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1. 发明申请

US20100248312A1 Alanine 2,3-aminomutases and related polynucleotides 有权
标题翻译：丙氨酸2,3-氨基变位酶和相关多核苷酸
公开(公告)号：US20100248312A1
公开(公告)日：2010-09-30
申请号：US11581946
申请日：2006-10-16
申请人： Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
发明人： Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
IPC分类号： C12P13/06 , C12N9/90 , C07H21/04 , C12N15/63 , C12N1/20
CPC分类号： C12N9/90 , C12P13/06
摘要： The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.
摘要翻译：本公开一般涉及具有改进的丙氨酸2,3-氨基变位酶（AAM）活性的多肽，编码AAM多肽的多核苷酸，以及用于表达AAM多肽的表达载体和宿主细胞。

2. 发明授权

US08030051B2 Alanine 2,3-aminomutases and related polynucleotides 有权
标题翻译：丙氨酸2,3-氨基变位酶和相关多核苷酸
公开(公告)号：US08030051B2
公开(公告)日：2011-10-04
申请号：US11581946
申请日：2006-10-16
申请人： Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
发明人： Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
IPC分类号： C12N9/90 , C12N1/20 , C12N15/70 , C12P13/06
CPC分类号： C12N9/90 , C12P13/06
摘要： The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.
摘要翻译：本公开一般涉及具有改进的丙氨酸2,3-氨基变位酶（AAM）活性的多肽，编码AAM多肽的多核苷酸，以及用于表达AAM多肽的表达载体和宿主细胞。

3. 发明申请

US20120040437A1 ALANINE 2,3-AMINOMUTASES AND RELATED POLYNUCLEOTIDES 审中-公开
标题翻译： ALANINE 2,3-AMINOMUTASES和相关多核苷酸
公开(公告)号：US20120040437A1
公开(公告)日：2012-02-16
申请号：US13223604
申请日：2011-09-01
申请人： Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
发明人： Svetlana Balatskaya , Birthe Borup , Ranjini Chatterjee , Ish Dhawan , Richard J. Fox , Kenneth W. Mitchell , Emily C. Mundorff , Les Partridge , Matthew Tobin
IPC分类号： C12N9/90
CPC分类号： C12N9/90 , C12P13/06
摘要： The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.
摘要翻译：本公开一般涉及具有改进的丙氨酸2,3-氨基变位酶（AAM）活性的多肽，编码AAM多肽的多核苷酸，以及用于表达AAM多肽的表达载体和宿主细胞。

4. 发明授权

US07790432B2 Alanine 2,3-aminomutases and related polynucleotides 有权
标题翻译：丙氨酸2,3-氨基变位酶和相关多核苷酸
公开(公告)号：US07790432B2
公开(公告)日：2010-09-07
申请号：US11919271
申请日：2005-10-25
申请人： Ranjini Chatterjee , Kenneth W. Mitchell , Susan Y. Louie , Richard J. Fox , Michelle Chen
发明人： Ranjini Chatterjee , Kenneth W. Mitchell , Susan Y. Louie , Richard J. Fox , Michelle Chen
IPC分类号： C12N9/88 , C12N1/20 , C12N1/00 , C12N15/00 , C07H21/02
CPC分类号： C12N9/90
摘要： The present invention is directed to polypeptides that have enhanced alanine 2,3-aminomutase (AAM) activity and/or thermostability relative to the wild-type enzymes that have incidental AAM activity as a result of cross reactivity with alanine. In addition, the present invention is directed to a polynucleotides that encodes for the AAM polypeptides of the present invention, to nucleic acid sequences comprising the polynucleotides, to expression vectors comprising the polynucleotides operatively linked to a promoter, to host cells transformed to express the AAM polypeptides, and to a method for producing the AAM polypeptides of the present invention.
摘要翻译：本发明涉及相对于具有与丙氨酸交叉反应性的结果具有附带的AAM活性的野生型酶具有增强的丙氨酸2,3-氨基变位酶（AAM）活性和/或热稳定性的多肽。此外，本发明涉及编码本发明的AAM多肽的多核苷酸，包含多核苷酸的核酸序列与包含与启动子可操作连接的多核苷酸的表达载体，转染以表达AAM的宿主细胞多肽，以及用于制备本发明的AAM多肽的方法。

