专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06949553B2 Aliphatic compounds, their synthesis method, and utilization of the same 失效
标题翻译：脂肪族化合物，其合成方法和利用相同
公开(公告)号：US06949553B2
公开(公告)日：2005-09-27
申请号：US10481062
申请日：2002-06-18
申请人： Tadakazu Tamai , Kazuyoshi Yoshikai , Masazumi Nishikawa , Kunio Ogasawara , Itsuki Murota
发明人： Tadakazu Tamai , Kazuyoshi Yoshikai , Masazumi Nishikawa , Kunio Ogasawara , Itsuki Murota
IPC分类号： A61K31/40 , A61K31/495 , A61P9/00 , A61P9/10 , A61P29/00 , C07D207/09 , C07D295/32 , C07D207/14
CPC分类号： C07D295/32 , A61K31/40 , A61K31/495 , C07D207/09
摘要： The present invention relates to aliphatic compounds of the formula I, or stereoisomers thereof, or their pharmaceutically acceptable salts: wherein A represents an optionally substituted CH3CnH(2n-2m)— (wherein n denotes an integer of 4 to 22, and m represents an unsaturation number which is an integer of 0 to 7), l represents an integer of 0 to 10, s represents 0 or 1, provided that when s is 0, p+q=4 or 5, but when s is 1, p+q=3 or 4, and in each case, either p or q is an integer of 1 or more, R represents an alkyl group having 1 to 10 carbon atoms which may be straight-chain or branched-chain, and RA represents hydrogen or an alkyl group having 1 to 10 carbon atoms which may be straight-chain or branched-chain, and their use in suppression of platelet aggregation, in suppression of inflammation, and in prevention and treatment of circulatory diseases.
摘要翻译：本发明涉及式I的脂肪族化合物或其立体异构体或其药学上可接受的盐：其中A表示任选取代的CH 3 N < （2n-2m） - （其中n表示4〜22的整数，m表示0〜7的整数的不饱和数），l表示0〜10的整数，s表示0或 1，条件是当s为0时，p + q = 4或5，但当s为1时，p + q = 3或4，并且在每种情况下，p或q为1或更大的整数，R表示可以是直链或支链的具有1-10个碳原子的烷基，R A表示氢或具有1-10个碳原子的烷基，其可以是直链或支链的并且它们用于抑制血小板聚集，抑制炎症以及预防和治疗循环系统疾病。

2. 发明授权

US07906557B2 Oral preventive/therapeutic agent for skin damage containing diacylglyceryl ether 有权
标题翻译：含有二酰基甘油醚的皮肤损伤的口服预防/治疗剂
公开(公告)号：US07906557B2
公开(公告)日：2011-03-15
申请号：US10517323
申请日：2003-06-17
申请人： Masazumi Nishikawa , Itsuki Murota , Tadakazu Tamai , Kazuyoshi Yoshikai
发明人： Masazumi Nishikawa , Itsuki Murota , Tadakazu Tamai , Kazuyoshi Yoshikai
IPC分类号： A61K31/08
CPC分类号： A61K31/232 , A61K31/23 , A61K31/231
摘要： The present invention provides an oral preventive or therapeutic agent for skin damage, containing diacylglyceryl ether as an active ingredient represented by the formula (I): wherein R1 denotes C12-24 aliphatic hydrocarbon group having a degree of unsaturation of between 0 and 2; R2 denotes C12-24 acyl group having a degree of unsaturation of between 0 and 6; and R3 denotes C12-24 acyl group having a degree of unsaturation of between 0 and 6.
摘要翻译：本发明提供一种皮肤损伤的口服预防或治疗剂，其含有二酰基甘油醚作为由式（I）表示的活性成分：其中R1表示不饱和度为0至2的C 12-24脂族烃基; R2表示不饱和度在0和6之间的C12-24酰基; R3表示不饱和度为0〜6的C 12-24酰基。

