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1. 发明申请

US20120070409A1 TETRACYCLIC FUSED HETEROCYCLIC COMPOUND AND USE THEREOF AS HCV POLYMERASE INHIBITOR 审中-公开
标题翻译：四氢呋喃杂交化合物及其作为HCV聚合酶抑制剂的用途
公开(公告)号：US20120070409A1
公开(公告)日：2012-03-22
申请号：US13020621
申请日：2011-02-03
申请人： Takahiro Oka , Kazutaka Ikegashira , Shintaro Hirashima , Hiroshi Yamanaka , Satoru Noji , Yasushi Niwa , Yoko Matsumoto , Toshihiro Sato , Izuru Ando , Yukihiro Nomura
发明人： Takahiro Oka , Kazutaka Ikegashira , Shintaro Hirashima , Hiroshi Yamanaka , Satoru Noji , Yasushi Niwa , Yoko Matsumoto , Toshihiro Sato , Izuru Ando , Yukihiro Nomura
IPC分类号： A61K31/553 , C07D487/04 , C07D498/04 , C07D513/04 , A61K31/5365 , A61K31/55 , A61K31/407 , A61K31/542 , A61P1/16 , A61K38/21 , A61P31/14 , A61K31/554 , C07D498/14 , C07D471/14 , C07D471/04 , A61K31/4745 , C07D519/00 , A61K31/5517
CPC分类号： C07D513/04 , C07D487/04 , C07D487/14 , C07D498/04 , C07D498/14
摘要： The present invention relates to a tetracyclic fused heterocyclic compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.
摘要翻译：本发明涉及由下式[I]表示的四环稠合杂环化合物，其中各符号如说明书中所定义，或其药学上可接受的盐，丙型肝炎病毒（HCV）聚合酶抑制剂和治疗剂含有该化合物的丙型肝炎。本发明化合物基于HCV聚合酶抑制活性显示抗HCV活性，可用作预防或治疗丙型肝炎的药剂。

2. 发明授权

US07977331B1 Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor 有权
标题翻译：四环稠合杂环化合物及其作为HCV聚合酶抑制剂的用途
公开(公告)号：US07977331B1
公开(公告)日：2011-07-12
申请号：US11962622
申请日：2007-12-21
申请人： Takahiro Oka , Kazutaka Ikegashira , Shintaro Hirashima , Hiroshi Yamanaka , Satoru Noji , Yasushi Niwa , Yoko Matsumoto , Toshihiro Sato , Izuru Ando , Yukihiro Nomura
发明人： Takahiro Oka , Kazutaka Ikegashira , Shintaro Hirashima , Hiroshi Yamanaka , Satoru Noji , Yasushi Niwa , Yoko Matsumoto , Toshihiro Sato , Izuru Ando , Yukihiro Nomura
IPC分类号： A61K31/53 , A61K31/495 , A61K31/519 , A61K31/44 , A61K31/415 , A61K31/40 , C07D253/00 , C07D487/00 , C07D239/02 , C07D471/02 , C07D209/80
CPC分类号： C07D513/04 , C07D487/04 , C07D487/14 , C07D498/04 , C07D498/14
摘要： The present invention relates to a tetracyclic fused heterocyclic compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.
摘要翻译：本发明涉及由下式[I]表示的四环稠合杂环化合物，其中各符号如说明书中所定义，或其药学上可接受的盐，丙型肝炎病毒（HCV）聚合酶抑制剂和治疗剂含有该化合物的丙型肝炎。本发明化合物基于HCV聚合酶抑制活性显示抗HCV活性，可用作预防或治疗丙型肝炎的药剂。

