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1. 发明申请

US20170136255A1 METHOD AND APPARATUS FOR PROVIDING TRANSCRANIAL MAGNETIC STIMULATION (TMS) TO A PATIENT 审中-公开
公开(公告)号：US20170136255A1
公开(公告)日：2017-05-18
申请号：US15281475
申请日：2016-09-30
申请人： The Methodist Hospital , Cornell University
发明人： Santosh A. Helekar , Henning U. Voss
IPC分类号： A61N2/00 , A61B5/04 , A42B1/04 , A42B1/24 , A61B5/0478 , A61N2/12 , A61B5/00
CPC分类号： A61N2/006 , A41D2300/32 , A42B1/04 , A42B1/242 , A61B5/04008 , A61B5/0476 , A61B5/0478 , A61B5/4836 , A61B5/6803 , A61B2503/42 , A61N2/12
摘要： Apparatus for applying Transcranial Magnetic Stimulation (TMS) to a patient, wherein the apparatus comprises: a head mount for disposition on the head of a patient; and a plurality of magnet assemblies for releasable mounting on the head mount, wherein each of the magnet assemblies comprises a magnet for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents in the brain of a patient so as to modify the natural electrical activity of the brain of the patient; wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each patient, whereby to provide patient-specific TMS therapy, to assist in diagnosis or to map out brain function in neuroscience research. In one preferred form of the invention, each of the magnet assemblies comprises a magnet for selectively providing a rapidly changing magnetic field of at least 500-600 Tesla/second corresponding to a magnet movement speed of no less than 400 Hertz.

2. 发明授权

US10398907B2 Method and apparatus for providing transcranial magnetic stimulation (TMS) to an individual 有权
公开(公告)号：US10398907B2
公开(公告)日：2019-09-03
申请号：US14912004
申请日：2014-08-15
申请人： The Methodist Hospital , Cornell University
发明人： Santosh A. Helekar , Henning U. Voss
IPC分类号： A61N2/00 , A61N2/12 , A61B5/0476 , A61B5/05 , A61B5/00 , A61N2/06
摘要： Apparatus for applying Transcranial Magnetic Stimulation (TMS) to an individual, wherein the apparatus comprises: a head mount for disposition on the head of an individual; and a plurality of magnet assemblies for releasable mounting on the head mount, wherein each of the magnet assemblies comprises a permanent magnet, and at least one of (i) a movement mechanism for moving the permanent magnet and/or (ii) a magnetic shield shutter mechanism, for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents in the brain of an individual so as to modify the natural electrical activity of the brain of the individual; wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each individual, whereby to provide individual-specific TMS therapy, to assist in diagnosis or to map out brain function in neuroscience research.

3. 发明申请

US20160193476A1 METHOD AND APPARATUS FOR PROVIDING TRANSCRANIAL MAGNETIC STIMULATION (TMS) TO AN INDIVIDUAL 审中-公开
标题翻译：用于向个体提供交叉磁性刺激（TMS）的方法和装置
公开(公告)号：US20160193476A1
公开(公告)日：2016-07-07
申请号：US14912004
申请日：2014-08-15
申请人： The Methodist Hospital , Cornell University
发明人： Santosh A. Helekar , Henning U. Voss
IPC分类号： A61N2/12 , A61B5/0476 , A61B5/00 , A61N2/06 , A61B5/05
CPC分类号： A61N2/12 , A61B5/0476 , A61B5/05 , A61B5/4064 , A61B5/6803 , A61N2/006 , A61N2/06
摘要： Apparatus for applying Transcranial Magnetic Stimulation (TMS) to an individual, wherein the apparatus comprises: a head mount for disposition on the head of an individual; and a plurality of magnet assemblies for releasable mounting on the head mount, wherein each of the magnet assemblies comprises a permanent magnet, and at least one of (i) a movement mechanism for moving the permanent magnet and/or (ii) a magnetic shield shutter mechanism, for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents in the brain of an individual so as to modify the natural electrical activity of the brain of the individual; wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each individual, whereby to provide individual-specific TMS therapy, to assist in diagnosis or to map out brain function in neuroscience research.
摘要翻译：用于将经颅磁刺激（TMS）施加到个体的装置，其中所述装置包括：用于设置在个人头部上的头部支架; 以及多个用于可拆卸地安装在所述头部安装件上的磁体组件，其中每个所述磁体组件包括永磁体，以及至少一个（i）用于移动所述永磁体的移动机构和/或（ii）磁屏蔽快门机构，用于选择性地提供能够诱导个体脑中的弱电流的快速变化的磁场，以便改变个体的大脑的自然电活动; 其中选择安装在头架上的磁体组件的数量，它们在磁头安装上的各自定位以及它们选择性地提供快速变化的磁场，以便允许磁场的空间，强度和时间特性被定制为每个人量身定制，从而提供个人特定的TMS治疗，以帮助诊断或绘制神经科学研究中的大脑功能。

