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1. 发明授权

US07357864B2 Microfluidic device 失效
标题翻译：微流控装置
公开(公告)号：US07357864B2
公开(公告)日：2008-04-15
申请号：US10548169
申请日：2004-03-10
申请人： Tetsuo Takada , Takanori Anazawa , Atsushi Teramae
发明人： Tetsuo Takada , Takanori Anazawa , Atsushi Teramae
IPC分类号： B01D15/08
CPC分类号： G01N30/6052 , G01N30/6095 , G01N2030/525 , G01N2030/562 , Y10T137/2224
摘要： The object of the present invention is to provide a production process of a microfluidic device in which a porous resin layer, which is capable of optimally fixing a large amount of enzyme, antigen or other protein or catalyst on the inner surface of a minute channel of a microfluidic device without obstructing said channel, is formed at a uniform thickness on the surface of said channel.In the present invention, by preliminarily forming a porous resin layer having a large number of pores in its surface on a substrate, and forming an indentation having a porous resin layer on its bottom surface by using an activating energy beam-curable composition on said porous resin layer, followed by forming a channel by adhering a member serving as a cover to said indentation, a porous resin layer can easily be formed at a uniform thickness on the surface of said channel.
摘要翻译：本发明的目的是提供一种微流体装置的制造方法，其中，能够将大量酶，抗原或其它蛋白质或催化剂最佳地固定在微通道的内表面上的多孔树脂层在所述通道的表面上以均匀的厚度形成不阻碍所述通道的微流体装置。在本发明中，通过在基板的表面上预先形成孔数多孔的多孔树脂层，在其底面上形成具有多孔树脂层的凹陷，在所述多孔性树脂层上使用活化能量束固化性组合物树脂层，然后通过将用作盖的部件粘附到所述压痕上形成通道，可以容易地在所述通道的表面上以均匀的厚度形成多孔树脂层。

2. 发明授权

US07238325B2 Very small chemical device and flow rate adjusting method therefor 失效
标题翻译：非常小的化学装置和流量调节方法
公开(公告)号：US07238325B2
公开(公告)日：2007-07-03
申请号：US10380469
申请日：2001-03-01
申请人： Takanori Anazawa , Atsushi Teramae
发明人： Takanori Anazawa , Atsushi Teramae
IPC分类号： B01L11/00
CPC分类号： B81B1/00 , B01J19/0093 , B01J2219/00783 , B01J2219/0086 , B01J2219/00891 , B01L3/502738 , B01L2300/0887 , B01L2400/0655 , B01L2400/082 , F16K99/0001 , F16K99/0017 , F16K99/0023 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G01N30/6095 , G01N2030/324 , G01N2030/6008 , Y10T137/1624 , Y10T137/1842 , Y10T137/206 , Y10T436/2575
摘要： There is provided a micro chemical device with a valve function for which the pressure resistance is high and the channel cross-sectional area does not depend on the fluid pressure, and which furthermore enables the suppression of the adsorption of biological matter and yet is easy to produce, as well as a flow regulation method using such a device. This has a valve function, in which a member (B) is bonded to a member (A) with a groove in the surface thereof, via the surface of the member (A) in which the groove is formed, a capillary type channel of width from 1 to 1000 μm and height from 1 to 1000 μm is formed by the groove of the member (A) and the member (B) at the bonding surface between the member (A) and the member (B), a cavity section is formed partway along the channel and the width of this cavity section is from 0.5 to 100 fold the width of the capillary type channel and the ratio of maximum height/maximum width for the cavity section is no more than 1, and either one of the member (A) and the member (B) is formed from a soft material with a tensile modulus of elasticity within a range from 0.1 MPa to 700 MPa, at least within the portion which corresponds with the position of the cavity section, wherein by selectively compressing the cavity section from the external surface of the member (A) and/or the member (B), the volume of the cavity section can be reduced in a reversible manner.
摘要翻译：提供了具有阀功能的微型化学装置，其耐压性高，通道横截面积不依赖于流体压力，并且还能够抑制生物物质的吸附，而且容易产生，以及使用这种装置的流量调节方法。这具有阀功能，其中构件（B）经由其形成有凹槽的构件（A）的表面结合到具有其表面的凹槽的构件（A），毛细管型通道在构件（A）和构件（B）之间的接合表面处由构件（A）和构件（B）的槽形成1至1000μm的宽度和1至1000μm的高度，空腔部沿着通道形成中途，并且该空腔部分的宽度为毛细管型通道的宽度的0.5至100倍，空腔部分的最大高度/最大宽度比不大于1，并且构件（A）和构件（B）由柔软材料形成，拉伸弹性模量在0.1MPa至700MPa的范围内，至少在与空腔部分的位置对应的部分内，其中通过选择性地从构件（A）和/或构件（B）的外表面压缩空腔部分，可以以可逆的方式减小空腔部分的体积。

