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1. 发明申请

US20170072368A1 POROUS MEMBRANE AND WATER PURIFIER 审中-公开
标题翻译：多孔膜和水净化器
公开(公告)号：US20170072368A1
公开(公告)日：2017-03-16
申请号：US15123491
申请日：2015-03-10
申请人： TORAY Industries, Inc.
发明人： Shiro NOSAKA , Yoshiyuki UENO , Masahiro OSABE
IPC分类号： B01D69/08 , C02F1/44 , B01D69/02
CPC分类号： B01D69/08 , B01D69/02 , B01D2325/022 , B01D2325/04 , B01D2325/26 , C02F1/44 , C02F2303/04 , C02F2307/10
摘要： There is provided a porous membrane capable of achieving both virus-removing performance and water permeability. The porous membrane according to the present invention has an average pore minor axis diameter of 10 nm or more and 90 nm or less in at least one surface of the porous membrane; a thickness of 60 μm to 300 μm; and an overall adsorption capacity with respect to bacteriophage MS2 of 8×109 PFU/g or more.
摘要翻译：提供能够实现病毒除去性能和透水性的多孔膜。根据本发明的多孔膜在多孔膜的至少一个表面中的平均孔短轴直径为10nm以上且90nm以下，厚度为60μm〜300μm; 和相对于噬菌体MS2的总吸附能力为8×10 9 PFU / g以上。

2. 发明申请

US20200215253A1 IMMUNOSUPPRESSIVE LEUKOCYTE ADSORPTION MATERIAL AND ADSORPTION COLUMN 审中-公开
公开(公告)号：US20200215253A1
公开(公告)日：2020-07-09
申请号：US16638570
申请日：2018-09-07
申请人： TORAY INDUSTRIES, INC. , NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
发明人： Yoshiyuki UENO , Junichi KASUYA , Toru ARAKANE , Ryo MATSUNAGA , Yumiko SEKIYA , Yuji UEDA , Kazuo TERAMOTO , Kazumasa OGASAWARA
IPC分类号： A61M1/36 , B01J20/26 , B01J20/28
摘要： An objective of the present disclosure is to provide an adsorption material that can selectively adsorb immunosuppressive leukocyte. The present disclosure provides an adsorption material for immunosuppressive leukocyte. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae are bound. A form of the water-insoluble carrier is a fiber or a particle, a diameter of the fiber or the particle is 15 to 50 μm, and an arithmetic mean roughness of a surface of the water-insoluble carrier is 0.1 to 3.0 μm.

