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1. 发明申请

US20060100429A1 Alkynylpurine compounds and production methods thereof 审中-公开
标题翻译：炔烃嘌呤化合物及其制备方法
公开(公告)号：US20060100429A1
公开(公告)日：2006-05-11
申请号：US10517599
申请日：2003-06-10
申请人： Taketo Hayashi , Takehiko Kawakami , Hiroharu Kumazawa , Andras Kotschy , Antal Csampai , Andras Nagy
发明人： Taketo Hayashi , Takehiko Kawakami , Hiroharu Kumazawa , Andras Kotschy , Antal Csampai , Andras Nagy
IPC分类号： C07D473/02
CPC分类号： C07H19/16 , C07D473/00 , C07D473/30 , C07D473/34 , Y02P20/55
摘要： The present invention relates to alkynylpurine compounds represented by the following formula (I-1) and the formula (I-2): wherein each symbol is as defined in the present specification, salts thereof, and production methods thereof. According to the present invention, a method of producing an alkynylpurine compound and a salt thereof useful as an intermediate for medicament production safely, conveniently and economically from the corresponding purine compound and a salt thereof, as well as an alkynylpurine compound and a salt thereof useful as an intermediate for production of medicaments can be provided.
摘要翻译：本发明涉及由下式（I-1）和式（I-2）表示的炔基嘌呤化合物：其中各符号如本说明书中所定义，其盐及其制备方法。根据本发明，可以从相应的嘌呤化合物及其盐安全，经济地制备用作药物生产中间体的炔基嘌呤化合物及其盐的方法以及炔基嘌呤化合物及其盐可以提供作为药物生产的中间体。

2. 发明申请

US20050090666A1 Process for producing 2,6-dihalogenopurine 失效
标题翻译： 2,6-二卤代嘌呤的制备方法
公开(公告)号：US20050090666A1
公开(公告)日：2005-04-28
申请号：US10991505
申请日：2004-11-19
申请人： Naruhito Masai , Taketo Hayashi , Hiroharu Kumazawa , Junichi Nishikawa , Istvan Barta , Takehiko Kawakami
发明人： Naruhito Masai , Taketo Hayashi , Hiroharu Kumazawa , Junichi Nishikawa , Istvan Barta , Takehiko Kawakami
IPC分类号： C07D473/40 , C07D473/00
CPC分类号： C07D473/40 , Y02P20/55
摘要： A process for conveniently and efficiently preparing a 2,6-halogenopurine using an inexpensive starting material. A process for preparing a 2,6-dihalogenopurine, comprising treating a 2-amino-6-halogenopurine having a protective group at 7th position or 9th position with a diazotizating agent and a halogen source; and a process for preparing a 9-acyl-2-amino-6-halogenopurine, comprising treating a 2-amino-6-halogenopurine with an acylating agent in the presence of a base.
摘要翻译：使用廉价起始原料方便有效地制备2,6-卤代嘌呤的方法。一种制备2,6-二卤代嘌呤的方法，包括用重氮化剂和卤素源处理在第7位或第9位具有保护基的2-氨基-6-卤代嘌呤; 以及制备9-酰基-2-氨基-6-卤代嘌呤的方法，包括在碱的存在下用酰化剂处理2-氨基-6-卤代嘌呤。

3. 发明授权

US07321035B2 Process for producing 2,6-dihalogenopurine 失效
标题翻译： 2,6-二卤代嘌呤的制备方法
公开(公告)号：US07321035B2
公开(公告)日：2008-01-22
申请号：US10991505
申请日：2004-11-19
申请人： Naruhito Masai , Taketo Hayashi , Hiroharu Kumazawa , Junichi Nishikawa , Istvan Barta , Takehiko Kawakami
发明人： Naruhito Masai , Taketo Hayashi , Hiroharu Kumazawa , Junichi Nishikawa , Istvan Barta , Takehiko Kawakami
IPC分类号： C07D473/40
CPC分类号： C07D473/40 , Y02P20/55
摘要： A process for conveniently and efficiently preparing a 2,6-dihalogenopurine using an inexpensive starting material. A process for preparing a 2,6-dihalogenopurine, comprising treating a 2-amino-6-halogenopurine having a protective group at 7th position or 9th position with a diazotizating agent and a halogen source; and a process for preparing a 9-acyl-2-amino-6-halogenopurine, comprising treating a 2-amino-6-halogenopurine with an acylating agent in the presence of a base.
摘要翻译：使用廉价起始原料方便有效地制备2,6-二卤代嘌呤的方法。一种制备2,6-二卤代嘌呤的方法，包括用重氮化处理在第7位或第9位具有保护基的2-氨基-6-卤代嘌呤代理和卤素源; 以及制备9-酰基-2-氨基-6-卤代嘌呤的方法，包括在碱的存在下用酰化剂处理2-氨基-6-卤代嘌呤。

