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1. 发明授权

US08785462B2 5-hydroxypyrimidine-4-carboxamide derivative 有权
标题翻译： 5-羟基嘧啶-4-甲酰胺衍生物
公开(公告)号：US08785462B2
公开(公告)日：2014-07-22
申请号：US13503340
申请日：2010-10-20
申请人： Takeshi Kuribayashi , Hideki Kubota , Naoki Tanaka , Takeshi Fukuda , Takashi Tsuji , Riki Goto
发明人： Takeshi Kuribayashi , Hideki Kubota , Naoki Tanaka , Takeshi Fukuda , Takashi Tsuji , Riki Goto
IPC分类号： A61K31/505 , A61K31/40 , C07D239/02
CPC分类号： C07D401/06 , C07D401/14
摘要： The present invention provides a compound which enhances the production of erythropoietin. The present invention provides a compound represented by formula (1): [wherein, R1: formula (1A): [wherein, R4 and R5: H, halogen, or alkyl; R6: H, halogen, alkyl, or the like; R7: substitutable hydroxyalkyl, substitutable hydroxyhalo alkyl, substitutable alkoxyalkyl, or the like; substituent group α: oxo, hydroxy, amino, or the like; ring Q1: a monocyclic heterocyclic group; ring Q2: a monocyclic hydrocarbon ring group, or a monocyclic heterocyclic group; ring Q3: a monocyclic hydrocarbon ring group, or a monocyclic heterocyclic group; X: a single bond, methylene, ethylene, or the like]; R2: alkyl, or methylsulfanyl; and R3: H, or methyl], or the like.
摘要翻译：本发明提供了促进促红细胞生成素生成的化合物。本发明提供由式（1）表示的化合物：[其中，R1：式（1A）：[其中，R4和R5：H，卤素或烷基; R6：H，卤素，烷基等; R7：可取代的羟烷基，可取代的羟基卤代烷基，可取代的烷氧基烷基等; 取代基组α：氧代，羟基，氨基等; 环Q1：单环杂环基; 环Q2：单环烃环基或单环杂环基; 环Q3：单环烃环基或单环杂环基; X：单键，亚甲基，亚乙基等）; R2：烷基或甲硫基; 和R 3：H或甲基]等。

2. 发明申请

US20120220609A1 5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE DERIVATIVE 有权
标题翻译： 5-羟基嘧啶-4-羧酰胺衍生物
公开(公告)号：US20120220609A1
公开(公告)日：2012-08-30
申请号：US13503340
申请日：2010-10-20
申请人： Takeshi Kuribayashi , Hideki Kubota , Naoki Tanaka , Takeshi Fukuda , Takashi Tsuji , Riki Goto
发明人： Takeshi Kuribayashi , Hideki Kubota , Naoki Tanaka , Takeshi Fukuda , Takashi Tsuji , Riki Goto
IPC分类号： A61K31/506 , C07D401/14 , A61P7/06 , C07D401/06
CPC分类号： C07D401/06 , C07D401/14
摘要： The present invention provides a compound which enhances the production of erythropoietin. The present invention provides a compound represented by formula (1): [wherein, R1: formula (1A): [wherein, R4 and R5: H, halogen, or alkyl; R6: H, halogen, alkyl, or the like; R7: substitutable hydroxyalkyl, substitutable hydroxyhalo alkyl, substitutable alkoxyalkyl, or the like; substituent group α: oxo, hydroxy, amino, or the like; ring Q1: a monocyclic heterocyclic group; ring Q2: a monocyclic hydrocarbon ring group, or a monocyclic heterocyclic group; ring Q3: a monocyclic hydrocarbon ring group, or a monocyclic heterocyclic group; X: a single bond, methylene, ethylene, or the like]; R2: alkyl, or methylsulfanyl; and R3: H, or methyl], or the like.
摘要翻译：本发明提供了促进促红细胞生成素生成的化合物。本发明提供由式（1）表示的化合物：[其中，R1：式（1A）：[其中，R4和R5：H，卤素或烷基; R6：H，卤素，烷基等; R7：可取代的羟烷基，可取代的羟基卤代烷基，可取代的烷氧基烷基等; 取代基组α：氧代，羟基，氨基等; 环Q1：单环杂环基; 环Q2：单环烃环基或单环杂环基; 环Q3：单环烃环基或单环杂环基; X：单键，亚甲基，亚乙基等）; R2：烷基或甲硫基; 和R 3：H或甲基]等。

