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1. 发明授权

US07264793B2 Numb protein expression inhibitors by Musashi 有权
标题翻译： Musashi的Numb蛋白表达抑制剂
公开(公告)号：US07264793B2
公开(公告)日：2007-09-04
申请号：US10343311
申请日：2001-11-22
申请人： Takao Imai , Akinori Tokunaga , Tetsu Yoshida , Katsuhiko Mikoshiba , Masato Nakafuku , Hideyuki Okano
发明人： Takao Imai , Akinori Tokunaga , Tetsu Yoshida , Katsuhiko Mikoshiba , Masato Nakafuku , Hideyuki Okano
IPC分类号： A61K49/00 , A61K38/00 , C12P21/06 , C12N5/00 , C12N15/00 , C12N15/63
CPC分类号： C07K14/47 , A61K38/00
摘要： An Numb protein expression inhibitor comprising, as active ingredient, Musashi protein, a polypeptide having an amino acid sequence obtained by replacement, deletion, addition or insertion of at least one amino acid in an amino acid sequence of Musashi protein, or a gene encoding said polypeptide.By the present invention, a new function of Musashi protein has been elucidated. Described specifically, Musashi protein inhibits expression of Numb protein having a neuronal differentiation regulating function and potentiates the activity of the Notch signaling system, so that Musashi protein can be used as a therapeutic for various diseases of the central nervous system.
摘要翻译：一种Numb蛋白质表达抑制剂，其包含Musashi蛋白质作为活性成分的具有通过在Musashi蛋白质的氨基酸序列中替换，缺失，添加或插入至少一个氨基酸而获得的氨基酸序列的多肽，或编码所述多肽。通过本发明，已经阐明了Musashi蛋白质的新功能。具体地说，Musashi蛋白抑制具有神经元分化调节功能的Numb蛋白的表达，并增强Notch信号系统的活性，使得Musashi蛋白可以用作中枢神经系统各种疾病的治疗剂。

2. 发明申请

US20100167314A1 CONTROL OF INTRACELLULAR TARGET MOLECULE BY IP3 RECEPTOR-BINDING PROTEIN 有权
标题翻译：通过IP3受体结合蛋白控制细胞内目标分子
公开(公告)号：US20100167314A1
公开(公告)日：2010-07-01
申请号：US12293681
申请日：2007-03-20
申请人： Katsuhiko Mikoshiba , Hideaki Ando , Akihiro Mizutani
发明人： Katsuhiko Mikoshiba , Hideaki Ando , Akihiro Mizutani
IPC分类号： G01N33/50 , C07K14/00 , C07H21/04 , C07K16/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a composition comprising an IP3 receptor-binding protein (IRBIT), a nucleic acid that controls the expression and translation of IRBIT, or an antibody against IRBIT for controlling at least one intracellular biological function selected from the group consisting of (1) protein synthesis, (2) phosphatidylinositol metabolism, and (3) intracellular pH.
摘要翻译：本发明提供一种组合物，其包含IP3受体结合蛋白（IRBIT），控制IRBIT的表达和翻译的核酸或针对IRBIT的抗体，用于控制至少一种选自下组的细胞内生物学功能：（1 ）蛋白质合成，（2）磷脂酰肌醇代谢，和（3）细胞内pH。

3. 发明申请

US20060019261A1 RNA-binding protein 审中-公开
标题翻译： RNA结合蛋白
公开(公告)号：US20060019261A1
公开(公告)日：2006-01-26
申请号：US10943015
申请日：2004-09-17
申请人： Katsuhiko Mikoshiba , Akihiro Mizutani
发明人： Katsuhiko Mikoshiba , Akihiro Mizutani
IPC分类号： C12Q1/68 , C12P21/06 , C12N9/22 , C07H21/04
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/47
摘要： The present invention provides Synaptotagmin-binding and yet RNA-binding proteins and genes encoding the proteins. The invention relates to a recombinant protein selected from the group consisting of the following (a) and (b), as well as a gene encoding the protein: (a) a protein comprising the amino acid sequence as shown in SEQ ID NO: 2 (b) a protein which comprises the amino acid sequence as shown in SEQ ID NO: 2 having deletion, substitution or addition of one or several amino acids and which has RNA binding activity.
摘要翻译：本发明提供了Synaptotagmin结合蛋白和编码蛋白质的RNA结合蛋白和基因。本发明涉及选自以下（a）和（b）的重组蛋白质，以及编码该蛋白质的基因：（a）包含SEQ ID NO：2所示的氨基酸序列的蛋白质（b）包含SEQ ID NO：2所示的具有缺失，取代或添加一个或几个氨基酸并具有RNA结合活性的氨基酸序列的蛋白质。

