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1. 发明申请

US20160298936A1 BLAST/IMPACT FREQUENCY TUNING AND MITIGATION 有权
标题翻译： BLAST / IMPACT频率调谐和缓解
公开(公告)号：US20160298936A1
公开(公告)日：2016-10-13
申请号：US15036293
申请日：2014-11-14
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： Michael THOULESS , Ellen M. ARRUDA , Tanaz RAHIMZADEH , Anthony M. WAAS
IPC分类号： F41H5/04 , B32B7/02 , F41H1/04
CPC分类号： F41H5/04 , B32B7/02 , B32B15/08 , B32B2250/03 , B32B2307/10 , B32B2571/00 , F41H1/04 , F42D5/045
摘要： A protective device and method of design to protect against multiple blast and impact events for use in any application in which a delicate target has to be protected. The protective device for mitigating the effects of blast or impact employs a first layer having a first acoustic impedance and a second layer having a second acoustic impedance. The second acoustic impedance is different than the first acoustic impedance. The second layer is proximate to the first layer. The first layer and the second layer are chosen collectively to tune the stress waves from the blast or impact events to one or more specific tuned frequencies. A third layer of a visco-elastic material is employed having a critical damping frequency that matches one or more specific tuned frequencies to dissipate the stress waves of the blast and impact event. The third layer is proximate to the second layer.
摘要翻译：一种保护装置和设计方法，用于防止多种爆炸和冲击事件用于任何需要保护微妙目标的应用中。用于减轻爆炸或冲击的影响的保护装置采用具有第一声阻抗的第一层和具有第二声阻抗的第二层。第二声阻抗与第一声阻抗不同。第二层靠近第一层。集体选择第一层和第二层，以将来自爆炸或撞击事件的应力波调谐到一个或多个特定的调谐频率。使用第三层粘弹性材料，其具有匹配一个或多个特定调谐频率的临界阻尼频率以消散爆炸和撞击事件的应力波。第三层靠近第二层。

2. 发明申请

US20190153375A1 BIOREACTOR AND METHOD OF FORMING COMPLEX THREE-DIMENSIONAL TISSUE CONSTRUCTS 审中-公开
公开(公告)号：US20190153375A1
公开(公告)日：2019-05-23
申请号：US16197944
申请日：2018-11-21
申请人： The Regents of the University of Michigan
发明人： Lisa M. LARKIN , Ellen M. ARRUDA , Michael J. SMIETANA , Pablo MONCADA-LARROTIZ
IPC分类号： C12M1/12 , C12M1/42 , C12M1/00 , C12M1/24
摘要： A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.

3. 发明申请

US20170037354A1 BIOREACTOR AND METHOD OF FORMING COMPLEX THREE-DIMENSIONAL TISSUE CONSTRUCTS 审中-公开
标题翻译：生物反应器和形成复合三维组织结构的方法
公开(公告)号：US20170037354A1
公开(公告)日：2017-02-09
申请号：US15211501
申请日：2016-07-15
申请人： The Regents of The University of Michigan
发明人： Lisa M. LARKIN , Ellen M. ARRUDA , Michael J. SMIETANA , Pablo MONCADA-LARROTIZ
IPC分类号： C12M1/12 , C12N5/071 , C12N5/0775 , C12M1/00 , C12N5/00
CPC分类号： C12M25/14 , C12M23/04 , C12M23/08 , C12M23/34 , C12M23/50 , C12M29/10 , C12M35/08
摘要： A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.
摘要翻译：在单个培养室中形成复杂的三维组织构建体的生物反应器和方法。生物反应器和方法可用于形成具有在单个培养室中由多种细胞类型形成的组织的多阶段组织构建体。生物反应器包括至少一个平移机构，以促进一个或多个组织构建体的平移，而无需直接的用户干预，从而为复杂的组织制造提供封闭的无菌环境。生物反应器可以用作独立装置，也可以用作包括许多生物反应器的大规模系统的一部分。大规模系统可以包括监测和调节组织培养环境的灌注系统。

4. 发明申请

US20210348105A1 BIOREACTOR AND METHOD OF FORMING COMPLEX THREE-DIMENSIONAL TISSUE CONSTRUCTS 有权
公开(公告)号：US20210348105A1
公开(公告)日：2021-11-11
申请号：US17380833
申请日：2021-07-20
申请人： The Regents of the University of Michigan
发明人： Lisa M. LARKIN , Ellen M. ARRUDA , Michael J. SMIETANA , Pablo MONCADA-LARROTIZ
IPC分类号： C12M1/12 , C12M1/24 , C12M1/42 , C12M1/00
摘要： A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.

