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1. 发明申请

US20110269826A1 Method 审中-公开
标题翻译：方法
公开(公告)号：US20110269826A1
公开(公告)日：2011-11-03
申请号：US13128813
申请日：2009-11-11
申请人： Susan M. Kingsman , Alan J. Kingsman , Scott Ralph , Kyriacos A. Mitrophanous , Stephane Palfi , Bechir Jarraya
发明人： Susan M. Kingsman , Alan J. Kingsman , Scott Ralph , Kyriacos A. Mitrophanous , Stephane Palfi , Bechir Jarraya
IPC分类号： A61K48/00 , A61P25/14 , A61P25/16
CPC分类号： A61K48/005 , C12N9/0073 , C12N9/78 , C12N9/88 , C12N2799/027 , C12N2799/04 , C12N2840/206 , C12N2840/50
摘要： The present invention provides methods for: (i) treating and/or preventing Parkinson's disease in a subject without causing cognitive impairment by using dopamine replacement gene therapy to maintain or restore constant physiological dopaminergic tone in both the dorsal and ventral striatum of the subject; (ii) normalising neuronal electrical activity in basal ganglia and/or subthalamic nucleus in a Parkinson's disease subject; and (iii) treating and/or preventing dyskinesias associated with oral L-dopa administration in a Parkinson's disease subject by administration of a vector system for dopamine replacement gene therapy to the subject.
摘要翻译：本发明提供了以下方法：（i）通过使用多巴胺替代基因治疗在受试者的背侧和腹侧纹状体中维持或恢复不断的生理多巴胺能调节，治疗和/或预防受试者中的帕金森病，而不引起认知障碍; （ii）在帕金森病受试者的基底神经节和/或丘脑底核中归一化神经元电活动; 和（iii）通过向受试者施用用于多巴胺替代基因治疗的载体系统来治疗和/或预防与帕金森病患者口服左旋多巴给药相关的运动障碍。

2. 发明授权

US06818209B1 Retroviral delivery system 失效
标题翻译：逆转录病毒递送系统
公开(公告)号：US06818209B1
公开(公告)日：2004-11-16
申请号：US09701014
申请日：2000-11-22
申请人： Kyriacos A. Mitrophanous , Deva Patil , Alan J. Kingsman , Susan M. Kingsman , Fiona M. Ellard
发明人： Kyriacos A. Mitrophanous , Deva Patil , Alan J. Kingsman , Susan M. Kingsman , Fiona M. Ellard
IPC分类号： A61K4800
CPC分类号： C12N15/86 , A61K48/00 , C12N2740/13043 , C12N2740/13045 , C12N2740/15043 , C12N2740/15045 , C12N2740/16043 , C12N2740/16045 , C12N2810/60
摘要： A retroviral delivery system capable of transducing a target site is described. The retroviral delivery system comprises a first nucleotide sequence coding for at least a part of an envelope protein; and one or more other nucleotide sequences derivable from a retrovirus that ensure transduction of the target site by the retroviral delivery system; wherein the first nucleotide sequence is heterologous with respect to at least one of the other nucleotide sequences; and wherein the first nucleotide sequence codes for at least a part of a rabies G protein or a mutant, variant, derivative or fragment thereof that is capable or recognising the target site.
摘要翻译：描述了能够转导靶位点的逆转录病毒递送系统。逆转录病毒递送系统包含编码包膜蛋白的至少一部分的第一核苷酸序列; 以及一种或多种其它可逆转录病毒的核苷酸序列，其通过逆转录病毒递送系统确保靶位点的转导; 其中所述第一核苷酸序列相对于所述其它核苷酸序列中的至少一个是异源的; 并且其中所述第一核苷酸序列编码能够或识别所述靶位点的狂犬病G蛋白或突变体，变体，衍生物或片段的至少一部分。