4. 发明授权

US07307167B2 Production method of 2,6-dihalopurine 失效
标题翻译： 2,6-二卤嘌呤的制备方法
公开(公告)号：US07307167B2
公开(公告)日：2007-12-11
申请号：US10509802
申请日：2003-04-03
申请人： Taketo Hayashi , Hiroharu Kumazawa , Takehiko Kawakami
发明人： Taketo Hayashi , Hiroharu Kumazawa , Takehiko Kawakami
IPC分类号： C07D473/40 , C07B39/00
CPC分类号： C07D473/40
摘要： By reacting the compound of the formula [Ia] or [Ib] with halosilane compound and an agent for diazo reaction, 2,6-dihalopurine of the formula [II] can be produced conveniently in a high yield and can be easily isolated, wherein each symbol is as defined in the specification
摘要翻译：通过使式[Ia]或[Ib]的化合物与卤代硅烷化合物和重氮反应试剂反应，可以方便地以高产率制备式[II]的2,6-二卤代嘌呤，并且可以容易地分离，其中每个符号如规范中所定义

5. 发明授权

US06936713B2 Process for producing 2,6-dihalogenopurine 失效
标题翻译： 2,6-二卤代嘌呤的制备方法
公开(公告)号：US06936713B2
公开(公告)日：2005-08-30
申请号：US10296234
申请日：2002-04-03
申请人： Naruhito Masai , Taketo Hayashi , Hiroharu Kumazawa , Junichi Nishikawa , István Barta , Takehiko Kawakami
发明人： Naruhito Masai , Taketo Hayashi , Hiroharu Kumazawa , Junichi Nishikawa , István Barta , Takehiko Kawakami
IPC分类号： C07D473/40
CPC分类号： C07D473/40 , Y02P20/55
摘要： A process for conveniently and efficiently preparing a 2,6-dihalogenopurine using an inexpensive starting material. A process for preparing a 2,6-dihalogenopurine, comprising treating a 2-amino-6-halogenopurine having a protective group at 7th position or 9th position with a diazotizating agent and a halogen source; and a process for preparing a 9-acyl-2-amino-6-halogenopurine, comprising treating a 2-amino-6-halogenopurine with an acylating agent in the presence of a base.
摘要翻译：使用廉价起始原料方便有效地制备2,6-二卤代嘌呤的方法。一种制备2,6-二卤代嘌呤的方法，包括用重氮化处理在第7位或第9位具有保护基的2-氨基-6-卤代嘌呤代理和卤素源; 以及制备9-酰基-2-氨基-6-卤代嘌呤的方法，包括在碱的存在下用酰化剂处理2-氨基-6-卤代嘌呤。

6. 发明申请

US20050131229A1 Production method of 2,6-dihalopurine 失效
标题翻译： 2,6-二卤嘌呤的制备方法
公开(公告)号：US20050131229A1
公开(公告)日：2005-06-16
申请号：US10509802
申请日：2003-04-03
申请人： Taketo Hayashi , Hiroharu Kumazawa , Takehiko Kawakami
发明人： Taketo Hayashi , Hiroharu Kumazawa , Takehiko Kawakami
IPC分类号： C07D473/40 , C07D473/00
CPC分类号： C07D473/40
摘要： By reacting the compound of the formula [Ia] or [Ib] with halosilane compound and an agent for diazo reaction, 2,6-dihaliopurine of the formula [II] can be produced conveniently in a high yield and can be easily isolated, wherein each symbol is as defined in the specification.
摘要翻译：通过使式[Ia]或[Ib]的化合物与卤代硅烷化合物和重氮反应试剂反应，式[II]的2,6-二卤代嘌呤可以方便地以高产率制备，并且可以容易地分离，其中每个符号如规范中所定义。