3. 发明申请

US20150343394A1 HOLLOW FIBER MEMBRANE MODULE, METHOD FOR PRODUCING HOLLOW FIBER MEMBRANE, AND METHOD FOR PRODUCING HOLLOW FIBER MEMBRANE MODULE 审中-公开
标题翻译：中空纤维膜模块，中空纤维膜的制造方法以及中空纤维膜模块的制造方法
公开(公告)号：US20150343394A1
公开(公告)日：2015-12-03
申请号：US14649679
申请日：2014-02-13
申请人： TORAY INDUSTRIES, INC.
发明人： Akihiro HAYASHI , Masahiro OSABE , Yoshiyuki UENO
IPC分类号： B01D71/68 , B01D69/08 , A61M1/34 , B01D67/00 , A61M1/16 , B01D63/02 , B01D69/02
CPC分类号： B01D65/022 , A61M1/16 , A61M1/1621 , A61M1/3496 , B01D63/02 , B01D63/021 , B01D67/002 , B01D69/02 , B01D69/08 , B01D69/085 , B01D71/38 , B01D71/40 , B01D71/44 , B01D71/68 , B01D2323/12 , B01D2323/42 , B01D2325/36 , B01D2325/38 , C08L39/06 , C08L41/00
摘要： An object of the present invention is to provide a dry-type hollow fiber membrane module which is excellent in blood compatibility and elutes little eluted substance, and a hollow fiber membrane built in the module, and a method for producing a hollow fiber membrane module. Disclosed is a hollow fiber membrane module including a built-in hollow fiber membrane including a hydrophobic polymer and a hydrophilic group-containing polymer, the hollow fiber membrane module satisfying the following items: (a) the water content of the hollow fiber membrane is 10% by weight or less relative to the tare weight of the hollow fiber membrane, (b) the hydrophobic polymer contains no nitrogen, the hydrophilic group-containing polymer contains nitrogen, and the nitrogen content of the hollow fiber membrane is 0.05% by weight or more and 0.4% byweight or less, (c) the content of the hydrophilic group-containing polymer in the inner surface of the membrane is 20% by weight or more and 45% by weight or less, and (d) the consumption amount of an aqueous potassium permanganate solution (2.0×10−3 mol/L) used for titrating an eluted substance in 10 mL of a last part of a priming liquid is 0.2 mL or less per 1 m2 of a membrane area.
摘要翻译：本发明的目的是提供一种干燥型中空纤维膜组件，其具有优异的血液相容性和洗脱少量洗脱物质，以及内置于该组件中的中空纤维膜，以及中空纤维膜组件的制造方法。公开了一种中空纤维膜组件，其包括含有疏水性聚合物和含亲水性基团的聚合物的内置中空纤维膜，中空纤维膜组件满足以下条件：（a）中空纤维膜的含水量为10 （b）疏水性聚合物不含有氮，含亲水性基团的聚合物含有氮，中空纤维膜的氮含量为0.05重量％，或更多且0.4重量％以下，（c）膜内表面的含亲水基聚合物的含量为20重量％以上且45重量％以下，（d）用于滴定10ml初始液体的最后部分中的洗脱物质的高锰酸钾溶液（2.0×10 -3 mol / L）每1m 2膜面积为0.2mL以下。

4. 发明申请

US20210154642A1 SEA-ISLAND COMPOSITE FIBER, CARRIER FOR ADSORPTION, AND MEDICAL COLUMN PROVIDED WITH CARRIER FOR ADSORPTION 有权
公开(公告)号：US20210154642A1
公开(公告)日：2021-05-27
申请号：US16625992
申请日：2018-08-31
申请人： TORAY INDUSTRIES, INC.
发明人： Ryo MATSUNAGA , Junichi KASUYA , Yoshiyuki UENO , Hirofumi YAMANAKA , Yasunori KANEMORI , Masato MASUDA , Joji FUNAKOSHI
IPC分类号： B01J20/26 , D01F8/04 , B01D15/38 , A61M1/36 , B01J20/28 , B01J20/288
摘要： An object of the present invention is to provide a ligand-immobilized sea-island composite fiber in which generation of fine particles due to peeling of a sea component from an island component and generation of fine particles due to destruction of a fragile sea component are both suppressed. The present invention provides a sea-island composite fiber comprising a sea component and island components, in which a value (L/S) obtained by dividing the average total length (L) of the perimeter of all island components in a cross section perpendicular to the fiber axis by the average cross-sectional area (S) of the cross section is from 1.0 to 50.0 μm−1, a distance from the surface to the outermost island component is 1.9 μm or less, and an amino group-containing compound is covalently bonded to a polymer constituting the sea component at a charge density of 0.1 μmol or more and less than 500 μmol per 1 gram dry weight.

5. 发明申请

US20200246776A1 IMMUNOSUPPRESSIVE PROTEIN ADSORPTION MATERIAL AND ADSORPTION COLUMN 审中-公开
公开(公告)号：US20200246776A1
公开(公告)日：2020-08-06
申请号：US16638586
申请日：2018-09-07
申请人： TORAY INDUSTRIES, INC. , NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
发明人： Junichi KASUYA , Ryo MATSUNAGA , Yoshiyuki UENO , Yuji UEDA , Kazuo TERAMOTO , Kazumasa OGASAWARA
IPC分类号： B01J20/26 , C07K14/495 , A61M1/36
摘要： An objective of the present disclosure is to provide an adsorption material that has a carrier material with retained physical strength, and efficiently adsorbs an immunosuppressive protein. The present disclosure provides an adsorption material for immunosuppressive protein. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae is bound. A total content of amino groups on the water-insoluble carrier is more than 0 μmol and 2500 μmol or less per 1 g, and a content of primary amino groups on the water-insoluble carrier is 450 μmol or less per 1 g.

