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1. 发明授权

US07378555B2 Method of synthesizing camptothecin-relating compounds 有权
标题翻译：合成喜树碱相关化合物的方法
公开(公告)号：US07378555B2
公开(公告)日：2008-05-27
申请号：US11517621
申请日：2006-09-08
申请人： Takanori Ogawa , Hiroyuki Nishiyama , Miyuki Uchida , Seigo Sawada
发明人： Takanori Ogawa , Hiroyuki Nishiyama , Miyuki Uchida , Seigo Sawada
IPC分类号： C07C209/36
CPC分类号： C07D213/64 , C07C205/22 , C07C205/37 , C07C205/44 , C07C205/45 , C07C225/22 , C07D491/04 , C07D491/14 , Y02P20/55
摘要： The present invention is to prepare efficiently 2′-amino-5′-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis, which is a starting material for irinotecan hydrochloride and various kinds of camptothecin derivatives, and to provide stably CPT and its derivatives.
摘要翻译：本发明是为了有效地制备对应于喜树碱（CPT）骨架的AB-环部分的2'-氨基-5'-羟基苯丙酮和对应于CDE-环部分的三环酮，以便通过全合成提供高效的CPT ，其为盐酸伊立替康和各种喜树碱衍生物的起始原料，并提供稳定的CPT及其衍生物。

2. 发明申请

US20070010674A1 Method of synthesizing camptothecin-relating compounds 有权
标题翻译：合成喜树碱相关化合物的方法
公开(公告)号：US20070010674A1
公开(公告)日：2007-01-11
申请号：US11517621
申请日：2006-09-08
申请人： Takanori Ogawa , Hiroyuki Nishiyama , Miyuki Uchida , Seigo Sawada
发明人： Takanori Ogawa , Hiroyuki Nishiyama , Miyuki Uchida , Seigo Sawada
IPC分类号： C07D471/14
CPC分类号： C07D213/64 , C07C205/22 , C07C205/37 , C07C205/44 , C07C205/45 , C07C225/22 , C07D491/04 , C07D491/14 , Y02P20/55
摘要： The present invention is to prepare efficiently 2′-amino-5′-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis, which is a starting material for irinotecan hydrochloride and various kinds of camptothecin derivatives, and to provide stably CPT and its derivatives.
摘要翻译：本发明是为了有效地制备对应于喜树碱（CPT）骨架的AB-环部分的2'-氨基-5'-羟基苯丙酮和对应于CDE-环部分的三环酮，以便通过全合成提供有效的CPT ，其为盐酸伊立替康和各种喜树碱衍生物的起始原料，并提供稳定的CPT及其衍生物。

3. 发明授权

US07126000B2 Method of synthesizing camptothecin-relating compounds 有权
标题翻译：合成喜树碱相关化合物的方法
公开(公告)号：US07126000B2
公开(公告)日：2006-10-24
申请号：US10467987
申请日：2002-02-21
申请人： Takanori Ogawa , Hiroyuki Nishiyama , Miyuki Uchida , Seigo Sawada
发明人： Takanori Ogawa , Hiroyuki Nishiyama , Miyuki Uchida , Seigo Sawada
IPC分类号： C07D491/052
CPC分类号： C07D213/64 , C07C205/22 , C07C205/37 , C07C205/44 , C07C205/45 , C07C225/22 , C07D491/04 , C07D491/14 , Y02P20/55
摘要： The present invention is to prepare efficiently 2′-amino-5′-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis, which is a starting material for irinotecan hydrochloride and various kinds of camptothecin derivatives, and to provide stably CPT and its derivatives.
摘要翻译：本发明是为了有效地制备对应于喜树碱（CPT）骨架的AB-环部分的2'-氨基-5'-羟基苯丙酮和对应于CDE-环部分的三环酮，以便通过全合成提供有效的CPT ，其为盐酸伊立替康和各种喜树碱衍生物的起始原料，并提供稳定的CPT及其衍生物。

