the transfer trays (14) carries wet PTFE powder. In the irradiation zones (31-34), the tray units (10) sequentially move from the first irradiation zone (31) to the fourth irradiation zone (34), and the microwave is laterally applied to the transfer trays (14).
摘要翻译：作为干燥装置的前置单元（20）包括水平取向的主壳体（21）。主壳体（21）内的空间分为四个照射区（31-34）。每个照射区域（31-34）包含一个托盘单元（10）。每个托盘单元（10）包含在垂直方向上排列的四个金属转移托盘（14），转移托盘（14）之间的距离设置为微波的一半波长（λ/ 2）或更大。每个转移盘（14）携带湿PTFE粉末。在照射区域（31-34）中，托盘单元（10）从第一照射区域（31）顺序地移动到第四照射区域（34），并且微波被横向地施加到转印盘（14）。

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