6. 发明申请

US20190292288A1 COPOLYMER, SEPARATION MEMBRANE, MEDICAL DEVICE, AND BLOOD PURIFIER USING THE COPOLYMER 审中-公开
公开(公告)号：US20190292288A1
公开(公告)日：2019-09-26
申请号：US16319557
申请日：2017-08-04
申请人： TORAY INDUSTRIES, INC.
发明人： Takeshi BABA , Tomonori KAWAKAMI , Suguru USHIRO , Yoshiyuki UENO
IPC分类号： C08F226/10 , C08F218/10 , C08F220/56 , C08F220/12 , B01D71/76 , B01D71/38 , B01D71/40 , B01D61/24
摘要： A copolymer is excellent in water permeability, suppression of platelet adhesion, and suppression of protein adhesion, and a separation membrane, a medical device, and a separation membrane module for medical use using the copolymer. The copolymer includes monomer units derived from two or more types of monomers, wherein the hydration energy density of the copolymer is 158.992 to 209.200 kJ·mol−1·nm−3, the monomer unit with the highest hydration energy density in the monomer units is a monomer unit not containing a hydroxy group, the volume fraction of the monomer unit with the highest hydration energy density in the monomer units is 35 to 90%, and the difference in hydration energy density is 71.128 to 418.400 kJ·mol−1·nm−3.

7. 发明申请

US20160220965A1 POROUS MEMBRANE, BLOOD PURIFYING MODULE INCORPORATING POROUS MEMBRANE, AND METHOD FOR PRODUCING POROUS MEMBRANE 有权
标题翻译：多孔膜，含有多孔膜的血液净化模块和多孔膜生产方法
公开(公告)号：US20160220965A1
公开(公告)日：2016-08-04
申请号：US14913919
申请日：2014-09-26
申请人： TORAY INDUSTRIES, INC.
发明人： Akihiro HAYASHI , Shiro NOSAKA , Yoshiyuki UENO
IPC分类号： B01D67/00 , B01D69/02 , A61M1/16 , B01D71/58 , B01D71/68 , B01D69/08
CPC分类号： B01D67/0013 , A61M1/16 , B01D63/02 , B01D67/0016 , B01D69/02 , B01D69/08 , B01D71/58 , B01D71/68 , B01D2323/02 , B01D2325/02 , B01D2325/36
摘要： The purpose of the present invention is to provide a porous membrane that has both high water permeability and excellent protein fractionation performance. Provided is a method for producing a porous membrane, said method comprising a step for discharging a membrane-forming dope that contains a hydrophilic polymer from a slit formed in a mouthpiece, and a step for, after the passage of the discharged membrane-forming dope through a dry part, solidifying the membrane-forming dope in a coagulation bath to give a porous membrane, wherein the cross-section area of the slit is 3-30 times inclusive as large as the cross-section area of the solidified porous membrane.
摘要翻译：本发明的目的是提供具有高透水性和优异的蛋白质分级性能的多孔膜。提供一种多孔膜的制造方法，其特征在于，包括从形成在口部的狭缝中排出含有亲水性聚合物的成膜用涂料的工序，以及在排出的成膜原液通过后的工序通过干燥部分，在凝固浴中固化膜形成原液以得到多孔膜，其中狭缝的横截面面积为固化多孔膜的横截面面积的3-30倍。

