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1. 发明申请

US20140343248A1 METHOD FOR ENHANCING IMMUNE RESPONSE WITH PEPTIDE 审中-公开
标题翻译：用于增强与肽的免疫应答的方法
公开(公告)号：US20140343248A1
公开(公告)日：2014-11-20
申请号：US14313007
申请日：2014-06-24
申请人： THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE
发明人： Junichi MATSUDA , Kazuyoshi Kaminaka , Chikateru Nozaki
IPC分类号： C07K14/47
CPC分类号： A61K39/0007 , A61K31/711 , C07K14/4711
摘要： An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β peptide that induces an enhanced immune response. An amyloid β peptide or a portion thereof with addition or insertion of cysteine and a method for enhancing an immune response using the peptide or a method for enhancing an immune response using the peptide together with an adjuvant. A medicament for preventing or treating Alzheimer disease comprising an amyloid β peptide or a portion thereof that induces an enhanced immune response. A DNA vaccine, that may have the same effect, comprising the gene encoding an amyloid β peptide or a portion thereof that induces an enhanced immune response with addition or insertion of cysteine.
摘要翻译：本发明的目的是提供一种用于增强免疫应答的安全有效的方法和用于预防或治疗阿尔茨海默氏病的药物，其包括淀粉样蛋白诱导增强的免疫应答的肽。淀粉样蛋白肽或其部分，其中加入或插入半胱氨酸，以及使用肽增强免疫应答的方法或使用肽与佐剂一起增强免疫应答的方法。一种用于预防或治疗阿尔茨海默病的药物，其包含淀粉样蛋白肽或其部分诱导增强的免疫应答。可能具有相同作用的DNA疫苗，其包含编码淀粉样蛋白的基因; 肽或其部分，其通过加入或插入半胱氨酸诱导增强的免疫应答。

2. 发明申请

US20140044743A1 METHOD FOR ENHANCING IMMUNE RESPONSE WITH PEPTIDE 有权
标题翻译：用于增强与肽的免疫应答的方法
公开(公告)号：US20140044743A1
公开(公告)日：2014-02-13
申请号：US14018495
申请日：2013-09-05
申请人： The Chemo-Sero-Therapeutic Research Institute
发明人： Junichi MATSUDA , Kazuyoshi Kaminaka , Chikateru Nozaki
IPC分类号： A61K39/00
CPC分类号： A61K39/0007 , A61K31/711 , C07K14/4711
摘要： An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β peptide that induces an enhanced immune response. An amyloid β peptide or a portion thereof with addition or insertion of cysteine and a method for enhancing an immune response using the peptide or a method for enhancing an immune response using the peptide together with an adjuvant. A medicament for preventing or treating Alzheimer disease comprising an amyloid β peptide or a portion thereof that induces an enhanced immune response. A DNA vaccine, that may have the same effect, comprising the gene encoding an amyloid β peptide or a portion thereof that induces an enhanced immune response with addition or insertion of cysteine.
摘要翻译：本发明的目的是提供一种用于增强免疫应答的安全有效的方法和用于预防或治疗阿尔茨海默病的药物，其包含诱导增强的免疫应答的淀粉样蛋白β肽。具有添加或插入半胱氨酸的淀粉样蛋白β肽或其部分，以及使用肽增强免疫应答的方法或使用肽与佐剂一起增强免疫应答的方法。一种用于预防或治疗阿尔茨海默病的药物，其包含诱导增强的免疫应答的淀粉样蛋白β肽或其部分。可以具有相同效果的DNA疫苗，其包含编码淀粉样蛋白β肽或其部分的基因，其通过加入或插入半胱氨酸诱导增强的免疫应答。

3. 发明申请

US20160051731A1 HYBRID GEL COMPRISING PARTICULATE DECELLULARIZED TISSUE 审中-公开
标题翻译：混合凝胶包裹颗粒状细胞组织
公开(公告)号：US20160051731A1
公开(公告)日：2016-02-25
申请号：US14888871
申请日：2014-05-02
申请人： THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE , NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY , SAPPORO MEDICAL UNIVERSITY , ADEKA CORPORATION
发明人： Junichi MATSUDA , Sumika MIYABASHIRA , Satomi HARANO , Akio KISHIDA , Tsuyoshi KIMURA , Jun NEGISHI , Tetsuya HIGAMI , Seiichi FUNAMOTO , Ken-ichiro HIWATARI , Akiko TASAKI
IPC分类号： A61L27/52 , A61L27/22 , A61L27/26 , C12N5/00 , A61L27/36
CPC分类号： A61L27/52 , A61K35/22 , A61K35/30 , A61K35/34 , A61K35/407 , A61K35/42 , A61K38/363 , A61K38/4833 , A61L27/225 , A61L27/26 , A61L27/3633 , A61L27/3683 , A61L27/3691 , A61L27/3695 , A61L27/54 , A61L2430/00 , A61L2430/20 , A61L2430/32 , C12N5/0068 , C12N2533/50 , C12N2533/56 , C12N2533/90
摘要： A hybrid gel comprising a particulate decellularized tissue (obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues)), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel of the present invention exerts the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases.
摘要翻译：一种混合凝胶，其包含颗粒脱细胞组织（通过粉碎去细胞化的（来自脱细胞的生物组织）的动物衍生的生物组织），纤维蛋白原和凝血酶获得; 包含所述杂交凝胶的细胞培养物质; 制备混合凝胶的方法; 并提供了包含颗粒脱细胞组织和生物组织粘合剂的试剂盒。本发明的混合凝胶发挥促进干细胞分化和增殖功能的效果以及对各种疾病的治疗效果。

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