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1. 发明授权

US07968546B2 Pyridazinone kinase inhibitors 失效
标题翻译：哒嗪酮激酶抑制剂
公开(公告)号：US07968546B2
公开(公告)日：2011-06-28
申请号：US12359754
申请日：2009-01-26
申请人： Swen Hoelder , Gunter Muller , Karl Schoenafinger , David William Will , Hans Matter , Martin Bossart , Cecile Combeau , Christine Delaisi , Ingrid Sassoon , Anke Steinmetz , Didier Benard
发明人： Swen Hoelder , Gunter Muller , Karl Schoenafinger , David William Will , Hans Matter , Martin Bossart , Cecile Combeau , Christine Delaisi , Ingrid Sassoon , Anke Steinmetz , Didier Benard
IPC分类号： C07D401/04 , A61K31/501 , A61P29/00 , A61P7/12 , A61P3/10 , A61P25/28 , A61P35/00
CPC分类号： C07D403/04 , C07D401/14
摘要： Disclosed are compounds of Formula I wherein X is and R2, R1, A, B, D, E, R9 are as defined herein useful for treating cancers.
摘要翻译：公开了式I的化合物，其中X和R 2，R 1，A，B，D，E，R 9如本文所定义，可用于治疗癌症。

2. 发明授权

US07754713B2 4-benzimidazol-2-ylpyridazin-3-one derivatives 失效
标题翻译： 4-苯并咪唑-2-基哒嗪-3-酮衍生物
公开(公告)号：US07754713B2
公开(公告)日：2010-07-13
申请号：US12251572
申请日：2008-10-15
申请人： Swen Hoelder , Karl Schoenafinger , David William Will , Hans Matter , Gunter Muller , Cecile Combeau , Christine Delaisi , Anke Steinmetz , Ingrid Sassoon
发明人： Swen Hoelder , Karl Schoenafinger , David William Will , Hans Matter , Gunter Muller , Cecile Combeau , Christine Delaisi , Anke Steinmetz , Ingrid Sassoon
IPC分类号： A61K31/501 , A61K31/5355 , A61P35/00 , C07D401/14 , C07D403/04 , C07D413/14
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D471/04
摘要： Disclosed are compounds of the general formula (I), where the definition of the substituents A, B, D, E, R1 and R2 are detailed in the description, and the physiologically tolerated salts thereof, a process for the preparation of these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2).
摘要翻译：公开了通式（I）的化合物，其中取代基A，B，D，E，R 1和R 2的定义在说明书中详细描述，以及其生理上可耐受的盐，这些化合物的制备方法和它们用作药物。这些化合物是激酶抑制剂，特别是激酶CDK2（细胞周期蛋白依赖性激酶2）的抑制剂。

3. 发明授权

US07507734B2 Pyridazinone derivatives 失效
标题翻译：哒嗪酮衍生物
公开(公告)号：US07507734B2
公开(公告)日：2009-03-24
申请号：US11560620
申请日：2006-11-16
申请人： Swen Hoelder , Gunter Muller , Karl Schoenafinger , David William Will , Hans Matter , Martin Bossart , Cecile Combeau , Christine Delaisi , Ingrid Sassoon , Anke Steinmetz , Didier Benard
发明人： Swen Hoelder , Gunter Muller , Karl Schoenafinger , David William Will , Hans Matter , Martin Bossart , Cecile Combeau , Christine Delaisi , Ingrid Sassoon , Anke Steinmetz , Didier Benard
IPC分类号： A61K31/501 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D487/04 , A61K31/53 , A61K31/5355 , A61P35/00
CPC分类号： C07D403/04 , C07D401/14
摘要： Disclosed are compounds according to the general formula (I), where the definitions of the substituents X, R1 and R2 are detailed in the description, as well as their physiologically acceptable salts and solvate, methods for producing these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2).
摘要翻译：公开了根据通式（I）的化合物，其中取代基X，R 1和R 2的定义在说明书中详细描述，以及它们的生理上可接受的盐和溶剂合物，这些化合物的制备方法及其作为药物的用途。这些化合物是激酶抑制剂，特别是激酶CDK2（细胞周期蛋白依赖性激酶2）的抑制剂。

