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1. 发明申请

US20050053646A1 Pressure-sensitive adhesive and patch employing the same 有权
标题翻译：压敏粘合剂和使用其的贴剂
公开(公告)号：US20050053646A1
公开(公告)日：2005-03-10
申请号：US10502474
申请日：2003-01-24
申请人： Takashi Yasukochi , Toshiro Yamaguchi , Tetsuro Tateishi , Naruhito Higo
发明人： Takashi Yasukochi , Toshiro Yamaguchi , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K9/70 , A61K47/04 , A61K47/32 , C09J4/00 , C09J11/04 , C08F8/42
CPC分类号： A61K9/7061
摘要： An adhesive which comprises aqueous and nonaqueous polymers suitable for holding an lipophilic drug, etc., and has tackiness and cohesiveness which are sufficient for the plaster of a patch; and a patch employing the adhesive. The adhesive contains a polymer which comprises one or more kinds of acrylic or methacrylic monomer units, at least one kind of the monomer units having a hydroxy group, and which has been crosslinked with a boron compound.
摘要翻译：一种粘合剂，其包含适于保持亲脂性药物的水性和非水性聚合物等，并且具有足够的贴剂粘贴性和粘性; 和使用粘合剂的贴剂。粘合剂含有包含一种或多种丙烯酸或甲基丙烯酸单体单元，至少一种具有羟基的单体单元并且已经与硼化合物交联的聚合物。

2. 发明授权

US08173155B2 Adhesive patch 有权
标题翻译：胶贴
公开(公告)号：US08173155B2
公开(公告)日：2012-05-08
申请号：US11141727
申请日：2005-05-31
申请人： Takashi Yasukochi , Tetsuro Tateishi , Naruhito Higo
发明人： Takashi Yasukochi , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61F13/02
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K9/7076
摘要： The present invention relates an adhesive patch comprising a backing layer and an adhesive layer that contains a drug, wherein the adhesive layer contains a mixed adhesive base containing a hydrocarbon rubber and a silicon-containing polymer. The adhesive patch of the invention shows extremely superior skin absorbability of a drug in a preparation, reduced skin irritation, and excellent aging stability of the drug in the preparation, and can achieve easiness of drug-taking methods and improvement in compliance.
摘要翻译：本发明涉及包含背衬层和含有药物的粘合剂层的粘合贴剂，其中粘合剂层含有含有烃橡胶和含硅聚合物的混合粘合剂基料。本发明的贴剂在制剂中显示出极好的药物在皮肤吸收性，皮肤刺激性降低，以及药物优良的老化稳定性，并且可以实现药物吸收方法的容易性和依从性的提高。

3. 发明申请

US20050119385A1 Process for production of pressure-sensitive adhesive moldings comprising crosslinked polymers as the main component 审中-公开
标题翻译：用于生产包含交联聚合物作为主要成分的压敏粘合剂模制品的方法
公开(公告)号：US20050119385A1
公开(公告)日：2005-06-02
申请号：US10502412
申请日：2003-01-24
申请人： Takashi Yasukochi , Toshiro Yamaguchi , Tetsuro Tateishi , Naruhito Higo
发明人： Takashi Yasukochi , Toshiro Yamaguchi , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K9/70 , A61K47/12 , A61L15/24 , A61L15/58 , C08J5/00 , C08L1/00
CPC分类号： C09J133/04 , A61K9/7061 , A61K47/12 , A61L15/24 , A61L15/58 , C08J5/00 , C08L2312/00 , C08L33/08
摘要： The invention provides a process for production of pressure-sensitive adhesive shaped products which enables proper shaping of a tacky polymer through proper control of the rate of crosslinking thereof, specifically, a process for production of pressure-sensitive adhesive shaped products which comprises mixing a polymer bearing hydroxyl or carboxyl groups with one or more crosslinking agents selected from the group consisting of metal alcoholates and boron compounds in the presence of a lower alcohol and then subjecting the obtained mixture to shaping either accompanied with or followed by thermal crosslinking.
摘要翻译：本发明提供了一种用于生产压敏粘合剂成型产品的方法，其通过适当地控制其交联速率，特别是生产压敏粘合剂成型产品的方法，使粘性聚合物能够适当地成形，该方法包括将聚合物在低级醇的存在下，使用一种或多种选自金属醇化物和硼化合物的交联剂负载羟基或羧基，然后使所得混合物在伴随或随后进行热交联的条件下进行成型。