5. 发明申请

US20100099143A1 Alanine 2,3-aminomutases and related polynucleotides 有权
公开(公告)号：US20100099143A1
公开(公告)日：2010-04-22
申请号：US11919271
申请日：2005-10-25
申请人： Ranjini Chatterjee , Kenneth W. Mitchell , Susan Y. Louie , Richard J. Fox , Michelle Chen
发明人： Ranjini Chatterjee , Kenneth W. Mitchell , Susan Y. Louie , Richard J. Fox , Michelle Chen
IPC分类号： C12P21/02 , C12N9/10 , C12N15/11 , C12N15/00 , C12N1/21
CPC分类号： C12N9/90
摘要： The present invention is directed to polypeptides that have enhanced alanine 2,3-aminomutase (AAM) activity and/or thermostability relative to the wild-type enzymes that have incidental AAM activity as a result of cross reactivity with alanine. In addition, the present invention is directed to a polynucleotides that encodes for the AAM polypeptides of the present invention, to nucleic acid sequences comprising the polynucleotides, to expression vectors comprising the polynucleotides operatively linked to a promoter, to host cells transformed to express the AAM polypeptides, and to a method for producing the AAM polypeptides of the present invention.

6. 发明授权

US08430036B1 Multiple diverging projectile system 失效
标题翻译：多发射射弹系统
公开(公告)号：US08430036B1
公开(公告)日：2013-04-30
申请号：US13585868
申请日：2012-08-15
申请人： Mark H. Machina , Michael Raleigh , Kristopher P. Mount , Kenneth W. Mitchell , Michael A. Bohnet
发明人： Mark H. Machina , Michael Raleigh , Kristopher P. Mount , Kenneth W. Mitchell , Michael A. Bohnet
IPC分类号： F42B5/03
CPC分类号： F42B10/40 , F41F1/08 , F42B10/60
摘要： A system for firing multiple projectiles in a parallel or diverging manner is provided. The system can comprise tail-end portions of projectiles that add structure to a cartridge, provide for efficient combustion, allow projectiles to transition from a straight configuration in the cartridge to a splayed configuration in a chamber, and ensure complete evacuation of the chamber. The system can include a tail-end portion of a particular projectile with openings that distribute energy from combustion of an ignition charge, facilitating firing of multiple projectiles. A tail-end portion of a projectile can include a ball joint upon which the body portion of the projectile moves causing an angle between the body portion and the tail-end portion. A space can exist in the body portion adjacent to the ball joint to allow off-center shifting of the body portion with respect to the ball joint.
摘要翻译：提供了以平行或分散的方式发射多个射弹的系统。系统可以包括将弹药结构添加到药筒的尾端部分，提供有效的燃烧，允许弹丸从药筒中的直线构型转变为腔室中的张开形状，并确保腔室的完全抽空。该系统可以包括具有开口的特定抛射体的尾端部分，所述开口能够从点火装置的燃烧分配能量，从而有助于多个射弹的燃烧。射弹的尾端部分可以包括一个球窝接头，射弹的主体部分在该球窝接头上移动，导致主体部分和尾端部分之间的角度。在与球接头相邻的主体部分中可以存在空间，以允许主体部分相对于球窝接头偏离中心位移。

7. 发明授权

US08430029B2 Inertial delay fuse 失效
标题翻译：惯性延时保险丝
公开(公告)号：US08430029B2
公开(公告)日：2013-04-30
申请号：US12023320
申请日：2008-01-31
申请人： Michael A. Bohnet , Yeshayahu S. Goldstein , Mark H. Machina , Kristopher P. Mount , Kenneth W. Mitchell
发明人： Michael A. Bohnet , Yeshayahu S. Goldstein , Mark H. Machina , Kristopher P. Mount , Kenneth W. Mitchell
IPC分类号： F42C19/06
CPC分类号： F42C1/00 , F42C1/10 , F42C1/12
摘要： An inertial delay mechanism for use in an explosive projectile is provided. The delay mechanism consists of an inertial delay fuse that is precise, doesn't require sensitive primary explosives and doesn't utilize electronic circuitry. The inertial delay fuse includes a free sliding charge element that strikes an anvil located opposite to the sliding charge element. A delay gap is provided between the sliding charge element and the anvil. Upon impact, the sliding charge element slides forward and impacts the anvil, thereby inducing a shock wave in an initiator charge that subsequently results in detonation of main charges. The design is mechanically simple and robust enough to withstand severe g-loading forces that occur during firing and penetration of a projectile.
摘要翻译：提供了一种用于爆炸弹药的惯性延迟机构。延迟机构由精确的惯性延迟保险丝组成，不需要敏感的主要爆炸物并且不使用电子电路。惯性延迟保险丝包括撞击位于与滑动充电元件相对的砧座的自由滑动充电元件。在滑动充电元件和砧座之间提供延迟间隙。碰撞时，滑动充电元件向前滑动并撞击砧座，从而在起动器充电中引起冲击波，随后导致主电荷的爆震。该设计机械简单，坚固耐用，可承受在射弹射击和穿透期间发生的严重的g-载荷力。