4. 发明申请

US20070173503A1 Novel 4-benzimidazol-2-ylpyridazin-3-one derivatives 失效
标题翻译：新的4-苯并咪唑-2-基哒嗪-3-酮衍生物
公开(公告)号：US20070173503A1
公开(公告)日：2007-07-26
申请号：US11513574
申请日：2006-08-31
申请人： Swen Hoelder , Karl Schoenafinger , David Will , Hans Matter , Gunter Muller , Cecile Combeau , Christine Delaisi , Anke Steinmetz , Ingrid Sassoon
发明人： Swen Hoelder , Karl Schoenafinger , David Will , Hans Matter , Gunter Muller , Cecile Combeau , Christine Delaisi , Anke Steinmetz , Ingrid Sassoon
IPC分类号： A61K31/53 , A61K31/501 , A61K31/52 , C07D487/02
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D471/04
摘要： Disclosed are compounds of the general formula (I), where the definition of the substituents A, B, D, E, R1 and R2 are detailed in the description, and the physiologically tolerated salts thereof, a process for the preparation of these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2)
摘要翻译：公开了通式（I）的化合物，其中取代基A，B，D，E，R 1和R 2的定义在说明书中详细描述，及其生理上耐受的盐，这些化合物的制备方法及其作为药物的用途。这些化合物是激酶抑制剂，特别是激酶CDK2（细胞周期蛋白依赖性激酶2）的抑制剂，

5. 发明申请

US20070259870A1 Novel Pyridazinone Derivatives 失效
标题翻译：新型哒嗪酮衍生物
公开(公告)号：US20070259870A1
公开(公告)日：2007-11-08
申请号：US11560620
申请日：2006-11-16
申请人： Swen HOELDER , Gunter Muller , Karl Schoenafinger , David Will , Hans Matter , Martin Bossart , Cecile Combeau , Christine Delaisi , Ingrid Sassoon , Anke Steinmetz , Didier Bernard
发明人： Swen HOELDER , Gunter Muller , Karl Schoenafinger , David Will , Hans Matter , Martin Bossart , Cecile Combeau , Christine Delaisi , Ingrid Sassoon , Anke Steinmetz , Didier Bernard
IPC分类号： A61K31/501 , A61K31/5377 , A61P35/00 , A61P35/02 , C07D401/14 , C07D403/04 , C07D413/14
CPC分类号： C07D403/04 , C07D401/14
摘要： Disclosed are compounds according to the general formula (I), where the definitions of the substituents X, R1 and R2 are detailed in the description, as well as their physiologically acceptable salts and solvate, methods for producing these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2).
摘要翻译：公开了根据通式（I）的化合物，其中取代基X，R 1和R 2的定义在说明书中详细描述，以及它们的生理学可接受的盐和溶剂化物，制备这些化合物的方法及其作为药物的用途。这些化合物是激酶抑制剂，特别是激酶CDK2（细胞周期蛋白依赖性激酶2）的抑制剂。

6. 发明授权

US09644017B2 Insulin derivatives having an extremely delayed time-action profile 有权
公开(公告)号：US09644017B2
公开(公告)日：2017-05-09
申请号：US12820722
申请日：2010-06-22
申请人： Paul Habermann , Gerhard Seipke , Roland Kurrle , Gunter Muller , Mark Sommerfeld , Norbert Tennagels , Georg Tschank , Ulrich Werner
发明人： Paul Habermann , Gerhard Seipke , Roland Kurrle , Gunter Muller , Mark Sommerfeld , Norbert Tennagels , Georg Tschank , Ulrich Werner
IPC分类号： A61K38/00 , C07K2/00 , C07K14/62
CPC分类号： C07K14/62 , A61K38/00
摘要： The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid residue such as lysine or arginine amide; b) the N-terminal amino acid residue of the insulin A chain is a lysine or arginine radical; c) the amino acid position A8 is occupied by a histidine radical; d) the amino acid position A21 is occupied by a glycine radical; and e) one or more substitutions and/or additions of negatively charged amino acid residues are carried out in the positions A5, A15, A18, B-1, B0, B1, B2, B3 and B4.

7. 发明申请

US20090076068A1 IMIDAZOPYRIDIN-2-ONE DERIVATIVES AS INHIBITORS OF LIPASES AND PHOSPHOLIPASES 有权
标题翻译：作为药物和磷脂抑制剂的咪达唑啶-2-酮衍生物
公开(公告)号：US20090076068A1
公开(公告)日：2009-03-19
申请号：US12235053
申请日：2008-09-22
申请人： Gerhard Zoller , Stefan Petry , Markus Follmann , Gunter Muller , Norbert Tennagels
发明人： Gerhard Zoller , Stefan Petry , Markus Follmann , Gunter Muller , Norbert Tennagels
IPC分类号： A61K31/4355 , C07D471/04 , A61K31/437 , A61P3/10 , A61P3/06 , A61P9/10
CPC分类号： C07D471/04
摘要： The present invention relates to imidazopyridin-2-one derivatives of the formula I with the definitions specified in the description, to their pharmaceutically usable salts and to their use as medicaments.
摘要翻译：本发明涉及式I的咪唑并吡啶-2-酮衍生物，其描述中定义的定义，其药学上可用的盐及其作为药物的用途。

