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1. 发明授权

US4598095A Antiviral isothiosemicarbazones 失效
标题翻译：抗病毒异硫代氨基脲
公开(公告)号：US4598095A
公开(公告)日：1986-07-01
申请号：US472407
申请日：1983-03-04
申请人： Tamio Nishimura , Hiroshige Toku , Shin Yoshii , Harumi Fukuyasu , Kuniomi Matsumoto , Youzo Kazuno , Tetsuro Watanabe
发明人： Tamio Nishimura , Hiroshige Toku , Shin Yoshii , Harumi Fukuyasu , Kuniomi Matsumoto , Youzo Kazuno , Tetsuro Watanabe
IPC分类号： A61K31/175 , A01N20060101 , A01N37/52 , A01N47/42 , A61K31/155 , A61P31/12 , C07C337/08
CPC分类号： A61K31/175 , A01N47/42
摘要： An antiviral drug contains as its effective component an isothiosemicarbazone represented by the following general formula (I) or an acidic salt thereof: ##STR1## wherein R.sub.1 represents a halogen atom, a lower (C.sub.1 -C.sub.6) alkyl group, a hydroxy group, a phenyl group which may be or may not be substituted with an alkoxy group containing 1 to 12 carbon atoms, or an unsubstituted or substituted phenylethynyl group represented by the following general formula (II): ##STR2## (wherein R.sub.5 and R.sub.6 may be the same or different, and they each represent a hydrogen atom, a halogen atom, a lower (C.sub.1 -C.sub.6) alkyl group, a hydroxy group or an alkoxy group containing 1 to 12 carbon atoms); R.sub.2 represents a hydrogen atom or a lower (C.sub.1 -C.sub.6) alkyl group; R.sub.3 represents a lower (C.sub.1 -C.sub.6) alkyl group or a benzyl group; R.sub.4 represents a hydrogen atom or a lower (C.sub.1 -C.sub.6) alkyl group. Many of these effective component compounds not only have antiviral activity (especially against influenza virus), but also prevent the breeding of and exterminate plant pathogenic molds.
摘要翻译：抗病毒药物含有作为其有效成分的由以下通式（I）表示的异硫代缩氨基脲或其酸性盐：其中R1表示卤素原子，低级（C1-C6）烷基，羟基（II）表示的未取代或取代的苯基乙炔基的取代基可以被取代，也可以不被碳原子数1〜12的烷氧基取代的苯基或下述通式（II）表示的未取代或取代的苯基乙炔基。和R6可以相同或不同，它们各自表示氢原子，卤素原子，低级（C1-C6）烷基，羟基或含有1至12个碳原子的烷氧基）; R2表示氢原子或低级（C1-C6）烷基; R3表示低级（C1-C6）烷基或苄基; R4表示氢原子或低级（C1-C6）烷基。许多这些有效成分的化合物不仅具有抗病毒活性（特别是针对流感病毒），而且还防止了植物病原菌的繁殖和灭绝。

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