4. 发明授权

US06921648B2 Neurogenesis inducing genes 失效
标题翻译：神经发生诱导基因
公开(公告)号：US06921648B2
公开(公告)日：2005-07-26
申请号：US10244367
申请日：2002-09-16
申请人： Katsuhiko Mikoshiba , Jun Aruga , Takeharu Nagai , Katsunori Nakata
发明人： Katsuhiko Mikoshiba , Jun Aruga , Takeharu Nagai , Katsunori Nakata
IPC分类号： C07K14/46 , C12P21/06 , C07H21/04 , C12N15/00
CPC分类号： C07K14/463
摘要： The present invention relates to neurogenesis inducing genes. In particular, the present invention provides neurogenesis inducing genes coding for Zic proteins, vectors containing such genes, host cells containing such vectors, proteins produced by such host cells, antibodies raised to such proteins, and therapeutic agents or agents for gene therapy for nervous diseases.
摘要翻译：本发明涉及神经发生诱导基因。特别地，本发明提供了编码Zic蛋白质的神经发生诱导基因，含有这些基因的载体，含有该载体的宿主细胞，由该宿主细胞产生的蛋白质，产生于该蛋白质的抗体，以及用于神经疾病基因治疗的治疗剂或药剂。

5. 发明授权

US08853424B2 Protein cross-linking inhibitor 有权
标题翻译：蛋白质交联抑制剂
公开(公告)号：US08853424B2
公开(公告)日：2014-10-07
申请号：US13058647
申请日：2009-08-11
申请人： Katsuhiko Mikoshiba , Nobuyuki Nukina , Shoichiro Ozaki , Kouzo Hamada , Jun-Ichi Goto , Akinobu Suzuki , Etsuko Ebisui , Akiko Terauchi
发明人： Katsuhiko Mikoshiba , Nobuyuki Nukina , Shoichiro Ozaki , Kouzo Hamada , Jun-Ichi Goto , Akinobu Suzuki , Etsuko Ebisui , Akiko Terauchi
IPC分类号： C07D333/00 , A61K31/67 , C07F5/02 , A61K31/69
CPC分类号： C07F5/025 , A61K31/69
摘要： The present invention provides a protein cross-linking inhibitor containing a compound represented by any of the following formulas (1)-(13), or a pharmaceutically acceptable salt thereof: R3—[—X—B(ZR1)—Y—B(ZR2)—W—]n—R4, (1) R3—[—X—B(ZR1)—Y—]n—R4, (2) R3—[—B(ZR1)—Y—B(ZR2)—W—]n—R4, (3) R3—[—X—B(ZR1)—]n—R4, (4) R3—[—B(ZR2)—W—]n—R4, (5) R3—X—B(ZR1)-T[B(ZR2)—W—R4]2, (6) R3—B(OH)2, (7) R3—B(ZR1)—X—B(ZR2)—R4, (8) R3—B(R1)—O—B(R2)—R4, (9) R3—[—X—B(ZR1)—Y—B(ZR2)—]n—R4, (10) R3—[—X—B(ZR1)—Y—B(ZR2)—W-Q-]n—R4, (11) R3—[—P—X—B(ZR1)—Y—B(ZR2)—W—]n—R4, (12) [R3—X—B(ZR1)—Y]2B(ZR2), (13) wherein each symbol is as defined in the DESCRIPTION.
摘要翻译：本发明提供一种蛋白质交联抑制剂，其含有下述式（1） - （13）中任一项所示的化合物或其药学上可接受的盐：R3 - [ - X-B（ZR1）-Y-B ZR2）-W-] n-R4，（1）R3 - [ - X-B（ZR1）-Y-] n-R4，（2）R3 - [ - B（ZR1）-Y-B（ZR2） - W - ] n-R4，（3）R3 - [ - X-B（ZR1） - ] n-R4，（4）R3 - [ - B（ZR2）-W-] n-R4，（5） X-B（ZR1）-T [B（ZR2）-W-R4] 2，（6）R3-B（OH）2，（7）R3-B（ZR1）-X-B（ZR2）-R4，（8）R3-B（R1）-O-B（R2）-R4，（9）R3 - [ - X-B（ZR1）-Y-B（ZR2） - ] n-R4，（10） [-X-B（ZR1）-Y-B（ZR2）-WQ-] n-R4，（11）R3 - [ - P-X-B（ZR1）-Y-B（ZR2）-W-] n -R4，（12）[R3-X-B（ZR1）-Y] 2B（ZR2），（13）其中每个符号如说明书中所定义。