4. 发明授权

US11491341B2 Method and apparatus for providing transcranial magnetic stimulation (TMS) to an individual 有权
公开(公告)号：US11491341B2
公开(公告)日：2022-11-08
申请号：US16556817
申请日：2019-08-30
申请人： CORNELL UNIVERSITY , THE METHODIST HOSPITAL
发明人： Santosh A. Helekar , Henning U. Voss
IPC分类号： A61N2/00 , A61B5/00 , A61N2/12 , A61B5/05 , A61B5/245 , A61B5/291 , A61B5/369 , A42B1/04 , A42B1/242 , A61N2/06
摘要： Apparatus for applying Transcranial Magnetic Stimulation (TMS) to an individual, wherein the apparatus comprises: a head mount for disposition on the head of an individual; and a plurality of magnet assemblies for releasable mounting on the head mount, wherein each of the magnet assemblies comprises a permanent magnet, and at least one of (i) a movement mechanism for moving the permanent magnet and/or (ii) a magnetic shield shutter mechanism, for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents in the brain of an individual so as to modify the natural electrical activity of the brain of the individual; wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each individual, whereby to provide individual-specific TMS therapy, to assist in diagnosis or to map out brain function in neuroscience research.

5. 发明授权

US11291853B2 Method and apparatus for providing transcranial magnetic stimulation (TMS) to a patient 有权
公开(公告)号：US11291853B2
公开(公告)日：2022-04-05
申请号：US16682811
申请日：2019-11-13
申请人： THE METHODIST HOSPITAL , CORNELL UNIVERSITY
发明人： Santosh A. Helekar , Henning U. Voss
IPC分类号： A61N2/00 , A61B5/00 , A61B5/0476 , A61N2/12 , A61B5/05 , A42B1/04 , A42B1/24 , A61B5/04 , A61B5/0478 , A61B5/245 , A61B5/291 , A61B5/369 , A42B1/242 , A61N2/06
摘要： Apparatus for applying Transcranial Magnetic Stimulation (TMS) to a patient, the apparatus including a head mount for disposition on the head of a patient; and a plurality of magnet assemblies for releasable mounting on the head mount, wherein each of the magnet assemblies includes a magnet for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents in the brain of a patient so as to modify the natural electrical activity of the brain of the patient; wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each patient, whereby to provide patient-specific TMS therapy, to assist in diagnosis or to map out brain function in neuroscience research.

6. 发明申请

US20190381333A1 METHOD AND APPARATUS FOR PROVIDING TRANSCRANIAL MAGNETIC STIMULATION (TMS) TO AN INDIVIDUAL 审中-公开
公开(公告)号：US20190381333A1
公开(公告)日：2019-12-19
申请号：US16556817
申请日：2019-08-30
申请人： CORNELL UNIVERSITY , THE METHODIST HOSPITAL
发明人： Santosh A. Helekar , Henning U. Voss
IPC分类号： A61N2/12 , A61B5/0476 , A61B5/05 , A61B5/00 , A61N2/00
摘要： Apparatus for applying Transcranial Magnetic Stimulation (TMS) to an individual, wherein the apparatus comprises: a head mount for disposition on the head of an individual; and a plurality of magnet assemblies for releasable mounting on the head mount, wherein each of the magnet assemblies comprises a permanent magnet, and at least one of (i) a movement mechanism for moving the permanent magnet and/or (ii) a magnetic shield shutter mechanism, for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents in the brain of an individual so as to modify the natural electrical activity of the brain of the individual; wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each individual, whereby to provide individual-specific TMS therapy, to assist in diagnosis or to map out brain function in neuroscience research.

7. 发明申请

US20190209855A1 METHOD AND APPARATUS FOR PROVIDING TRANSCRANIAL MAGNETIC STIMULATION (TMS) TO AN INDIVIDUAL 审中-公开
公开(公告)号：US20190209855A1
公开(公告)日：2019-07-11
申请号：US16099125
申请日：2017-05-05
申请人： THE METHODIST HOSPITAL , CORNELL UNIVERSITY
发明人： Santosh A. Helekar , Henning U. Voss
IPC分类号： A61N2/00 , A61B5/0476 , A61N2/06 , A61N2/12 , A61B5/05
CPC分类号： A61N2/006 , A61B5/0476 , A61B5/05 , A61B5/4836 , A61N2/06 , A61N2/12
摘要： An apparatus for applying Transcranial Magnetic Stimulation (TMS) to the brain of an individual comprising: a head mount; a plurality of magnet assemblies for releasable mounting on the head mount; each of the magnet assemblies comprises a permanent magnet, and at least one of (i) a movement mechanism for moving the permanent magnet and/or (ii) a magnetic shield shutter mechanism, to provide a rapidly changing magnetic field; and a computerized controller for operating at least one of the movement mechanism and the magnetic shield shutter mechanism of at least one of the magnet assemblies to apply a rapidly changing magnetic field to the brain of the individual, wherein the computerized controller is configured to provide one of intermittent oscillatory stimulation and continuous oscillatory stimulation, to induce weak electric currents in the brain of an individual so as to modify the natural electrical activity of the brain of the individual.