3. 发明授权

US4918166A Particulate hybrid HIV antigens 失效
标题翻译：颗粒杂交HIV抗原
公开(公告)号：US4918166A
公开(公告)日：1990-04-17
申请号：US112083
申请日：1987-10-26
申请人： Alan J. Kingsman , Susan M. Kingsman , Sally E. Adams
发明人： Alan J. Kingsman , Susan M. Kingsman , Sally E. Adams
IPC分类号： C07K14/11 , C07K14/16 , C12N15/62 , C12N15/81 , C12N15/90
CPC分类号： C12N15/90 , C07K14/005 , C12N15/62 , C12N15/81 , C07K2319/00 , C07K2319/40 , C12N2740/16122 , Y10S530/806 , Y10S530/812 , Y10S530/824 , Y10S530/826
摘要： Fusion proteins comprise a77 first amino acid sequence and a second amino acid sequence. The first amino acid sequence is derived from a retrotransposon or an RNA retrovirus and confers on the fusion protein the ability to assemble into particles; an example is the product of the YTA gene of the yeast retrotransposon Ty. The second amino acid sequence is an HIV antigen. So particles formed of the fusion proteins may be useful in vaccines or in diagnostic or purification applications.
摘要翻译：融合蛋白包含77个第一氨基酸序列和第二个氨基酸序列。第一个氨基酸序列衍生自反转录转座子或RNA逆转录病毒，并赋予融合蛋白质组装成粒子的能力; 一个例子是酵母反转录转座子Ty的YTA基因的产物。第二个氨基酸序列是HIV抗原。因此，由融合蛋白形成的颗粒可用于疫苗或诊断或纯化应用。

4. 发明授权

US4615974A Yeast expression vectors 失效
标题翻译：酵母表达载体
公开(公告)号：US4615974A
公开(公告)日：1986-10-07
申请号：US408826
申请日：1982-08-17
申请人： Alan J. Kingsman , Susan M. Kingsman
发明人： Alan J. Kingsman , Susan M. Kingsman
IPC分类号： C12N15/09 , C07H21/04 , C07K14/56 , C12N1/16 , C12N15/00 , C12N15/81 , C12P21/00 , C12R1/865 , C12N1/18 , C12P21/02
CPC分类号： C07K14/56 , C12N15/81 , Y10S930/142
摘要： There are described a number of plasmid vectors suitable for the expression of genetic material, at various levels in yeasts. The plasmids each comprise a yeast selective marker, a yeast replication origin and a yeast promoter positioned relative to a unique restriction site in such a way that expression may be obtained of a polypeptide coding sequence inserted at the restriction site. The promoters used are derived from the 5' region of a gene coding for a yeast glycolytic enzyme e.g. phosphoglycerate kinase (PGK), or from the 5' region of the yeast TRP1 gene. In one Example a plasmid contains a promoter derived from both the 3' and 5' regions of the PGK gene. The replication systems used involve the yeast 2.mu. replication origin or an autonomous replicating sequence (ARS) stabilized with an ARS stabilizing sequence (ASS). The replication systems allow for a choice of high or low copy number per cell. The promoter sequences allow for a choice of high or low expression level. A kit including vectors having a combination of these alternative features is described. Yeast expression vectors including a gene for coding for human interferon-.alpha. are described.
摘要翻译：描述了许多适于在酵母中各种水平表达遗传物质的质粒载体。质粒各自包含酵母选择性标记，酵母复制起点和相对于独特的限制性位点定位的酵母启动子，使得可以获得插入限制性位点的多肽编码序列的表达。所用的启动子来源于编码酵母糖酵解酶的基因的5'区域，磷酸甘油酸激酶（PGK），或来自酵母TRP1基因的5'区。在一个实施例中，质粒含有源自PGK基因的3'和5'区两者的启动子。所使用的复制系统涉及用ARS稳定序列（ASS）稳定的酵母2微复制起点或自主复制序列（ARS）。复制系统允许每个单元格选择高或低拷贝数。启动子序列允许选择高或低表达水平。描述了包括具有这些替代特征的组合的载体的试剂盒。描述了包含用于编码人类干扰素-α的基因的酵母表达载体。