8. 发明授权

US07681504B2 Method and apparatus for displacing material and projectile thereof 失效
标题翻译：用于移动其材料和抛射体的方法和装置
公开(公告)号：US07681504B2
公开(公告)日：2010-03-23
申请号：US10648847
申请日：2003-08-26
申请人： Mark H. Machina , Kenneth W. Mitchell , Floyd P. Swiggett , Michael D. Burke
发明人： Mark H. Machina , Kenneth W. Mitchell , Floyd P. Swiggett , Michael D. Burke
IPC分类号： F42B12/22
CPC分类号： F42B12/367 , F42B10/06
摘要： Hard material can be displaced by firing a frangible projectile from a firing device. The projectile has a rear portion that engages the bore of the barrel of the firing device and a front portion that is rotatably journaled to the rear portion. The front portion can be frangible to allow maximum displacement of the hard material. Specifically, the front portion has a core and a plurality of fins extending from the core. At impact, as the fins penetrate the target, the fins separate from the core and spread radially outwardly from the core.
摘要翻译：硬质材料可以通过从发射装置中射出易碎的射弹来移动。抛射体具有与烧制装置的筒的孔接合的后部和可旋转地轴颈支撑在后部的前部。前部可以是易碎的，以允许硬材料的最大位移。具体而言，前部具有芯部和从芯部延伸的多个翅片。在撞击时，当散热片穿透靶时，翅片与芯分离并从芯径向向外扩散。

9. 发明授权

US06542913B1 Integrated document output management in a hybrid environment 失效
标题翻译：在混合环境中集成文档输出管理
公开(公告)号：US06542913B1
公开(公告)日：2003-04-01
申请号：US09465472
申请日：1999-12-16
申请人： Michael E. Deriso , Michael J. Herrmann , Judy L. Lahti , Kenneth W. Mitchell , Joseph A. Larosa
发明人： Michael E. Deriso , Michael J. Herrmann , Judy L. Lahti , Kenneth W. Mitchell , Joseph A. Larosa
IPC分类号： G06S1500
CPC分类号： G06F17/21
摘要： A customer document management system, which includes customer information store on a mainframe computer, said customer information being updateable from multiple sources. A data consolidator operates on the customer information to compile customer documents, including data reconfiguration into a customer document output database and multiple format output devices driven from the customer document output database.
摘要翻译：一种客户文档管理系统，其包括在主机计算机上的客户信息存储，所述客户信息可从多个来源更新。数据整合器根据客户信息来编译客户文档，包括将数据重新配置到客户文档输出数据库和从客户文档输出数据库驱动的多格式输出设备。

10. 发明授权

US08272327B2 Multiple diverging projectile system 失效
标题翻译：多发射射弹系统
公开(公告)号：US08272327B2
公开(公告)日：2012-09-25
申请号：US12604018
申请日：2009-10-22
申请人： Mark H. Machina , Michael Raleigh , Kristopher P. Mount , Kenneth W. Mitchell , Michael A. Bohnet
发明人： Mark H. Machina , Michael Raleigh , Kristopher P. Mount , Kenneth W. Mitchell , Michael A. Bohnet
IPC分类号： F42B10/06
CPC分类号： F42B10/40 , F41F1/08 , F42B10/60
摘要： A system for firing multiple projectiles in a parallel or diverging manner is provided. The system can comprise tail-end portions of projectiles that add structure to a cartridge, provide for efficient combustion, allow projectiles to transition from a straight configuration in the cartridge to a splayed configuration in a chamber, and ensure complete evacuation of the chamber. The system can include a tail-end portion of a particular projectile with openings that distribute energy from combustion of an ignition charge, facilitating firing of multiple projectiles. A tail-end portion of a projectile can include a ball joint upon which the body portion of the projectile moves causing an angle between the body portion and the tail-end portion. A space can exist in the body portion adjacent to the ball joint to allow off-center shifting of the body portion with respect to the ball joint.
摘要翻译：提供了以平行或分散的方式发射多个射弹的系统。系统可以包括将弹药结构添加到药筒的尾端部分，提供有效的燃烧，允许弹丸从药筒中的直线构型转变为腔室中的张开形状，并确保腔室的完全抽空。该系统可以包括具有开口的特定抛射体的尾端部分，所述开口能够从点火装置的燃烧分配能量，从而有助于多个射弹的燃烧。射弹的尾端部分可以包括一个球窝接头，射弹的主体部分在该球窝接头上移动，从而在主体部分和尾端部分之间产生角度。在与球接头相邻的主体部分中可以存在空间，以允许主体部分相对于球窝接头偏离中心位移。

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