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1. 发明申请

US20150344420A1 PACLITAXEL ENHANCER COMPOUNDS 审中-公开
标题翻译： PACLITAXEL增强化合物
公开(公告)号：US20150344420A1
公开(公告)日：2015-12-03
申请号：US14826889
申请日：2015-08-14
申请人： Synta Pharmaceuticals Corp.
发明人： Keizo Koya , Lijun Sun , Shoujun Chen , Noriaki Tatsuta , Yaming Wu , Mitsumori Ono
IPC分类号： C07C327/56
CPC分类号： A61K31/381 , A61K31/16 , A61K31/165 , A61K31/277 , A61K31/337 , A61K31/44 , A61K31/505 , A61K31/53 , A61K47/58 , C07C327/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D209/42 , C07D209/44 , C07D213/83 , C07D261/18 , C07D305/14 , C07D307/68 , C07D333/38 , C07D333/68 , C07D407/12
摘要： Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C═Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or —C(R7R8)—.R1 and R2 are independently an aryl group or a substituted aryl group, R3 and R4 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group.R5-R6 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group.R7 and R8 are each independently —H, an aliphatic or substituted aliphatic group, or R7 is —H and R8 is a substituted or unsubstituted aryl group, or, R7 and R8, taken together, are a C2-C6 substituted or unsubstituted alkylene group.Z is ═O or ═S.Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent.Also disclosed is a method of treating a subject with cancer by administering to the subject a compound of Structural Formula (I) in combination with Paclitaxel or an analog of Paclitaxel.
摘要翻译：公开了由结构式（I）表示的化合物：Y是共价键，亚苯基或取代或未取代的直链烃基。此外，Y与它所键合的两个> C = Z基团一起是取代或未取代的芳族基团。优选Y为共价键或-C（R 7 R 8） - 。 R 1和R 2独立地是芳基或取代的芳基，R 3和R 4独立地是-H，脂族基团，取代的脂族基团，芳基或取代的芳基。 R5-R6独立地是-H，脂族基团，取代的脂族基团，芳基或取代的芳基。 R 7和R 8各自独立地为-H，脂族或取代的脂族基团，或者R 7为-H且R 8为取代或未取代的芳基，或者R 7和R 8一起为C 2 -C 6取代或未取代的亚烷基。 Z为═O或═S。还公开了包含本发明化合物和药学上可接受的载体或稀释剂的药物组合物。还公开了通过向受试者施用结合式（I）的化合物与紫杉醇或紫杉醇的类似物组合来治疗患有癌症的受试者的方法。

2. 发明申请

US20150266829A1 COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES 有权
标题翻译：用于炎症和免疫相关用途的化合物
公开(公告)号：US20150266829A1
公开(公告)日：2015-09-24
申请号：US14731862
申请日：2015-06-05
申请人： Synta Pharmaceuticals Corp.
发明人： Lijun Sun , Shoujun Chen , Jun Jiang , Yu Xie , Chih-Yi Yu
IPC分类号： C07D241/20 , C07D417/14 , C07D413/14 , C07D401/12 , C07D413/10
CPC分类号： C07D241/20 , A61K31/495 , A61K31/4965 , A61K31/497 , A61K31/50 , A61K31/505 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/14 , Y02A50/422
摘要： The invention relates to compounds of structural formula (I) and structural formula (VI): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein R, R1, R2, Z, L, and n are defined herein. Those compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译：本发明涉及结构式（I）和结构式（VI）的化合物或其药学上可接受的盐，溶剂化物，包合物或前药，其中R，R 1，R 2，Z，L和n如本文所定义。这些化合物可用作免疫抑制剂和用于治疗和预防炎性病症，过敏性疾病和免疫疾病。

3. 发明申请

US20140242099A1 COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES 审中-公开
公开(公告)号：US20140242099A1
公开(公告)日：2014-08-28
申请号：US14354644
申请日：2012-10-26
申请人： Synta Pharmaceuticals Corp.
发明人： Shoujun Chen , Junyi Zhang , Jun Jiang , Teresa Kowalczyk-Przewloka , Zhiqiang Xia , Shijie Zhang
IPC分类号： C07D417/14 , A61K31/4439 , C07D403/10 , C07D401/12 , C07D401/14 , C07D417/04 , A61K45/06
CPC分类号： C07D417/14 , A61K31/4439 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/10 , C07D417/04
摘要： The invention relates to certain compounds or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

4. 发明申请

US20140107134A1 COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES 审中-公开
标题翻译：用于炎症和免疫相关用途的化合物
公开(公告)号：US20140107134A1
公开(公告)日：2014-04-17
申请号：US14040310
申请日：2013-09-27
申请人： Synta Pharmaceuticals Corp.
发明人： Yu Xie , Mats Holmqvist , Jerome Mahiou , Mitsunori Ono , Lijun Sun , Shoujun Chen , Shijie Zhang , Jun Jiang , Dinesh Chimmanamada , Chih-Yi Yu
IPC分类号： C07C233/66 , C07C237/42 , C07D333/38 , C07D239/28 , C07D263/34 , C07D231/14 , C07D285/06 , C07D213/81 , C07D277/56
CPC分类号： C07C233/66 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/535 , C07C237/42 , C07D213/81 , C07D231/14 , C07D239/28 , C07D263/34 , C07D277/56 , C07D285/06 , C07D333/38 , Y02A50/422
摘要： The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中X，Y，A，Z，L和n如本文所定义。这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症和免疫疾病。

