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1. 发明授权

US07544361B2 Hetero type pentamer recombinant vaccine 失效
标题翻译：异种五聚体重组疫苗
公开(公告)号：US07544361B2
公开(公告)日：2009-06-09
申请号：US10565595
申请日：2004-07-23
申请人： Takeshi Arakawa , Masanao Kikukawa , Isao Shimabukuro , Masayuki Tadano , Yasunobu Matsumoto , Naotoshi Tsuji , Yoshiya Sato
发明人： Takeshi Arakawa , Masanao Kikukawa , Isao Shimabukuro , Masayuki Tadano , Yasunobu Matsumoto , Naotoshi Tsuji , Yoshiya Sato
IPC分类号： A61K39/385 , A61K39/12 , A61K39/295 , A61K9/28 , C07K19/00 , C07K17/00 , C12N15/62 , C12N15/63 , C12N1/21
CPC分类号： A61K39/12 , A61K39/385 , A61K2039/541 , A61K2039/6037 , A61K2039/627 , A61K2039/64 , A61K2039/645 , C07K14/005 , C07K14/245 , C07K14/28 , C07K2319/00 , C07K2319/55 , C07K2319/74 , C12N2770/24122 , C12N2770/24134 , Y02A50/39
摘要： A heteropentamer composed of a fusion monomer (32) comprising a fusion protein of an antigenic amino acid sequence and an amino acid sequence of a monomer of a mucous membrane-binding protein and a nonfusion monomer (20) of an amino acid sequence of a monomer of a mucous membrane-binding protein. A homopentamer composed of a fusion monomer including a fusion protein of an antigen derived from an envelope protein of Japanese encephalitis virus and an amino acid sequence of a monomer of a mucous membrane-binding protein. These heteropentamer and the homopentamer can be used as a vaccine.
摘要翻译：由包含抗原性氨基酸序列的融合蛋白和粘膜结合蛋白的单体的氨基酸序列和单体的氨基酸序列的非融合单体（20）的融合单体（32）组成的异戊二敏单体的粘膜结合蛋白。由包含源自日本脑炎病毒的包膜蛋白的抗原的融合蛋白和粘膜结合蛋白的单体的氨基酸序列的融合单体构成的同销口。这些异戊酸和异戊酸可以用作疫苗。

2. 发明申请

US20060246087A1 Hetero type pentamer recombinant vaccine 失效
标题翻译：异种五聚体重组疫苗
公开(公告)号：US20060246087A1
公开(公告)日：2006-11-02
申请号：US10565595
申请日：2004-07-23
申请人： Takeshi Arakawa , Masanao Kikukawa , Isao Shimabukuro , Masayuki Tadano , Yasunobu Matsumoto , Naotoshi Tsuji , Yoshiya Sato
发明人： Takeshi Arakawa , Masanao Kikukawa , Isao Shimabukuro , Masayuki Tadano , Yasunobu Matsumoto , Naotoshi Tsuji , Yoshiya Sato
IPC分类号： A61K39/12 , C07H21/04 , C12N15/86 , C07K14/18
CPC分类号： A61K39/12 , A61K39/385 , A61K2039/541 , A61K2039/6037 , A61K2039/627 , A61K2039/64 , A61K2039/645 , C07K14/005 , C07K14/245 , C07K14/28 , C07K2319/00 , C07K2319/55 , C07K2319/74 , C12N2770/24122 , C12N2770/24134 , Y02A50/39
摘要： A heteropentamer composed of a fusion monomer (32) comprising a fusion protein of an antigenic amino acid sequence and an amino acid sequence of a monomer of a mucous membrane-binding protein and a nonfusion monomer (20) of an amino acid sequence of a monomer of a mucous membrane-binding protein. A homopentamer composed of a fusion monomer including a fusion protein of an antigen derived from an envelope protein of Japanese encephalitis virus and an amino acid sequence of a monomer of a mucous membrane-binding protein. These heteropentamer and the homopentamer can be used as a vaccine.
摘要翻译：由包含抗原性氨基酸序列的融合蛋白和粘膜结合蛋白的单体的氨基酸序列和单体的氨基酸序列的非融合单体（20）的融合单体（32）组成的异戊二敏单体的粘膜结合蛋白。由包含衍生自日本脑炎病毒的包膜蛋白的抗原的融合蛋白和粘膜结合蛋白的单体的氨基酸序列的融合单体组成的同销口。这些异戊酸和异戊酸可以用作疫苗。