5. 发明授权

US5041385A Vector expressing fusion proteins and particles 失效
标题翻译：载体表达融合蛋白和颗粒
公开(公告)号：US5041385A
公开(公告)日：1991-08-20
申请号：US36807
申请日：1987-04-10
申请人： Alan J. Kingsman , Susan M. Kingsman , Sally E. Adams , Michael H. Malim , Elizabeth-Jane C. Mellor
发明人： Alan J. Kingsman , Susan M. Kingsman , Sally E. Adams , Michael H. Malim , Elizabeth-Jane C. Mellor
IPC分类号： C07K14/11 , C07K14/16 , C07K14/555 , C12N15/33 , C12N15/62 , C12N15/81 , C12N15/90
CPC分类号： C07K14/005 , C07K14/555 , C12N15/62 , C12N15/81 , C12N15/90 , C07K2319/00 , C07K2319/40 , C07K2319/75 , C12N2740/16122 , C12N2740/16222 , C12N2760/16022 , C12N2760/16122
摘要： Fusion proteins comprising a first amino acid sequence and a second amino acid sequence are disclosed. The first amino acid sequence is derived from a retrotransposon or an RNA retrovirus and confers on the fusion protein the ability to assemble into particles. The TYA gene of the yeast retrotransposon Ty codes for the first amino acid sequence. The second amino acid sequence is a biologically active antigen. The particles formed by the fusion proteins are useful in vaccines or in diagnostic or purification applications.
摘要翻译：公开了包含第一氨基酸序列和第二氨基酸序列的融合蛋白。第一个氨基酸序列衍生自反转录转座子或RNA逆转录病毒，并赋予融合蛋白质组装成粒子的能力。酵母反转录转座子Ty的TYA基因编码第一个氨基酸序列。第二个氨基酸序列是一种生物活性抗原。由融合蛋白形成的颗粒可用于疫苗或诊断或纯化应用。

6. 发明授权

US07276488B2 Vector system 失效
标题翻译：矢量系统
公开(公告)号：US07276488B2
公开(公告)日：2007-10-02
申请号：US10060585
申请日：2002-01-29
申请人： Alan J. Kingsman , Christopher R. Bebbington , Miles W. Carroll , Fiona M. Ellard , Susan M. Kingsman , Kevin A. Myers
发明人： Alan J. Kingsman , Christopher R. Bebbington , Miles W. Carroll , Fiona M. Ellard , Susan M. Kingsman , Kevin A. Myers
IPC分类号： A61K48/00
CPC分类号： C07K14/485 , A61K2039/505 , C07K14/70532 , C07K16/28 , C07K16/30 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C12N15/87 , C12N2799/027
摘要： The present invention provides a vector system comprising a nucleotide sequence coding for an antibody. In particular, the present invention relates to the use of such a vector system in a subject, where the nucleotide sequence is expressed in vivo to produce said antibody.
摘要翻译：本发明提供了包含编码抗体的核苷酸序列的载体系统。特别地，本发明涉及这样的载体系统在受试者中的用途，其中核苷酸序列在体内表达以产生所述抗体。

7. 发明授权

US5463024A Fusion proteins and particles 失效
标题翻译：融合蛋白和颗粒
公开(公告)号：US5463024A
公开(公告)日：1995-10-31
申请号：US115397
申请日：1993-09-01
申请人： Alan J. Kingsman , Susan M. Kingsman , Sally E. Adams , Elizabeth J. C. Mellor , Michael H. Malim
发明人： Alan J. Kingsman , Susan M. Kingsman , Sally E. Adams , Elizabeth J. C. Mellor , Michael H. Malim
IPC分类号： C07K14/11 , C07K14/16 , C07K14/555 , C12N15/33 , C12N15/62 , C12N15/81 , C12N15/90 , C07K1/00 , C12N15/58
CPC分类号： C07K14/005 , C07K14/555 , C12N15/62 , C12N15/81 , C12N15/90 , C07K2319/00 , C07K2319/40 , C07K2319/75 , C12N2740/16122 , C12N2740/16222 , C12N2760/16022 , C12N2760/16122
摘要： Fusion proteins comprise a first amino acid sequence and a second amino acid sequence. The first amino acid sequence is derived from a retrotransposon or an RNA retrovirus and confers on the fusion protein the ability to assemble into particles; an example is the product of the TYA gene of the yeast retrotransposon Ty. The second amino acid sequence is biologically active; for example it may be antigenic. So particles formed of the fusion proteins may be useful in vaccines or in diagnostic or purification applications.
摘要翻译：融合蛋白质包含第一个氨基酸序列和第二个氨基酸序列。第一个氨基酸序列衍生自反转录转座子或RNA逆转录病毒，并赋予融合蛋白质组装成粒子的能力; 一个例子是酵母反转录转座子Ty的TYA基因的产物。第二个氨基酸序列具有生物活性; 例如它可能是抗原性的。因此，由融合蛋白形成的颗粒可用于疫苗或诊断或纯化应用。