3. 发明申请

US20110112103A1 5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE COMPOUND 审中-公开
标题翻译： 5-羟基嘧啶-4-羧酰胺化合物
公开(公告)号：US20110112103A1
公开(公告)日：2011-05-12
申请号：US12988947
申请日：2009-04-21
申请人： Takeshi Kuribayashi , Hideki Kubota , Takeshi Fukuda , Rieko Takano , Takashi Tsuji , Koji Sasaki , Naoki Tanaka
发明人： Takeshi Kuribayashi , Hideki Kubota , Takeshi Fukuda , Rieko Takano , Takashi Tsuji , Koji Sasaki , Naoki Tanaka
IPC分类号： A61K31/513 , C07D401/06 , C07D401/14 , C07D409/14 , C07D417/14 , C07D413/14 , C07D403/14 , C07D405/14 , C07D401/10 , C07D405/06 , A61P7/06
CPC分类号： C07D239/34 , C07D239/52 , C07D239/56 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14 , C07D451/02 , C07D471/04
摘要： The present invention provides compounds which promote erythropoietin production. Compounds represented by the following general formula (1) or pharmacologically acceptable salts thereof are provided: [wherein, R1 represents a group —X-Q1, X-Q1-Y-Q2 or X-Q1-Y-Q2-Z-Q3, X represents a single bond, —CH2— or the like, Q1 represents a monocyclic or bicyclic heterocyclic group which may have substituent(s), Y represents a single bond, —CH2—, or the like, Q2 represents a monocyclic or bicyclic hydrocarbon ring group which may have substituent(s) or a monocyclic or bicyclic heterocyclic group which may have substituent(s), Z represents a single bond, —CR11R12— or the like, R11 and R12 each independently represents a hydrogen atom, a halogen atom or the like, Q3 represents a phenyl group which may have substituent(s), a C3-C7 cycloalkyl group which may have substituent(s), a C3-C7 cycloalkenyl group which may have substituent(s) or a monocyclic or bicyclic heterocyclic group which may have substituent(s), R2 represents a C1-C3 alkyl group or the like, and R3 represents a hydrogen atom or a methyl group].
摘要翻译：本发明提供促进促红细胞生成素生成的化合物。提供了由以下通式（1）表示的化合物或其药理学上可接受的盐：[其中，R1表示-X-Q1，X-Q1-Y-Q2或X-Q1-Y-Q2-Z-Q3， X表示单键，-CH 2 - 等，Q 1表示可具有取代基的单环或双环杂环基，Y表示单键，-CH 2 - 等，Q 2表示单环或双环烃可以具有取代基的环基或可以具有取代基的单环或双环杂环基，Z表示单键，-CR 11 R 12 - 等，R 11和R 12各自独立地表示氢原子，卤素原子 Q3表示可具有取代基的苯基，可具有取代基的C3-C7环烷基，可具有取代基的C3-C7环烯基或单环或双环杂环可以具有取代基的基团，R2表示C1-C3烷基等，R3表示呈现氢原子或甲基]。

4. 发明授权

US08426588B2 Phenylalanine derivatives 有权
标题翻译：苯丙氨酸衍生物
公开(公告)号：US08426588B2
公开(公告)日：2013-04-23
申请号：US13524318
申请日：2012-06-15
申请人： Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
发明人： Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
IPC分类号： C07D253/08
CPC分类号： C07D239/22 , C07D239/54 , C07D239/78 , C07D239/80 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D265/26 , C07D285/16 , C07D285/24 , C07D401/12 , C07D471/04 , C07D475/02 , C07D487/04 , Y02P20/582
摘要： Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译：指定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗活性。它们被用作关于α4整联蛋白的各种疾病的治疗剂。

5. 发明授权

US08361709B2 Method of producing tooth, set of teeth, and method of producing tissue 有权
标题翻译：产生牙齿，牙齿组合的方法和生产组织的方法
公开(公告)号：US08361709B2
公开(公告)日：2013-01-29
申请号：US11921233
申请日：2006-05-30
申请人： Takashi Tsuji , Kazuhisa Nakao
发明人： Takashi Tsuji , Kazuhisa Nakao
IPC分类号： C12Q1/68 , A01N1/00 , C12N5/00
CPC分类号： C12N5/0062 , A61K35/12 , A61L27/3813 , A61L27/3834 , A61L27/3865 , A61L27/3886 , A61L2430/12 , C12N5/0627 , C12N5/0654 , C12N2502/097 , C12N2533/54
摘要： A first cell mass substantially containing only either one of mesenchymal cells or epithelial cells and a second cell mass substantially containing only the other one of the cells are positioned in contact with each other inside a support carrier which can maintain a condition of cell contact; and cultured to obtain a tooth having a specific cell placement. Preferably, after the culturing, the support carrier having both cell masses is cultured with kidney cells.
摘要翻译：基本上仅含有间充质细胞或上皮细胞中的任一种的第一细胞团和基本上仅含有另一个细胞的第二细胞团彼此定位在可保持细胞接触状态的载体载体内彼此接触; 并培养以获得具有特定细胞放置的牙齿。优选培养后，将具有两个细胞块的载体载体与肾细胞一起培养。

6. 发明申请

US20120253041A1 NEW PHENYLALANINE DERIVATIVES 有权
标题翻译：新的苯乙烯胺衍生物
公开(公告)号：US20120253041A1
公开(公告)日：2012-10-04
申请号：US13524318
申请日：2012-06-15
申请人： Shingo MAKINO , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
发明人： Shingo MAKINO , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
IPC分类号： C07D253/08
CPC分类号： C07D239/22 , C07D239/54 , C07D239/78 , C07D239/80 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D265/26 , C07D285/16 , C07D285/24 , C07D401/12 , C07D471/04 , C07D475/02 , C07D487/04 , Y02P20/582
摘要： Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译：指定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。它们被用作关于α4整联蛋白的各种疾病的治疗剂。

7. 发明申请

US20120047586A9 POLYPEPTIDE HAVING ENHANCED EFFECTOR FUNCTION 审中-公开
标题翻译：具有增强效应功能的多肽
公开(公告)号：US20120047586A9
公开(公告)日：2012-02-23
申请号：US12739480
申请日：2008-10-23
申请人： Takashi Tsuji , Yasuhiro Kajihara , Katsunari Tezuka , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai
发明人： Takashi Tsuji , Yasuhiro Kajihara , Katsunari Tezuka , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai
IPC分类号： C12P21/02 , C07H21/04 , A01H5/00 , C12N5/10 , A01K67/00 , C07K16/28 , C12N15/63
CPC分类号： C07K16/00 , A61K38/00 , C07K16/2887 , C07K2317/72 , C07K2317/732 , C07K2319/30 , C07K2319/33
摘要： Disclosed is a polypeptide having an enhanced effector function. Specifically disclosed are: a polypeptide having a modified Fc region; a nucleic acid encoding the polypeptide; a vector carrying the nucleic acid; a host cell or a host organism harboring the vector; a pharmaceutical composition comprising the polypeptide; a method for producing the polypeptide; a method for enhancing the effector function of an antibody; and a method for producing a cell capable of producing an antibody having a high effector function.
摘要翻译：公开了具有增强的效应子功能的多肽。具体公开的是：具有修饰的Fc区的多肽; 编码该多肽的核酸; 携带核酸的载体; 携带载体的宿主细胞或宿主生物体; 包含该多肽的药物组合物; 一种生产该多肽的方法; 用于增强抗体的效应子功能的方法; 以及能够产生具有高效应功能的抗体的细胞的制备方法。

8. 发明授权

US07732861B2 Trench MOS type silicon carbide semiconductor device 有权
标题翻译：沟槽MOS型碳化硅半导体器件
公开(公告)号：US07732861B2
公开(公告)日：2010-06-08
申请号：US12461713
申请日：2009-08-21
申请人： Takashi Tsuji
发明人： Takashi Tsuji
IPC分类号： H01L21/336 , H01L29/788
CPC分类号： H01L29/7813 , H01L21/047 , H01L29/0623 , H01L29/0696 , H01L29/0878 , H01L29/1608 , H01L29/41766 , H01L29/66068
摘要： A trench MOS type SiC semiconductor device includes a first conductivity semiconductor substrate, a first conductivity drift layer on the substrate, a second conductivity base layer on the drift layer, a first conductivity source layer on the base layer, a stripe shaped trench reaching from the surface of the source layer to the drift layer and having a gate electrode via a gate oxide film, a second conductivity layer on the bottom of the trench, and a second conductivity type region thereon on across-the-width side walls of at least one end of the trench, electrically coupling the second conductivity layer with the base layer. The device allows a low on-resistance without newly forming an electrode connected to the second conductivity layer even in the case of a device in which the second conductivity layer has to be grounded.
摘要翻译：沟槽MOS型SiC半导体器件包括第一导电半导体衬底，衬底上的第一电导率漂移层，漂移层上的第二导电性基底层，基底层上的第一导电源层，源极层的表面到漂移层，并且通过栅极氧化膜具有栅电极，在沟槽的底部具有第二导电层，并且在其上的至少一个的宽度侧壁上的第二导电类型区域沟槽的端部，将第二导电层与基底层电耦合。即使在第二导电层必须接地的装置的情况下，该装置也允许低导通电阻而不新形成连接到第二导电层的电极。

9. 发明申请

US20100129771A1 METHOD FOR PRODUCTION OF TOOTH, AND TOOTH PRODUCED BY THE METHOD 失效
标题翻译：用于生产牙齿的方法，以及通过该方法生产的牙齿
公开(公告)号：US20100129771A1
公开(公告)日：2010-05-27
申请号：US12528936
申请日：2008-02-28
申请人： Takashi Tsuji , Nobuo Sakuragawa
发明人： Takashi Tsuji , Nobuo Sakuragawa
IPC分类号： A61C13/225 , C12N5/077
CPC分类号： A61L27/22 , A61L27/3813 , A61L27/3834 , A61L27/3865 , A61L27/3891 , A61L2430/12 , C12N5/0654 , C12N2502/097 , C12N2506/025
摘要： Disclosed is a method for producing a tooth, which comprises the steps of: positioning a first cell mass substantially comprising either one of amniotic mesenchymal cells or epithelial cells, and a second cell mass substantially comprising the other one in the inside of a support carrier while keeping them in close contact with each other without being mixed together; and culturing the first and second cell masses in the inside of the support carrier.
摘要翻译：公开了一种生产牙齿的方法，其包括以下步骤：将基本上包含羊膜间充质细胞或上皮细胞之一的第一细胞群和基本上包含另一种的第二细胞团定位在载体载体的内部，同时保持彼此紧密接触而不混合在一起; 并且在支撑载体的内部培养第一和第二细胞块。

10. 发明申请

US20100080794A1 MUTANT POLYPEPTIDE HAVING EFFECTOR FUNCTION 审中-公开
标题翻译：具有影响功能的突变多肽
公开(公告)号：US20100080794A1
公开(公告)日：2010-04-01
申请号：US12296901
申请日：2007-04-12
申请人： Takashi Tsuji , Yasuhiro Kajihara , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai , Akihiro Murakami
发明人： Takashi Tsuji , Yasuhiro Kajihara , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai , Akihiro Murakami
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/00
CPC分类号： C07K14/47 , C07K16/2887 , C07K2317/41 , C07K2317/72 , C07K2317/732
摘要： Mutant polypeptides of the present invention contain an Fc region in which a cysteine residue is substituted for the second amino acid from the glycosylation site to the N terminal side in the Fc region. The Fc region is preferably a human IgG Fc region. The mutant polypeptides of the present invention may also contain an N-linked sugar chain at the glycosylation site in Fc region. Furthermore, a polypeptide domain other than the Fc region of the mutant polypeptides of the present invention may be a polypeptide molecule that recognizes a human cell surface molecule.
摘要翻译：本发明的突变体多肽含有Fc区，其中半胱氨酸残基取代Fc区中糖基化位点至N末端侧的第二个氨基酸。 Fc区优选为人IgG Fc区。本发明的突变体多肽还可以在Fc区的糖基化位点含有N-连接的糖链。此外，本发明的突变多肽的Fc区以外的多肽结构域可以是识别人细胞表面分子的多肽分子。

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