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    • 6. 发明授权
    • Process for the production of tetrahydropyran-3-one derivatives
    • 四氢吡喃-3-酮衍生物的制备方法
    • US4837345A
    • 1989-06-06
    • US140211
    • 1987-12-31
    • Tatsuo NumataMasataka HatanakaJunichi Watanabe
    • Tatsuo NumataMasataka HatanakaJunichi Watanabe
    • B01J23/42B01J23/46B01J23/75B01J23/755B01J23/86C07B61/00C07D309/30C07D309/32
    • C07D309/30
    • A process for producing a tetrahydropyran-3-one derivative of the formula: ##STR1## wherein R is a hydrogen atom; a straight chained or branched C.sub.1 -C.sub.10 alkyl group which is unsubstituted or substituted by a halogen atom, a hydroxyl group, a C.sub.1 -C.sub.6 alkoxy group, a C.sub.1 -C.sub.6 alkylthio group, a C.sub.1 -C.sub.6 alkylcarbonyloxy group, a C.sub.1 -C.sub.6 alkoxycarbonyl group, a C.sub.1 -C.sub.6 mono- or dialkylamino group, a C.sub.3 -C.sub.6 cycloaklyl group, a C.sub.1 -C.sub.6 alkylaminocarbonyl group, a C.sub.1 -C.sub.6 alkylcarbonylamino group, a C.sub.1 -C.sub.6 alkylcarbonyl group or a phenyl or benzoyl group which is unsubstituted or substituted by a halogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.1 -C.sub.6 alkoxy group, a C.sub.1 -C.sub.6 alkythio group or a C.sub.1 -C.sub.6 alkoxycarbonyl group; a C.sub.3 -C.sub.6 cycloalkyl group; or a phenyl or biphenyl group which is unsubstituted or substituted by a halogen atom, a C.sub.1 -C.sub.6 alkoxy group or C.sub.1 -C.sub.6 alkylthio group, which comprises reacting a 2H-pyran-3(6H)-one derivative of the formula: ##STR2## wherein R is as defined above, and R' is a straight chained or branched C.sub.1 -C.sub.6 acyl group which is unsubstituted or substituted by a halogen atom; a benzoyl group; a C.sub.1 -C.sub.6 alkoxycarbonyl group; or a mono- or dialkylaminocarbonyl group which is unsubstituted or substituted by a C.sub.1 -C.sub.3 alkyl group or a phenyl group, with hydrogen in the presence of a catalyst selected from the group consisting of cobalt, nickel, ruthenium, rhodium, palladium, iridium, platinum and copper chromite.
    • 一种制备下式的四氢吡喃-3-酮衍生物的方法:其中R是氢原子; 未被取代或被卤素原子,羟基,C1-C6烷氧基,C1-C6烷硫基,C1-C6烷基羰氧基,C1-C6烷氧基羰基取代的直链或支链C1-C10烷基 基团,C1-C6单 - 或二烷基氨基,C3-C6环烯基,C1-C6烷基氨基羰基,C1-C6烷基羰基氨基,C1-C6烷基羰基或未取代或取代的苯基或苯甲酰基 C 1 -C 6烷基,C 1 -C 6烷氧基,C 1 -C 6链炔基或C 1 -C 6烷氧基羰基; C3-C6环烷基; 或未被取代或被卤素原子,C1-C6烷氧基或C1-C6烷硫基取代的苯基或联苯基,其包括使下式的2H-吡喃-3(6H) - 酮衍生物: