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1. 发明授权

US08216597B2 Oil-in-water emulsion composition and method for producing the same 有权
标题翻译：水包油乳液组合物及其制备方法
公开(公告)号：US08216597B2
公开(公告)日：2012-07-10
申请号：US12670895
申请日：2008-07-22
申请人： Takashi Oka , Reiji Miyahara , Takashi Teshigawara
发明人： Takashi Oka , Reiji Miyahara , Takashi Teshigawara
IPC分类号： A61K8/02 , A61K8/00 , A61K9/14 , A61K9/66 , A61Q19/02
CPC分类号： A61K8/0295 , A61K8/062 , A61K8/342 , A61K8/361 , A61K8/375 , A61K8/553 , A61K8/63 , A61K8/86 , A61K9/1075 , A61K47/10 , A61K47/12 , A61K47/14 , A61K2800/21 , A61Q19/00 , B01J13/046
摘要： The present invention provides: an oil-in-water emulsion composition, into which an oil-soluble drug is stably incorporated and which is excellent in feeling during use; and a method for producing the aforementioned composition, which does not require complicated operations. An oil-in-water emulsion composition comprising; (A) a polyoxyethylene phytosterol, (B) a glycerin fatty acid diester, (C) a polyoxyethylene-polyoxypropylene random copolymer dialkyl ether, (D) an oil-soluble drug, (E) oil, and (F) water; wherein a layered gel structure composed of the components (A) and (B) is present in an emulsion particle in the emulsion composition.
摘要翻译：本发明提供一种油包水乳液组合物，其中稳定地掺入油溶性药物，使用时的感觉优异; 以及不需要复杂操作的上述组合物的制造方法。一种水包油乳液组合物，其包含：（A）聚氧乙烯植物甾醇，（B）甘油脂肪酸二酯，（C）聚氧乙烯 - 聚氧丙烯无规共聚物二烷基醚，（D）油溶性药物，（E）油和（F）水; 其中由所述组分（A）和（B）组成的分层凝胶结构物存在于所述乳液组合物中的乳液颗粒中。

2. 发明申请

US20100284949A1 Water-Containing Composition Which Can Be Used As External Composition 审中-公开
标题翻译：含水组合物可作为外部成分使用
公开(公告)号：US20100284949A1
公开(公告)日：2010-11-11
申请号：US12810183
申请日：2008-12-25
申请人： Takashi Teshigawara , Reiji Miyahara , Takashi Oka
发明人： Takashi Teshigawara , Reiji Miyahara , Takashi Oka
IPC分类号： A61K8/33 , A61Q17/04
CPC分类号： A61K8/63 , A61K8/4966 , A61K8/86 , A61K9/0014 , A61K31/575 , A61K47/28 , A61K47/34 , A61Q17/04 , A61Q19/00
摘要： An object of the present invention is to provide means for enhancing ability to solubilize a low water-soluble substance or to disperse the substance in water. The present invention provides a water-containing composition containing water; at least one polyoxyethylene-polyoxypropylene-added phytosterol or phytostanol represented by the following formula (1): [wherein R represents a phytosterol residue or a phytostanol residue; m is a number from 5 to 100; and n is a number from 5 to 100]; and at least one low water-soluble substance which is in a dissolved state.
摘要翻译：本发明的目的是提供增强溶解低水溶性物质或将物质分散在水中的能力的方法。本发明提供含有水的含水组合物，由下式（1）表示的至少一种聚氧乙烯 - 聚氧丙烯添加的植物甾醇或植物甾醇：[其中R表示植物甾醇残基或植物甾醇残基; m是从5到100的数字; n为5〜100的数。和至少一种处于溶解状态的低水溶性物质。

3. 发明申请

US20100196429A1 Oil-In-Water Emulsion Composition And Method For Producing The Same 有权
标题翻译：水包油乳液组合物及其制备方法
公开(公告)号：US20100196429A1
公开(公告)日：2010-08-05
申请号：US12670895
申请日：2008-07-22
申请人： Takashi Oka , Reiji Miyahara , Takashi Teshigawara
发明人： Takashi Oka , Reiji Miyahara , Takashi Teshigawara
IPC分类号： A61K8/04 , A61K9/14 , A61K9/48 , A61P29/00 , A61P43/00 , A61Q17/00 , A61Q19/02 , A61Q19/00
CPC分类号： A61K8/0295 , A61K8/062 , A61K8/342 , A61K8/361 , A61K8/375 , A61K8/553 , A61K8/63 , A61K8/86 , A61K9/1075 , A61K47/10 , A61K47/12 , A61K47/14 , A61K2800/21 , A61Q19/00 , B01J13/046
摘要： The present invention provides: an oil-in-water emulsion composition, into which an oil-soluble drug is stably incorporated and which is excellent in feeling during use; and a method for producing the aforementioned composition, which does not require complicated operations. An oil-in-water emulsion composition comprising; (A) a polyoxyethylene phytosterol, (B) a glycerin fatty acid diester, (C) a polyoxyethylene-polyoxypropylene random copolymer dialkyl ether, (D) an oil-soluble drug, (E) oil, and (F) water; wherein a layered gel structure composed of the components (A) and (B) is present in an emulsion particle in the emulsion composition.
摘要翻译：本发明提供一种油包水乳液组合物，其中稳定地掺入油溶性药物，使用时的感觉优异; 以及不需要复杂操作的上述组合物的制造方法。一种水包油乳液组合物，其包含：（A）聚氧乙烯植物甾醇，（B）甘油脂肪酸二酯，（C）聚氧乙烯 - 聚氧丙烯无规共聚物二烷基醚，（D）油溶性药物，（E）油和（F）水; 其中由所述组分（A）和（B）组成的分层凝胶结构物存在于所述乳液组合物中的乳液颗粒中。

4. 发明申请

US20110129429A1 Water-Containing Composition 审中-公开
标题翻译：含水组合物
公开(公告)号：US20110129429A1
公开(公告)日：2011-06-02
申请号：US13002005
申请日：2009-07-01
申请人： Takashi Teshigawara , Reiji Miyahara , Masatoshi Ochiai , Takashi Oka
发明人： Takashi Teshigawara , Reiji Miyahara , Masatoshi Ochiai , Takashi Oka
IPC分类号： A61K8/39 , A61K8/49 , A61Q17/04 , A61Q19/00
CPC分类号： A61K47/22 , A61K8/63 , A61K8/86 , A61K9/0014 , A61K31/195 , A61K31/375 , A61K31/60 , A61K47/34 , A61Q17/04
摘要： When a poorly water-soluble ultraviolet ray absorber is used, it is difficult to solubilize a sufficient amount of the poorly water-soluble ultraviolet ray absorber by using a surfactant such as a polyoxyethylene alkyl ether or a polyoxyethylene hydrogenated castor oil. Thus, an object aims to provide a water-containing composition in which a poorly water-soluble ultraviolet ray absorber is solubilized or dispersed in water. Another object aims to dissolve a poorly water-soluble ultraviolet ray absorber in water and allow the poorly water-soluble ultraviolet ray absorber to co-exist with a water-soluble component such as a water-soluble medicinal agent and a water-soluble dye in the water to thereby stabilize the water-soluble component. The water-containing composition comprises the components (1) to (3) shown below and may additionally comprise a water-soluble medicinal agent and/or a water-soluble dye: (1) a polyoxyethylene adduct compound represented by formula (I) HO(CH2CH2O)a—R (I) [wherein R represents a phytosterol residue or a phytostanol residue; and n represents a number of 5 to 100]; (2) a poorly water-soluble ultra-violet ray absorber; and (3) water.
摘要翻译：当使用水溶性差的紫外线吸收剂时，难以通过使用聚氧乙烯烷基醚或聚氧乙烯氢化蓖麻油等表面活性剂溶解足够量的难溶于水的紫外线吸收剂。因此，目的在于提供一种水难溶性组合物，其中难溶于水的紫外线吸收剂溶解或分散在水中。另一个目的是将难溶于水的紫外线吸收剂溶解在水中，使难溶于水的紫外线吸收剂与水溶性成分如水溶性药剂和水溶性染料共存，水，从而稳定水溶性成分。含水组合物包含下述成分（1）〜（3），还可以含有水溶性药剂和/或水溶性染料：（1）由式（I）表示的聚氧乙烯加合物，HO （CH 2 CH 2 O）a -R（I）[其中R表示植物甾醇残基或植物甾醇残基; n表示5〜100的数。（2）水溶性差的紫外线吸收剂; 和（3）水。

