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1. 发明申请

US20160030699A1 SYNTHESIS OF NITRIC OXIDE GAS FOR INHALATION 审中-公开
标题翻译：用于吸入的氮氧化物气体的合成
公开(公告)号：US20160030699A1
公开(公告)日：2016-02-04
申请号：US14777084
申请日：2014-03-14
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Warren M. Zapol , Binglan Yu , Paul Hardin , Matthew Hickcox
IPC分类号： A61M16/12 , A61M16/10 , A61M16/00
摘要： In some additional aspects, an apparatus can include a chamber having an inlet valve for receiving a reactant gas and an outlet valve for delivering a product gas, a piston positioned inside the chamber and configured to move along a length of the chamber for adjusting pressure in the chamber, a sensor for collecting information related to one or more conditions of a respiratory system associated with a patient, a controller for determining one or more control parameters based on the collected information, and one or more pairs of electrodes positioned inside the chamber for initiating a series of electric arcs external to the patient to generate nitric oxide based on the determined control parameters.
摘要翻译：在一些另外的方面，设备可以包括具有用于接收反应物气体的入口阀和用于输送产物气体的出口阀的室，位于室内的活塞，并且构造成沿室的长度移动以调节压力所述室，用于收集与患者相关联的呼吸系统的一个或多个条件相关的信息的传感器，用于基于所收集的信息确定一个或多个控制参数的控制器和位于所述腔室内的一对或多对电极，基于所确定的控制参数，启动患者外部的一系列电弧以产生一氧化氮。

2. 发明授权

US10279139B2 Synthesis of nitric oxide gas for inhalation 有权
公开(公告)号：US10279139B2
公开(公告)日：2019-05-07
申请号：US15880018
申请日：2018-01-25
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Warren M. Zapol , Binglan Yu , Paul Hardin , Matthew Hickcox
IPC分类号： A61M16/10 , C01B21/20 , A61M16/12 , B01D53/56 , A61M16/00 , A61M16/04 , A61M16/06 , A61M16/20 , A61M15/02
摘要： In some additional aspects, an apparatus can include a chamber having an inlet valve for receiving a reactant gas and an outlet valve for delivering a product gas, a piston positioned inside the chamber and configured to move along a length of the chamber for adjusting pressure in the chamber, a sensor for collecting information related to one or more conditions of a respiratory system associated with a patient, a controller for determining one or more control parameters based on the collected information, and one or more pairs of electrodes positioned inside the chamber for initiating a series of electric arcs external to the patient to generate nitric oxide based on the determined control parameters.

3. 发明申请

US20180221619A1 SYNTHESIS OF NITRIC OXIDE GAS FOR INHALATION 审中-公开
公开(公告)号：US20180221619A1
公开(公告)日：2018-08-09
申请号：US15880018
申请日：2018-01-25
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Warren M. Zapol , Binglan Yu , Paul Hardin , Matthew Hickcox
IPC分类号： A61M16/12 , A61M16/00 , A61M16/10 , A61M16/20 , C01B21/20 , A61M16/06 , A61M15/02 , A61M16/04 , B01D53/56
CPC分类号： A61M16/12 , A61M15/02 , A61M16/0003 , A61M16/0057 , A61M16/0063 , A61M16/0072 , A61M16/0465 , A61M16/06 , A61M16/10 , A61M16/101 , A61M16/107 , A61M16/108 , A61M16/20 , A61M16/202 , A61M16/209 , A61M2016/0021 , A61M2016/0033 , A61M2016/1025 , A61M2016/1035 , A61M2202/0208 , A61M2202/0216 , A61M2202/0275 , A61M2205/04 , A61M2205/33 , A61M2205/3303 , A61M2205/3334 , A61M2205/3553 , A61M2205/3561 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/3606 , A61M2205/366 , A61M2205/50 , A61M2205/7545 , A61M2210/1032 , A61M2230/40 , B01D53/56 , B01D2251/304 , B01D2251/306 , B01D2251/404 , C01B21/203
摘要： In some additional aspects, an apparatus can include a chamber having an inlet valve for receiving a reactant gas and an outlet valve for delivering a product gas, a piston positioned inside the chamber and configured to move along a length of the chamber for adjusting pressure in the chamber, a sensor for collecting information related to one or more conditions of a respiratory system associated with a patient, a controller for determining one or more control parameters based on the collected information, and one or more pairs of electrodes positioned inside the chamber for initiating a series of electric arcs external to the patient to generate nitric oxide based on the determined control parameters.