3. 发明申请

US20070049593A1 Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor 审中-公开
标题翻译：四环稠合杂环化合物及其作为HCV聚合酶抑制剂的用途
公开(公告)号：US20070049593A1
公开(公告)日：2007-03-01
申请号：US11064319
申请日：2005-02-23
申请人： Takahiro Oka , Kazutaka Ikegashira , Shintaro Hirashima , Hiroshi Yamanaka , Satoru Noji , Yasushi Niwa , Yoko Matsumoto , Toshihiro Sato , Izuru Ando , Yukihiro Nomura
发明人： Takahiro Oka , Kazutaka Ikegashira , Shintaro Hirashima , Hiroshi Yamanaka , Satoru Noji , Yasushi Niwa , Yoko Matsumoto , Toshihiro Sato , Izuru Ando , Yukihiro Nomura
IPC分类号： C07D471/02 , A61K31/53 , A61K31/519 , A61K31/498 , A61K31/503 , A61K31/4745
CPC分类号： C07D513/04 , C07D487/04 , C07D487/14 , C07D498/04 , C07D498/14
摘要： The present invention relates to a tetracyclic fused heterocyclic compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.
摘要翻译：本发明涉及由下式[I]表示的四环稠合杂环化合物，其中各符号如说明书中所定义，或其药学上可接受的盐，丙型肝炎病毒（HCV）聚合酶抑制剂和治疗剂含有该化合物的丙型肝炎。本发明化合物基于HCV聚合酶抑制活性显示抗HCV活性，可用作预防或治疗丙型肝炎的药剂。

4. 发明申请

US20120322837A1 AMIDE COMPOUND AND MEDICINAL USE THEREOF 有权
标题翻译： AMIDE化合物和药物使用
公开(公告)号：US20120322837A1
公开(公告)日：2012-12-20
申请号：US13457844
申请日：2012-04-27
申请人： Takaki Maeba , Katsuya Maeda , Masayuki Kotoku , Kazuyuki Hirata , Noriyoshi Seki , Hiroshi Yamanaka , Takayuki Sakai , Shintaro Hirashima , Shingo Obika , Makoto Shiozaki , Masahiro Yokota
发明人： Takaki Maeba , Katsuya Maeda , Masayuki Kotoku , Kazuyuki Hirata , Noriyoshi Seki , Hiroshi Yamanaka , Takayuki Sakai , Shintaro Hirashima , Shingo Obika , Makoto Shiozaki , Masahiro Yokota
IPC分类号： C07D261/08 , C07D249/04 , A61K31/4192 , A61P37/06 , A61P3/10 , A61P3/00 , A61P19/02 , A61P17/06 , A61P1/00 , A61K31/42 , A61P37/08
CPC分类号： A61K31/4192 , A61K31/42 , C07D249/04 , C07D261/08 , C07D417/06
摘要： A compound of formula [I-W]: wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.
摘要翻译：式[I-W]化合物或其药学上可接受的盐，其中每个符号如说明书中所定义。

5. 发明授权

US08604069B2 Amide compound and medicinal use thereof 有权
标题翻译：酰胺化合物及其药用
公开(公告)号：US08604069B2
公开(公告)日：2013-12-10
申请号：US13457844
申请日：2012-04-27
申请人： Takaki Maeba , Katsuya Maeda , Masayuki Kotoku , Kazayuki Hirata , Noriyoshi Seki , Hiroshi Yamanaka , Takayuki Sakai , Shintaro Hirashima , Shingo Obika , Makoto Shiozaki , Masahiro Yokota
发明人： Takaki Maeba , Katsuya Maeda , Masayuki Kotoku , Kazayuki Hirata , Noriyoshi Seki , Hiroshi Yamanaka , Takayuki Sakai , Shintaro Hirashima , Shingo Obika , Makoto Shiozaki , Masahiro Yokota
IPC分类号： A61K31/42 , C07D261/08
CPC分类号： A61K31/4192 , A61K31/42 , C07D249/04 , C07D261/08 , C07D417/06
摘要： A compound of formula [I-W]: wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.
摘要翻译：式[I-W]化合物或其药学上可接受的盐，其中每个符号如说明书中所定义。

