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1. 发明授权

US10524707B2 System and method for photoluminescence detection 有权
公开(公告)号：US10524707B2
公开(公告)日：2020-01-07
申请号：US15114951
申请日：2015-02-02
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Zongxi Li , Conor L. Evans , Alexander J. Nichols
IPC分类号： A61B5/1455 , A61B5/1477 , A61B5/00 , A61F13/00
摘要： In one aspect, the present disclosure provides a system A system, including a light source, a detector, and a controller in electrical communication with the light source and the detector. The controller is configured to execute a program stored in the controller to trigger the light source to emit a first pulse of light having a first pulse duration for illumination of a target, actuate the detector after a first delay time following emission of the first pulse of light to begin detecting a first signal from the target for a first detection time, and repeat the steps of triggering the light source and actuating the detector at least once, varying for each repetition at least one of the first pulse duration, the first delay time, and the first detection time.

2. 发明申请

US20200171172A1 COMPOUNDS, SYSTEMS, AND METHODS FOR MONITORING AND TREATING A SURFACE OF A SUBJECT 审中-公开
公开(公告)号：US20200171172A1
公开(公告)日：2020-06-04
申请号：US16787480
申请日：2020-02-11
申请人： The General Hospital Corporation
发明人： Conor L. Evans , Gabriela Apiou , Alexander J. Nichols , Emmanouil Rousakis , Zongxi Li
IPC分类号： A61K49/00 , C07D487/22 , A61B5/00 , A61B5/1455 , A61B90/00
摘要： Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

3. 发明申请

US20220257797A1 COMPOUNDS, SYSTEMS, AND METHODS FOR MONITORING AND TREATING A SURFACE OF A SUBJECT 有权
公开(公告)号：US20220257797A1
公开(公告)日：2022-08-18
申请号：US17583997
申请日：2022-01-25
申请人： The General Hospital Corporation
发明人： Conor L. Evans , Gabriela Apiou , Alexander J. Nichols , Emmanouil Rousakis , Zongxi Li
IPC分类号： A61K49/00 , A61B5/00 , A61B5/1455 , A61B90/00 , C07D487/22
摘要： Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

4. 发明授权

US11253613B2 Compounds, systems, and methods for monitoring and treating a surface of a subject 有权
公开(公告)号：US11253613B2
公开(公告)日：2022-02-22
申请号：US16787480
申请日：2020-02-11
申请人： The General Hospital Corporation
发明人： Conor L. Evans , Gabriela Apiou , Alexander J. Nichols , Emmanouil Rousakis , Zongxi Li
IPC分类号： C07D487/22 , A61K49/00 , A61B5/00 , A61B5/1455 , A61B90/00 , A61F13/00
摘要： Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing that includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen. The matrix is at least partially permeable to the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration. The metallated porphyrin can be prepared from a phosphorescent meso-unsubstituted porphyrin having the Formula (I): wherein M is a metal, wherein each R is independently an atom or a group of atoms, and wherein at least one R is —O(C)OR′, wherein R′ is optionally substituted alkyl.

5. 发明授权

US10039842B2 Compounds, systems, and methods for monitoring and treating a surface of a subject 有权
公开(公告)号：US10039842B2
公开(公告)日：2018-08-07
申请号：US15684040
申请日：2017-08-23
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Conor L. Evans , Gabriela Apiou , Alexander J. Nichols , Emmanouil Rousakis , Zongxi Li
IPC分类号： A61K49/00 , A61B5/00 , A61B5/1455 , C07D487/22
摘要： Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration. The porphyrin can have the Formula (II): wherein R1 includes a moiety selected from the group consisting of alkynl groups, triazolyl groups, alkylglutamate groups, and a pair of alkylglutamate groups.

