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1. 发明申请

US20110256154A1 ANTI-ERBB3 ANTIBODIES 有权
标题翻译：抗ERBB3抗体
公开(公告)号：US20110256154A1
公开(公告)日：2011-10-20
申请号：US13082852
申请日：2011-04-08
申请人： Sylvie Vincent , William M. Winston, JR. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Botega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
发明人： Sylvie Vincent , William M. Winston, JR. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Botega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
IPC分类号： A61K39/395 , C07H21/00 , C12P21/00 , C12N15/63 , C12N1/00 , C12N5/10 , C07K16/28 , A61P35/00
CPC分类号： C07K16/32 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3.
摘要翻译：公开了结合并抑制表皮生长因子受体相关成分ErbB3 / HER3活化的单克隆抗体。抗体可用于治疗与ErbB3 / HER3的激活相关的细胞增殖性疾病和病症，包括某些形式的癌症。

2. 发明授权

US08481687B2 Anti-ErbB3 antibodies 有权
标题翻译：抗ErbB3抗体
公开(公告)号：US08481687B2
公开(公告)日：2013-07-09
申请号：US13082852
申请日：2011-04-08
申请人： Sylvie Vincent , William M. Winston, Jr. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Bottega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
发明人： Sylvie Vincent , William M. Winston, Jr. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Bottega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
IPC分类号： C07K16/28
CPC分类号： C07K16/32 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3.
摘要翻译：公开了结合并抑制表皮生长因子受体相关成分ErbB3 / HER3活化的单克隆抗体。抗体可用于治疗与ErbB3 / HER3的激活相关的细胞增殖性疾病和病症，包括某些形式的癌症。

3. 发明申请

US20050282649A1 Golf flagstick ferrule and method of use 有权
标题翻译：高尔夫旗杆套圈及使用方法
公开(公告)号：US20050282649A1
公开(公告)日：2005-12-22
申请号：US10870836
申请日：2004-06-17
申请人： Scott Hottle , Steven Tyler
发明人： Scott Hottle , Steven Tyler
IPC分类号： A63B57/00 , A63B69/36
CPC分类号： A63B57/357 , A63B57/40
摘要： A ferrule that includes a ledge having an underside with indentations. The indentations cooperating with a golf putting cup that has a ferrule socket formed by a plurality of primary fins. The ferrule and ferrule socket cooperating to prevent spinning of the flag, resist wear, and provide a straight standing flagstick.
摘要翻译：一种套圈，其包括具有凹陷的下侧的凸缘。与高尔夫球杯配合的凹槽具有由多个主翅片形成的套圈座。套圈和套管座配合防止旗子旋转，抵抗磨损，并提供直立的旗杆。

4. 发明申请

US20130066342A1 GRIPPER PUSHER MECHANISM FOR TISSUE APPOSITION SYSTEMS 有权
公开(公告)号：US20130066342A1
公开(公告)日：2013-03-14
申请号：US13231586
申请日：2011-09-13
申请人： Kent Dell , Theodore Ketai , Tanmay Mishra , Stephanie Jones , Jacob Greenberg , Michael Hong , Daniel Hale , Francisco Valencia , Steven Tyler
发明人： Kent Dell , Theodore Ketai , Tanmay Mishra , Stephanie Jones , Jacob Greenberg , Michael Hong , Daniel Hale , Francisco Valencia , Steven Tyler
IPC分类号： A61B17/03
CPC分类号： A61B17/083 , A61B17/08 , A61B17/10 , A61B2017/00243 , A61F2/2454 , A61F2/2466
摘要： The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.

5. 发明申请

US20060076064A1 Valve assembly 有权
标题翻译：阀组件
公开(公告)号：US20060076064A1
公开(公告)日：2006-04-13
申请号：US11198339
申请日：2005-08-05
申请人： Jeffrey Carter , Kelly McCloy , Steven Tyler
发明人： Jeffrey Carter , Kelly McCloy , Steven Tyler
IPC分类号： F17D1/20
CPC分类号： B08B3/026 , B08B3/02 , F16K15/044 , Y10T137/7866 , Y10T137/86413 , Y10T137/87547 , Y10T137/87555
摘要： A valve assembly, includes a first lumen; a second lumen providing fluid communication between a plurality of points in said first lumen; and a ball and spring assembly sealingly disposed in said first lumen between said plurality of points, wherein said spring exerts a force on said ball to seal said first lumen; wherein said valve assembly is configured to oscillate a pressure of a fluid passing through said valve assembly.
摘要翻译：阀组件包括第一管腔; 第二内腔，其在所述第一管腔中的多个点之间提供流体连通; 以及密封地设置在所述多个点之间的所述第一内腔中的球和弹簧组件，其中所述弹簧对所述球施加力以密封所述第一腔; 其中所述阀组件被构造成摆动通过所述阀组件的流体的压力。

