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1. 发明申请

US20120164165A1 ZONA PELLUCIDA BINDING PEPTIDES, EXPRESSION VECTORS, COMPOSITIONS, AND METHODS FOR SPECIES-SPECIFIC IMMUNOCONTRACEPTION OF ANIMALS 有权
标题翻译： ZONA PELLUCIDA BINDING PEPTIDES，表达载体，组合物和物种特异性免疫动物免疫的方法
公开(公告)号：US20120164165A1
公开(公告)日：2012-06-28
申请号：US13416348
申请日：2012-03-09
申请人： Tatiana I. Samoylova , Henry J. Baker , Nancy Cox , Stephen Ditchkoff , Kent Van Kampen
发明人： Tatiana I. Samoylova , Henry J. Baker , Nancy Cox , Stephen Ditchkoff , Kent Van Kampen
IPC分类号： A61K39/00 , C07K7/08 , C07H21/04 , A61P37/04 , C12N5/10 , C12P21/06 , A61P15/00 , C40B30/04 , C12N15/63
CPC分类号： C07K7/08 , A61K39/0006 , A61K2039/53 , G01N33/50 , G01N33/53 , Y10S424/811 , Y10S435/853
摘要： Disclosed are methods, compositions, zona pellucida binding peptides and polypeptides, and expression vectors for use in species-specific immunocontraception of animals. The disclosed compositions may include immunogenic compositions or vaccines.
摘要翻译：公开了方法，组合物，透明带结合肽和多肽，以及用于动物物种特异性免疫避孕的表达载体。所公开的组合物可以包括免疫原性组合物或疫苗。

2. 发明授权

US08492516B2 Zona pellucida binding peptides for species specific immunocontraception of animals 有权
标题翻译：透明带结合肽用于动物的物种特异性免疫避孕
公开(公告)号：US08492516B2
公开(公告)日：2013-07-23
申请号：US13416348
申请日：2012-03-09
申请人： Tatiana I. Samoylova , Henry J. Baker , Nancy Cox , Stephen Ditchkoff , Kent Van Kampen
发明人： Tatiana I. Samoylova , Henry J. Baker , Nancy Cox , Stephen Ditchkoff , Kent Van Kampen
IPC分类号： C07K5/00
CPC分类号： C07K7/08 , A61K39/0006 , A61K2039/53 , G01N33/50 , G01N33/53 , Y10S424/811 , Y10S435/853
摘要： Disclosed are methods, compositions, zona pellucida binding peptides and polypeptides, and expression vectors for use in species-specific immunocontraception of animals. The disclosed compositions may include immunogenic compositions or vaccines.
摘要翻译：公开了方法，组合物，透明带结合肽和多肽，以及用于动物物种特异性免疫避孕的表达载体。所公开的组合物可以包括免疫原性组合物或疫苗。

3. 发明授权

US08158366B2 Methods of identifying peptides and compositions that bind to oocytes in a species-specific manner 有权
标题翻译：以物种特异性方式鉴定与卵母细胞结合的肽和组合物的方法
公开(公告)号：US08158366B2
公开(公告)日：2012-04-17
申请号：US12419883
申请日：2009-04-07
申请人： Tatiana I. Samoylova , Henry J. Baker , Nancy Cox , Stephen Ditchkoff
发明人： Tatiana I. Samoylova , Henry J. Baker , Nancy Cox , Stephen Ditchkoff
IPC分类号： G01N33/53
CPC分类号： C07K7/08 , A61K39/0006 , A61K2039/53 , G01N33/50 , G01N33/53 , Y10S424/811 , Y10S435/853
摘要： Disclosed are methods of identifying peptides and compositions that bind to oocytes of animals in a species-specific manner. The methods utilize phage libraries and oocytes isolated from target species and non-target species.
摘要翻译：公开了以物种特异性方式鉴定与动物卵母细胞结合的肽和组合物的方法。该方法利用从目标物种和非目标物种分离的噬菌体文库和卵母细胞。

4. 发明申请

US20110044989A1 Zona Pellucida Binding Peptides, Expression Vectors, Compositions, and Methods for Species Specific Immunocontraception of Animals 有权
标题翻译： Zona Pellucida结合肽，表达载体，组合物和物种特异性免疫避孕动物方法
公开(公告)号：US20110044989A1
公开(公告)日：2011-02-24
申请号：US12419883
申请日：2009-04-07
申请人： Tatiana I. Samoylova , Henry J. Baker , Nancy Cox , Stephen Ditchkoff , Kent Van Kampen
发明人： Tatiana I. Samoylova , Henry J. Baker , Nancy Cox , Stephen Ditchkoff , Kent Van Kampen
IPC分类号： A61K39/395 , C40B30/04 , C07K7/08 , C07H21/00 , C12N15/63 , C12N5/10 , C12P21/02 , A61K39/00 , A61P15/00 , A61P37/04
CPC分类号： C07K7/08 , A61K39/0006 , A61K2039/53 , G01N33/50 , G01N33/53 , Y10S424/811 , Y10S435/853
摘要： Disclosed are methods, compositions, zona pellucida binding peptides and polypeptides, and expression vectors for use in species-specific immunocontraception of animals. The disclosed compositions may include immunogenic compositions or vaccines.
摘要翻译：公开了方法，组合物，透明带结合肽和多肽，以及用于动物物种特异性免疫避孕的表达载体。所公开的组合物可以包括免疫原性组合物或疫苗。