5. 发明申请

US20130236481A1 HETEROCYCLE -ARYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES 审中-公开
标题翻译：用于炎症和免疫相关用途的异喹啉化合物
公开(公告)号：US20130236481A1
公开(公告)日：2013-09-12
申请号：US13855803
申请日：2013-04-03
申请人： SYNTA PHARMACEUTICALS CORP.
发明人： Shoujun Chen
IPC分类号： A61K39/00
CPC分类号： A61K39/00 , C07D333/22 , C07D333/38 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The invention relates to compounds that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译：本发明涉及可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病的化合物。

6. 发明申请

US20170231984A1 COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES 审中-公开
公开(公告)号：US20170231984A1
公开(公告)日：2017-08-17
申请号：US15424097
申请日：2017-02-03
申请人： Synta Pharmaceuticals Corp.
发明人： Shoujun Chen , Gary Bohnert , Jun Jiang , Zhiqiang Xia
IPC分类号： A61K31/497
CPC分类号： C07D417/14 , A61K31/165 , A61K31/44 , A61K31/497 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14
摘要： The invention relates to certain compounds or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.

7. 发明授权

US09175022B2 Compounds for the treatment of proliferative disorders 有权
公开(公告)号：US09175022B2
公开(公告)日：2015-11-03
申请号：US13956534
申请日：2013-08-01
申请人： Synta Pharmaceuticals Corp.
发明人： Zachary Demko , Christopher Borella , Shoujun Chen , Lijun Sun
IPC分类号： A61K31/4192 , A61K31/422 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/501 , A61K31/506 , A61K31/675 , C07F9/6518 , C07D249/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D401/10 , C07D403/10 , C07D403/12 , C07D405/04 , C07D413/10
CPC分类号： C07F9/6518 , A61K31/4192 , A61K31/422 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/501 , A61K31/506 , A61K31/675 , C07D249/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/10
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.

8. 发明申请

US20150005320A9 COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES 审中-公开
标题翻译：用于炎症和免疫相关用途的化合物
公开(公告)号：US20150005320A9
公开(公告)日：2015-01-01
申请号：US14040310
申请日：2013-09-27
申请人： Synta Pharmaceuticals Corp.
发明人： Yu Xie , Mats Holmqvist , Jerome Mahiou , Mitsunori Ono , Lijun Sun , Shoujun Chen , Shijie Zhang , Jun Jiang , Dinesh Chimmanamada , Chih-Yi Yu
IPC分类号： C07C233/66 , C07C237/42 , C07D333/38 , C07D239/28 , C07D263/34 , C07D231/14 , C07D285/06 , C07D213/81 , C07D277/56
CPC分类号： C07C233/66 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/535 , C07C237/42 , C07D213/81 , C07D231/14 , C07D239/28 , C07D263/34 , C07D277/56 , C07D285/06 , C07D333/38 , Y02A50/422
摘要： The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中X，Y，A，Z，L和n如本文所定义。这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症和免疫疾病。

9. 发明申请

US20140242120A1 SUBSTITUTED AROMATIC COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES 审中-公开
标题翻译：取代的芳香化合物用于炎症和免疫相关用途
公开(公告)号：US20140242120A1
公开(公告)日：2014-08-28
申请号：US14272727
申请日：2014-05-08
申请人： Synta Pharmaceuticals Corp.
发明人： Shoujun Chen , Lijun Sun , Yu Xie
IPC分类号： C07D263/32 , C07C275/42 , C07D413/12 , C07D213/75 , C07D277/28 , C07D417/12
CPC分类号： C07D263/32 , C07C243/38 , C07C275/42 , C07D213/75 , C07D237/20 , C07D239/42 , C07D271/10 , C07D277/28 , C07D277/56 , C07D333/34 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein Y, L, A, W1, W2, and R′1 are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译：本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中Y，L，A，W1，W2和R'1如本文所定义。这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病。

10. 发明申请

US20140107132A1 SUBSTITUTED PYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES 审中-公开
标题翻译：用于炎症和免疫相关用途的替代吡啶化合物
公开(公告)号：US20140107132A1
公开(公告)日：2014-04-17
申请号：US14108864
申请日：2013-12-17
申请人： Synta Pharmaceuticals Corp.
发明人： Shoujun Chen , Junyi Zhang , Jun Jiang , Gary Bohnert , Nha Huu Vo , Qinglin Che , Zhiqiang Xia , Lijun Sun
IPC分类号： C07D417/14 , C07D409/06 , C07D409/14 , C07D417/04
CPC分类号： C07D417/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The invention relates to certain compounds of Formula (I): or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译：本发明涉及可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病的某些式（I）化合物或其药学上可接受的盐，溶剂合物，包合物或前药。

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