5. 发明申请

US20110135587A1 Hair Conditioning Composition 审中-公开
标题翻译：头发调理组成
公开(公告)号：US20110135587A1
公开(公告)日：2011-06-09
申请号：US13057329
申请日：2009-08-07
申请人： Kouichi Kinoshita , Reiji Miyahara , Takashi Teshigawara , Yuko Nagare , Kenji Kurokawa
发明人： Kouichi Kinoshita , Reiji Miyahara , Takashi Teshigawara , Yuko Nagare , Kenji Kurokawa
IPC分类号： A61K8/84 , A61K8/40 , A61Q5/12
CPC分类号： A61K8/86 , A61K8/342 , A61K8/345 , A61K8/361 , A61K8/39 , A61K8/416 , A61K8/42 , A61Q5/12
摘要： The present invention provides an easily-handled hair conditioning composition with a very low water content. The hair conditioning composition of the present invention is a composition comprising: (a) 10 to 90% by mass of one or more components selected from higher alcohols, higher fatty acids, and derivatives thereof, (b) 5 to 35% by mass of a cationic surfactant, and (c) a polyhydric alcohol and/or polyethylene glycol having a melting point of 155° C. or less, characterized in that the endothermic peak of a gel which is formed from (a) and (b) in the composition is 50° C. or more as measured by a differential scanning calorimeter (DSC) and that the water content is 10% by mass or less.
摘要翻译：本发明提供了一种容易处理的具有非常低含水量的头发调理组合物。本发明的头发调理组合物是包含：（a）10〜90质量％的选自高级醇，高级脂肪酸及其衍生物的一种或多种成分，（b）5〜35质量％阳离子表面活性剂，和（c）熔点为155℃以下的多元醇和/或聚乙二醇，其特征在于，在（a）和（b）中形成的凝胶的吸热峰组成为差示扫描量热计（DSC）测定的50℃以上，含水率为10质量％以下。

6. 发明申请

US20110110877A1 Hair Cosmetic 有权
标题翻译：头发化妆品
公开(公告)号：US20110110877A1
公开(公告)日：2011-05-12
申请号：US12999767
申请日：2009-06-19
申请人： Tomoko Watanabe , Tomoyuki Kawasoe , Takashi Teshigawara , Reiji Miyahara , Masatoshi Ochiai , Taizo Fujiyama
发明人： Tomoko Watanabe , Tomoyuki Kawasoe , Takashi Teshigawara , Reiji Miyahara , Masatoshi Ochiai , Taizo Fujiyama
IPC分类号： A61K8/49 , A61K8/86 , A61Q5/00 , A61Q5/02
CPC分类号： A61Q5/02 , A61K8/4966 , A61K8/86 , A61Q5/00 , A61Q5/06 , A61Q5/12 , A61Q17/04
摘要： An object of the present invention is to establish means for reliably incorporating a poorly soluble UV-absorbing agent into a hair cosmetic composition, to thereby provide a hair cosmetic composition which has excellent effect of preventing UV-hair damage and which exhibits favorable sensation in use thereof. Specifically, the object can be attained through provision of a hair cosmetic composition including the following ingredients (1) and (2): (1) a polyoxy(lower alkylene) addition compound represented by formula (I): wherein R represents a phytosterol residue or a phytostanol residue; m is a number from 0 to 100; and n is a number from 5 to 100, and (2) a UV-absorbing agent having a triazine group.
摘要翻译：本发明的目的在于建立将难溶性紫外线吸收剂可靠地引入到毛发化妆品中的手段，从而提供具有优异的防止紫外线毛发损伤的效果并且在使用中具有良好感觉的毛发化妆品其中。具体地，可以通过提供包含以下成分（1）和（2）的毛发化妆品组合物来实现：（1）由式（I）表示的聚氧化（低级亚烷基）加成化合物：其中R表示植物甾醇残基或植物甾醇残基; m是从0到100的数字; n为5〜100的数，（2）具有三嗪基的紫外线吸收剂。