4. 发明申请

US20050266063A1 Adhesive patch 有权
标题翻译：胶贴
公开(公告)号：US20050266063A1
公开(公告)日：2005-12-01
申请号：US11141727
申请日：2005-05-31
申请人： Takashi Yasukochi , Tetsuro Tateishi , Naruhito Higo
发明人： Takashi Yasukochi , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K9/70
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K9/7076
摘要： The present invention relates an adhesive patch comprising a backing layer and an adhesive layer that contains a drug, wherein the adhesive layer contains a mixed adhesive base containing a hydrocarbon rubber and a silicon-containing polymer. The adhesive patch of the invention shows extremely superior skin absorbability of a drug in a preparation, reduced skin irritation, and excellent aging stability of the drug in the preparation, and can achieve easiness of drug-taking methods and improvement in compliance.
摘要翻译：本发明涉及包含背衬层和含有药物的粘合剂层的粘合贴剂，其中粘合剂层含有含有烃橡胶和含硅聚合物的混合粘合剂基料。本发明的贴剂在制剂中显示出极好的药物在皮肤吸收性，皮肤刺激性降低，以及药物优良的老化稳定性，并且可以实现药物吸收方法的容易性和依从性的提高。

5. 发明授权

US07034083B2 Pressure-sensitive adhesive and patch employing the same 有权
标题翻译：压敏粘合剂和使用其的贴剂
公开(公告)号：US07034083B2
公开(公告)日：2006-04-25
申请号：US10502474
申请日：2003-01-24
申请人： Takashi Yasukochi , Toshiro Yamaguchi , Tetsuro Tateishi , Naruhito Higo
发明人： Takashi Yasukochi , Toshiro Yamaguchi , Tetsuro Tateishi , Naruhito Higo
IPC分类号： C08F8/00
CPC分类号： A61K9/7061
摘要： An adhesive which comprises aqueous and nonaqueous polymers suitable for holding an lipophilic drug, etc., and has tackiness and cohesiveness which are sufficient for the plaster of a patch; and a patch employing the adhesive. The adhesive contains a polymer which comprises one or more kinds of acrylic or methacrylic monomer units, at least one kind of the monomer units having a hydroxy group, and which has been crosslinked with a boron compound.
摘要翻译：一种粘合剂，其包含适于保持亲脂性药物的水性和非水性聚合物等，并且具有足够的贴剂粘贴性和粘性; 和使用粘合剂的贴剂。粘合剂含有包含一种或多种丙烯酸或甲基丙烯酸单体单元，至少一种具有羟基的单体单元并且已经与硼化合物交联的聚合物。

6. 再颁专利

USRE45936E1 Pressure-sensitive adhesive and patch employing the same 有权
公开(公告)号：USRE45936E1
公开(公告)日：2016-03-22
申请号：US12108934
申请日：2008-04-24
申请人： Takashi Yasukochi , Toshiro Yamaguchi , Tetsuro Tateishi , Naruhito Higo
发明人： Takashi Yasukochi , Toshiro Yamaguchi , Tetsuro Tateishi , Naruhito Higo
IPC分类号： C08F8/00 , A61K9/70 , A61K47/04 , A61K47/32 , C09J4/00 , C09J11/04
CPC分类号： A61K9/7061 , A61K9/7069
摘要： An adhesive which comprises aqueous and nonaqueous polymers suitable for holding an lipophilic drug, etc., and has tackiness and cohesiveness which are sufficient for the plaster of a patch; and a patch employing the adhesive. The adhesive contains a polymer which comprises one or more kinds of acrylic or methacrylic monomer units, at least one kind of the monomer units having a hydroxy group, and which has been crosslinked with a boron compound.

7. 发明申请

US20080226697A1 Patch for External Use with Elevated Content of Absorption Promoter in Pressure-Sensitive Adhesive Base 审中-公开
标题翻译：吸附促进剂在压敏粘合剂基质中含量高的外用补片
公开(公告)号：US20080226697A1
公开(公告)日：2008-09-18
申请号：US11578892
申请日：2005-04-21
申请人： Toshiro Yamaguchi , Tsuyoshi Endo , Tetsuro Tateishi , Naruhito Higo
发明人： Toshiro Yamaguchi , Tsuyoshi Endo , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K9/70 , A61K31/216
CPC分类号： A61K9/7053 , A61K9/7061 , A61K31/216 , A61K47/12 , A61K47/32
摘要： A pressure-sensitive adhesive composition for transdermal absorption which contains a drug and a transdermal absorption promoter for the drug, characterized by further containing polyvinylpyrrolidone so as to stabilize the transdermal absorption promoter contained in the adhesive composition. Thus, the transdermal absorption promoter can be prevented from vaporization or degradation and a patch for external use containing the transdermal absorption promoter at a high concentration in using can be provided.
摘要翻译：一种用于透皮吸收的压敏粘合剂组合物，其包含用于药物的药物和透皮吸收促进剂，其特征在于进一步含有聚乙烯吡咯烷酮以稳定粘合剂组合物中所含的经皮吸收促进剂。因此，可以防止透皮吸收促进剂的蒸发或降解，并且可以提供在使用中含有高浓度的含有透皮吸收促进剂的外用贴片。