5. 发明申请

US20180224246A1 BLAST/IMPACT FREQUENCY TUNING AND MITIGATION 审中-公开
公开(公告)号：US20180224246A1
公开(公告)日：2018-08-09
申请号：US15948505
申请日：2018-04-09
申请人： The Regents of The University of Michigan
发明人： Michael THOULESS , Ellen M. ARRUDA , Tanaz RAHIMZADEH , Levon CIMONIAN , Marie RICE
IPC分类号： F41H5/04 , B32B1/00 , B32B5/18 , B32B7/02 , B32B7/12 , B32B27/40 , B32B27/30 , B32B27/32 , B32B27/36 , B32B27/06 , A42B3/12 , F41H1/04
CPC分类号： F41H5/04 , A42B3/128 , B32B1/00 , B32B5/18 , B32B7/02 , B32B7/12 , B32B27/065 , B32B27/32 , B32B27/365 , B32B27/40 , B32B2250/03 , B32B2250/04 , B32B2255/26 , B32B2266/0228 , B32B2274/00 , B32B2307/102 , B32B2307/302 , B32B2307/51 , B32B2307/558 , B32B2307/56 , B32B2307/732 , B32B2571/00 , F41H1/04
摘要： A tuning and mitigation system and method for mitigating a blast or impact event having an elastic layer having an acoustic impedance chosen to tune stress waves resulting from the blast or impact to one or more specific tuned frequencies, and a dissipative layer made of a viscoelastic material having a critical damping frequency that matches at least one or more specific tuned frequencies.

6. 发明申请

US20180224245A1 BLAST/IMPACT FREQUENCY TUNING MITIGATION 审中-公开
公开(公告)号：US20180224245A1
公开(公告)日：2018-08-09
申请号：US15948273
申请日：2018-04-09
申请人： The Regents of The University of Michigan
发明人： Michael THOULESS , Ellen M. ARRUDA , Tanaz RAHIMZADEH , Anthony M. WAAS
IPC分类号： F41H5/04 , F41H1/04 , B32B7/02 , B32B15/08 , F42D5/045
CPC分类号： F41H5/04 , B32B7/02 , B32B15/08 , B32B2250/03 , B32B2307/10 , B32B2571/00 , F41H1/04 , F42D5/045
摘要： A protective device and method of design to protect against multiple blast and impact events for use in any application in which a delicate target has to be protected. The protective device for mitigating the effects of blast or impact employs a first layer having a first acoustic impedance and a second layer having a second acoustic impedance. The second acoustic impedance is different than the first acoustic impedance. The second layer is proximate to the first layer. The first layer and the second layer are chosen collectively to tune the stress waves from the blast or impact events to one or more specific tuned frequencies. A third layer of a visco-elastic material is employed having a critical damping frequency that matches one or more specific tuned frequencies to dissipate the stress waves of the blast and impact event. The third layer is proximate to the second layer.

7. 发明申请

US20170016700A1 BLAST/IMPACT FREQUENCY TUNING AND MITIGATION 审中-公开
标题翻译： BLAST / IMPACT频率调谐和缓解
公开(公告)号：US20170016700A1
公开(公告)日：2017-01-19
申请号：US15182843
申请日：2016-06-15
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： Michael THOULESS , Ellen M. ARRUDA , Tanaz RAHIMZADEH , Levon CIMONIAN , Marie RICE
IPC分类号： F41H5/04 , B32B7/02 , B32B27/40 , B32B27/06 , B32B27/30 , F41H1/04 , B32B5/18
CPC分类号： F41H5/04 , A42B3/128 , B32B1/00 , B32B5/18 , B32B7/02 , B32B7/12 , B32B27/065 , B32B27/32 , B32B27/365 , B32B27/40 , B32B2250/03 , B32B2250/04 , B32B2255/26 , B32B2266/0228 , B32B2274/00 , B32B2307/102 , B32B2307/302 , B32B2307/51 , B32B2307/558 , B32B2307/56 , B32B2307/732 , B32B2571/00 , F41H1/04
摘要： A tuning and mitigation system for mitigating a blast or impact event having a tuning layer assembly having an acoustic impedance chosen to tune stress waves resulting from the blast or impact to one or more specific tuned frequencies, and a dissipative layer assembly made of a viscoelastic material having a critical damping frequency that matches at least one or more specific tuned frequencies.
摘要翻译：一种用于减轻爆炸或冲击事件的调谐和减轻系统，具有调谐层组件，该调谐层组件具有选择的声阻抗，以调谐由爆炸或冲击产生的应力波到一个或多个特定调谐频率，以及由粘弹性材料制成的耗散层组件具有与至少一个或多个特定调谐频率匹配的临界阻尼频率。

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