8. 发明申请

US20160052804A1 POROUS MEMBRANE AND WATER PURIFIER 审中-公开
标题翻译：多孔膜和水净化器
公开(公告)号：US20160052804A1
公开(公告)日：2016-02-25
申请号：US14780275
申请日：2014-03-12
申请人： TORAY INDUSTRIES, INC.
发明人： Shiro NOSAKA , Yoshiyuki UENO , Masahiro OSABE
IPC分类号： C02F1/44 , B01D61/02 , B01D69/02 , C02F1/00
CPC分类号： C02F1/442 , B01D61/027 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2325/02 , C02F1/003 , C02F2303/04
摘要： The present invention addresses the problem of providing a porous membrane for a water purification purpose, which can be used even under high water pressures and which has both virus-removing performance and water permeability. The problem can be solved as follows: a porous membrane is provided, wherein the average pore shorter-axis diameter in one surface is smaller than that in the other surface, and in a cross section of the membrane in the thickness direction, the pore diameters increase from one surface toward the other surface to have at least one maximum value and then decrease. The membrane has a layer which is provided on the side of the surface having a larger average pore shorter-axis diameter and which has pore diameters of 130 nm or less in the cross section of the membrane, wherein the layer has a thickness of 0.5 to 20 μm inclusive and the layer has pores each having a pore diameter of 100 to 130 nm inclusive.
摘要翻译：本发明解决了提供用于水净化目的的多孔膜的问题，即使在高水压下也可以使用，并且具有除病性能和透水性。该问题可以解决如下：提供多孔膜，其中一个表面中的平均孔隙短轴直径小于另一个表面中的平均孔隙短轴直径，并且在膜的厚度方向上的截面中，孔径从一个表面向另一个表面增加至少一个最大值然后减小。所述膜具有在所述表面的侧面上具有较大的平均孔隙短轴直径并且在所述膜的横截面中具有130nm以下的孔径的层，其中所述层的厚度为0.5〜并且该层具有孔径为100〜130nm的孔。

9. 发明申请

US20220379000A1 FIBER BUNDLE, METHOD FOR PRODUCING SAME, AND PURIFICATION COLUMN 有权
公开(公告)号：US20220379000A1
公开(公告)日：2022-12-01
申请号：US17765660
申请日：2020-10-07
申请人： TORAY Industries, Inc.
发明人： Tomoaki OSUKA , Hiroaki FUJIEDA , Yoshiyuki UENO , Hirokazu SAKAGUCHI
IPC分类号： A61M1/36 , B01J20/28
摘要： An object of the present invention is to provide a purification column which is a small purification column in which a volume of a liquid to be treated is reduced in order to reduce the amount of blood to be taken out and which realizes a low pressure loss and has high adsorption performance. The present invention provides a fiber bundle including a plurality of porous fibers that satisfies the following requirements (A) to (E):
(A) the porous fiber has a non-hollow shape,
(B) an arithmetic average roughness (dry Ra value) of a surface of the porous fiber in a dry state is 11 nm or more and 30 nm or less,
(C) an arithmetic average roughness (wet Ra value) of a surface of the porous fiber in a wet state is 12 nm or more and 40 nm or less,
(D) a value represented by wet Ra/dry Ra is 1.05 or more, and
(E) a linear rate of the fiber bundle represented by (length of fiber bundle)/(length of one porous fiber) is 0.97 or more and 1.00 or less.

10. 发明申请

US20210213394A1 POROUS HOLLOW FIBER MEMBRANE 有权
公开(公告)号：US20210213394A1
公开(公告)日：2021-07-15
申请号：US17049806
申请日：2019-05-24
申请人： TORAY INDUSTRIES, INC.
发明人： Akihiro HAYASHI , Kaori AKAIKE , Suguru USHIRO , Yoshiyuki UENO
IPC分类号： B01D69/02 , B01D69/08 , B01D71/68 , B01D71/40 , B01D71/62 , B01D63/02 , C08J9/26
摘要： Disclosed is a porous hollow fiber membrane containing a polysulfone-based polymer as a main component, which has an asymmetric structure in which the inner surface side is dense and the outer surface side is coarse, wherein an average of a minor axis diameter of pores of an inner surface is 20 nm or more and 40 nm or less, an open porosity of the inner surface is 10% or more and 30% or less, and a polymer including a monocarboxylic acid vinyl ester unit is supported on at least one of the outer surface and the inner surface. The present invention provides a hollow fiber membrane which has excellent removing performance of substances to be separated such as viruses, and can be used as a separation membrane having high permeability even in a treatment under low pressure.

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