8. 发明授权

US09456784B2 Method and apparatus for providing transcranial magnetic stimulation (TMS) to a patient 有权
标题翻译：用于向患者提供经颅磁刺激（TMS）的方法和装置
公开(公告)号：US09456784B2
公开(公告)日：2016-10-04
申请号：US13829349
申请日：2013-03-14
申请人： The Methodist Hospital , Cornell University
发明人： Santosh A. Helekar , Henning U. Voss
IPC分类号： A61N1/00 , A61B5/00 , A61B5/0476 , A61N2/00 , A61N2/12
CPC分类号： A61N2/006 , A41D2300/32 , A42B1/04 , A42B1/242 , A61B5/04008 , A61B5/0476 , A61B5/0478 , A61B5/4836 , A61B5/6803 , A61B2503/42 , A61N2/12
摘要： Apparatus for applying Transcranial Magnetic Stimulation (TMS) to a patient, the apparatus including a head mount for disposition on the head of a patient; and a plurality of magnet assemblies for releasable mounting on the head mount, wherein each of the magnet assemblies includes a magnet for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents in the brain of a patient so as to modify the natural electrical activity of the brain of the patient; wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each patient, whereby to provide patient-specific TMS therapy, to assist in diagnosis or to map out brain function in neuroscience research.
摘要翻译：用于将经颅磁刺激（TMS）施用于患者的装置，该装置包括用于设置在患者头部上的头部支架; 以及用于可释放地安装在头架上的多个磁体组件，其中每个磁体组件包括用于选择性地提供快速变化的磁场的磁体，所述磁场能够诱发患者脑部的弱电流，从而改变自然电患者脑部活动; 其中选择安装在头架上的磁体组件的数量，它们在磁头安装上的各自定位以及它们选择性地提供快速变化的磁场，以便允许磁场的空间，强度和时间特性被定制为每个患者量身定制，从而提供患者特异性TMS治疗，以帮助诊断或绘制神经科学研究中的脑功能。

9. 发明申请

US20220168585A1 Dynamically Controlling Self-Directed Magnetic Stimulation 有权
公开(公告)号：US20220168585A1
公开(公告)日：2022-06-02
申请号：US17434646
申请日：2020-03-04
申请人： THE METHODIST HOSPITAL
发明人： Santosh A. Helekar
IPC分类号： A61N2/00 , A61N2/12
摘要： To generate operational parameters for Transcranial Magnetic Stimulation (TMS), training data that includes indications of previously conducted TMS sessions is generated. A machine learning model is trained using the training data. The trained machine learning model is applied to one or more parameters related to an individual to generate operational parameters for a TMS session. A device for applying TMS to conduct a TMS session with the individual is operated in accordance with the generate operational parameters.

10. 发明申请

US20230043685A1 METHOD AND APPARATUS FOR PROVIDING TRANSCRANIAL MAGNETIC STIMULATION (TMS) TO AN INDIVIDUAL 有权
公开(公告)号：US20230043685A1
公开(公告)日：2023-02-09
申请号：US17969523
申请日：2022-10-19
申请人： THE METHODIST HOSPITAL , CORNELL UNIVESITY
发明人： Santosh A. Helekar , Henning U. Voss
IPC分类号： A61N2/00 , A61B5/00 , A61N2/12 , A61B5/05 , A61B5/245 , A61B5/291 , A61B5/369 , A42B1/04 , A42B1/242
摘要： Apparatus for applying Transcranial Magnetic Stimulation (TMS) to an individual, wherein the apparatus comprises: a head mount for disposition on the head of an individual; and a plurality of magnet assemblies for releasable mounting on the head mount, wherein each of the magnet assemblies comprises a permanent magnet, and at least one of (i) a movement mechanism for moving the permanent magnet and/or (ii) a magnetic shield shutter mechanism, for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents in the brain of an individual so as to modify the natural electrical activity of the brain of the individual; wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each individual, whereby to provide individual-specific TMS therapy, to assist in diagnosis or to map out brain function in neuroscience research.

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