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    • 1. 发明授权
    • Porous hydroxyapatite material for artificial bone substitute
    • 多孔羟基磷灰石材料为人造骨替代品
    • US4629464A
    • 1986-12-16
    • US770722
    • 1985-08-29
    • Susumu TakataShoichi WakabayashiHiroyasu NomaTatsuya Wakatsuki
    • Susumu TakataShoichi WakabayashiHiroyasu NomaTatsuya Wakatsuki
    • A61F2/00A61F2/28A61F2/30A61L27/12A61L27/46C04B35/447C04B38/00C07C61/06
    • C04B38/0051A61F2/28A61F2/30767A61L27/12A61L27/46C04B35/447A61F2002/30011A61F2002/3092A61F2002/30968A61F2250/0023A61F2310/00293C04B2111/00836
    • The sintered microporous hydroxyapatite material of the invention is useful as an artificial bone substitute material either in a granular and slurried from in a physiological saline solution used as a filling material for lost portions or cavities of bones or in a form of a shaped prosthetic bone substitute member. The inventive material is characteristic in the open pore structure of micropores with a pore diameter distribution in the range from 0.01 to 0.10 mm and a porosity in the range from 20 to 50%. When the material is used in the form of a granular bone filling, the particle diameter thereof should be in the range from 0.1 to 2.0 mm. When the material is used as the prosthetic bone substitute member, the shaped body should be formed of the matrix of the inventive microporous material and pores with a pore diameter distribution in the range from 0.2 to 2.0 mm. When an increased bending strength is desired, the prosthetic member should preferably have a core-and-crust structure of which the matrix of the core portion and the crust layer having a thickness of 0.1 to 2 mm are formed of the inventive microporous material, the core portion being formed of the matrix and pores of 0.2 to 2.0 mm diameter distribution throughout the matrix.
    • 本发明的烧结微孔羟基磷灰石材料可用作颗粒状并在生理盐水溶液中制成的人造骨替代材料,所述生理盐水溶液用作骨丢失部分或空腔的填充材料或成形的假体骨替代物 会员。 本发明的材料在孔径分布范围为0.01至0.10mm,孔隙率为20至50%的微孔的开孔结构中是特征的。 当以粒状骨填充的形式使用材料时,其粒径应在0.1〜2.0mm的范围内。 当该材料用作假体骨替代部件时,成形体应由本发明的微孔材料的基体和孔径分布范围为0.2至2.0mm的孔形成。 当需要增加的弯曲强度时,假体构件应该优选具有芯壳结构,其中核心部分的基体和厚度为0.1至2mm的外壳层由本发明的微孔材料形成, 核心部分由矩阵形成,并且整个矩阵的直径分布为0.2至2.0mm的孔。