5. 发明申请

US20090280137A1 Methods, Compositions, and Sequences of ZP-Binding Peptides for Immunocontraception of Dogs and Other Animals 有权
标题翻译：用于狗和其他动物免疫避孕的ZP结合肽的方法，组合物和序列
公开(公告)号：US20090280137A1
公开(公告)日：2009-11-12
申请号：US12266944
申请日：2008-11-07
申请人： Tatiana I. Samoylova , Henry J. Baker , Brenda Griffin , Kristina Pendergrass , Ludmila P. Globa , M. Daniel Givens , Kay P. Riddell , Nancy Cox
发明人： Tatiana I. Samoylova , Henry J. Baker , Brenda Griffin , Kristina Pendergrass , Ludmila P. Globa , M. Daniel Givens , Kay P. Riddell , Nancy Cox
IPC分类号： A61K39/00 , C40B30/04 , C07K7/08 , C07K7/06 , C07H21/00 , C12N5/00 , C12P21/00 , C07K17/00 , A61K38/08 , A61K38/10 , A61P37/04
CPC分类号： C12N15/1037 , A61K39/0006 , A61K2039/552 , A61K2039/55505 , A61K2039/55561 , A61K2039/6081 , C07K7/08 , G01N33/5044 , Y10S424/811 , Y10S530/853
摘要： Disclosed are methods, compositions, and zona pellucida binding peptides and polypeptides for use in immunocontraception of canines and other animals. The disclosed compositions may include pharmaceutical compositions.
摘要翻译：公开了用于犬和其他动物的免疫避孕的方法，组合物和透明带结合肽和多肽。所公开的组合物可以包括药物组合物。

6. 发明授权

US08057992B2 Methods for identifying peptides that bind to intact oocytes 有权
标题翻译：识别与完整卵母细胞结合的肽的方法
公开(公告)号：US08057992B2
公开(公告)日：2011-11-15
申请号：US12266944
申请日：2008-11-07
申请人： Tatiana I. Samoylova , Henry J. Baker , Brenda Griffin , Kristina Pendergrass , Ludmila P. Globa , M. Daniel Givens , Kay P. Riddell , Nancy Cox
发明人： Tatiana I. Samoylova , Henry J. Baker , Brenda Griffin , Kristina Pendergrass , Ludmila P. Globa , M. Daniel Givens , Kay P. Riddell , Nancy Cox
IPC分类号： G01N33/53
CPC分类号： C12N15/1037 , A61K39/0006 , A61K2039/552 , A61K2039/55505 , A61K2039/55561 , A61K2039/6081 , C07K7/08 , G01N33/5044 , Y10S424/811 , Y10S530/853
摘要： Disclosed are methods, compositions, and zona pellucida binding peptides and polypeptides for use in immunocontraception of canines and other animals. The disclosed compositions may include pharmaceutical compositions. Methods for identifying peptides that bind to intact oocytes also are provided, in particular methods for identifying peptides that bind to zona pellucida of intact oocytes.
摘要翻译：公开了用于犬和其他动物的免疫避孕的方法，组合物和透明带结合肽和多肽。所公开的组合物可以包括药物组合物。还提供了用于鉴定与完整卵母细胞结合的肽的方法，特别是用于鉴定与完整卵母细胞透明带结合的肽的方法。