4. 发明授权

US10646682B2 Inspiratory synthesis of nitric oxide 有权
公开(公告)号：US10646682B2
公开(公告)日：2020-05-12
申请号：US16593718
申请日：2019-10-04
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Warren M. Zapol , Binglan Yu , Paul Hardin , Matthew Hickcox
IPC分类号： A61M16/12 , A61M16/10 , C01B21/20 , A61M15/02 , A61M16/00 , B01D53/56 , A61M16/04 , A61M16/06 , A61M16/20
摘要： A system for generating nitric oxide can include an apparatus positioned in a trachea of a mammal, the apparatus including a respiration sensor for collecting information related to one or more triggering events associated with the trachea, an oxygen sensor for collecting information related to a concentration of oxygen in a gas, and one or more pairs of electrodes for initiating a series of electric arcs to generate nitric oxide, and the system for generating nitric oxide can also include a controller for determining one or more control parameters based on the information collected by the respiration sensor and the oxygen sensor, wherein the series of electric arcs is initiated based on the control parameters determined by the controller.

5. 发明申请

US20190070383A1 INSPIRATORY SYNTHESIS OF NITRIC OXIDE 审中-公开
公开(公告)号：US20190070383A1
公开(公告)日：2019-03-07
申请号：US16058797
申请日：2018-08-08
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Warren M. Zapol , Binglan Yu , Paul Hardin , Matthew Hickcox
IPC分类号： A61M16/12 , A61M16/00 , A61M16/10 , A61M16/20 , C01B21/20 , A61M16/06 , A61M15/02 , A61M16/04 , B01D53/56
摘要： A system for generating nitric oxide can include an apparatus positioned in a trachea of a mammal, the apparatus in eluding a respiration sensor for collecting information related to one or more triggering events associated with the trachea, an oxygen sensor for collecting information related to a concentration of oxygen in a gas, and one or more pairs of electrodes for initiating a series of electric arcs to generate nitric oxide, and the system for generating nitric oxide can also include a controller for determining one or more control parameters based on the information collected by the respiration sensor and the oxygen sensor, wherein the series of electric arcs is initiated based on the control parameters determined by the controller.

6. 发明申请

US20180242916A1 ELECTROENCEPHALOGRAM MONITORING SYSTEM AND METHOD OF USE OF THE SAME 审中-公开
公开(公告)号：US20180242916A1
公开(公告)日：2018-08-30
申请号：US15756933
申请日：2016-09-02
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Patrick L. Purdon , Michael J. Prerau , Nathaniel M. Sims , Matthew Hickcox
IPC分类号： A61B5/00 , A61B5/0478 , A61B5/0492 , A61B5/0408 , A61B5/04 , A61B5/0205
CPC分类号： A61B5/7203 , A61B5/0006 , A61B5/0205 , A61B5/04017 , A61B5/04085 , A61B5/04087 , A61B5/0478 , A61B5/0492 , A61B5/0533 , A61B5/1118 , A61B5/4812 , A61B5/4821 , A61B5/4824 , A61B5/4848 , A61B5/7232 , A61B2560/0204 , A61B2560/0412 , A61B2560/0456 , A61B2562/0209 , A61B2562/164 , A61B2562/182
摘要： A system and method for monitoring a subject are provided. In some aspects, a provided electroencephalogram (“EEG”) system includes an electrode patch assembly configured to attach to a subject's skin, the assembly including a flexible circuit layer having electrical leads configured to acquire EEG signals from the subject, the flexible circuit layer having a shielding layer configured to substantially reduce a coupling of the plurality of electrical leads to external sources of noise, and a holder to which the flexible circuit layer is secured. The system also includes an electronics module removably coupled to the holder and configured to engage electrical contacts on the flexible circuit layer, the module including a front-end module configured to perform an active noise cancellation process on the acquired EEG signals and generate digitized data using noise cancelled signals, and a processor configured to transmit the digitized data using a wireless communication module.

7. 发明申请

US20200345966A1 SYNTHESIS OF NITRIC OXIDE GAS FOR INHALATION 审中-公开
公开(公告)号：US20200345966A1
公开(公告)日：2020-11-05
申请号：US16933666
申请日：2020-07-20
申请人： The General Hospital Corporation
发明人： Warren M. Zapol , Binglan Yu , Paul Hardin , Matthew Hickcox
IPC分类号： A61M16/12 , A61M16/00 , A61M16/10 , C01B21/20 , A61M15/02 , B01D53/56 , A61M16/04 , A61M16/06 , A61M16/20
摘要： In some additional aspects, an apparatus for generating nitric oxide (NO) can include one or more pairs of electrodes configured to initiate a series of electric arcs to synthesize a reactant gas into a product gas comprising NO, a sensor configured to measure a flow of a gas in a respiratory system into which the product gas is provided, a controller in communication with the one or more pairs of electrodes and the sensor. The controller is configured to adjust at least one of a pulse width, pulse period, pulse count per pulse group, pulse groups per second, energy generated by the one or more pairs of electrodes, arc frequency, arc current, and a voltage supplied to the one or more pairs of electrodes based on the measured flow to control a concentration of nitric oxide in the product gas.