6. 发明授权

US07464724B2 Valve assembly 有权
标题翻译：阀组件
公开(公告)号：US07464724B2
公开(公告)日：2008-12-16
申请号：US11198339
申请日：2005-08-05
申请人： Jeffrey W. Carter , Kelly H. McCloy , Steven Tyler
发明人： Jeffrey W. Carter , Kelly H. McCloy , Steven Tyler
IPC分类号： F16K15/04 , F16K11/10
CPC分类号： B08B3/026 , B08B3/02 , F16K15/044 , Y10T137/7866 , Y10T137/86413 , Y10T137/87547 , Y10T137/87555
摘要： A valve assembly, includes a first lumen; a second lumen providing fluid communication between a plurality of points in said first lumen; and a ball and spring assembly sealingly disposed in said first lumen between said plurality of points, wherein said spring exerts a force on said ball to seal said first lumen; wherein said valve assembly is configured to oscillate a pressure of a fluid passing through said valve assembly.
摘要翻译：阀组件包括第一管腔; 第二内腔，其在所述第一管腔中的多个点之间提供流体连通; 以及密封地设置在所述多个点之间的所述第一内腔中的球和弹簧组件，其中所述弹簧对所述球施加力以密封所述第一腔; 其中所述阀组件被构造成摆动通过所述阀组件的流体的压力。

7. 发明申请

US20070191926A1 Stent pattern for high stent retention 审中-公开
标题翻译：高支架保留的支架图案
公开(公告)号：US20070191926A1
公开(公告)日：2007-08-16
申请号：US11353391
申请日：2006-02-14
申请人： Alexander Nikanorov , Keif Fitzgerald , Steven Tyler , Boris Anukhin
发明人： Alexander Nikanorov , Keif Fitzgerald , Steven Tyler , Boris Anukhin
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/825 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2230/0054
摘要： An expandable stent has larger cells located at the distal end of the stent than in the body portion so that a catheter balloon can more easily protrude into the cells to increase stent retention relative to the balloon. The intravascular stent has a plurality of cylindrical rings connected by links, the spacing of which is a factor in defining the cell size. The stent can be compressed or crimped onto a balloon catheter to a very low profile and maintain a high degree of stent retention due to increased spacing between rings in the region of the distal end ring.
摘要翻译：可扩张支架具有位于支架远端的较大的细胞，而不是在体部，使得导管球囊可以更容易地突出到细胞中，以增加相对于球囊的支架保留。血管内支架具有通过链节连接的多个圆柱形环，其间距是限定细胞大小的因素。可以将支架压缩或卷曲到气球导管上以非常低的轮廓并且由于远端环区域中的环之间的间隔增加而保持高度的支架保持。

8. 发明授权

US08945177B2 Gripper pusher mechanism for tissue apposition systems 有权
标题翻译：用于组织并置系统的夹爪推动机构
公开(公告)号：US08945177B2
公开(公告)日：2015-02-03
申请号：US13231586
申请日：2011-09-13
申请人： Kent Dell , Theodore Ketai , Tanmay Mishra , Stephanie Jones , Jacob Greenberg , Michael Hong , Daniel Hale , Francisco Valencia , Steven Tyler
发明人： Kent Dell , Theodore Ketai , Tanmay Mishra , Stephanie Jones , Jacob Greenberg , Michael Hong , Daniel Hale , Francisco Valencia , Steven Tyler
IPC分类号： A61B17/03 , A61B17/08 , A61B17/10 , A61F2/24 , A61B17/00
CPC分类号： A61B17/083 , A61B17/08 , A61B17/10 , A61B2017/00243 , A61F2/2454 , A61F2/2466
摘要： The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site. In addition, many of the devices and systems of the invention are adapted to be reversible and removable from the patient at any point without interference with or trauma to internal tissues.
摘要翻译：本发明提供了用于在治疗部位组织近似和修复的装置，系统和方法。本发明的装置，系统和方法将用于各种治疗方法，包括血管内，微创和开放性外科手术，并可用于各种解剖学领域，包括腹部，胸部，心血管系统，心脏，肠道，胃，尿道，膀胱，肺和其他器官，血管和组织。本发明在需要微创或血管内进入远程组织位置的那些程序中特别有用，其中所使用的仪器必须协商到治疗部位的长，窄和曲折的路径。此外，本发明的许多装置和系统适于在任何点处可逆地从患者移除，而不会干扰或损伤内部组织。

9. 发明授权

US06499434B1 Dog kennel 失效
标题翻译：狗窝
公开(公告)号：US06499434B1
公开(公告)日：2002-12-31
申请号：US09767275
申请日：2001-01-23
申请人： Steven Tyler
发明人： Steven Tyler
IPC分类号： A01K3107
CPC分类号： A01K1/0272 , B60R9/00
摘要： The kennel for mounting on a pick-up truck has left and right kennel support plates. Front and rear trusses have their ends fixed to the left and right support plates. A roof panel is attached to the front and rear trusses. A rear wall is pivotally attached to the rear truss and extends vertically downward from a horizontal pivot axis when in a closed position. The rear wall pivots about the pivot axis to a vertical position above the pivot axis and adjacent to the rear side of the rear truss to provide ingress and egress. Side openings in the kennel permit a dog to extend his nose and at least part of his head from the kennel. An adjustable bar changes the height and the size of each side opening. The support plates hold the entire weight of the kennel.
摘要翻译：用于安装在皮卡车上的狗舍具有左右狗舍支撑板。前后桁架的端部固定在左右支撑板上。顶板与前后桁架连接。后壁可枢转地附接到后部桁架，并且当处于关闭位置时从后部竖向向下延伸。后壁围绕枢转轴线枢转到枢转轴线上方的垂直位置并且邻近后部桁架的后侧以提供入口和出口。狗窝的侧面开口允许一只狗伸出鼻子，至少部分头部从狗窝里伸出来。可调节杆可以改变每个侧面开口的高度和尺寸。支撑板保持狗窝的整个重量。

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