3. 发明申请

US20100196407A1 TICK GALECTIN 失效
公开(公告)号：US20100196407A1
公开(公告)日：2010-08-05
申请号：US12426999
申请日：2009-04-21
申请人： Kozo Fujisaki , Hideyuki Nagasawa , Ikuo Igarashi , Hiroshi Suzuki , Chihiro Sugimoto , Gakunan Gen , Kimie Kadota , Noboru Inoue , Naoaki Yokoyama , Naotoshi Tsuji
发明人： Kozo Fujisaki , Hideyuki Nagasawa , Ikuo Igarashi , Hiroshi Suzuki , Chihiro Sugimoto , Gakunan Gen , Kimie Kadota , Noboru Inoue , Naoaki Yokoyama , Naotoshi Tsuji
IPC分类号： A61K39/00 , A61K38/16 , A61P43/00
CPC分类号： C07K14/43531 , A61K39/00 , C07K14/4726 , C07K16/18
摘要： A novel galectin, a polynucleotide encoding the same, a vector and a transformant comprising the polynucleotide, an antibody against the galectin, and a screening method for screening a substance capable of modifying the galectin, are disclosed. According to the galectin, polynucleotide, or vector, it is possible, for example, to exterminate ticks, or to treat or prevent tick-borne infections such as rickettsiosis, filariasis, Q fever, African recurrent fever, or viral encephalitis.
摘要翻译：公开了一种新型半乳凝素，编码该多聚核苷酸的多核苷酸，载体和包含该多核苷酸的转化体，抗半乳凝素的抗体，以及筛选能够修饰半乳凝素的物质的筛选方法。根据半乳凝素，多核苷酸或载体，例如可以灭绝蜱，或治疗或预防蜱传播感染如立克次氏体感染，丝虫病，Q发热，非洲复发性发热或病毒性脑炎。

4. 发明申请

US20090274715A1 TICK CHITINASE 审中-公开
公开(公告)号：US20090274715A1
公开(公告)日：2009-11-05
申请号：US12342111
申请日：2008-12-23
申请人： Kozo Fujisaki , Hideyuki Nagasawa , Ikuo Igarashi , Hiroshi Suzuki , Chihiro Sugimoto , Gakunan Gen , Myonjo Yu , Naotoshi Tsuji
发明人： Kozo Fujisaki , Hideyuki Nagasawa , Ikuo Igarashi , Hiroshi Suzuki , Chihiro Sugimoto , Gakunan Gen , Myonjo Yu , Naotoshi Tsuji
IPC分类号： A61K39/00 , A61K38/46
CPC分类号： C07K16/40 , A61K38/00 , C12N9/2442 , C12Q1/34 , C12Y302/01014 , G01N2500/00
摘要： A novel chitinase, a polynucleotide encoding the same, a vector and a transformant comprising the polynucleotide, an antibody against the chitinase, and a screening method for screening a substance capable of modifying the chitinase, are disclosed. According to the chitinase, polynucleotide, or vector, it is possible, for example, to exterminate ticks, or to treat or prevent tick-borne infections such as piroplasmosis, Q fever, or viral encephalitis.
摘要翻译：公开了一种新颖的几丁质酶，编码该多核苷酸的多核苷酸，载体和包含多核苷酸的转化体，抗几丁质酶的抗体以及筛选能够修饰几丁质酶的物质的筛选方法。根据几丁质酶，多核苷酸或载体，例如可以灭绝蜱，或治疗或预防蜱传播感染，例如弓形体病，Q发热或病毒性脑炎。

5. 发明授权

US5854051A Parasitic helminth asparaginase proteins, nucleic acid molecules, and uses thereof 失效
公开(公告)号：US5854051A
公开(公告)日：1998-12-29
申请号：US929501
申请日：1997-09-15
申请人： Ramaswamy Chandrashekar , Naotoshi Tsuji
发明人： Ramaswamy Chandrashekar , Naotoshi Tsuji
IPC分类号： A61K38/00 , A61K39/00 , A61P33/00 , C12N9/82 , C12N15/55 , C07H21/04 , C12N1/20
CPC分类号： C12N9/82 , A61K2039/51 , A61K38/00 , A61K39/00
摘要： The present invention relates to: parasitic helminth asparaginase proteins; parasitic helminth asparaginase nucleic acid molecules, including those that encode such asparaginase proteins; antibodies raised against such asparaginase proteins; and compounds that inhibit parasitic helminth asparaginase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.