7. 发明申请

US20050080098A1 Crystal and solvate of 2-amino-6-benzyloxypurine and production methods thereof 有权
标题翻译： 2-氨基-6-苄氧基嘌呤的结晶和溶剂合物及其制备方法
公开(公告)号：US20050080098A1
公开(公告)日：2005-04-14
申请号：US10500451
申请日：2003-04-03
申请人： Taketo Hayashi , Takehiko Kawakami , Yoshihiko Iwanaga , Yosuke Watanabe
发明人： Taketo Hayashi , Takehiko Kawakami , Yoshihiko Iwanaga , Yosuke Watanabe
IPC分类号： C07D473/18 , A61K31/522 , C07D473/14
CPC分类号： C07D473/18
摘要： The present invention can provide a solvate, a cubic crystal and a columnar crystal of 2-amino-6-benzyloxypurine by crystallization from (1) a solvent containing at least one kind of solvent selected from the group consisting of alcohol and water, (2) alcohol or (3) a water-containing solvent.
摘要翻译：本发明可以通过从（1）含有选自醇和水中的至少一种溶剂的溶剂（2）得到2-氨基-6-苄氧基嘌呤的溶剂合物，立方晶体和柱状晶体，（2））醇或（3）含水溶剂。

8. 发明授权

US07345170B2 Crystal and solvate of 2-amino-6-benzyloxypurine and production methods thereof 有权
标题翻译： 2-氨基-6-苄氧基嘌呤的结晶和溶剂合物及其制备方法
公开(公告)号：US07345170B2
公开(公告)日：2008-03-18
申请号：US10500451
申请日：2003-04-03
申请人： Taketo Hayashi , Takehiko Kawakami , Yoshihiko Iwanaga , Yosuke Watanabe
发明人： Taketo Hayashi , Takehiko Kawakami , Yoshihiko Iwanaga , Yosuke Watanabe
IPC分类号： C07D473/18
CPC分类号： C07D473/18
摘要： The present invention can provide a solvate, a cubic crystal and a columnar crystal of 2-amino-6-benzyloxypurine by crystallization from (1) a solvent containing at least one kind of solvent selected from the group consisting of alcohol and water, (2) alcohol or (3) a water-containing solvent.
摘要翻译：本发明可以通过从（1）含有选自醇和水中的至少一种溶剂的溶剂（2）得到2-氨基-6-苄氧基嘌呤的溶剂合物，立方晶体和柱状晶体，（2））醇或（3）含水溶剂。

9. 发明申请

US20100219228A1 REFLOW APPARATUS 审中-公开
标题翻译：反光装置
公开(公告)号：US20100219228A1
公开(公告)日：2010-09-02
申请号：US12159453
申请日：2006-12-19
申请人： Fumihiro Yamashita , Shoichiro Matsuhisa , Takehiko Kawakami
发明人： Fumihiro Yamashita , Shoichiro Matsuhisa , Takehiko Kawakami
IPC分类号： B23K3/04
CPC分类号： B23K1/008 , H05K3/3442 , H05K3/3494 , H05K2201/10636 , H05K2203/111 , Y02P70/611
摘要： The present invention provides a reflow apparatus capable of precisely adjusting the heating temperature and heating time when heating a work for reflow. A work transfer conveyor for transferring a work into a furnace body is disposed, wherein a plurality of preheating zones through for preheating the work, a plurality of reflow zones for heating the work for reflow, and a plurality of cooling zones for cooling the work are successively arranged along the work transfer conveyor in the furnace body. The individual reflow zones are formed shorter than the individual preheating zones in the work transfer direction. It is preferable that the sizes of the individual reflow zones in the transfer direction are shortened to approximately 65% to 85% with respect to the individual preheating zones or the conventional individual reflow zones.
摘要翻译：本发明提供一种回流装置，其能够在加热回流工件时精确地调节加热温度和加热时间。设置用于将工件输送到炉体的工件传送输送器，其中通过预热工件的多个预热区，用于加热回流工件的多个回流区和用于冷却工件的多个冷却区，沿着工件输送机在炉体中连续布置。单独的回流区形成为比工件传送方向上的各个预热区域短。相对于各个预热区域或传统的单个回流区域，传送方向上的各个回流区域的尺寸优选缩短至约65％至85％。

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