7. 发明授权

US07642063B2 Methods for targeting and killing glioma cells 失效
标题翻译：靶向和杀死神经胶质瘤细胞的方法
公开(公告)号：US07642063B2
公开(公告)日：2010-01-05
申请号：US11132879
申请日：2005-05-19
申请人： Tatiana I. Samoylova , Henry J. Baker , Nancy R. Cox , Ludmila P. Globa , Nancy E. Morrison
发明人： Tatiana I. Samoylova , Henry J. Baker , Nancy R. Cox , Ludmila P. Globa , Nancy E. Morrison
IPC分类号： A61K38/17 , A61K51/00 , G01N33/574
CPC分类号： G01N33/574 , G01N33/5011 , G01N2500/10
摘要： A diagnostic technique for matching anti-cancer peptide drugs to the molecular profiles of individual cancer tumors, and a method using the technique for a patient-specific treatment of tumors in mammals. This strategy matches anti-cancer peptide drugs to the molecular profiles of individual tumors, and includes the development of two banks, both of which use the same targeting peptides. Targeting peptides are identified using biopsies or other tissue materials from multiple cancer patients and placed into two banks. For a bank of probes, targeting peptides are linked to a label such as a fluorescent or a radioisotope. For a bank of drugs, targeting peptides are linked to a cytotoxic peptide to form a “targeting peptide drug”. Peptide probes are used to establish molecular profiles of individual tumors. Based on these molecular profiles, a patient-specific combination of targeting drugs from the bank of peptide drugs is prepared and the patient is treated. Any currently used cytotoxic agent that can be linked to targeting peptides may be used in place of cytotoxic peptides.
摘要翻译：将抗癌肽药物与个体癌症肿瘤的分子特征匹配的诊断技术，以及使用该技术用于哺乳动物肿瘤患者特异性治疗的方法。这种策略将抗癌肽药物与单个肿瘤的分子谱相匹配，并且包括两个银行的发展，两个银行都使用相同的靶向肽。使用来自多个癌症患者的活组织检查或其他组织材料鉴定靶向肽，并将其置于两个组中。对于一组探针，靶向肽与标记如荧光或放射性同位素连接。对于一批药物，靶向肽与细胞毒肽连接以形成“靶向肽药物”。肽探针用于建立单个肿瘤的分子谱。基于这些分子谱，制备来自肽药物库的靶向药物的患者特异性组合，并对患者进行治疗。可以使用任何目前使用的可以与靶向肽连接的细胞毒性剂来代替细胞毒性肽。

8. 发明授权

US07094868B2 Peptides for recognition and targeting of GLIAL cell tumors 失效
公开(公告)号：US07094868B2
公开(公告)日：2006-08-22
申请号：US10357929
申请日：2003-02-04
申请人： Tatiana I. Samoylova , Valery A. Petrenko , Nancy R. Cox , Nancy E. Morrison , Henry J. Baker , Ludmila P. Globa
发明人： Tatiana I. Samoylova , Valery A. Petrenko , Nancy R. Cox , Nancy E. Morrison , Henry J. Baker , Ludmila P. Globa
IPC分类号： C07K7/04 , C07K7/06 , C07K5/00 , C07K17/00 , C12Q1/70 , G01N33/574 , C12N7/01 , C12N15/00
CPC分类号： C07K7/06 , A61K38/00
摘要： Compositions for use in characterization, diagnosis, prognosis, and therapy of cancer cells are provided. The compositions comprise peptides and variants thereof which were isolated based on their ability to selectively bind glioma cells.

9. 发明授权

US06465438B1 Nucleic acid vaccination for parvoviral infections 有权
标题翻译：核酸疫苗接种细小病毒感染
公开(公告)号：US06465438B1
公开(公告)日：2002-10-15
申请号：US09171425
申请日：1998-10-19
申请人： Joachim Schorr , Henry J. Baker , Bruce F. Smith
发明人： Joachim Schorr , Henry J. Baker , Bruce F. Smith
IPC分类号： A61K4800
CPC分类号： C07K14/005 , A61K2039/51 , C12N2750/14322
摘要： The general field of the invention is a method for nucleic acid vaccination for animals to protect them from parvoviral infection. This invention is more particularly related to the preparation and use of parvoviral DNA and its administration to dogs, cats and mink so as to induce an immune response that can protect these animals from disease caused by virulante parvovirus. Nucleic acid immunogens are designed to include the antigenic portions of the parvoviral genome which are incorporated into bacterial plasmids. These plasmids produce the desired parvoviral gene product when introduced into host cells by transfection. Host cells transfected with the parvoviral immunogen expressing plasmids produce a stream ot antigenic proteins to which the host immune system will mount a protective immune response.
摘要翻译：本发明的一般领域是用于动物的核酸疫苗接种以保护它们免受细小病毒感染的方法。本发明更特别涉及细小病毒DNA的制备和使用及其对狗，猫和貂的施用，以便诱导可以保护这些动物免受病毒细小病毒引起的疾病的免疫应答。核酸免疫原被设计为包括并入细菌质粒的细小病毒基因组的抗原部分。当通过转染引入宿主细胞时，这些质粒产生所需的细小病毒基因产物。用细小病毒免疫原表达质粒转染的宿主细胞产生抗原蛋白质的流，宿主免疫系统将对其施加保护性免疫应答。

10. 发明授权

US06399575B1 Methods and compositions for targeting compounds to the central nervous system 失效
标题翻译：将化合物靶向中枢神经系统的方法和组合物
公开(公告)号：US06399575B1
公开(公告)日：2002-06-04
申请号：US09438150
申请日：1999-11-10
申请人： Bruce F. Smith , Tatiana I. Samoilova , Henry J. Baker
发明人： Bruce F. Smith , Tatiana I. Samoilova , Henry J. Baker
IPC分类号： A61K3808
CPC分类号： C07K7/06 , A61K38/00
摘要： Compositions for use in targeting therapies to central nervous system (CNS) cells are provided. The compositions comprise peptides which are capable of binding CNS cells in vivo.
摘要翻译：提供了用于靶向中枢神经系统（CNS）细胞疗法的组合物。该组合物包含能体内结合CNS细胞的肽。

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