8. 发明授权

US5008373A Fusion proteins and particles 失效
标题翻译：融合蛋白和颗粒
公开(公告)号：US5008373A
公开(公告)日：1991-04-16
申请号：US112082
申请日：1987-10-26
申请人： Alan J. Kingsman , Susan M. Kingsman , Sally E. Adams , Elizabeth J. C. Mellor , Michael H. Malim
发明人： Alan J. Kingsman , Susan M. Kingsman , Sally E. Adams , Elizabeth J. C. Mellor , Michael H. Malim
IPC分类号： C07K14/11 , C07K14/16 , C07K14/555 , C12N15/33 , C12N15/62 , C12N15/81 , C12N15/90 , C07K3/00 , C12N15/11
CPC分类号： C07K14/005 , C07K14/555 , C12N15/62 , C12N15/81 , C12N15/90 , C07K2319/00 , C07K2319/40 , C07K2319/75 , C12N2740/16122 , C12N2740/16222 , C12N2760/16022 , C12N2760/16122
摘要： Fusion proteins comprise a first amino acid sequence and a second amino acid sequence. The first amino acid sequence is derived from a retrotransposon or an RNA retrovirus and confers on the fusion protein the ability of assemble into particles; an example is the product of the TYA gene of the yeast retrotransposon Ty. The second amino acid sequence is biologically active; for example, it may be antigenic. So particles formed of the fusion proteins may be useful in vaccines or in diagnostic or purification applications
摘要翻译：融合蛋白质包含第一个氨基酸序列和第二个氨基酸序列。第一个氨基酸序列来源于反转录转座子或RNA逆转录病毒，并赋予融合蛋白质组装成粒子的能力; 一个例子是酵母反转录转座子Ty的TYA基因的产物。第二个氨基酸序列具有生物活性; 例如，它可以是抗原性的。因此，由融合蛋白形成的颗粒可用于疫苗或诊断或纯化应用

9. 发明授权

US4898823A DNA sequence 失效
标题翻译： DNA序列
公开(公告)号：US4898823A
公开(公告)日：1990-02-06
申请号：US165388
申请日：1988-02-29
申请人： Alan J. Kingsman , Susan M. Kingsman
发明人： Alan J. Kingsman , Susan M. Kingsman
IPC分类号： C12N15/00 , C12N1/21 , C12N15/09 , C12N15/81
CPC分类号： C12N15/81
摘要： An upstream activator sequence derived from the yeast PGK gene. The upstream activator sequence is contained in the 5' region of the yeast PGK gene between nucleotides -324 and -455. The upstream activator sequence has synthetic linkers attached to either end to facilitate attachment to a vector. Vectors including the upstream activator sequence and a heterologous promoter sequence are described. The upstream activator sequence is used in a method for increasing the expression level of a yeast expression vector.
摘要翻译： PCT No.PCT / GB84 / 00189 Sec。 371日期1985年1月30日 102（e）日期1985年1月30日PCT申请日1984年5月31日PCT公布。公开号WO84 / 04757 日期1984年12月6日。来自酵母PGK基因的上游激活物序列。上游激活物序列包含在酵母PGK基因的5'区域之间，核苷酸-324和-455之间。上游活化剂序列具有连接到任一端的合成接头以便于与载体的连接。描述了包含上游活化剂序列和异源启动子序列的载体。上游活化剂序列用于增加酵母表达载体的表达水平的方法中。

10. 发明申请

US20080175819A1 VECTOR SYSTEM 审中-公开
标题翻译：矢量系统
公开(公告)号：US20080175819A1
公开(公告)日：2008-07-24
申请号：US11834649
申请日：2007-08-06
申请人： Alan J. Kingsman , Christopher R. Bebbington , Miles W. Carroll , Fiona M. Ellard , Susan M. Kingsman , Kevin A. Myers
发明人： Alan J. Kingsman , Christopher R. Bebbington , Miles W. Carroll , Fiona M. Ellard , Susan M. Kingsman , Kevin A. Myers
IPC分类号： A61K48/00 , A61K31/7088 , A61P31/00 , A61P27/00 , A61P25/00
CPC分类号： C07K14/485 , A61K2039/505 , C07K14/70532 , C07K16/28 , C07K16/30 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C12N15/87 , C12N2799/027
摘要： The present invention provides a vector system comprising a nucleotide sequence coding for an antibody. In particular, the present invention relates to the use of such a vector system in a subject, where the nucleotide sequence is expressed in vivo to produce said antibody.
摘要翻译：本发明提供了包含编码抗体的核苷酸序列的载体系统。特别地，本发明涉及这样的载体系统在受试者中的用途，其中核苷酸序列在体内表达以产生所述抗体。

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