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    • 1. 发明申请
    • Composition Containing Anti-Dementia Drug
    • 含抗痴呆药物的组合物
    • US20090023778A1
    • 2009-01-22
    • US11919416
    • 2006-04-28
    • Susumu KimuraYosuke UekiMasami NoharaYukifumi DotaSatomi Horiike
    • Susumu KimuraYosuke UekiMasami NoharaYukifumi DotaSatomi Horiike
    • A61K31/4353A61K31/13
    • A61K47/38A61K9/2027A61K9/2054A61K9/209A61K9/2846A61K9/2866A61K9/5084A61K31/13A61K31/445A61K45/06A61K2300/00
    • An object of the present invention is to provide, for the case of implementing a therapeutic method in which at least two kinds of anti-dementia drugs are used together, a composition that has a good therapeutic effect on dementia, and also gives excellent compliance. Another object of the present invention is to provide a composition containing at least two kinds of anti-dementia drugs, in which release of the anti-dementia drugs from the composition is controlled, whereby a combined effect of the anti-dementia drugs can be achieved well. Still another object of the present invention is to provide a composition for which the frequency of administration and the amount taken are reduced and hence compliance can be improved, and a method of manufacturing such a composition. According to the present invention, there is provided a composition containing at least two kinds of anti-dementia drugs; such a composition containing at least one sustained-release portion containing an anti-dementia drug; and such a composition containing at least one cholinesterase inhibitor, and at least one N-methyl-D-aspartate receptor antagonist.
    • 本发明的目的是提供一种治疗方法,其中使用至少两种抗痴呆药物,对痴呆具有良好治疗效果的组合物,并且还具有优异的依从性。 本发明的另一个目的是提供一种含有至少两种抗痴呆药物的组合物,其中控制抗痴呆药物从组合物的释放,由此可以实现抗痴呆药物的组合效果 好。 本发明的另一个目的是提供一种组合物,其给药频率和使用量减少,因此可以提高顺应性,以及制备这种组合物的方法。 根据本发明,提供了含有至少两种抗痴呆药物的组合物, 这种组合物含有至少一种含有抗痴呆药物的缓释部分; 和含有至少一种胆碱酯酶抑制剂和至少一种N-甲基-D-天冬氨酸受体拮抗剂的组合物。
    • 2. 发明申请
    • Composition containing anti-dementia drug
    • 含有抗痴呆药物的组合物
    • US20060246003A1
    • 2006-11-02
    • US11414367
    • 2006-06-29
    • Susumu KimuraYosuke UekiSatoshi FujiokaMasami NoharaYukifumi Dota
    • Susumu KimuraYosuke UekiSatoshi FujiokaMasami NoharaYukifumi Dota
    • A61K51/00
    • A61K9/2018A61K9/209A61K31/13A61K31/445A61K45/06A61K2300/00
    • An object of the present invention is to provide, for the case of implementing a therapeutic method in which at least two kinds of anti-dementia drugs are used together, a composition that has a good therapeutic effect on dementia, and also gives excellent compliance. Another object of the present invention is to provide a composition containing at least two kinds of anti-dementia drugs, in which release of the anti-dementia drugs from the composition is controlled, whereby a combined effect of the anti-dementia drugs can be achieved well. Still another object of the present invention is to provide a composition for which the frequency of administration and the amount taken are reduced and hence compliance can be improved, and a method of manufacturing such a composition. According to the present invention, there is provided a composition containing at least two kinds of anti-dementia drugs; such a composition containing at least one sustained-release portion containing an anti-dementia drug; and such a composition containing at least one cholinesterase inhibitor, and at least one N-methyl-D-aspartate receptor antagonist.
    • 本发明的目的是提供一种治疗方法,其中使用至少两种抗痴呆药物,对痴呆具有良好治疗效果的组合物,并且还具有优异的依从性。 本发明的另一个目的是提供一种含有至少两种抗痴呆药物的组合物,其中控制抗痴呆药物从组合物的释放,由此可以实现抗痴呆药物的组合效果 好。 本发明的另一个目的是提供一种组合物,其给药频率和使用量减少,因此可以提高顺应性,以及制备这种组合物的方法。 根据本发明,提供了含有至少两种抗痴呆药物的组合物, 这种组合物含有至少一种含有抗痴呆药物的缓释部分; 和含有至少一种胆碱酯酶抑制剂和至少一种N-甲基-D-天冬氨酸受体拮抗剂的组合物。