6. 发明授权

US08252547B2 In vitro control of protein synthesis in mammalian cells by IP3 receptor-binding protein 有权
标题翻译：通过IP3受体结合蛋白体外控制哺乳动物细胞中的蛋白质合成
公开(公告)号：US08252547B2
公开(公告)日：2012-08-28
申请号：US12293681
申请日：2007-03-20
申请人： Katsuhiko Mikoshiba , Hideaki Ando , Akihiro Mizutani
发明人： Katsuhiko Mikoshiba , Hideaki Ando , Akihiro Mizutani
IPC分类号： A61K38/00 , A61K31/7088 , C07K14/47 , C12Q1/02 , G01N33/15
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a composition comprising an IP3 receptor-binding protein (IRBIT), a nucleic acid that controls the expression and translation of IRBIT, or an antibody against IRBIT for controlling at least one intracellular biological function selected from the group consisting of (1) protein synthesis, (2) phosphatidylinositol metabolism, and (3) intracellular pH.
摘要翻译：本发明提供了包含IP3受体结合蛋白（IRBIT），控制IRBIT的表达和翻译的核酸或针对IRBIT的抗体的组合物，用于控制至少一种细胞内生物学功能，所述细胞内生物学功能选自（1 ）蛋白质合成，（2）磷脂酰肌醇代谢，和（3）细胞内pH。

7. 发明授权

US07276582B2 Control of function of intracellular Ca ion 失效
标题翻译：细胞内Ca离子的功能控制
公开(公告)号：US07276582B2
公开(公告)日：2007-10-02
申请号：US11283193
申请日：2005-11-18
申请人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
发明人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
IPC分类号： A61K38/44 , A61K38/00
CPC分类号： A61K38/1709 , C07K14/4702
摘要： Analysis of substance capable of binding with inositol-1, 4,5-triphosphate (IP3) receptor (IP3R), preferably with a regulation domain of IP3R; analysis of the function of IP3R; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IP3R. In particular, control of the activity of intracellular Ca2+ release. More specifically, a regulator for the activity of inositol-1,4, 5-triphosphate (IP3) receptor (IP3R), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calsium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.
摘要翻译：分析能够与肌醇-1,4,5-三磷酸（IP 3 N 3）受体（IP 3 R R）结合的物质，优选具有IP 3 < 分析IP 3的功能; 以及建立与IP 3 R相关的各种故障和疾病的治疗或诊断方法。特别地，控制细胞内Ca 2+释放的活性。更具体地，由碳酸酐酶相关蛋白质（肌醇-1,5,5-三磷酸（IP 3 N 3 R））的肌醇-1,4,5-三磷酸（IP 3 N 3 R）活性调节剂鲤鱼）; 由碳酸酐酶相关蛋白（CARP）组成的用于细胞内钙离子释放的控制剂; 及其控制方法。