7. 发明授权

US08580235B2 Hair cosmetic 有权
标题翻译：头发化妆品
公开(公告)号：US08580235B2
公开(公告)日：2013-11-12
申请号：US12999767
申请日：2009-06-19
申请人： Tomoko Watanabe , Tomoyuki Kawasoe , Takashi Teshigawara , Reiji Miyahara , Masatoshi Ochiai , Taizo Fujiyama
发明人： Tomoko Watanabe , Tomoyuki Kawasoe , Takashi Teshigawara , Reiji Miyahara , Masatoshi Ochiai , Taizo Fujiyama
IPC分类号： A61K8/49 , A61K8/86 , A61K31/704 , A61Q5/00 , A61Q5/02
CPC分类号： A61Q5/02 , A61K8/4966 , A61K8/86 , A61Q5/00 , A61Q5/06 , A61Q5/12 , A61Q17/04
摘要： An object of the present invention is to establish means for reliably incorporating a poorly soluble UV-absorbing agent into a hair cosmetic composition, to thereby provide a hair cosmetic composition which has excellent effect of preventing UV-hair damage and which exhibits favorable sensation in use thereof. Specifically, the object can be attained through provision of a hair cosmetic composition including the following ingredients (1) and (2): (1) a polyoxy(lower alkylene) addition compound represented by formula (I): wherein R represents a phytosterol residue or a phytostanol residue; m is a number from 0 to 100; and n is a number from 5 to 100, and (2) a UV-absorbing agent having a triazine group.
摘要翻译：本发明的目的在于建立将难溶性紫外线吸收剂可靠地引入到毛发化妆品中的手段，从而提供具有优异的防止紫外线毛发损伤的效果并且在使用中具有良好感觉的毛发化妆品其中。具体地，可以通过提供包含以下成分（1）和（2）的毛发化妆品组合物来实现：（1）由式（I）表示的聚氧化（低级亚烷基）加成化合物：其中R表示植物甾醇残基或植物甾醇残基; m是从0到100的数字; n为5〜100的数，（2）具有三嗪基的紫外线吸收剂。

8. 发明授权

US09655830B2 Cosmetic composition 有权
公开(公告)号：US09655830B2
公开(公告)日：2017-05-23
申请号：US13519348
申请日：2010-12-27
申请人： Minako Sato , Takashi Teshigawara , Kei Watanabe
发明人： Minako Sato , Takashi Teshigawara , Kei Watanabe
IPC分类号： A61Q19/00 , A61K8/55 , A61K8/34 , A61K8/36
CPC分类号： A61K8/553 , A61K8/342 , A61K8/345 , A61K8/361 , A61K2800/262 , A61Q19/00
摘要： To provide a transparent to translucent cosmetic composition which is highly stable, and can impart excellent actual feelings of effectiveness in use, such as a feeling of skin penetration, a feeling of non-stickiness, and a skin-softening effect after application thereof to the skin. A transparent to translucent cosmetic composition comprising: (a) a hydrogenated phospholipid, (b) one or more selected from among branched higher fatty acids and higher alcohols, and (c) a polyalcohol that acts as a good solvent and/or a poor solvent for component (a). Preferably, component (b) is isostearic acid and/or isostearyl alcohol. Preferably, the ratio of component (a)/component (b) is from 1/0.01 to 1/0.4 (by mass).