8. 发明申请

US20060275319A1 Saccharomyces cerevisiae yeast strain with functional expression of a GLUT transporter 有权
标题翻译：具有葡萄糖转运蛋白功能性表达的酿酒酵母菌株
公开(公告)号：US20060275319A1
公开(公告)日：2006-12-07
申请号：US11399990
申请日：2006-04-07
申请人： Gunter Muller , Klaus-Peter Koller , Eckhard Boles , Roman Wieczorke , Silke Dlugai
发明人： Gunter Muller , Klaus-Peter Koller , Eckhard Boles , Roman Wieczorke , Silke Dlugai
IPC分类号： A61K36/06 , C12N15/74 , C12N1/18
CPC分类号： C12R1/865 , C12N1/18
摘要： The invention relates to a strain of the yeast Saccharomyces cerevisiae which, owing to deletion of the genomic sequences, no longer synthesizes hexose transporters and, as a consequence, can no longer grow on substrates with hexoses as the only carbon source, and whose ability of growing on a substrate with a hexose as the only carbon source is restored when it expresses a GLUT4 gene.
摘要翻译：本发明涉及酵母酿酒酵母菌株，其由于基因组序列的缺失而不再合成己糖转运蛋白，因此不能再以己糖作为唯一的碳源在底物上生长，并且其能力生长在具有己糖的底物上，当其表达GLUT4基因时，唯一的碳源被还原。

9. 发明申请

US20060218851A1 Insect trap device 审中-公开
标题翻译：昆虫陷阱装置
公开(公告)号：US20060218851A1
公开(公告)日：2006-10-05
申请号：US11094341
申请日：2005-03-30
申请人： Robert Weiss , Gunter Muller , E. Nelson
发明人： Robert Weiss , Gunter Muller , E. Nelson
IPC分类号： A01M1/08 , A01M1/02
CPC分类号： A01M1/08 , A01M1/023 , A01M2200/012
摘要： A device is disclosed for trapping mosquitoes. The device includes a housing, a bag and a fan located in the housing. The fan creates capture zone with an air flow towards the bag. A plurality of light sources attract mosquitoes to the capture zone. The light sources include an ultraviolet light, a plurality of light emitting diodes, and an incandescent light. A heat source also attracts the mosquitoes to the capture zone.
摘要翻译：公开了一种用于捕获蚊子的装置。该装置包括壳体，袋子和位于壳体中的风扇。风扇创建捕获区域，气流朝向袋子。多个光源将蚊子吸引到捕获区域。光源包括紫外光，多个发光二极管和白炽灯。热源也将蚊子吸引到捕获区。

10. 发明授权

US5040587A Foundry mold forming production method and system 失效
标题翻译：铸造模具成型生产方法和系统
公开(公告)号：US5040587A
公开(公告)日：1991-08-20
申请号：US490090
申请日：1990-03-07
申请人： Gunter Muller
发明人： Gunter Muller
IPC分类号： B22C11/10 , B22C11/04 , B22C15/02
CPC分类号： B22C11/04 , B22C15/02
摘要： To permit greater through-put of a mold box filling and compacting system, mold boxes are moved vertically by a lifting table which passes through the station transport turret (10) to place a pattern or mold carrier plate (11, 12) in the mold box, and, upon continued vertical movement, placing a filling frame (14) about the mold box, and, upon further vertical movement, placing the thus formed subassembly in engagement with a sand filling apparatus (15). Upon subsequent lowering, the subassembly is returned to the turret, the turret rotates and places the subassembly in position for alignment with a compacting station, raises the subassembly to the compacting station for compaction of the sand about the model or pattern. The subassembly is then lowered; after lowering for a short distance, the fill pattern transport, for example another turret or pivotable arm system, is placed in interfering position with the filling frame so that it is stripped off the mold box which is then lowered on a removal conveyor, for removal from the compacting station; continued downward movement at the compacting station table then places the now freed pattern or model carrier plate again on the station transport turret for return to the first position. Sand filling and compaction can be carried out simultaneously on sequentially arriving mold boxes under control of a control system (C) which controls appropriate sequencing.
摘要翻译：为了允许模具盒填充和压实系统的更大的通过，模具箱通过提升台垂直移动，该提升台通过站运输转台（10），以将图案或模具托板（11,12）放置在模具并且在连续的垂直移动时，将填充框架（14）放置在模具箱周围，并且在进一步的垂直运动时，将如此形成的子组件放置成与填砂装置（15）接合。在随后的下降之后，子组件返回到转台，转台旋转并将子组件放置在与压实工位对准的位置，将组件升高到压实工位，以压实围绕模型或模式的沙子。然后将组件降低; 在下降很短距离之后，填充图案传送，例如另一个转塔或可枢转臂系统被放置在与填充框架的干涉位置，使其从模具盒剥离，然后将其下降到移除输送机上，以便移除从压实站; 在压实站台继续向下运动，然后将现在释放的模式或模型载板再次放置在站运输转塔上以返回到第一位置。在控制适当测序的控制系统（C）的控制下，可以在顺序到达的模具箱上同时进行填沙和压实。

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