8. 发明授权

US07041440B2 IP3-binding polypeptides and methods of using them 有权
标题翻译： IP3结合多肽及其使用方法
公开(公告)号：US07041440B2
公开(公告)日：2006-05-09
申请号：US10227338
申请日：2002-08-23
申请人： Katsuhiko Mikoshiba , Teiichi Furuichi , Fumio Yoshikawa , Tsuyoshi Uchiyama
发明人： Katsuhiko Mikoshiba , Teiichi Furuichi , Fumio Yoshikawa , Tsuyoshi Uchiyama
IPC分类号： C12Q1/00 , A61K38/17 , C07K14/435
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention provides a high affinity polypeptide having a binding activity to inositol 1,4,5-trisphosphate, to a gene encoding the polypeptide, to a recombinant vector including the gene, to a transformant including the vector and to a method for producing the high affinity polypeptide having a binding activity to inositol 1,4,5-trisphosphate.
摘要翻译：本发明向包含该载体的转化体提供了对1,4,5-三磷酸肌醇与编码该多肽的基因与包含该基因的重组载体的结合活性的高亲和性多肽和一种生产具有与1,4,5-三磷酸肌醇结合活性的高亲和力多肽。

9. 发明授权

US06465211B1 Nucleic acids, vectors and transformed cells for making and using high affinity IP-3 binding polypeptides 有权
标题翻译：用于制备和使用高亲和力IP-3结合多肽的核酸，载体和转化细胞
公开(公告)号：US06465211B1
公开(公告)日：2002-10-15
申请号：US09385222
申请日：1999-08-26
申请人： Katsuhiko Mikoshiba , Teiichi Furuichi , Fumio Yoshikawa , Tsuyoshi Uchiyama
发明人： Katsuhiko Mikoshiba , Teiichi Furuichi , Fumio Yoshikawa , Tsuyoshi Uchiyama
IPC分类号： C07H2100
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention provides a high affinity polypeptide having a binding activity to inositol 1,4,5-trisphosphate, to a gene encoding the polypeptide, to a recombinant vector including the gene, to a transformant including the vector and to a method for producing the high affinity polypeptide having a binding activity to inositol 1,4,5-trisphosphate.
摘要翻译：本发明向包含该载体的转化体提供了对1,4,5-三磷酸肌醇与编码该多肽的基因与包含该基因的重组载体的结合活性的高亲和性多肽和一种生产具有与1,4,5-三磷酸肌醇结合活性的高亲和力多肽。

10. 发明申请

US20130296230A1 METHOD FOR TREATING MALARIA, METHOD FOR KILLING MALARIA PARASITE, AND USE OF THE METHODS 审中-公开
标题翻译：用于治疗疟疾的方法，杀死疟原虫的方法和方法的使用
公开(公告)号：US20130296230A1
公开(公告)日：2013-11-07
申请号：US13881653
申请日：2011-10-27
申请人： Katsuhiko Mikoshiba , Masahiro Enomoto , Shin-Ichiro Kawazu
发明人： Katsuhiko Mikoshiba , Masahiro Enomoto , Shin-Ichiro Kawazu
IPC分类号： A61K31/69 , A61K31/4045
CPC分类号： A61K31/69 , A61K31/4045 , A61K38/1709 , G01N33/56905 , G01N2500/10 , Y02A50/411
摘要： A method of the present invention for treating malaria includes the step of administering, to a human or an animal, a therapeutically effective amount of drug for suppressing calcium ion exit from an intracellular organelle of the malaria parasite to an outside of the intracellular organelle and/or calcium ion entry from an outside of a cell of the malaria parasite into the cell.
摘要翻译：本发明治疗疟疾的方法包括向人或动物施用治疗有效量的药物以抑制钙离子从疟原虫的细胞内细胞器离开细胞内细胞器外的步骤和/ 或钙离子从疟原虫细胞的外部进入细胞。

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