6. 发明授权

US08609647B2 Nitrogen-containing spirocyclic compounds and pharmaceutical uses thereof 有权
标题翻译：含氮螺环化合物及其药物用途
公开(公告)号：US08609647B2
公开(公告)日：2013-12-17
申请号：US12847025
申请日：2010-07-30
申请人： Satoru Noji , Makoto Shiozaki , Tomoya Miura , Yoshinori Hara , Hiroshi Yamanaka , Katsuya Maeda , Akimi Hori , Masafumi Inoue , Yasunori Hase
发明人： Satoru Noji , Makoto Shiozaki , Tomoya Miura , Yoshinori Hara , Hiroshi Yamanaka , Katsuya Maeda , Akimi Hori , Masafumi Inoue , Yasunori Hase
IPC分类号： C07D487/04 , A61K31/519 , A61P19/02 , A61P37/00 , A61P17/06 , A61P27/04 , A61P29/00
CPC分类号： C07D487/10 , A61K31/437 , A61K31/438 , A61K31/519 , A61K31/55 , C07D471/10 , C07D519/00
摘要： A compound of the following general formula [I]: wherein each symbol has the same meaning as defined herein, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a pharmaceutical use of the same in treating organ transplant rejection, graft versus host reaction after transplantation, autoimmune disease, allergic disease and chronic myeloproliferative disease.
摘要翻译：下列通式[I]的化合物：其中每个符号具有如本文所定义的相同含义，或其药学上可接受的盐或其溶剂合物，以及其用于治疗器官移植排斥，移植物抗宿主移植后反应，自身免疫性疾病，过敏性疾病和慢性骨髓增生性疾病。

7. 发明申请

US20110136778A1 NITROGEN-CONTAINING SPIROCYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF 有权
标题翻译：含氮的螺旋化合物及其药物用途
公开(公告)号：US20110136778A1
公开(公告)日：2011-06-09
申请号：US12847025
申请日：2010-07-30
申请人： Satoru Noji , Makoto Shiozaki , Tomoya Miura , Yoshinori Hara , Hiroshi Yamanaka , Katsuya Maeda , Akimi Hori , Masafumi Inoue , Yasunori Hase
发明人： Satoru Noji , Makoto Shiozaki , Tomoya Miura , Yoshinori Hara , Hiroshi Yamanaka , Katsuya Maeda , Akimi Hori , Masafumi Inoue , Yasunori Hase
IPC分类号： A61K31/397 , C07D471/10 , A61K31/519 , C07D487/10 , A61K31/55 , A61P37/06 , A61P37/08 , A61P19/02 , A61P17/06
CPC分类号： C07D487/10 , A61K31/437 , A61K31/438 , A61K31/519 , A61K31/55 , C07D471/10 , C07D519/00
摘要： A compound of the following general formula [I]: wherein each symbol has the same meaning as defined herein, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a pharmaceutical use of the same in treating organ transplant rejection, graft versus host reaction after transplantation, autoimmune disease, allergic disease and chronic myeloproliferative disease.
摘要翻译：下列通式[I]的化合物：其中每个符号具有如本文所定义的相同含义，或其药学上可接受的盐或其溶剂合物，以及其用于治疗器官移植排斥，移植物抗宿主移植后反应，自身免疫性疾病，过敏性疾病和慢性骨髓增生性疾病。

8. 发明授权

US09478682B2 IR sensor package including a cover member and a sensor chip recessed into the package body 有权
标题翻译：红外传感器封装包括一个盖构件和一个嵌入封装体内的传感器芯片
公开(公告)号：US09478682B2
公开(公告)日：2016-10-25
申请号：US13806111
申请日：2011-06-23
申请人： Masao Kirihara , Hiroshi Yamanaka , Yoshiharu Sanagawa , Takanori Aketa , Yushi Nakamura , Mitsuhiko Ueda
发明人： Masao Kirihara , Hiroshi Yamanaka , Yoshiharu Sanagawa , Takanori Aketa , Yushi Nakamura , Mitsuhiko Ueda
IPC分类号： H01L31/0232 , H01L31/024 , G01J5/04 , G01J5/06 , G01J5/08 , G01J5/12
CPC分类号： H01L31/024 , G01J5/04 , G01J5/045 , G01J5/06 , G01J5/08 , G01J5/0806 , G01J5/0831 , G01J5/12 , H01L2924/0002 , H01L2924/00
摘要： The infrared sensor includes: an infrared sensor chip in which a plurality of pixel portions each including a temperature-sensitive portion formed of a thermopile is disposed in an array on one surface side of a semiconductor substrate; and an IC chip that processes an output signal of the infrared sensor chip. A package includes a package main body on which the infrared sensor chip and the IC chip are mounted to be arranged side-by-side, and a package cover that has a lens transmitting infrared rays and is hermetically bonded to the package main body. The package is provided therein with a cover member that includes a window hole through which infrared rays pass into the infrared sensor chip and equalizes amounts of temperature change of hot junctions and cold junctions among the pixel portions, the temperature change resulting from heating of the IC chip.
摘要翻译：红外线传感器包括：红外线传感器芯片，其中在半导体衬底的一个表面侧上排列有包括由热电堆形成的温度敏感部分的多个像素部分; 以及处理红外线传感器芯片的输出信号的IC芯片。一种包装体，包括并排设置红外线传感器芯片和IC芯片的封装主体，以及具有透射红外线的透镜并与封装主体气密结合的封装盖。该封装件设置有盖构件，该盖构件包括窗孔，红外线通过该孔穿过红外线传感器芯片，并使像素部之间的热接点和冷接点的温度变化量相等，由IC加热引起的温度变化芯片。