9. 发明申请

US20120010169A1 Solubilized Composition 审中-公开
标题翻译：溶解组合物
公开(公告)号：US20120010169A1
公开(公告)日：2012-01-12
申请号：US13257691
申请日：2010-03-09
申请人： Takashi Teshigawara , Kei Watanabe , Hidefumi Araki
发明人： Takashi Teshigawara , Kei Watanabe , Hidefumi Araki
IPC分类号： A61K8/58 , A61Q19/00
CPC分类号： C08L71/02 , A61K8/04 , A61K8/39 , A61K8/86 , A61K8/891 , A61Q19/00 , C08G77/14 , C08K5/5419 , C08L83/06 , C08L83/04
摘要： This invention provides a solubilized composition in which a carboxy-modified silicone is solubilized in a large amount and stably. The solubilized composition is characterized by consisting of (a) one or more nonionic surfactant(s), having a weighted average of the HLB value of 10 to 15, selected from polyoxyethylene alkyl ether type nonionic surfactant represented by the following formula (I) or (II): wherein R1 represents a branched chain alkyl group having 8 to 18 carbon atoms; a represents an integer satisfying 3≦a≦40; any one or more of R2, R3 and R4 are each a branched chain alkyl group having 8 to 18 carbon atoms and the other(s) is a hydroxy group; and b, c and d each represent an integer satisfying 3≦b+c+d≦40,(b) a carboxy-modified silicone, and(c) water, andwherein the amount of (b) the carboxy-modified silicone is three times or less the weight of (a) the nonionic surfactant(s).
摘要翻译：本发明提供一种溶解组合物，其中羧基改性的硅氧烷大量且稳定地溶解。该溶解组合物的特征在于：（a）一种或多种HLB值加权平均值为10〜15的非离子表面活性剂，其选自由下式（I）表示的聚氧乙烯烷基醚型非离子表面活性剂或（II）表示：其中R1表示碳原子数为8〜18的支链烷基; a表示满足3＆nlE的整数; a＆nlE; 40; R 2，R 3和R 4中的任何一个或多个各自为具有8至18个碳原子的支链烷基，而另一个为羟基; b，c和d分别表示满足3＆nlE; b + c + d＆nlE; 40，（b）羧基改性硅氧烷和（c）水的整数，其中（b）羧基改性硅氧烷的量为（a）非离子表面活性剂的重量的三倍或更少。

10. 发明申请

US20100316581A1 Skin External Preparations 审中-公开
标题翻译：皮肤外用剂
公开(公告)号：US20100316581A1
公开(公告)日：2010-12-16
申请号：US12745906
申请日：2008-12-05
申请人： Eriko Takeoka , Takashi Teshigawara , Kentaro Kusaba , Akira Matsuo , Junko Tamura
发明人： Eriko Takeoka , Takashi Teshigawara , Kentaro Kusaba , Akira Matsuo , Junko Tamura
IPC分类号： A61K8/92 , A61K31/07 , A61K31/355 , A61P17/00 , A61Q19/08 , A61Q19/02 , A61Q17/04 , A61Q19/00
CPC分类号： A61K31/355 , A61K8/0241 , A61K8/044 , A61K8/39 , A61K8/86 , A61K8/92 , A61K8/922 , A61K31/07 , A61K31/375 , A61K2800/56 , A61K2800/652 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： To provide skin external preparations characterized in that the initial permeation rate of oil-soluble drugs (e.g. retinol and tocopherol acetate) is controlled to achieve their sustained release to thereby reduce skin irritation and that they also possess a fresh feel while featuring high degrees of safety and stability. A skin external preparation which comprises a finely dispersed, oil-soluble drug containing wax composition, the composition containing a solid or semisolid wax, a nonionic surfactant, an aqueous dispersion medium, and an oil-soluble drug, the mass ratio of the nonionic surfactant to the wax being 1.0 or more, and the wax, with the oil-soluble drug contained therein, being finely dispersed in solid or semisolid form in the aqueous dispersion medium.
摘要翻译：提供皮肤外用制剂，其特征在于控制油溶性药物（例如视黄醇和生育酚乙酸酯）的初始渗透速率以实现其持续释放，从而减少皮肤刺激，并且还具有清新的感觉，同时具有高度的安全性和稳定性。包含细分散的油溶性药物的蜡组合物的皮肤外用剂，含有固体或半固体蜡的组合物，非离子表面活性剂，水性分散介质和油溶性药物，非离子表面活性剂蜡为1.0以上，并且其中含有油溶性药物的蜡在水性分散介质中以固体或半固体形式精细分散。

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