4. 发明申请

US20090023927A1 Process for producing tricyclic ketone 失效
标题翻译：三环酮生产方法
公开(公告)号：US20090023927A1
公开(公告)日：2009-01-22
申请号：US11921776
申请日：2006-06-08
申请人： Hiroyuki Nishiyama , Seigo Sawada
发明人： Hiroyuki Nishiyama , Seigo Sawada
IPC分类号： C07D491/147 , C07D213/63 , C07D491/22
CPC分类号： C07D213/70 , C07C233/18 , C07D213/64 , C07D491/14 , C07D491/147 , C07F7/0814
摘要： In order to efficiently supply CPT, which is a starting compound of irinotecan hydrochloride and a variety of camptothecin derivatives, by a practical total synthesis, the invention provides a means of efficiently preparing a tricyclic ketone that corresponds to a CDE ring moiety of a camptothecin (CPT) skeleton.
摘要翻译：为了有效地提供作为盐酸伊立替康的起始化合物和各种喜树碱衍生物的CPT，通过实际的全合成，提供了有效制备对应于喜树碱的CDE环部分的三环酮的方法（ CPT）骨架。

5. 发明申请

US20120041204A1 PROCESS FOR PRODUCING TRICYCLIC KETONE 失效
标题翻译：生产三氯甲酮的方法
公开(公告)号：US20120041204A1
公开(公告)日：2012-02-16
申请号：US13278579
申请日：2011-10-21
申请人： Hiroyuki Nishiyama , Seigo Sawada
发明人： Hiroyuki Nishiyama , Seigo Sawada
IPC分类号： C07D491/22 , C07D491/147 , C07C233/18
CPC分类号： C07D213/70 , C07C233/18 , C07D213/64 , C07D491/14 , C07D491/147 , C07F7/0814
摘要： In order to efficiently supply CPT, which is a starting compound of irinotecan hydrochloride and a variety of camptothecin derivatives, by a practical total synthesis, the invention provides a means of efficiently preparing a tricyclic ketone that corresponds to a CDE ring moiety of a camptothecin (CPT) skeleton.
摘要翻译：为了有效地提供作为盐酸伊立替康的起始化合物和各种喜树碱衍生物的CPT，通过实际的全合成，提供了有效制备对应于喜树碱的CDE环部分的三环酮的方法（ CPT）骨架。

6. 发明授权

US08466287B2 Process for producing tricyclic ketone 失效
公开(公告)号：US08466287B2
公开(公告)日：2013-06-18
申请号：US13278579
申请日：2011-10-21
申请人： Hiroyuki Nishiyama , Seigo Sawada
发明人： Hiroyuki Nishiyama , Seigo Sawada
IPC分类号： C07D491/147 , C07D491/22 , C07C223/02
CPC分类号： C07D213/70 , C07C233/18 , C07D213/64 , C07D491/14 , C07D491/147 , C07F7/0814
摘要： In order to efficiently supply CPT, which is a starting compound of irinotecan hydrochloride and a variety of camptothecin derivatives, by a practical total synthesis, the invention provides a means of efficiently preparing a tricyclic ketone that corresponds to a CDE ring moiety of a camptothecin (CPT) skeleton.

7. 发明授权

US08067595B2 Process for producing tricyclic ketone 失效
标题翻译：三环酮生产方法
公开(公告)号：US08067595B2
公开(公告)日：2011-11-29
申请号：US11921776
申请日：2006-06-08
申请人： Hiroyuki Nishiyama , Seigo Sawada
发明人： Hiroyuki Nishiyama , Seigo Sawada
IPC分类号： C07F7/02 , C07D213/64
CPC分类号： C07D213/70 , C07C233/18 , C07D213/64 , C07D491/14 , C07D491/147 , C07F7/0814
摘要： In order to efficiently supply CPT, which is a starting compound of irinotecan hydrochloride and a variety of camptothecin derivatives, by a practical total synthesis, the invention provides a means of efficiently preparing a tricyclic ketone that corresponds to a CDE ring moiety of a camptothecin (CPT) skeleton.
摘要翻译：为了有效地提供作为盐酸伊立替康的起始化合物和各种喜树碱衍生物的CPT，通过实际的全合成，提供了有效制备对应于喜树碱的CDE环部分的三环酮的方法（ CPT）骨架。