8. 发明申请

US20200345965A1 INSPIRATORY SYNTHESIS OF NITRIC OXIDE 审中-公开
公开(公告)号：US20200345965A1
公开(公告)日：2020-11-05
申请号：US16833104
申请日：2020-03-27
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Warren M. Zapol , Binglan Yu , Paul Hardin , Matthew Hickcox
IPC分类号： A61M16/12 , A61M16/00 , A61M16/10 , C01B21/20 , A61M15/02 , B01D53/56 , A61M16/04 , A61M16/06 , A61M16/20
摘要： A system for generating nitric oxide can include an apparatus positioned in a trachea of a mammal, the apparatus including a respiration sensor for collecting information related to one or more triggering events associated with the trachea, an oxygen sensor for collecting information related to a concentration of oxygen in a gas, and one or more pairs of electrodes for initiating a series of electric arcs to generate nitric oxide, and the system for generating nitric oxide can also include a controller for determining one or more control parameters based on the information collected by the respiration sensor and the oxygen sensor, wherein the series of electric arcs is initiated based on the control parameters determined by the controller.

9. 发明申请

US20200030567A1 INSPIRATORY SYNTHESIS OF NITRIC OXIDE 审中-公开
公开(公告)号：US20200030567A1
公开(公告)日：2020-01-30
申请号：US16593718
申请日：2019-10-04
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Warren M. Zapol , Binglan Yu , Paul Hardin , Matthew Hickcox
IPC分类号： A61M16/12 , A61M16/00 , A61M16/10 , C01B21/20 , A61M15/02 , B01D53/56 , A61M16/04 , A61M16/06 , A61M16/20
摘要： A system for generating nitric oxide can include an apparatus positioned in a trachea of a mammal, the apparatus in-eluding a respiration sensor for collecting information related to one or more triggering events associated with the trachea, an oxygen sensor for collecting information related to a concentration of oxygen in a gas, and one or more pairs of electrodes for initiating a series of electric arcs to generate nitric oxide, and the system for generating nitric oxide can also include a controller for determining one or more control parameters based on the information collected by the respiration sensor and the oxygen sensor, wherein the series of electric arcs is initiated based on the control parameters determined by the controller.

10. 发明授权

US12011544B2 Inspiratory synthesis of nitric oxide 有权
公开(公告)号：US12011544B2
公开(公告)日：2024-06-18
申请号：US16833104
申请日：2020-03-27
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Warren M. Zapol , Binglan Yu , Paul Hardin , Matthew Hickcox
IPC分类号： A61M16/12 , A61M15/02 , A61M16/00 , A61M16/04 , A61M16/06 , A61M16/10 , A61M16/20 , B01D53/56 , C01B21/20
CPC分类号： A61M16/12 , A61M15/02 , A61M16/0003 , A61M16/0063 , A61M16/0072 , A61M16/0465 , A61M16/06 , A61M16/10 , A61M16/101 , A61M16/20 , B01D53/56 , C01B21/203 , A61M2016/0021 , A61M2016/0033 , A61M16/0057 , A61M2016/1025 , A61M2016/1035 , A61M16/107 , A61M16/108 , A61M16/202 , A61M16/209 , A61M2202/0208 , A61M2202/0216 , A61M2202/0275 , A61M2205/04 , A61M2205/33 , A61M2205/3303 , A61M2205/3334 , A61M2205/3553 , A61M2205/3561 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/3606 , A61M2205/366 , A61M2205/50 , A61M2205/7545 , A61M2210/1032 , A61M2230/40 , B01D2251/304 , B01D2251/306 , B01D2251/404
摘要： A system for generating nitric oxide can include an apparatus positioned in a trachea of a mammal, the apparatus including a respiration sensor for collecting information related to one or more triggering events associated with the trachea, an oxygen sensor for collecting information related to a concentration of oxygen in a gas, and one or more pairs of electrodes for initiating a series of electric arcs to generate nitric oxide, and the system for generating nitric oxide can also include a controller for determining one or more control parameters based on the information collected by the respiration sensor and the oxygen sensor, wherein the series of electric arcs is initiated based on the control parameters determined by the controller.

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