3. 发明申请

US20050220844A1 Oral preventive/therapeutic agent for skin damage containing diacylglyceryl ether 有权
标题翻译：含有二酰基甘油醚的皮肤损伤的口服预防/治疗剂
公开(公告)号：US20050220844A1
公开(公告)日：2005-10-06
申请号：US10517323
申请日：2003-06-17
申请人： Masazumi Nishikawa , Itsuki Murota , Tadakazu Tamai , Kazuyoshi Yoshikai
发明人： Masazumi Nishikawa , Itsuki Murota , Tadakazu Tamai , Kazuyoshi Yoshikai
IPC分类号： A61K31/23 , A61K31/231 , A61K31/232 , A61P17/00 , A61P17/16 , A61P35/00 , A61K7/135 , A61K47/00
CPC分类号： A61K31/232 , A61K31/23 , A61K31/231
摘要： The present invention provides an oral preventive or therapeutic agent for skin damage, containing diacylglyceryl ether as an active ingredient represented by the formula (I): wherein R1 denotes C12-24 aliphatic hydrocarbon group having a degree of unsaturation of between 0 and 2; R2 denotes C12-24 acyl group having a degree of unsaturation of between 0 and 6; and R3 denotes C12-24 acyl group having a degree of unsaturation of between 0 and 6.
摘要翻译：本发明提供了含有二酰基甘油醚作为由式（I）表示的活性成分的皮肤损伤口服预防或治疗剂：其中R 1表示C 12-24 >不饱和度为0〜2的脂族烃基; R 2表示不饱和度为0-6之间的C 12-24酰基; R 3表示不饱和度为0-6之间的C 12-24酰基。

4. 发明申请

US20050222010A1 Composition for treating or preventing hyperuricemia 审中-公开
标题翻译：用于治疗或预防高尿酸血症的组合物
公开(公告)号：US20050222010A1
公开(公告)日：2005-10-06
申请号：US10514732
申请日：2003-05-16
申请人： Itsuki Murota , Masazumi Nishikawa , Tadakazu Tamai , Kazuyoshi Yoshiaki , Minoru Kihasa
发明人： Itsuki Murota , Masazumi Nishikawa , Tadakazu Tamai , Kazuyoshi Yoshiaki , Minoru Kihasa
IPC分类号： A23L1/30 , A23L1/305 , A23L1/308 , A23L1/31 , A23L1/39 , A61K35/32 , A61K35/56 , A61K35/58 , A61K35/60 , A61K38/00 , A61K38/18 , A61P3/00 , A61P7/00 , A61P19/06 , A61K38/39 , C07K14/78
CPC分类号： A61K36/28 , A23L13/06 , A23L23/00 , A23L33/17 , A23L33/28 , A23V2002/00 , A61K31/737 , A61K35/60 , A61K36/899 , A61K38/014 , A23V2250/21 , A23V2250/7044 , A23V2250/708 , A23V2250/612 , A23V2250/5108 , A23V2250/5422 , A61K2300/00
摘要： A composition for treating or preventing hyperuricemia which contains a chondroitin sulfate protein complex as an effective ingredient. Because of having an effect of lowering serum uric acid level, this composition makes it possible to provide a novel method of the treatment, the prevention and the relief of gout.
摘要翻译：一种治疗或预防高尿酸血症的组合物，其含有硫酸软骨素蛋白复合物作为有效成分。由于具有降低血清尿酸水平的效果，所以能够提供治疗，预防和缓解痛风的新方法。

5. 发明申请

US20060142391A1 PPARGAMMA-ACTIVATING PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译： PPARGAMMA活化药物组合物
公开(公告)号：US20060142391A1
公开(公告)日：2006-06-29
申请号：US11277123
申请日：2006-03-21
申请人： Tadakazu Tamai , Kazuyoshi Yoshikai , Masazumi Nishikawa
发明人： Tadakazu Tamai , Kazuyoshi Yoshikai , Masazumi Nishikawa
IPC分类号： A61K31/202
CPC分类号： A61K31/202
摘要： The present invention relates to PPARγ-activating pharmaceutical compositions comprising a hydroxylated derivative of a C20-22 polyunsaturated fatty acid or a pharmaceutically acceptable salt thereof, preferably PPARγ-activating pharmaceutical compositions containing a hydroxylated derivative of docosahexaenoic acid (DHA) or a hydroxylated derivative of eicosapentaenoic acid (EPA) or a pharmaceutically acceptable salt thereof, as well as uses of the PPARγ-activating pharmaceutical compositions for treating circulatory diseases, arteriosclerosis, lipid metabolism disorder, diabetes and inflammatory diseases.
摘要翻译：本发明涉及包含C20-22多不饱和脂肪酸的羟基化衍生物或其药学上可接受的盐的PPARγ活化药物组合物，优选含有二十二碳六烯酸（DHA）羟基化衍生物的PPARγ-活化药物组合物或羟化衍生物二十碳五烯酸（EPA）或其药学上可接受的盐，以及PPARγ活化药物组合物用于治疗循环系统疾病，动脉硬化，脂质代谢障碍，糖尿病和炎性疾病的用途。