8. 发明申请

US20090211906A1 AMMONIUM GAS SENSOR 有权
标题翻译：氨气传感器
公开(公告)号：US20090211906A1
公开(公告)日：2009-08-27
申请号：US12390567
申请日：2009-02-23
申请人： Satoshi SUGAYA , Shiro Kakimoto , Hiroyuki Nishiyama , Wataru Matsutani
发明人： Satoshi SUGAYA , Shiro Kakimoto , Hiroyuki Nishiyama , Wataru Matsutani
IPC分类号： G01N27/26
CPC分类号： G01N27/4077 , G01N27/4075 , G01N33/0054 , Y02A50/246
摘要： An ammonium gas sensor is provided. The ammonium gas sensor includes: a solid electrolyte layer having oxygen ion conductivity; a detection electrode formed on one surface of the solid electrolyte layer; a reference electrode that is a counter electrode of the detection electrode; a selective reaction layer covering the detection electrode; and a protection layer covering the selective reaction layer and made from a porous material; wherein the detection electrode includes a noble metal as a main component; the selective reaction layer includes oxide represented by AxMyOz as a main component, where A is one or more kind(s) of metal, M is vanadium, tungsten, or molybdenum and x, y, z are atomic ratios; and the protection layer includes the oxide that is in an amount smaller than a content of the oxide included in the selective reaction layer.
摘要翻译：提供了一种铵气体传感器。铵气体传感器包括：具有氧离子传导性的固体电解质层; 形成在所述固体电解质层的一个表面上的检测电极; 作为检测电极的对电极的参考电极; 覆盖检测电极的选择性反应层; 以及覆盖选择性反应层并由多孔材料制成的保护层; 其中所述检测电极包括贵金属作为主要成分; 选择性反应层包括由AxMyOz表示的氧化物作为主要成分，其中A是一种或多种金属，M是钒，钨或钼，x，y，z是原子比; 并且保护层包括的量小于选择性反应层中包含的氧化物的含量的氧化物。

9. 发明申请

US20060065486A1 Connection structure of oil passage 审中-公开
标题翻译：油路连接结构
公开(公告)号：US20060065486A1
公开(公告)日：2006-03-30
申请号：US11213346
申请日：2005-08-26
申请人： Kenji Matsubara , Hiromi Taguchi , Yasuhiko Kunii , Katsutoshi Amano , Hiroyuki Nishiyama
发明人： Kenji Matsubara , Hiromi Taguchi , Yasuhiko Kunii , Katsutoshi Amano , Hiroyuki Nishiyama
IPC分类号： F16H57/04
CPC分类号： F16H57/0421 , F16H57/0489 , F16H61/00
摘要： A large diameter part is formed in a case-side oil passage, an O-ring is fitted into the large diameter part, and an oil pump is installed to the transmission case by adjusting a discharge hole thereof and the case-side oil passage in alignment with each other. A notch is formed in radial direction from an inner peripheral surface of the large diameter part to an outer peripheral surface of a seat part. When the discharge hole and the case-side oil passage are communicated without the O-ring in the large diameter part, an oil passing through the discharge hole leaks from the notch. Thus in a state the O-ring is not assembled, an oil pressure is not increased by positively leaking the oil through the notch, whereby it can be easily detected that the O-ring is not assembled by mistake.
摘要翻译：大直径部分形成在壳体侧油路中，O形环装配到大直径部分中，并且通过调节其排出孔和壳体侧油通道将油泵安装到变速箱上相互对齐。从大径部的内周面到座部的外周面的径向形成有切口。当排出孔和壳体侧油路在大直径部分中没有O形环连通时，通过排出孔的油从凹口泄漏。因此，在O形圈未组装的状态下，通过使油通过切口正向泄漏，不会增加油压，因此可以容易地检测到O型圈未被错误组装。

10. 发明授权

US09211399B2 Disposable electrode and automatic information recognition apparatus 有权
标题翻译：一次性电极和自动信息识别装置
公开(公告)号：US09211399B2
公开(公告)日：2015-12-15
申请号：US12558464
申请日：2009-09-11
申请人： Ikuhiro Tsumura , Hiroyuki Nishiyama , Yuji Igawa , Yohiyuki Hamauzu
发明人： Ikuhiro Tsumura , Hiroyuki Nishiyama , Yuji Igawa , Yohiyuki Hamauzu
IPC分类号： A61N1/08 , A61N1/04
CPC分类号： A61N1/046 , A61N1/0492
摘要： A disposable electrode includes: an electrode pad; and a connector, connecting the electrode pad to a defibrillator, and including an information holder that can be provided with a transmissive opening or a light reflective member, the information holder holding information about at least an expiration date, depending on presence or absence of the transmissive opening or the light reflective member, the information holder allowing the information to be notified from the defibrillator when the connector is connected to the defibrillator.
摘要翻译：一次性电极包括：电极垫; 以及将电极焊盘连接到除颤器的连接器，并且包括可以设置有透射开口或光反射部件的信息保持器，所述信息保持器根据有无所述信息保持器是否存在关于至少过期日期的信息透光开口或光反射构件，当连接器连接到除颤器时，信息保持器允许从除颤器通知信息。

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