6. 发明授权

US12059481B2 Compounds, systems, and methods for monitoring and treating a surface of a subject 有权
公开(公告)号：US12059481B2
公开(公告)日：2024-08-13
申请号：US17583997
申请日：2022-01-25
申请人： The General Hospital Corporation
发明人： Conor L. Evans , Gabriela Apiou , Alexander J. Nichols , Emmanouil Rousakis , Zongxi Li
IPC分类号： C07D487/22 , A61B5/00 , A61B5/1455 , A61B90/00 , A61K49/00 , A61F13/00
CPC分类号： A61K49/0015 , A61B5/14551 , A61B5/14552 , A61B5/14556 , A61B5/443 , A61B5/6833 , A61B90/39 , C07D487/22 , A61B5/0022 , A61B5/4839 , A61B5/743 , A61B2562/12 , A61F2013/0097
摘要： Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

7. 发明授权

US10905780B2 Compounds, systems, and methods for monitoring and treating a surface of a subject 有权
公开(公告)号：US10905780B2
公开(公告)日：2021-02-02
申请号：US16054028
申请日：2018-08-03
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Conor L. Evans , Gabriela Apiou , Alexander J. Nichols , Emmanouil Rousakis , Zongxi Li
IPC分类号： C07D487/22 , A61K49/00 , A61B5/00 , A61B5/1455 , A61B90/00 , A61F13/00
摘要： Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

8. 发明申请

US20180344878A1 COMPOUNDS, SYSTEMS, AND METHODS FOR MONITORING AND TREATING A SURFACE OF A SUBJECT 审中-公开
公开(公告)号：US20180344878A1
公开(公告)日：2018-12-06
申请号：US16054028
申请日：2018-08-03
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Conor L. Evans , Gabriela Apiou , Alexander J. Nichols , Emmanouil Rousakis , Zongxi Li
IPC分类号： A61K49/00 , C07D487/22 , A61B5/1455 , A61B5/00 , A61B90/00 , A61F13/00
CPC分类号： A61K49/0015 , A61B5/0022 , A61B5/14551 , A61B5/14552 , A61B5/14556 , A61B5/443 , A61B5/4839 , A61B5/6832 , A61B5/6833 , A61B5/743 , A61B90/39 , A61B2562/12 , A61F2013/0097 , C07D487/22
摘要： Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

9. 发明申请

US20170348437A1 COMPOUNDS, SYSTEMS, AND METHODS FOR MONITORING AND TREATING A SURFACE OF A SUBJECT 审中-公开
公开(公告)号：US20170348437A1
公开(公告)日：2017-12-07
申请号：US15684040
申请日：2017-08-23
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Conor L. Evans , Gabriela Apiou , Alexander J. Nichols , Emmanouil Rousakis , Zongxi Li
IPC分类号： A61K49/00 , A61B5/00 , A61B5/1455 , C07D487/22
CPC分类号： A61K49/0015 , A61B5/0022 , A61B5/14551 , A61B5/14552 , A61B5/14556 , A61B5/443 , A61B5/4839 , A61B5/6832 , A61B5/6833 , A61B5/743 , A61B90/39 , A61B2562/12 , A61F2013/0097 , C07D487/22
摘要： Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

10. 发明申请

US20160338631A1 SYSTEM AND METHOD FOR PHOTOLUMINESCENCE DETECTION 审中-公开
标题翻译：用于光致发光检测的系统和方法
公开(公告)号：US20160338631A1
公开(公告)日：2016-11-24
申请号：US15114951
申请日：2015-02-02
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Zongxi Li , Conor L. Evans , Alexander J. Nichols
IPC分类号： A61B5/1455 , A61B5/1477 , A61B5/00 , A61F13/00
摘要： In one aspect, the present disclosure provides a system A system, including a light source, a detector, and a controller in electrical communication with the light source and the detector. The controller is configured to execute a program stored in the controller to trigger the light source to emit a first pulse of light having a first pulse duration for illumination of a target, actuate the detector after a first delay time following emission of the first pulse of light to begin detecting a first signal from the target for a first detection time, and repeat the steps of triggering the light source and actuating the detector at least once, varying for each repetition at least one of the first pulse duration, the first delay time, and the first detection time.
摘要翻译：一方面，本公开提供一种系统A系统，包括光源，检测器和与光源和检测器电连通的控制器。控制器被配置为执行存储在控制器中的程序以触发光源发射具有用于照射目标的第一脉冲持续时间的第一脉冲光，在发射第一脉冲的第一延迟时间之后激活检测器光开始检测来自目标的第一信号以进行第一检测时间，并且重复以下步骤：触发光源并致动检测器至少一次，对于每次重复，对于第一脉冲持续时间，第一延迟时间，和第一次检测时间。

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