6. 发明授权

US07951782B2 Composition effective to prevent or treat adult disease 有权
标题翻译：成分有效预防或治疗成人疾病
公开(公告)号：US07951782B2
公开(公告)日：2011-05-31
申请号：US12065984
申请日：2006-09-28
申请人： Itsuki Murota , Tadakazu Tamai , Takashi Baba , Kenji Sato
发明人： Itsuki Murota , Tadakazu Tamai , Takashi Baba , Kenji Sato
IPC分类号： A61K38/08 , A61K38/06 , A61K38/07
CPC分类号： A61K35/60 , A61K38/07 , A61K38/1706
摘要： Disclosed is a composition comprising, as an active ingredient, an enzyme digest that is produced by digesting a basic fraction of an animal-derived cartilage extract with an enzyme. Also disclosed is a polypeptide composition comprising, as an active ingredient, at least one polypeptide selected from specific polypeptides including a polypeptide comprising an amino acid sequence depicted in any one of SEQ ID NOs: 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10.
摘要翻译：公开了一种组合物，其包含通过用酶消化动物来源的软骨提取物的碱性部分而产生的酶消化物作为活性成分。还公开了一种多肽组合物，其包含作为活性成分的至少一种选自特定多肽的多肽，所述多肽包括多肽，所述多肽包含SEQ ID NO：1,2,3,4,5,6， 7,8,9和10。

7. 发明申请

US20100004182A1 COMPOSITION EFFECTIVE TO PREVENT OR TREAT ADULT DISEASE 有权
标题翻译：有效预防或治疗成人疾病的组合物
公开(公告)号：US20100004182A1
公开(公告)日：2010-01-07
申请号：US12065984
申请日：2006-09-28
申请人： Itsuki Murota , Tadakazu Tamai , Takashi Baba , Kenji Sato
发明人： Itsuki Murota , Tadakazu Tamai , Takashi Baba , Kenji Sato
IPC分类号： A61K38/05 , A61K38/07 , A61K38/08 , A61K38/06
CPC分类号： A61K35/60 , A61K38/07 , A61K38/1706
摘要： Disclosed is a composition comprising, as an active ingredient, an enzyme digest that is produced by digesting a basic fraction of an animal-derived cartilage extract with an enzyme. Also disclosed is a polypeptide composition comprising, as an active ingredient, at least one polypeptide selected from specific polypeptides including a polypeptide comprising an amino acid sequence depicted in any one of SEQ ID NOs: 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10.
摘要翻译：公开了一种组合物，其包含通过用酶消化动物来源的软骨提取物的碱性部分而产生的酶消化物作为活性成分。还公开了一种多肽组合物，其包含作为活性成分的至少一种选自特定多肽的多肽，所述多肽包括多肽，所述多肽包含SEQ ID NO：1,2,3,4,5,6， 7,8,9和10。

8. 发明授权

US06613897B1 Compounds having glucuronic acid derivatives and glucosamine derivative in the structure, process for producing the same and utilization thereof 失效
标题翻译：在结构中具有葡萄糖醛酸衍生物和葡糖胺衍生物的化合物及其制备方法及其应用
公开(公告)号：US06613897B1
公开(公告)日：2003-09-02
申请号：US09674252
申请日：2000-10-30
申请人： Nobuaki Yatsuka , Nobuyuki Sato , Shigeru Moriyama , Tadakazu Tamai , Masazumi Nishikawa
发明人： Nobuaki Yatsuka , Nobuyuki Sato , Shigeru Moriyama , Tadakazu Tamai , Masazumi Nishikawa
IPC分类号： A61K3170
CPC分类号： C12P19/26 , A61L27/20 , C08B37/0063 , C08B37/0072 , C08L5/00
摘要： {circle around (1)} Compounds of the following general formula (1) having a glucuronic acid derivative and a glucosamine derivative in the structure thereof, pharmacologically acceptable salts and solvates of the compounds, or solvates of the salts, {circle around (2)} a method for producing the compounds {circle around (1)}, {circle around (3)} a pharmaceutical composition containing the compounds {circle around (1)}, {circle around (4)} polymers having at least one of the compounds {circle around (1)} as a side chain structure, {circle around (5)} a coating agent containing the compound {circle around (1)} or the polymer as one of active ingredients, and {circle around (6)} molded products, artificial organs, medical devices, and equipment for cell culture, which have been produced using the polymer {circle around (4)} and/or the coating agent {circle around (5)}.
摘要翻译： {围绕（1个具有葡萄糖醛酸衍生物和葡糖胺衍生物的结构中的通式（1）的化合物，化合物的药理学上可接受的盐和溶剂化物，或盐的溶剂合物{圆周（2）用于制备化合物（1，{圆周（3）含有化合物的药物组合物（圆周周围的圆周（1周围（4个具有至少一个化合物的聚合物（圆周（1）作为侧链结构围绕（围绕（围绕（1或聚合物作为活性成分的聚合物）和{圆周（6个模制产品，人造器官，医疗装置和细胞培养的设备使用聚合物制造（围绕圆周（4和/或涂层剂{圆周（5。