3. 发明授权

US07220334B2 Method of manufacturing microdevice having laminated structure 失效
标题翻译：具有层叠结构的微型装置的制造方法
公开(公告)号：US07220334B2
公开(公告)日：2007-05-22
申请号：US10297625
申请日：2001-06-20
申请人： Takanori Anazawa , Atsushi Teramae
发明人： Takanori Anazawa , Atsushi Teramae
IPC分类号： B44C1/17 , B31B1/60 , B29C65/00 , B32B37/00 , B01L3/02
CPC分类号： B32B3/20 , B01J19/0093 , B01J2219/00783 , B01J2219/00824 , B01J2219/00826 , B01J2219/00837 , B01J2219/00891 , B01L3/502707 , B01L2200/12 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0622 , B01L2400/0638 , B29C64/135 , B29K2995/0073 , B29L2031/756 , Y10T156/10
摘要： The present invention provides a method of manufacturing a microdevice having a fine capillary cavity formed as a cut portion of a very thin layer which is likely to be broken, particularly a method of manufacturing a microdevice having complicated passages formed in three dimensions with high productivity. Also, the present invention provides a multi-functional microdevice which has a fine capillary passage formed by laminating plural resin layers, fine capillary cavities piercing through the respective layers to communicate and intersect three-dimensionally with each other, a space which should serve as a reaction chamber, a diaphragm valve, and a stopper structure. The method includes the steps of forming a semi-cured coating film having a cut portion made of an active energy ray curable composition on a coating substrate, laminating the semi-cured coating film with another member and removing the substrate, irradiating the semi-cured coating film again with an active energy ray before and/or after the removal of the substrate, thereby curing the coating film and bonding with said another member. The microdevice has a multi-layered structure wherein a member (J′) {selected from a member having a cut portion piercing through the member, a member having a recessed cut portion on the surface, and a member having a cut portion piercing through the member and a recessed cut portion on the surface}, a member (K′) and one or more active energy ray curable resin layers (X′) having a cut portion at a portion of the layer, the cut portion having a minimum width within a range from 1 to 1000 μm, are laminated and two or more cut portions in the members are connected to form a cavity.
摘要翻译：本发明提供了一种制造具有微细毛细管腔的微型装置的方法，所述微细管腔形成为可能被破裂的非常薄的层的切割部分，特别是制造具有生产率高的三维复杂通道的微型装置的方法。此外，本发明提供一种多功能微型装置，其具有通过层叠多个树脂层而形成的细微毛细通道，穿过各层的细毛细管腔彼此三维地连通和相交，应当作为反应室，隔膜阀和止动结构。该方法包括以下步骤：在涂覆基板上形成具有由活性能量射线固化性组合物制成的切割部分的半固化涂膜，将半固化涂膜与另一部件层压，并除去基板，照射半固化在去除基板之前和/或之后，用活性能量射线再次涂覆膜，从而固化涂膜并与所述另一个部件结合。微型装置具有多层结构，其中，构件（J'）{选自具有穿过构件的切割部分的构件，具有在表面上具有凹入切割部分的构件，以及具有穿过该构件的切割部分的构件构件和表面上的凹入部分}，构件（K'）和一层或多层在层的一部分具有切割部分的活性能量射线固化树脂层（X'），切割部分具有最小宽度 1〜1000μm的范围被层压，并且构件中的两个或更多个切口部分连接以形成空腔。

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