6. 发明授权

US08057801B2 Tick galectin 失效
标题翻译：滴眼液
公开(公告)号：US08057801B2
公开(公告)日：2011-11-15
申请号：US12426999
申请日：2009-04-21
申请人： Kozo Fujisaki , Hideyuki Nagasawa , Ikuo Igarashi , Hiroshi Suzuki , Chihiro Sugimoto , Gakunan Gen , Kimie Kadota , Noboru Inoue , Naoaki Yokoyama , Naotoshi Tsuji
发明人： Kozo Fujisaki , Hideyuki Nagasawa , Ikuo Igarashi , Hiroshi Suzuki , Chihiro Sugimoto , Gakunan Gen , Kimie Kadota , Noboru Inoue , Naoaki Yokoyama , Naotoshi Tsuji
IPC分类号： A61K39/00 , A61K38/16 , A61P43/00
CPC分类号： C07K14/43531 , A61K39/00 , C07K14/4726 , C07K16/18
摘要： A novel galectin, a polynucleotide encoding the same, a vector and a transformant comprising the polynucleotide, an antibody against the galectin, and a screening method for screening a substance capable of modifying the galectin, are disclosed. According to the galectin, polynucleotide, or vector, it is possible, for example, to exterminate ticks, or to treat or prevent tick-borne infections such as rickettsiosis, filariasis, Q fever, African recurrent fever, or viral encephalitis.
摘要翻译：公开了一种新型半乳凝素，编码该多聚核苷酸的多核苷酸，载体和包含该多核苷酸的转化体，抗半乳凝素的抗体，以及筛选能够修饰半乳凝素的物质的筛选方法。根据半乳凝素，多核苷酸或载体，例如可以灭绝蜱，或治疗或预防蜱传播感染如立克次氏体感染，丝虫病，Q发热，非洲复发性发热或病毒性脑炎。

7. 发明授权

US07547682B2 Tick galectin 失效
标题翻译：滴眼液
公开(公告)号：US07547682B2
公开(公告)日：2009-06-16
申请号：US11525044
申请日：2006-09-22
申请人： Kozo Fujisaki , Hideyuki Nagasawa , Ikuo Igarashi , Hiroshi Suzuki , Chihiro Sugimoto , Gakunan Gen , Kimie Kadota , Noboru Inoue , Naoaki Yokoyama , Naotoshi Tsuji
发明人： Kozo Fujisaki , Hideyuki Nagasawa , Ikuo Igarashi , Hiroshi Suzuki , Chihiro Sugimoto , Gakunan Gen , Kimie Kadota , Noboru Inoue , Naoaki Yokoyama , Naotoshi Tsuji
IPC分类号： A61K31/70 , A61K48/00 , C07H21/02 , C07H21/04
CPC分类号： C07K14/43531 , A61K39/00 , C07K14/4726 , C07K16/18
摘要： A novel galectin, a polynucleotide encoding the same, a vector and a transformant comprising the polynucleotide, an antibody against the galectin, and a screening method for screening a substance capable of modifying the galectin, are disclosed. According to the galectin, polynucleotide, or vector, it is possible, for example, to exterminate ticks, or to treat or prevent tick-borne infections such as rickettsiosis, filariasis, Q fever, African recurrent fever, or viral encephalitis.
摘要翻译：公开了一种新型半乳凝素，编码该多聚核苷酸的多核苷酸，载体和包含该多核苷酸的转化体，抗半乳凝素的抗体，以及筛选能够修饰半乳凝素的物质的筛选方法。根据半乳凝素，多核苷酸或载体，例如可以灭绝蜱，或治疗或预防蜱传播感染如立克次氏体感染，丝虫病，Q发热，非洲复发性发热或病毒性脑炎。