9. 发明授权

US06894034B1 Sebum production inhibitors 失效
标题翻译：皮脂产生抑制剂
公开(公告)号：US06894034B1
公开(公告)日：2005-05-17
申请号：US10089179
申请日：2000-09-27
申请人： Nobuaki Yatsuka , Nobuyuki Sato , Masazumi Nishikawa , Tadakazu Tamai , Shigeru Moriyama
发明人： Nobuaki Yatsuka , Nobuyuki Sato , Masazumi Nishikawa , Tadakazu Tamai , Shigeru Moriyama
IPC分类号： C07H7/033 , A61K8/00 , A61K8/11 , A61K8/60 , A61K8/72 , A61K8/73 , A61K31/7012 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K31/726 , A61P17/00 , A61P17/08 , A61P17/10 , A61P17/14 , A61Q1/00 , A61Q1/12 , A61Q5/00 , A61Q7/00 , A61Q15/00 , A61Q19/00 , A61Q19/08 , C07H13/04 , C07H15/04 , C07H17/04 , C08B37/00 , A61K31/728
CPC分类号： A61Q5/006 , A61K8/60 , A61K8/602 , A61K31/7012 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K31/726 , A61Q1/12 , A61Q7/00 , A61Q15/00 , A61Q19/00 , A61Q19/08 , C07H13/04 , C07H15/04 , C07H17/04 , C08B37/0063
摘要： Sebum production inhibitors containing as an active ingredient a compound of general formula (1) below having a glucuronic acid derivative and a glucosamine derivative in the structure or a pharmacologically acceptable salt thereof
摘要翻译：含有下述通式（1）的化合物作为活性成分的皮脂产生抑制剂，其结构中含有葡萄糖醛酸衍生物和葡糖胺衍生物或其药理学上可接受的盐

10. 发明授权

US06835846B2 Aliphatic compounds, process for their preparation and their usage 失效
标题翻译：脂肪族化合物，其制备方法及其用途
公开(公告)号：US06835846B2
公开(公告)日：2004-12-28
申请号：US10398921
申请日：2003-04-11
申请人： Tadakazu Tamai , Masazumi Nishikawa , Kenji Mori
发明人： Tadakazu Tamai , Masazumi Nishikawa , Kenji Mori
IPC分类号： C07C23100
CPC分类号： C07C235/08
摘要： The present invention provides an aliphatic compound represented by the following formula (I) or pharmacologically acceptable salts thereof: where n denotes an integer of 1 to 11, and 1 denotes an integer of 1 to 16, the aliphatic compound being an optical isomer of the (2R,3S,2′S) configuration when the 8-position thereof is a double bond, or an optical isomer of the (2S,3R,2′RS) configuration when the 8-position is a single bond; methods for producing the compound or pharmacologically acceptable salts thereof; and uses of the compound in the treatment of cardiovascular diseases (e.g. arteriosclerosis, cardiac diseases), cancer, rheumatism, diabetic retinopathy, and respiratory diseases.
摘要翻译：本发明提供由下式（I）表示的脂族化合物或其药理学上可接受的盐：其中n表示1至11的整数，1表示1至16的整数，脂族化合物是（2S，3R，2'RS）构型的双键时的（2R，3S，2'S）构型或（2S，3R，2'RS）构型的旋光异构体; 制备化合物或其药理学上可接受的盐的方法; 以及该化合物在治疗心血管疾病（例如动脉硬化，心脏病），癌症，风湿病，糖尿病性视网膜病和呼吸系统疾病中的用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式