9. 发明授权

US06340923B1 High frequency relay 失效
标题翻译：高频继电器
公开(公告)号：US06340923B1
公开(公告)日：2002-01-22
申请号：US09739774
申请日：2000-12-20
申请人： Hiroshi Yamanaka , Toshiyuki Suzuki , Kazunobu Nakata
发明人： Hiroshi Yamanaka , Toshiyuki Suzuki , Kazunobu Nakata
IPC分类号： H01H5300
CPC分类号： H01H50/10 , H01H50/14 , H01H50/54 , H01H51/2272
摘要： A high frequency relay comprises a contact base block having pairs of fixed contacts, contact members with movable contacts, and an electromagnet for moving the contact members to open and close the fixed contacts by the movable contacts. The contact base block comprises an injection-molded base having projections on its front surface, first metal films formed as the fixed contacts on top surfaces of the projections, second metal films formed as connection terminals for outside devices on a rear surface of the base, each of which corresponds to one of the first metal films, through holes each having a conductive material on its inner surface to make an electrical connection between one of the first metal films and the corresponding second metal film in the shortest distance, and a third metal film formed on the base to provide electrical isolation from the first and second metal films, which works as electromagnetic shield as well as a ground.
摘要翻译：高频继电器包括具有成对的固定触点的触点基座，具有可动触点的触点构件，以及用于使触点构件移动以通过可动触点打开和闭合固定触点的电磁体。接触基块包括在其表面上具有突起的注射成型基底，在突起的顶表面上形成为固定触点的第一金属膜，形成在基底的后表面上的用于外部装置的连接端子的第二金属膜，每一个对应于第一金属膜中的一个，在其内表面上各自具有导电材料的通孔，以在最短距离内形成第一金属膜之一和相应的第二金属膜之间的电连接;以及第三金属形成在基底上的膜，以提供与第一和第二金属膜的电隔离，其作为电磁屏蔽以及地面。

10. 发明授权

US4650310A Toner density detecting device 失效
标题翻译：调色剂浓度检测装置
公开(公告)号：US4650310A
公开(公告)日：1987-03-17
申请号：US726999
申请日：1985-04-25
申请人： Masatoshi Hayashida , Takayuki Suga , Hiroshi Yamanaka
发明人： Masatoshi Hayashida , Takayuki Suga , Hiroshi Yamanaka
IPC分类号： G03G15/08 , G03G15/09
CPC分类号： G03G15/0853
摘要： A toner density detecting device is provided with a coil buried in a housing and a cover member provided on one end of the coil to prevent the developing agent from touching the coil. The cover member has a front end portion provided near the surface of the housing and extending along the developing agent flowing direction and an apex portion at the back of the front end portion with respect to the direction. The apex portion projects deeper into the developing agent than the front end portion. An edge connecting the front end portion and the apex portion extends in the direction to cross the central axis of the coil. A pair of faces extending in the direction on either side of the edge are gradually declined from the edge toward the surface of the housing.
摘要翻译：调色剂浓度检测装置设置有埋在壳体中的线圈和设置在线圈的一端上的盖构件，以防止显影剂接触线圈。盖构件具有设置在壳体的表面附近并沿着显影剂流动方向延伸的前端部和相对于该方向在前端部的后部的顶部。顶端部分比前端部分更深地突出到显影剂中。连接前端部分和顶端部分的边缘在与线圈的中心轴线交叉的方向上延伸。沿着边缘两侧的方向延伸的一对面从边缘朝向壳体的表面逐渐下降。

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