8. 发明申请

US20070144928A1 Packaging bag 有权
标题翻译：包装袋
公开(公告)号：US20070144928A1
公开(公告)日：2007-06-28
申请号：US10580014
申请日：2004-11-12
申请人： Naruhito Higo , Tetsuro Tateishi , Takeshi Ito
发明人： Naruhito Higo , Tetsuro Tateishi , Takeshi Ito
IPC分类号： A61B19/02 , B65D73/00
CPC分类号： A61F15/001 , A61J1/067 , B65D75/30 , B65D77/26
摘要： A packaging bag 1 according to the present invention comprises a pair of packaging films 7x, 7y that are disposed facing one another, and are sealed together around a perimeter thereof so as to form a housing portion 9 housing a plaster. On one of the packaging films 7x is provided a protrusion 10 that protrudes toward the other packaging film 7y. When the plaster 2 is packaged, only the protrusion 10 of the packaging film 7x contacts a plaster body 5. The portion contacted by the protrusion 10 is a portion, on the inside of the plaster body 5, that excludes an outer periphery of the plaster body 5. Therefore, even if adhesive sticks out of the outer periphery of the plaster body 5, this adhesive does not contact the packaging film 7x. As a result, the plaster 2 can be easily removed from the packaging bag 1.
摘要翻译：根据本发明的包装袋1包括一对彼此相对设置并且围绕其周边密封在一起的包装膜7x，7y，以形成容纳石膏的壳体部分9。在其中一个包装薄膜7x上设置有朝向另一个包装膜7y突出的突起10。当石膏2被包装时，只有包装膜7 x的突起10接触石膏体5。由突起10接触的部分是石膏体5的内部排除石膏体5的外周的部分。因此，即使粘合剂从膏体5的外周伸出，该粘合剂也不会与包装膜7 x接触。结果，可以容易地从包装袋1中取出石膏2。

9. 发明授权

US07785622B2 Adhesive patch for fentanyl administration 有权
标题翻译：芬太尼给药贴剂
公开(公告)号：US07785622B2
公开(公告)日：2010-08-31
申请号：US10527710
申请日：2003-09-12
申请人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
发明人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K31/445 , A61K9/70
CPC分类号： A61K31/4453 , A61K9/7053 , A61K9/7076
摘要： An adhesive patch for percutaneous fentanyl administration which is easily produced, has long-term continuity, and is excellent in adhesion and conformability to the skin. The adhesive patch comprises a backing layer and a pressure-sensitive adhesive layer formed on one side thereof, wherein the pressure-sensitive adhesive layer comprises fentanyl as an active ingredient, a pressure-sensitive adhesive base, and a tackifier resin, the pressure-sensitive adhesive base comprising polyisobutylene and a styrene/isoprene/styrene block copolymer, the proportion of the polyisobutylene in the adhesive base being, 8 to 15 wt. %, and the ratio of the concentration of the polyisobutylene to that of the styrene/isoprene/styrene block copolymer being from 2:3 to 3:2.
摘要翻译：用于经皮芬太尼给药的粘合贴剂易于生产，具有长期的连续性，并且具有优异的粘附性和对皮肤的适应性。粘合贴剂包括背衬层和在其一侧形成的压敏粘合剂层，其中压敏粘合剂层包含芬太尼作为活性成分，压敏粘合剂基底和增粘树脂，压敏粘合剂层包含聚异丁烯和苯乙烯/异戊二烯/苯乙烯嵌段共聚物的粘合剂基料，粘合剂基质中聚异丁烯的比例为8〜15wt。％，聚异丁烯与苯乙烯/异戊二烯/苯乙烯嵌段共聚物的浓度比例为2：3〜3：2。

10. 发明授权

US07754236B2 Patch with improved anchoring properties between a substrate and an adhesive 有权
标题翻译：具有改善的衬底和粘合剂之间的锚固性能的贴片
公开(公告)号：US07754236B2
公开(公告)日：2010-07-13
申请号：US10517468
申请日：2003-06-06
申请人： Tatsuaki Suzuki , Tetsuro Tateishi , Naruhito Higo
发明人： Tatsuaki Suzuki , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61F13/00
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/4468 , Y10T428/2852 , Y10T428/2883
摘要： The present invention relates to a patch which is free from any migration of a drug into a substrate and has favorable anchoring properties between the substrate and adhesive layer, in which the drug containing adhesive layer firmly adheres onto the substrate and which gives no adhesion residue when applied to the skin and then peeled off. Namely, a patch comprising a substrate made of a polyester-based film and a drug-containing adhesive layer laminated thereon wherein the surface roughness (also known as “the central line mean roughness” or “Ra”) of the polyester-based film surface in the side in contact with the adhesive layer is from 0.05 to 0.8 μm is provided.
摘要翻译：本发明涉及一种贴剂，其不含任何药物迁移到基质中，并且在基材和粘合剂层之间具有良好的锚定性能，其中含药物的粘合剂层牢固地粘附到基底上，并且当不含粘合剂残留物时不产生粘附残留应用于皮肤，然后剥离。即，将由聚酯系薄膜构成的基材和层叠有药物的粘合剂层的贴剂形成，其中聚酯类薄膜表面的表面粗糙度（也称为“中心线平均粗糙度”或“Ra”）在与粘合剂层接触的一侧为0.05〜0.8μm。

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