8. 发明授权

US07488488B2 Tick chitinase 失效
标题翻译：勾选几丁质酶
公开(公告)号：US07488488B2
公开(公告)日：2009-02-10
申请号：US10506010
申请日：2003-02-28
申请人： Kozo Fujisaki , Hideyuki Nagasawa , Ikuo Igarashi , Hiroshi Suzuki , Chihiro Sugimoto , Gakunan Gen , Myonjo Yu , Naotoshi Tsuji
发明人： Kozo Fujisaki , Hideyuki Nagasawa , Ikuo Igarashi , Hiroshi Suzuki , Chihiro Sugimoto , Gakunan Gen , Myonjo Yu , Naotoshi Tsuji
IPC分类号： A61K39/02
CPC分类号： C07K16/40 , A61K38/00 , C12N9/2442 , C12Q1/34 , C12Y302/01014 , G01N2500/00
摘要： A novel chitinase, a polynucleotide encoding the same, a vector and a transformant comprising the polynucleotide, an antibody against the chitinase, and a screening method for screening a substance capable of modifying the chitinase, are disclosed. According to the chitinase, polynucleotide, or vector, it is possible, for example, to exterminate ticks, or to treat or prevent tick-borne infections such as piroplasmosis, Q fever, or viral encephalitis.
摘要翻译：公开了一种新颖的几丁质酶，编码该多核苷酸的多核苷酸，载体和包含多核苷酸的转化体，抗几丁质酶的抗体以及筛选能够修饰几丁质酶的物质的筛选方法。根据几丁质酶，多核苷酸或载体，例如可以灭绝蜱，或治疗或预防蜱传播感染，例如弓形体病，Q发热或病毒性脑炎。

9. 发明申请

US20050129702A1 Tick chitinase 失效
标题翻译：勾选几丁质酶
公开(公告)号：US20050129702A1
公开(公告)日：2005-06-16
申请号：US10506010
申请日：2003-02-28
申请人： Kozo Fujisaki , Hideyuki Nagasawa , Ikuo Igarashi , Hiroshi Suzuki , Chihiro Sugimoto , Gakunan Gen , Myonjo Yu , Naotoshi Tsuji
发明人： Kozo Fujisaki , Hideyuki Nagasawa , Ikuo Igarashi , Hiroshi Suzuki , Chihiro Sugimoto , Gakunan Gen , Myonjo Yu , Naotoshi Tsuji
IPC分类号： A61K35/56 , A61K38/00 , A61P33/14 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N9/24 , C12N15/56 , C12P21/08 , C12Q1/34 , A61K39/00 , C07H21/04 , C12N5/06
CPC分类号： C07K16/40 , A61K38/00 , C12N9/2442 , C12Q1/34 , C12Y302/01014 , G01N2500/00
摘要： A novel chitinase, a polynucleotide encoding the same, a vector and a transformant comprising the polynucleotide, an antibody against the chitinase, and a screening method for screening a substance capable of modifying the chitinase, are disclosed. According to the chitinase, polynucleotide, or vector, it is possible, for example, to exterminate ticks, or to treat or prevent tick-borne infections such as piroplasmosis, Q fever, or viral encephalitis.
摘要翻译：公开了一种新颖的几丁质酶，编码该多核苷酸的多核苷酸，载体和包含多核苷酸的转化体，抗几丁质酶的抗体以及筛选能够修饰几丁质酶的物质的筛选方法。根据几丁质酶，多核苷酸或载体，例如可以灭绝蜱，或治疗或预防蜱传播感染，例如弓形体病，Q发热或病毒性脑炎。

10. 发明授权

US06352836B1 Dirofilaria and brugia thioredoxin peroxidase type-2 proteins and uses thereof 有权
标题翻译： Dirofilaria和brugia硫氧还蛋白过氧化物酶2型蛋白及其用途
公开(公告)号：US06352836B1
公开(公告)日：2002-03-05
申请号：US09633043
申请日：2000-08-04
申请人： Ramaswamy Chandrashekar , Naotoshi Tsuji
发明人： Ramaswamy Chandrashekar , Naotoshi Tsuji
IPC分类号： C12Q128
CPC分类号： C12N9/0065 , A61K38/00 , C07K16/40 , Y02A50/421
摘要： The present invention relates to: Dirofilaria and Brugia thioredoxin peroxidase type-2 (TPx-2) proteins; Dirofilaria and Brugia TPx-2 nucleic acid molecules, including those that encode such TPx-2 proteins; antibodies raised against such TPx-2 proteins; and compounds that inhibit Dirofilaria and Brugia TPx-2 activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译：本发明涉及：Dirofilaria和Brugia硫氧还蛋白过氧化物酶-2型（TPx-2）蛋白; Dirofilaria和Brugia TPx-2核酸分子，包括编码这种TPx-2蛋白的核酸分子; 针对这种TPx-2蛋白产生的抗体; 以及抑制Dirofilaria和Brugia TPx-2活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制化合物的治疗组合物，以及使用这些治疗组合物来保护动物免受寄生蠕虫引起的疾病。

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